Integrity Measurement Research Articles

Violence against Women: Legal, Neuropsychological and Bioethical Analysis in Peru and Mexico

This research study examines gender violence as an attack on human integrity and life as a supreme principle, and its relationship within the Peruvian and Mexican legal framework, with the commitments assumed from the perspective of bioethics. To do so, it investigates bioethics, human integrity and the theories that could promote violence directed at women. Gender violence constitutes a global and public health problem; it is, undoubtedly, a transgression of human rights, where life, human integrity and the right to medical care are clearly violated either by action or inaction in the management of rights and established commitments; that is why it is necessary to propose anticipatory, integrative measures, identify, manage and counteract invisibility, normalization, impunity and appreciate the recovery of the human integrity of each woman. These elements could serve as starting points to separate women from violence and carry out all the necessary actions to prevent violence.

Improved representation of soil moisture processes through incorporation of cosmic-ray neutron count measurements in a large-scale hydrologic model

Abstract. Profound knowledge of soil moisture and its variability plays a crucial role in hydrological modelling to support agricultural management, flood and drought monitoring and forecasting, and groundwater recharge estimation. Cosmic-ray neutron sensing (CRNS) has been recognised as a promising tool for soil moisture monitoring due to its hectare-scale footprint and decimetre-scale measurement depth. But since CRNS provides an integral measurement over several soil horizons, a direct comparison of observed and simulated soil moisture products is not possible. This study establishes a framework to assess the accuracy of soil moisture simulated by the mesoscale Hydrologic Model (mHM) by generating simulated neutron counts and comparing these with observed neutron measurements for the first time. We included three different approaches to estimate CRNS neutron counts in the mHM as a function of the simulated soil moisture profiles: two methods based on the Desilets equation and one based on the forward operator COSMIC (COsmic-ray Soil Moisture Interaction Code). For the Desilets method, we tested two different approaches to average the vertical soil moisture profiles: a uniform vs. a non-uniform weighting scheme depending on the CRNS measurement depth. The methods were tested at two agricultural sites, namely one pasture site and one forest site, in Germany. To explore the prior and posterior distributions of the mHM parameters when constrained by CRNS observations, we used a Monte Carlo method based on Latin hypercube sampling with a large sample size (S = 100 000). We found that all three methods performed well, with a Kling–Gupta efficiency > 0.75 and a percent bias < ± 10 % across the majority of investigated sites and for the best 1 % of parameter sets. The performance of the neutron forward models varied slightly across different land cover types. The non-uniform approach generally showed good performance, particularly at the agricultural sites. On the other hand, the COSMIC method performed slightly better at the forest site. The uniform approach showed slightly better results at the grassland site. We also demonstrated for the first time that the incorporation of CRNS measurements into the mHM could improve both the soil moisture and the evapotranspiration products of the mHM. This suggests that CRNS is capable of improving the model parameter space in general and adds a broader perspective on the potential of CRNS to support large-scale hydrological and land surface models.

Continuous temporal integration in the human visual system.

The human visual system is continuously processing visual information to maintain a coherent perception of the environment. Temporal integration, a critical aspect of this process, allows for the combination of visual inputs over time, enhancing the signal-to-noise ratio and supporting high-level cognitive functions. Traditional methods for measuring temporal integration often require a large number of trials made up of a fixation period, stimuli separated by a blank interval, a single forced choice, and then a pause before the next trial. This trial structure potentially introduces fatigue and biases. Here, we introduce a novel continuous temporal integration (CTI) task designed to overcome these limitations by allowing free visual exploration and continuous mouse responses to dynamic stimuli. Fifty participants performed the CTI, which involved adjusting a red bar to indicate the point where a flickering sine wave grating became indistinguishable from noise. Our results, modeled by an exponential function, indicate a reliable temporal integration window of ∼100 ms. The CTI's design facilitates rapid and reliable measurement of temporal integration, demonstrating potential for broader applications across different populations and experimental settings. This task provides a more naturalistic and efficient approach to understanding this fundamental aspect of visual perception.

Analysis of critical raw materials policy for electrical and electronic equipment: Planning for a truly circular economy

The European Union's objectives under the Green and Digital transitions, are contingent on the decarbonisation of essential sectors such as energy, transportation, and communications. At present, the EU does not have sufficient identified mineral resources, nor processing capacity, to supply many of its strategically defined materials. The success of these objectives hinges on the EU's ability to secure a stable and consistent supply of critical raw materials (CRM). Using a systematic three-part assessment of mandated and non-mandated EU policies, European Commission communications, and a review of CRM, the findings reveal that despite efforts to enhance local supply and diversify foreign sources of CRM, there is a lack of cross-sector coherence across social, economic, and technical aspects of recycling. This is further exacerbated by inefficient retention of waste-hosted critical raw materials. Failure to adopt integrative policy measures may result in the EU's continued dependency on undiversified foreign sources for its supply of critical raw materials, thereby compromising its strategic autonomy as well as the goals of the Green and Digital transitions. Improved design of electrical and electronic equipment and processing of waste from these products could conceivably provide a mechanism for a continuous and retained supply of critical raw materials, culminating in a potentially significant resource stream for the Union. The EU can improve resource efficiency, reduce its dependence on imports, and facilitate a truly circular economy by adopting a comprehensive and symbiotic policy framework that quantifies material resources in waste and that recognises the product design stage as an integral facet of the product recycling stage, herein referred to as “forwardcycling”.

Protecting National Honor: Advocating for Legislation Against Cyber Hate Targeting Pakistan’s Armed Forces

Abstract Cyber hate constitutes a great danger for the Armed Forces of Pakistan, being the reason for diminishing the reputation and culture of discipline among the forces while influencing the general opinion of civilians. Through the discussion of cyberattacks on the military, this article focuses on the ludic nature of military cyberattacks and underlines the necessity for legislative intervention. Lack of respective laws is the main factor behind online defamations and misinformation spread by the Armed Forces. Applying analogy to foreign experience, the article advocates for the implementation of integrated regulatory measures targeted at digital violence. Proposed models provide for jurisprudence and policy principles to provide for strong legal mechanisms that would help formulate holistic national approaches to safeguard the Armed Force’s honor, dignity, and reputation. Nevertheless, these solutions are short of the desired outcomes due to the already highlighted challenges, such as enforcement. The solution to facing these challenges should be to adopt legislative reforms as the main route to maintaining the respect of the Pakistan Armed Forces. Effectively, the reforms can lead the country to stand firmly against the threats that are inherent in the future.

Development of patient-specific pre-treatment verification procedure for FLASH proton therapy based on time resolved film dosimetry.

Pre-clinical studies demonstrate that delivering a high dose at a high dose rate result in less toxicity while maintaining tumor control, known as the FLASH effect. In proton therapy, clinical trials have started using 250MeV transmission beams and more trials are foreseen. A novel aspect of FLASH treatments, compared to conventional radiotherapy, is the importance of dose rate next to dose and geometry. Therefore, to ensure the safety and quality of FLASH treatments, patient-specific dose-rate verification before treatment is an important additional prerequisite. Various definitions of dose rate have been reported, however, the scanning proton beam (PBS) dose rate definition of Folkerts 2020 is currently the most used. It is the ratio between delta dose (ΔD) and delta time (Δt), subject to a predefined threshold, for a given position. Gafchromic film is a widely available detector used to perform relative and absolute integrated dose measurements. Since the response time of film is in the order of micro seconds it could also be suitable for pre-treatment verification of FLASH proton therapy. Development of a patient-specific pre-treatment verification procedure for FLASH proton therapy based on time resolved film dosimetry. The detector design is presented and validated using three tests. A dedicated setup was built that holds a Gafchromic film and a high-speed camera to record the film during the irradiations. The red color channel of the camera's readings was converted into optical density (OD) and an OD-to-dose calibration curve was applied to determine the relative dose accumulation over time. To undo the film measurement (film response) of the post-irradiation coloration process, it is assumed that each dose deposit (pulse) results in a similar film response function. The convolution of the film response function over the pulse provides the film response. First the film response function was obtained by fitting this parameter onto a known film response and corresponding pulse. Post-irradiation coloration correction was performed by deconvoluting all film measurement by the obtained film response function. From the integral of each measured pulse, the Δt was obtained. Several validation tests were conducted: compare the Δt film measurement to a reference detector, exclude that revisiting spots result in an unwanted artefact on the dose accumulation measurement and thereby Δt, and compare Δt distributions of film measurement and simulation (local gamma evaluation, criteria 10%/2 mm) for nine QA fields (dose values; 12, 15, and 20Gy, and, nozzle currents; 25, 120, and 215nA). A similar analysis was performed for three dose optimized treatment beams, with and without scan patterns optimized on local dose rate. Good agreement was found for Δt comparing film to the reference detector, but for Δt values smaller than ∼20ms the error becomes larger (≥15%). Dose accumulation measured with film over time from a single spot is independent of whether the dose is delivered at once, twice or thrice. All gamma evaluations resulted in a gamma pass rate of ≥90%. Time resolved film dosimetry to perform patient-specific pre-treatment verification in FLASH proton therapy is feasible.

No fences, good neighbors: measuring and explaining integration in European cross-border regions

ABSTRACT EU cross-border regions are defined as living laboratories of European integration by scholars and EU institutions. Nonetheless, on the research agenda of EU studies, the study of integration in cross-border regions is not central. Moreover, the dearth of explanatory research has hampered a comprehensive understanding of the determinants of cross-border integration. This article fills these gaps conceptually, theoretically, and empirically. It introduces a new conceptualization anchored in classic integration theories and a new measurement of integration in all 2014–2020 Interreg A programmes. Furthermore, by drawing on a post-functionalist framework and based on multiple linear regression analysis, the study shows that identity pressures, particularly linguistic proximity and a pro-European sentiment, and contextual effects, notably regional authority, are significantly positively correlated with cross-border integration, all other things being equal. The paper thus not only reveals to what extent cross-border regions are integrated but also which explanatory factors are associated with cross-border integration.

Radon Concentration Assessment in Urban Romanian Buildings: A Multistory Analysis

Radon (Rn 222) is a significant contributor to natural radiation exposure in residential environments such as single-family houses and multistory buildings. This study monitored radon activity concentration (RAC) in 455 apartments in 30 multistory buildings in Buzău, Romania. Integrated measurements of the RAC using CR-39 nuclear track detectors were conducted for a period of 3 to 4 months. The results revealed that the RAC varies between buildings, with an annual average between 33 and 77 Bq/m3. This variation may be attributed to poor ventilation and the chimney effect in common ventilation ducts, which may facilitate radon displacement vertically. Also, apartments with low occupancy or inadequate ventilation showed higher radon levels of up to 285 Bq/m3. The study highlights the potential risk of increased radon exposure in energy-efficient buildings due to poor ventilation, emphasizing the need for special attention to radon mitigation measures in building design. The results emphasize that the RAC is influenced by building characteristics, room use, and ventilation, with significant implications for health risks in urban residential environments.

IMPMH, direct tunable diode laser absorption spectroscopy for detection of water vapour under “Optically thick Condition”

Water vapour plays a crucial role in atmospheric processes. Hence, monitoring the altitude-related variations in water vapour properties is important to decipher atmospheric processes. Direct tunable diode laser absorption spectroscopy (dTDLAS) measures the concentration and temperature of gas molecules by scanning the rotation-vibration absorption lines using a high-spectral-resolution laser. In this study, we devised an integrated measurement and data processing method (integrative measurement and processing method for hygrometry, IMPMH) to enhance the in-situ airborne measurement capability of dTDLAS. We measured a wide range (240–18,000 ppm) of water vapour concentrations, aiming for atmospheric measurements in a highly water-saturated regime, called the “optically thick condition”. For recovering the full absorption spectra, the “integrative area” was defined and a difference factor D, which is the distance between two spectral regions with width corresponding to the half width of half maximum of the Voigt profile, was used to calculate the area. From the data, the low-bound concentration was measured to be 244 ppm. At D = 1.8, the transition concentration to the “optically thick condition” was measured to be 5,800 ppm. By increasing D from 1.8 to 2.8, the measurable upper-bound concentration increased to 17,993 ppm. IMPMH was applied to the measured data to estimate the final absorber density or water vapour concentration. The estimation was well-fitted with the measured detector signal with signal-to-noise ratio (SNR) of ∼ 300 of the residual spectrum, promising its applicability to in-situ airborne measurements. To validate IMPMH, the water vapour concentration range was divided into two regimes: (1) optically thick (5,800 < c < 18,000 ppm) and (2) optically thin (c < 5,800 ppm) conditions. Under the optically thick condition, IMPMH was validated by comparing the results between the short and long-path cells. In the optically thin condition, IMPMH was validated through comparison with the general dTDLAS method. Lastly, long-term stability of the dTDLAS system was validated by measuring 10 different concentrations (240–18,000 ppm) for 1000 s by characterising the precision and SNRs of the residual. The results demonstrate that IMPMH significantly enhances the in-situ airborne measurement capability of dTDLAS under both optically thick and thin conditions. Furthermore, requirements for the implementation of IMPMH in airborne measurement were investigated considering four aspects—sampling, low-pressure measurement, accuracy and precision, and multiplex detection. The results were examined with regard to atmospheric implications.

Influence of pre-torsion strengthening on the fatigue properties of 45 CrNiMoVA ultra-high strength steel

Aiming at the demand for fatigue life improvement of 45CrNiMoVA ultra-high strength steel shaft parts, a pre-torsion strengthening process using a combination of two different angles before and after was proposed based on the mechanisms of strain hardening, fine grain strengthening and dislocation strengthening. Through surface integrity measurement, torsional fatigue test and fatigue fracture characterization of the specimens, the main surface integrity factors affecting the fatigue life of the pre-torsion strengthening were analyzed. The results indicated that the grain size was refined and the plastic deformation was increased by the two-angle pre-torsion strengthening compared with the single-angle pre-torsion strengthening. The obtained surface residual compressive stress σx was the main factor affecting the fatigue life of pre-torsion strengthening, and the change in pre-torsion angle results in a significant secondary strengthening layer in the subsurface layer of the material. In summary, the study of the pre-torsion strengthening process with different combinations of angles has a guiding significance for improving the fatigue life of ultra-high strength steel.

Long-Term Afterglow Measurement of Scintillators after Gamma Irradiation

The long-term afterglow of scintillators is an important aspect, especially when the light signal from a scintillator is evaluated in the current mode. Scintillators used for radiation detection exhibit an afterglow, which usually comes from multiple components that have different decay times. A high level of afterglow usually has a negative influence on the detection parameters for the energy resolution in spectrometry measurements or X-ray and neutron imaging. The paper deals with the long-term afterglow of some types of scintillators, which is more significant for integral measurement when the current is measured in a photodetector. The range of decay times studied was in the order of tens of seconds to days. Seven types of scintillators were examined: BGO, CaF2(Eu), CdWO4, CsI(Tl), LiI(Eu), NaI(Tl), and plastic scintillator. The scintillators were excited by gamma-ray radiation. After irradiation, the detection unit, along with the scintillator, was moved to a laboratory where the anode current of the photomultiplier tube was measured using a picoammeter for at least a day. The measurements showed that CdWO4 and plastic scintillators have relatively low long-term afterglow signals in comparison to the other scintillators studied.

Ion sensors based on organic semiconductors acting as quasi-reference electrodes

Thin-film devices that transduce the chemical activity of ions into electronic signals are essential components in various applications, including healthcare diagnostics and environmental monitoring. Combinations of organic semiconductors (OSCs) and ion-selective materials have been explored for developing solution-processable ion sensors. However, the necessity of reference electrodes (REs) and operational stability in ion-permeable OSCs have posed questions regarding whether reliable measurements with thin-film components are attainable with OSCs. Herein, we report electric double-layer transistors (EDLTs) with OSCs in single-crystal forms for ion sensing. Our EDLTs demonstrated high operational stability, with a one-to-one relationship between the source electrode potential and device resistance, and served as quasi-REs (qRE). When our EDLT is served as qRE, its drift was as small as 0.5 mV/h and comparable to that of commonly employed REs. In our system, the semiconductor-electrolyte interface is self-passivated by the alkyl chains of OSCs in single-crystal structures, with the two-dimensional transport layer appearing unaltered upon gating. EDLT arrays with ion-selective and nonselective liquid junctions enable ion concentration sensing without a conventional RE. These findings provide opportunities to develop thin-film devices based on OSCs for easy integration and reliable measurements.

Comparison of feed-forward control strategies for simplified vertical hopping model with intrinsic muscle properties

To analyse walking, running or hopping motions, models with high degrees of freedom are usually used. However simple reductionist models are advantageous within certain limits. In a simple manner, the hopping motion is generally modelled by a spring-mass system, resulting in piecewise smooth dynamics with marginally stable periodic solutions. For a more realistic behaviour, the spring is replaced by a variety of muscle models due to which asymptotically stable periodic motions may occur. The intrinsic properties of the muscle model, i.e. preflexes, are usually taken into account in three complexities-constant, linear and Hill-type. In this paper, we propose a semi-closed form feed-forward control which represents the muscle activation and results in symmetrical hopping motion. The research question is whether hopping motions with symmetric force-time history have advantages over asymmetric ones in two aspects. The first aspect is its applicability for describing human motion. The second aspect is related to robotics where the efficiency is expressed in term of performance measures. The symmetric systems are compared with each other and with those from the literature using performance measures such as hopping height, energetic efficiency, stability of the periodic orbit, and dynamical robustness estimated by the local integrity measure (LIM). The paper also demonstrates that the DynIn MatLab Toolbox that has been developed for the estimation of the LIM of equilibrium points is applicable for periodic orbits.

Pre-natal and early life lead exposure and childhood inhibitory control: an item response theory approach to improve measurement precision of inhibitory control

BackgroundNeurodevelopmental performance tasks are often separately analyzed, even when they tap into a similar construct. This may yield mixed findings for associations of an exposure-neurobehavioral outcome. We develop an item response theory (IRT) approach to integrate multiple task variables together to improve measurement precision of the underlying construct. We apply this approach to create an integrative measure of childhood inhibitory control, and study impacts of pre/post-natal lead exposure.MethodsUsing data from a prospective cohort based in Mexico (N = 533), we created an inhibitory control scale that integrates accuracy and reaction time information from four inhibitory control tasks (Go/NoGo Letter, Go/NoGo Neutral, Go/NoGo Happy, Delis-Kaplan Executive Function System (D-KEFS) Color-Word Interference Test, Condition 3). Using a generalized partial credit item response theory model, we estimated an inhibitory control index for each participant. We then assessed adjusted associations between umbilical cord blood and 4-year lead and childhood inhibitory control. We developed a resampling approach to incorporate error estimates from the inhibitory control variable to confirm the consistency of the lead-inhibitory control associations. We modeled time-varying associations of lead with each inhibitory control measure separately.ResultsParticipants had a median age of 9 years; 51.4% were males. Umbilical cord blood [-0.06 (95% CI: -0.11, -0.01)] and 4-year lead [-0.07 (95% CI: -0.12, -0.02)] were associated with inhibitory control index at 8–10 years. A resampling approach confirmed that 4-year lead was consistently associated with childhood inhibitory control index. Umbilical cord blood and 4-year lead were each associated with 3 out of 8 measures in separate models.ConclusionThis is the first application of IRT in environmental epidemiology to create a latent variable for inhibitory control that integrates accuracy and reaction time information from multiple, related tasks. This framework can be applied to other correlated neurobehavioral assessments or other phenotype data.

Can We Succeed with Inclusive Education for Sámi Pupils?

Since Norwegian compulsory education increasingly recognises Sámi rights and the Sámi as an Indigenous people, the question of how we can provide inclusive education for Sámi pupils by recognising Sámi culture in teaching remains. I argue in this literary research, that inclusive education, both as a concept and as a practice in school, stems from a pathological field, targeting individual needs, and therefore misses the target when educating pupils with an Indigenous cultural belonging. Inclusion as a concept centres on practices such as fellowship, participation, equal access, quality, equity and justice, but its legacy is anchored in individual needs, influencing how we think about inclusion and implementing inclusive measures. This way of thinking still guides the national strategy for inclusive education but will not be sufficient for Sámi pupils, since they, as a group, are not disabled. So-called inclusive measures will rather enhance the integration of Sámi pupils into the Norwegian framework of schooling defined by the majority’s expectations for fellowship, participation and so forth. While Indigenous inclusion takes integrative measures which uphold the status quo, thus dependent on a majority perspective, indigenising has an Indigenous baseline. I argue that non-Sámi society needs to re-contextualise itself towards the Sámi society if we want an education for all.

Increasing the Growth of Bridal Tears Flower Stem Cuttings (Antigonon leptopus) by providing Plant Growth Regulators and Planting Media

It is imperative to implement integrated control measures for Oil Palm Leaf-Eating Caterpillars (UPDKS), as continual chemical management can result in pest resistance and environmental degradation. Utilizing natural enemies for biological control involves the utilization of predators, pest-consuming animals, as well as parasites or bacteria with pathogenic properties against pests. Examples of predators, including Sycanus leucomesus and Eocanthecona furcellata, egg parasitoids, such as Trichogrammatidea thoseae, and larval parasites, such as Chaetexorista javana, are a few of the many types of organisms that can have an impact on the populations of their prey. These indigenous predators sustain themselves by feeding on host plants within their natural habitat. The bridal tears flower (Antigonon leptopus) is considered to be one of the host plants. Thus, it is imperative to promote the growth of Antigonon leptopus in order to provide a habitat for the natural predators of the UPDKS pest. The objective of this research was to identify the components of the planting medium and to establish the most effective concentration of growth regulators for propagating bridal tears stem cuttings (Antigonon leptopus). The research was conducted at the Indonesian Palm Oil Technology Institute (ITSI) Practice Garden in Medan, North Sumatra. The research was conducted over three months, from February to April 2024. The Factorial Randomized Block Design (RAK) method was employed, with the first factor, namely S (Planting Media), comprising three levels: Top Soil without solid, Top Soil with 20% Solid, and Top Soil with 40% Solid. The second factor, namely Plant Growth Regulators, was also treated with three levels: without plant growth regulators, concentration of 100 Mg/l, and concentration of 200 Mg/l. Thus, the study comprises nine treatment combinations, each with four replications. The analysis of variance (ANOVA) table is employed to assess the significance of the observed differences, with the Duncan multiple range test (DMRT) conducted at a 5% level of significance when warranted.The findings from the research indicated that the manipulation of the planting medium composition (S) had a notable impact on the number of leaves, number of roots, and fresh weight of the roots. Additionally, it was found to have a highly significant influence on the height of the shoots. The optimal composition of the planting medium was identified as S2. The manipulation of growth regulators (R) concentration had a notable impact on shoot height and root fresh weight, as well as a highly significant effect on the number of leaves and roots. R2 exhibited the most optimal concentration of growth regulators. The growth of Antigonon leptopus stem cuttings was not affected by the combination of planting medium composition (S) and growth regulator concentration (R) in a non-interacting manner.

Virtual screening reveals fluorescent probes for detecting Pan-Zinc center activity in serum MMPs: A potential biomarker for early tumor screening

Early tumor screening is pivotal for enhancing tumor treatment efficacy and patient survival rates, yet identifying reliable biomarkers for early detection remains a challenge. Previous studies have explored different isoforms of matrix metalloproteinases (MMPs) in serum for their predictive value in tumor, but their results have been inconsistent. Herein, we introduce a novel fluorescent probe, C9 (N-oxide-8-hydroxyquinoline-5-sulfonic acid), designed to specifically label the pan zinc center activity of MMPs (PZCA-MMPs), which in a sense represents the overall MMPs activity in serum. The rational design of fluorescent probe C9 is based on its ability to bind the zinc ions in the structure of MMPs, facilitated by the oxides on hydroxyl (–OH) and nitro oxide (N→O) groups present in C9, as supported by theoretical calculations such as Gaussian and Schrödinger. Experimental validation confirmed its efficacy for detecting PZCA-MMPs in vitro and for fluorescence imaging of MMPs’ zinc ions in cellular contexts, validated through absolute integrated fluorescence intensity measurements at 510 nm. We also demonstrated through in vitro fluorescent analysis that neither metal ions nor abundant serum proteins such as albumin (BSA) and other metalloproteins interfere with the signal response of C9. Notably, in comparative analysis of serum samples from healthy controls and breast tumor patients, PZCA-MMPs showed a highly discriminatory area under the ROC curve (AUC) of 0.9377, surpassing established tumor biomarkers such as CA125, CA15-3, CA19-9, and CA72-4. In particular, for tumor patients, PZCA-MMPs can effectively distinguish between metastatic and non-metastatic patients (*P<0.05). Therefore, this provides a potential alternative biomarker for tumor screening. Future studies aim to further elucidate the clinical utility of PZCA-MMPs using a broader spectrum of clinical samples.

Could the Early Detection of Atrial Fibrillation Reduce the Risk of Developing Dementia?

Atrial fibrillation (AF) and dementia are major global public health issues and share common risk factors, especially after the age of 65 and regardless of the presence of stroke. Despite accounting for potential confounders, AF appears to be an independent risk factor for cognitive decline and dementia. The mechanisms are likely to be multifactorial and may include AF-related ischemic stroke, cerebral hypoperfusion, microbleeds, systemic inflammation, genetic factors, and small vessel disease, leading to brain atrophy and white matter damage. The early aggressive management of AF and comorbidities may reduce the risk of dementia. Indeed, the early detection of AF-related cognitive impairment should allow for the early implementation of measures to prevent the development of dementia, mainly through integrative approaches involving the correction of risk factors and maintenance of rhythm control. Well-designed prospective studies are needed to determine whether early detection and AF treatment can prevent dementia and identify whether optimal integrative measures are effective in preventing cognitive impairment and dementia.

Supply chain integration capability: A three-stage circular model of visibility, agility, and flexibility

This paper presents supply chain capabilities in a three-stage circular model. Different from most studies exploring supply chain integration (SCI) from the perspective of processes, this paper studies SCI from a holistic approach. By applying dynamic capability view (DCV), this study develops a measurement of SCI capability based on the three-stage circular model. The scale items were drawn from existing literature. A survey study gathered 187 responses from firms in New Zealand. Factor analysis was conducted to validate the measurement of supply chain integration in the New Zealand businesses. The paper defines the SCI capability as a second-order construct including several well-studied dynamic capabilities such as visibility, agility, and flexibility. The three-stage circular model enables firms to learn, response, and reconfigure to achieve rapid continuous improvement in supply chains. This paper provides new insights and practical implications in SCI and supply chain capability studies and practices in the Industry 4.0 era.

Integrative Proteomics-Metabolomics of In Vitro Degeneration of Cardiovascular Cell Lines.

Long-term cell culture is an important biological approach but is also characterized by degeneration in cellular morphology, proliferation rate, and function. To explore this phenomenon in a systematic way, we conducted an integrative proteomics-metabolomics measurement of two cardiovascular cell lines of AC16 and HUVECs. The 18th culturing passages, i.e., G18, showed as the turning points by cell metabolism profiles, in which the metabolomic changes demonstrated the dysfunction of energy, amino acid, and ribonucleotide metabolism metabolic pathways. Although active protein networks showed mitochondria abundance AC16 and oxidative/nitrative sensitive HUVECs indicated the different degeneration patterns, the G18 and G30 proteomics evidenced the senescence by processes of signal transduction, signaling by interleukins, programmed cell death, cellular responses to stimuli, cell cycle, mRNA splicing, and translation. Some crucial proteins (RPS8, HNRNPR, SOD2, LMNB1, PSMA1, DECR1, GOT2, OGDH, PNP, CBS, ATIC, and IMPDH2) and metabolites (L-glutamic acid, guanine, citric acid, guanosine, guanosine diphosphate, glucose 6-phosphate, and adenosine) that contributed to the dysregulation of cellular homeostasis are identified by using the integrative proteomic-metabolomic analysis, which highlighted the increased cellular instability. These findings illuminate some vital molecular processes when culturing serial passages, which contribute holistic viewpoints of in vitro biology with emphasis on the replicative senescence of cardiovascular cells.