Workflow Integration Research Articles

Using the SEIPS Model to Assess a Maternal Hemorrhage Risk Alert Tool

Deaths resulting from maternal hemorrhage (MH), for example, excessive blood loss related to childbirth, are preventable if the hemorrhage is identified in a timely manner. One approach to support timely identification is the use of alerts. However, alerts with low utility have negative, unanticipated consequences for both clinician and patient outcomes. This study has two objectives: (1) use the Systems Engineering Initiative for Patient Safety model to describe how the MH risk alert tool is used in the care process, and (2) evaluate the utility of the MH risk alert tool from the perspective of the care team. We performed observations to understand the care process and fielded a survey to evaluate the alarm utility. Our results showed that the MH risk alert tool is used throughout the care process, both antepartum and postpartum. Additionally, our results showed that workflow integration, usefulness, and trustworthiness of the alert need to be improved.

Exploring stakeholder perceptions about using artificial intelligence for the diagnosis of rare and atypical infections.

To evaluate critical care provider perspectives about diagnostic practices for rare and atypical infections and the potential for using artificial intelligence (AI) as a decision-support system (DSS). We conducted an anonymous web-based survey among critical care providers at Mayo Clinic Rochester between 11/25/2023 and 1/15/2024, to evaluate their experience with rare and atypical infection diagnostic processes and AI-based DSSs. We also assessed the perceived usefulness of AI-based DSSs, their potential impact on improving diagnostic practices for rare and atypical infections, and the perceived risks and benefits of their use. A total of 47/143 providers completed the survey. 38/47 agreed that there was a delay in diagnosing rare and atypical infections. Among those who agreed, limited assessment of specific patient factors and failure to consider them were the most frequently cited important contributing factors (33/38). 38/47 reported familiarity with the AI-based DSS applications available to critical care providers. Less than half (18/38) thought AI-based DSSs often provided valuable insights for patient care, but almost three quarters (34/47) thought AI-based DDSs often provided valuable insight when specifically asked about their ability to improve the diagnosis of rare and atypical infections. All respondents rated reliability as important in enhancing the perceived utility of AI-based DSSs (47/47) and almost all rated interpretability and integration into the workflow as important (45/47). The primary concern about implementing an AI-based DSS in this context was alert fatigue (44/47). Most critical care providers perceived that there are delays in diagnosing rare infections, indicating inadequate assessment and consideration of the diagnosis as the major contributors. Reliability, interpretability, workflow integration, and alert fatigue emerged as key factors impacting usability of AI-based DSS. These findings will inform the development and implementation of an AI-based diagnostic algorithm to aid in identifying rare and atypical infections.

Using Panel Management to Identify Adult Patients With High-Risk Metabolic Dysfunction-Associated Steatotic Liver Disease/Metabolic Dysfunction-Associated Steatohepatitis Fibrosis in a Primary Care Clinic: A Pilot Study.

As rates of metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH) rise, national organizations have released new guidance for primary care-driven detection of patients with advanced fibrosis who are most likely to have clinically relevant morbidity. Yet time constraints, workflow, and practitioner awareness limit integration of risk identification into clinical care. At the authors' primary care clinic, they implemented a panel management strategy that utilized the electronic health record to identify patients older than 35 years of age at risk for MASLD fibrosis with abnormal Fibrosis-4 (Fib-4) scores. Using a proactive model, these patients were offered elastography-based screening and follow-up appointments focused on metabolic health, with referrals to subspecialty care when indicated. Of 855 patients older than 35 years of age, 384 were identified as having risk factors for MASLD/MASH. Of these, 53 had abnormal Fib-4 scores with no prior work-up; 29 patients consented to a shear wave elastography; 16 underwent shear wave elastography; and 6 had moderate or high results concerning for at-risk fibrosis. Twenty patients attended MASLD-focused appointments. Reluctance to pursue testing was driven by skepticism surrounding preventative medicine, perceived cost, and desire to focus on other medical problems, some of which were life-limiting. Panel management represents a scalable strategy to quickly identify patients in primary care most likely to experience complications from MASLD/MASH and provides a targeted intervention to direct further management. Limitations include access to care, medical complexity, and patient acceptance.

Paper-and-Pencil vs. Electronic Patient Records: Analyzing Time Efficiency, Personnel Requirements, and Usability Impacts on Healthcare Administration.

Background: This study investigates the impact of transitioning from paper and pencil (P&P) methods to electronic patient records (EPR) on workflow and usability in surgical ward rounds. Methods: Surgical ward rounds were audited by two independent observers to evaluate the effects of transitioning from P&P to EPR. Key observations included the number of medical personnel and five critical workflow aspects before and after EPR implementation. Additionally, usability was assessed using the System Usability Scale (SUS) and the Post-Study System Usability Questionnaire (PSSUQ). Results: A total of 192 P&P and 160 EPR observations were analyzed. Physicians experienced increased administrative workload with EPR, while nurses adapted more easily. Ward teams typically consisted of two physicians and three or four nurses. Usability scores rated the system as "Not Acceptable" across all professional groups. Conclusions: The EPR system introduced usability challenges, particularly for physicians, despite potential benefits like improved data access. Usability flaws hindered system acceptance, highlighting the need for better workflow integration. Addressing these issues could improve efficiency and reduce administrative strain. As artificial intelligence becomes more integrated into clinical practice, healthcare professionals must critically assess AI-driven tools to ensure safe and effective patient care.

Implementation of a bundle to improve diagnosis in hospitalized patients: lessons learned.

The inpatient setting is a challenging clinical environment where systems and situational factors predispose clinicians to making diagnostic errors. Environmental complexities limit trialing of interventions to improve diagnostic error in active inpatient clinical settings. Informed by prior work, we piloted a multi-component intervention designed to reduce diagnostic error to understand its feasibility and uptake. From September 2018 to June 2019, we conducted a prospective, pre-test/post-test pilot study of hospital medicine physicians during admitting shifts at a tertiary-care, academic medical center. Optional intervention components included use of dedicated workspaces, privacy barriers, noise cancelling headphones, application-based breathing exercises, a differential diagnosis expander application, anda checklist to enable a diagnostic pause. Participants rated their confidence in patient diagnoses and completed a survey on intervention component use. Data on provider resource utilization and patient diagnoses were collected, and qualitative interviews were held with a subset of participants in order to better understand experience with the intervention. Data from 37 physicians and 160 patients were included. No intervention component was utilized by more than 50 % of providers, and no differences were noted in diagnostic confidence or number of diagnoses documented pre-vs. post-intervention. Lab utilization increased, but there were no other differences in resource utilization during the intervention. Qualitative feedback highlighted workflow integration challenges, among others, for poor intervention uptake. Our pilot study demonstrated poor feasibility and uptake of an intervention designed to reduce diagnostic error. This study highlights the unique challenges of implementing solutions within busy clinical environments.

Artificial Intelligence in Oral and Maxillofacial Surgery: Bridging the Gap between Technology and Clinical Practice a Narrative Review

Objective: To provide a comprehensive overview of current applications and future prospects of artificial intelligence (AI) in oral and maxillofacial surgery (OMFS), while critically analyzing implementation challenges and exploring potential advancements.  Methods A systematic literature review was conducted using PubMed/MEDLINE and Embase databases, encompassing English-language articles up to December 30, 2023. Search terms combined OMFS and AI concepts, with database-specific syntax employed.  Results AI applications in OMFS span multiple domains, including image analysis, surgical planning, intraoperative guidance, and clinical decision support. Deep learning models have demonstrated high accuracy in detecting mandibular fractures, performing cephalometric analyses, and classifying maxillofacial pathologies. AI-enhanced surgical planning and robotic systems show promise in improving precision and outcomes across various OMFS procedures. However, challenges persist in data quality, clinical validation, and seamless workflow integration.  Conclusions AI technologies have the potential to significantly enhance diagnostic accuracy, surgical precision, and treatment outcomes in OMFS. Future research directions include developing multimodal AI systems, advancing AI-powered surgical navigation, and exploring federated learning approaches. Successful implementation of AI in OMFS practice will require collaborative efforts among clinicians, researchers, engineers, and policymakers to address technical, ethical, and regulatory challenges. As these hurdles are overcome, AI is poised to become an integral part of OMFS, augmenting surgical capabilities and elevating patient care standards.

Optimizing Construction Management and Workflow Integration through Autonomous Robotics for Enhanced Productivity Safety and Precision on Modern Construction Sites

The construction industry is experiencing a technological transformation with the integration of robotics, fundamentally altering traditional construction management and process design. This review explores the role of construction robots in enhancing productivity, safety, and efficiency on construction sites. It examines the various types of robots used, such as bricklaying and welding robots, and analyzes their functions and real-world applications. The paper also addresses the design of workflows and processes around robots, highlighting the challenges and strategies involved in adapting construction projects to a robot-centric approach. Additionally, the impact of robotics on construction management, including shifts in roles, cost efficiency, and collaboration between humans and robots, is thoroughly explored. The review concludes by identifying future trends, challenges, and opportunities in the field of construction robotics, along with relevant policy and regulatory considerations. This paper aims to provide insights into how construction management must evolve to successfully integrate robots, leading to a more efficient, cost effective, and safe construction environment.

GenAI for Scientific Discovery in Electrochemical Energy Storage: State-of-the-Art and Perspectives from Nano- and Micro-Scale.

The transition to electric vehicles (EVs) and the increased reliance on renewable energy sources necessitate significant advancements in electrochemical energy storage systems. Fuel cells, lithium-ion batteries, and flow batteries play a key role in enhancing the efficiency and sustainability of energy usage in transportation and storage. Despite their potential, these technologies face limitations such as high costs, material scarcity, and efficiency challenges. This research introduces a novel integration of Generative AI (GenAI) within electrochemical energy storage systems to address these issues. By leveraging advanced GenAI techniques like Generative Adversarial Networks, autoencoders, diffusion and flow-based models, and multimodal large language models, this paper demonstrates significant improvements in material discovery, battery design, performance prediction, and lifecycle management across different types of electrochemical storage systems. The research further emphasizes the importance of nano- and micro-scale interactions, providing detailed insights into optimizing these interactions for improved efficiency and longevity. Additionally, the paper discusses the challenges and future directions for integrating GenAI in energy storage research, highlighting the importance of data quality, model transparency, workflow integration, scalability, and ethical considerations. By addressing these aspects, this research sets a new benchmark for the use of GenAI in battery development, promoting sustainable, efficient, and safer energy solutions.

End user experience of a widely used artificial intelligence based sepsis system.

Research on the Epic Sepsis System (ESS) has predominantly focused on technical accuracy, neglecting the user experience of healthcare professionals. Understanding these experiences is crucial for the design of Artificial Intelligence (AI) systems in clinical settings. This study aims to explore the socio-technical dynamics affecting ESS adoption and use, based on user perceptions and experiences. Resident doctors and nurses with recent ESS interaction were interviewed using purposive sampling until data saturation. A content analysis was conducted using Dedoose software, with codes generated from Sittig and Singh's and Salwei and Carayon's frameworks, supplemented by inductive coding for emerging themes. Interviews with 10 healthcare providers revealed mixed but generally positive or neutral perceptions of the ESS. Key discussion points included its workflow integration and usability. Findings were organized into 2 main domains: workflow fit, and usability and utility, highlighting the system's seamless electronic health record integration and identifying design gaps. This study offers insights into clinicians' experiences with the ESS, emphasizing the socio-technical factors that influence its adoption and effective use. The positive reception was tempered by identified design issues, with clinician perceptions varying by their professional experience and frequency of ESS interaction. The findings highlight the need for ongoing ESS refinement, emphasizing a balance between technological advancement and clinical practicality. This research contributes to the understanding of AI system adoption in healthcare, suggesting improvements for future clinical AI tools.

Integration of structural designers workflows into BIM

BIM has revolutionized architectural design workflows. In this process, the work of structural engineers is based on the work of many other disciplines, and their decisions are input data for them. However, these data are not always provided in a structured form. Live load and composite load values are typically such data, which may change very frequently during the design process. This research explores BIM-based tools for interdisciplinary collaboration between architectural and structural disciplines, focusing on managing design changes. In this article, automatic load definition possibilities were explored and adapted to the BIM methodology by using Archicad, Revit and Allplan. The software options and their logic differed greatly, but the principled methodology can be applied in each case. It was demonstrated that by linking the database-based load values to the model, the load cases can be generated more or less automatically for which the structural analysis can be run.

Real-world performance of integrative clinical genomics in pediatric precision oncology

Despite significant improvement in the survival of pediatric cancer patients, treatment outcomes for high-risk, relapsed, and refractory cancers remain unsatisfactory. Moreover, prolonged survival is frequently associated with long-term adverse effects due to intensive multimodal treatments. Accelerating the progress of pediatric oncology requires both therapeutic advances and strategies to mitigate the long-term cytotoxic side effects, potentially through targeting specific molecular drivers of pediatric malignancies. In this report, we present the results of integrative genomic and transcriptomic profiling of 230 patients with malignant solid tumors (the “primary cohort”) and 18 patients with recurrent or otherwise difficult-to-treat nonmalignant conditions (the “secondary cohort”). The integrative workflow for the primary cohort enabled the identification of clinically significant single-nucleotide variants, small insertions/deletions, and fusion genes, which were found in 55% and 28% of patients, respectively. For 38% of patients, molecularly informed treatment recommendations were made. In the secondary cohort, known or potentially driving alteration was detected in 89% of cases, including a suspected novel causal gene for patients with inclusion body infantile digital fibromatosis. Furthermore, 47% of findings also brought therapeutic implications for subsequent management. Across both cohorts, changes or refinements to the original histopathological diagnoses were achieved in 4% of cases. Our study demonstrates the efficacy of integrating advanced genomic and transcriptomic analyses to identify therapeutic targets, refine diagnoses, and optimize treatment strategies for challenging pediatric and young adult malignancies and underscores the need for broad implementation of precision oncology in clinical settings.

Integration of the passive energy balancing based actuation system into a camber morphing design

A spiral pulley mechanism can be used to passively balance the energy between the morphing structure and actuation system. Applying the energy balancing concept has the potential to improve the performance of the actuation system by reducing the external energy consumption. In the current study, the integration workflow for the passive energy balancing device is established and is adopted in a variable camber morphing wing. The design variables of the passive energy balancing system are optimised and the effects of the different parameters are discussed together with the adaptability of the passive energy balancing device when the load stiffness changes. An integrated demonstrator was also built to validate the mechanism by measuring the currents in the process of morphing actuation.

Systematic analysis of SARS-CoV-2 Omicron subvariants' impact on B and T cell epitopes.

Epitopes are specific structures in antigens that are recognized by the immune system. They are widely used in the context of immunology-related applications, such as vaccine development, drug design, and diagnosis / treatment / prevention of disease. The SARS-CoV-2 virus has represented the main point of interest within the viral and genomic surveillance community in the last four years. Its ability to mutate and acquire new characteristics while it reorganizes into new variants has been analyzed from many perspectives. Understanding how epitopes are impacted by mutations that accumulate on the protein level cannot be underrated. With a focus on Omicron-named SARS-CoV-2 lineages, including the last WHO-designated Variants of Interest, we propose a workflow for data retrieval, integration, and analysis pipeline for conducting a database-wide study on the impact of lineages' characterizing mutations on all T cell and B cell linear epitopes collected in the Immune Epitope Database (IEDB) for SARS-CoV-2. Our workflow allows us to showcase novel qualitative and quantitative results on 1) coverage of viral proteins by deposited epitopes; 2) distribution of epitopes that are mutated across Omicron variants; 3) distribution of Omicron characterizing mutations across epitopes. Results are discussed based on the type of epitope, the response frequency of the assays, and the sample size. Our proposed workflow can be reproduced at any point in time, given updated variant characterizations and epitopes from IEDB, thereby guaranteeing to observe a quantitative landscape of mutations' impact on demand. A big data-driven analysis such as the one provided here can inform the next genomic surveillance policies in combatting SARS-CoV-2 and future epidemic viruses.

Active diagnostic ingredients (ADIs) for PCR: A mini-bioreactor producing dNTPs with silica immobilized R5-kinases.

Low availability of routine nucleic acid amplification testing (NAAT) during infection outbreaks, especially in less resourced environments, was highlighted by the Covid pandemic. One of the barriers lies with the supply chain and cost of the active diagnostic ingredients (ADIs) that are the reagents for NAATs. This work explores a novel synthesis method to produce a key NAAT reagent, namely the 2'-deoxynucleoside 5'-triphosphate (dNTPs), via a reusable enzyme bioreactor, that can be integrated into a NAAT workflow. A self-immobilizing R5-silaffin kinase fusion enzyme was designed for immobilization on silica, converting dNMPs to their respective dNTP ADIs for PCR in a R5-kinase mini-bioreactor, designed to be implemented in a reusable device, stable over 2 months, when stored at 4°C. The performance is demonstrated for PCR reactions of the lambda genome and showed successful amplification up to 7.5 kb. In comparison with commercial dNTPs, in Plasmodium malariae NAATs, a high linear correlation was shown between the Ct value and the log(Copy Number), with lower incidence of false positives than with the commercial dNTPs. Overall a pathway to generate deoxynucleotides from monophosphate precursors was demonstrated, and an immobilized enzyme mini-bioreactor investigated as a proof-of-principle for work-flow integration with NAAT in low-resource research and diagnostics labs.

A Multi-step Integrative Workflow Implementation to Improve Documentation of Point of Care Ultrasound in Medical Intensive Care Unit.

Point of care ultrasound (POCUS) provides quick bedside assessment for diagnosing and managing life-threatening conditions in critical care medicine. There has been increasing interest in developing infrastructure to archive images, record clinical interpretation, assess quality, and recoup revenue for POCUS. We present a simple workflow by systems integration of electronic medical record, ultrasound machines, picture archiving, and communication system to facilitate POCUS documentation and billing. We recorded a trend on the number of POCUS performed before and after introduction of the structured integration. We observed and recorded a linear increase over time post-intervention. Our innovative and integrated POCUS workflow is an effective way to document and bill POCUS.

Reporting of asthma mobile health data for clinical practice: a qualitative study of pediatric provider perspectives

Objective Mobile health (mHealth), defined as the use of mobile phones or applications in healthcare, has been developed to enhance asthma care; yet implementation is inconsistent, and few studies have focused on provider perspectives on use in daily practice. The purpose of this study was to explore primary care pediatric provider perspectives regarding mHealth use in clinical practice for children with asthma. Methods A qualitative, descriptive approach was utilized to perform semi-structured interviews on asthma mHealth use with providers caring for children with asthma. Interview transcripts were coded by two independent investigators and any differences were reconciled. Interviews continued until thematic saturation was achieved. Results and Conclusions Seventeen pediatric providers were recruited and interviewed. Three themes identified included implementation benefits, implementation barriers, and reporting desires, with 11 subthemes. Many subthemes were consistent across providers (e.g. self-management benefits and electronic medical record integration), while others such as provider clinical burden and approach to integrating mHealth data reports into daily workflow demonstrated variability. Provider perspectives highlight the potential of mHealth applications in asthma self-management while offering challenges related to clinical burden and suggestions for reporting and workflow integration. These results provide valuable perspectives on mHealth use and reporting to ensure provider efficiency and technology-enhanced asthma care. This study investigates pediatric provider perspectives on asthma mobile health use and reporting in daily practice, a topic that has not sufficiently been explored within the literature. Results can guide best practices, encourage more consistent use, and maximize the benefits of asthma mHealth tools by providers.

The Role of Artificial Intelligence and Machine Learning in Cardiovascular Imaging and Diagnosis.

Cardiovascular diseases remain the leading cause of global mortality, underscoring the critical need for accurate and timely diagnosis. This narrative review examines the current applications and future potential of artificial intelligence (AI) and machine learning (ML) in cardiovascular imaging. We discuss the integration of these technologies across various imaging modalities, including echocardiography, computed tomography, magnetic resonance imaging, and nuclear imaging techniques. The review explores AI-assisted diagnosis in key areas such as coronary artery disease detection, valve disorders assessment, cardiomyopathy classification, arrhythmia detection, and prediction of cardiovascular events. AI demonstrates promise in improving diagnostic accuracy, efficiency, and personalized care. However, significant challenges persist, including data quality standardization, model interpretability, regulatory considerations, and clinical workflow integration. We also address the limitations of current AI applications and the ethical implications of their implementation in clinical practice. Future directions point towards advanced AI architectures, multimodal imaging integration, and applications in precision medicine and population health management. The review emphasizes the need for ongoing collaboration between clinicians, data scientists, and policymakers to realize the full potential of AI in cardiovascular imaging while ensuring ethical and equitable implementation. As the field continues to evolve, addressing these challenges will be crucial for the successful integration of AI technologies into cardiovascular care, potentially revolutionizing diagnostic capabilities and improving patient outcomes.

A large language model-based clinical decision support system for syncope recognition in the emergency department: A framework for clinical workflow integration

Differentiation of syncope from transient loss of consciousness can be challenging in the emergency department (ED). Natural Language Processing (NLP) enables the analysis of free text in the electronic medical records (EMR).The present paper aimed to develop a large language models (LLM) for syncope recognition in the ED and proposed a framework for model integration within the clinical workflow.Two models, based on both the Italian and Multilingual Bidirectional Encoder Representations from Transformers (BERT) language model, were developed using consecutive EMRs. The “triage” model was only based on notes contained in the “triage” section of the EMR. The “anamnesis” model added data contained in the “medical history” section. Interpretation and calibration plots were generated.The Italian and Multi BERT models were developed and tested on both 15,098 and 15,222 EMRs, respectively. The triage model had an AUC of 0·95 for the Italian BERT and 0·94 for the Multi BERT. The anamnesis model had an AUC of 0·98 for the Italian BERT and 0·97 for Multi BERT. The LLM identified syncope when not explicitly mentioned in the EMR and also recognized common prodromal symptoms preceding syncope.Both models identified syncope patients in the ED with a high discriminative capability from nurses and doctors’ notes, thus potentially acting as a tool helping physicians to differentiate syncope from others transient loss of consciousness.

Decentralized food safety and authentication on cellulose paper-based analytical platform: A review.

Food safety and authenticity analysis play a pivotal role in guaranteeing food quality, safeguarding public health, and upholding consumer trust. In recent years, significant social progress has presented fresh challenges in the realm of food analysis, underscoring the imperative requirement to devise innovative and expedient approaches for conducting on-site assessments. Consequently, cellulose paper-based devices (PADs) have come into the spotlight due to their characteristics of microchannels and inherent capillary action. This review summarizes the recent advances in cellulose PADs in various food products, comprising various fabrication strategies, detection methods such as mass spectrometry and multi-mode detection, sampling and processing considerations, as well as applications in screening food safety factors and assessing food authenticity developed in the past 3 years. According to the above studies, cellulose PADs face challenges such as limited sample processing, inadequate multiplexing capabilities, and the requirement for workflow integration, while emerging innovations, comprising the use of simplified sample pretreatment techniques, the integration of advanced nanomaterials, and advanced instruments such as portable mass spectrometer and the innovation of multimodal detection methods, offer potential solutions and are highlighted as promising directions. This review underscores the significant potential of cellulose PADs in facilitating decentralized, cost-effective, and simplified testing methodologies to maintain food safety standards. With the progression of interdisciplinary research, cellulose PADs are expected to become essential platforms for on-site food safety and authentication analysis, thereby significantly enhancing global food safety for consumers.

Archaeological investigation of burials preluded by ground penetrating radar and geospatial technologies

Ground penetrating radar (GPR) is a non-invasive and efficient scientific tool in burial analysis that can 'see the unseen,' answering both simple questions such as the existence and boundaries of burials, as well as more difficult questions like whether burials are intact or decayed. This paper reviews common reflection signatures associated with burials and applies the three fundamental GPR principles (dielectric contrast, scattering and polarity of reflections) to two distinct caseworks involving historical graves and civilian burials, which serve as benchmarks with known ground truth. It encompasses a third test case involving family tree research in a civilian cemetery, drawing upon the benchmarked results obtained from the first two caseworks. In adherence to geophysical signal reflection principles, our study discerns distinct hyperbolic traits associated with three burial types including intact shroud-wrapped, coffin burials, and decayed or mass-grave burials. A GPR-geospatial integration workflow incorporating GPR, aerial photogrammetry and global navigation satellite system - real time kinetics (GNSS-RTK), is derived to enhance the identification and investigation of burials using GPR. Our workflow encompasses a range of indicators for survey methods and burial classification, presenting a general framework for the systematic contextualization of tailored workflows to individual contexts. This work exemplifies the efficacy of GPR in the detection of burials that have been undisturbed for over a century in the soils of Hong Kong and how geophysics and geospatial science can address the limitations inherent in conventional desktop-based archaeological investigation. Its implications extend to professionals in diverse fields including historians, archaeologists, cemetery management officials, and even family members searching for their lost loved ones.