Agri-food global value chains (GVCs) have transformed food production and trade, fostering efficiency and specialization across international borders and also introducing new challenges. This paper synthesizes insights from a special issue focused on agri-food GVCs, addressing four critical areas essential for enhancing the resilience and sustainability of these chains. We explore how trade connections and specialization can drive economic growth, emphasizing the importance of GVC integration. We also examine the role of transportation and infrastructure in ensuring global trade efficiency, highlighting the need for strategic investments to support robust supply chains. Additionally, we assess the impact of trade policies on sustainability, market disruptions, and overall efficiency, underscoring the importance of regulatory frameworks that promote both economic and environmental goals. Finally, we consider the implications of domestic and trade policies on welfare and equity, particularly in developing regions where inclusive growth remains a pressing concern. By identifying these essential areas for robust policy frameworks, this paper provides actionable insights for enhancing the resilience and sustainability of the global food system, which can inform policies that enhance the benefits of agri-food GVC integration while mitigating their risks.