Caffeine Intake Research Articles

Coffee consumption and alertness: a study among office workers in Jakarta

BackgroundCoffee is widely consumed by office workers, primarily for its caffeine content, which plays an important role in improving alertness. For white-collar workers, alertness is crucial to maintaining productivity, and one measurable parameter of alertness is reaction time. Changes in reaction time can be classified as either shorter or longer compared to the initial measurement taken before coffee consumption, with a longer reaction indicating a decrease in alertness. The objective of this study is to investigate the relationship between coffee consumption and improvements in alertness.Materials and methodsThis cross-sectional study compared coffee drinkers and non-coffee drinkers, assessing their alertness using the Lakassidaya tool and collecting data on coffee consumption and caffeine intake through a 7-day fluid diary. Alertness was measured in the morning (baseline) and 30 min after coffee consumption (end line). Study participants were office workers from a company in Jakarta, Indonesia.ResultsA total of 121 participants completed the study, with 47.1% (n = 57) of them being coffee drinkers. No significant differences were found in the characteristics of the respondents. The average daily coffee consumption among these workers was 247 (157–391) mL/day, with a caffeine intake of 72 (36–121) mg/day, which was below the minimum amount typically required to trigger a positive alertness reaction. There was no significant association between coffee consumption and alertness (OR = 1.538, 95% CI: 0.288–1.467, p = 0.403), nor was there a significant difference in the change in reaction time between coffee drinkers and non-coffee drinkers (17.3 [1.4–32.2] ms vs. 13.0 [−3.9–26.0] ms, p-value = 0.111). However, there was a trend toward improved alertness in coffee drinkers, as indicated by shorter reaction times at baseline (180 [160–195.2] ms) compared to post-consumption (155 [146.6–170.2] ms).ConclusionThere was no significant association between coffee consumption and alertness improvement between coffee drinkers and non-coffee drinkers among office workers in Jakarta, Indonesia.

Acute change in resting energy expenditure and vital signs in response to white tea consumption in females: a pilot study

BackgroundWhite tea, derived from the Camellia sinensis plant like other teas, uses tender buds and young leaves and undergoes minimal processing. This results in higher levels of antioxidants and bioactive substances, which may enhance thermogenesis more effectively than other teas. This first human study aimed to investigate the acute effects of white tea consumption on resting energy expenditure (REE) and some vital signs, including blood pressure (BP), heart rate (HR), and body temperature (BT).MethodsThirty-two healthy female volunteers with normal initial BP and whose caffeine intakes were < 300 mg/d were enrolled in the study. The caffeine and total phenolic content of white tea samples were determined by the high-performance liquid chromatography method and the Folin-Ciocalteu colorimetric method, respectively. After baseline measurements, participants consumed white tea containing 6 mg of caffeine per kilogram of lean body mass, and the white tea was prepared with bottled drinking water at 80 °C and brewed for 3 min. REE, BP, and BT were assessed at various intervals (baseline, 30 min, 120 min, and 180 min) post-consumption of the white tea.ResultsThe results revealed a significant increase in REE by 8.7% at 180 min after the consumption. In particular, there was a substantial difference in both values between the intervals of 30 min to 180 min and baseline to 180 min for REE (p < 0.05). Maximal oxygen consumption and BT also increased significantly over time (p < 0.05) and the observed increment in BT suggests a thermogenic effect associated with white tea consumption. However, systolic BP, diastolic BP, and heart rate showed no significant difference.ConclusionsThese findings suggest white tea consumption may acutely enhance REE and maximal oxygen consumption, so the results are promising for body weight management. This study is the first human study in the literature about the effects of white tea on energy expenditure and vital signs.

FREQUENCY OF DIFFERENT CAUSES OF MASTALGIA WITHOUT NIPPLE DISCHARGE AMONG WOMEN PRESENTING AT TERTIARY CARE HOSPITAL

Mastalgia, or breast pain, is a common complaint among women, often impacting quality of life and requiring clinical attention. Understanding the underlying causes of mastalgia is essential to guide management and improve patient outcomes. Objective: The objective of this study was to determine the frequency and associated causes of mastalgia in women presenting to a tertiary care hospital. Methods: This cross-sectional study was conducted at the Department of Surgery, Civil Hospital, Karachi, from March 1, 2023, to August 30, 2023, after obtaining ethical approval from the institutional review board. A total of 176 female patients aged 18–49 years with complaints of mastalgia were included in the study through non-probability consecutive sampling. Both married and unmarried women were enrolled, and data were collected on demographic variables, lifestyle factors, and psychological factors. Statistical analysis was performed to evaluate associations between causes and mastalgia severity. Results:The most common causes of mastalgia identified were caffeine consumption (56%), depression (57%), and smoking (49%). Significant associations were found between mastalgia severity and both smoking (p=0.002) and caffeine consumption (p=0.003). Smokers and caffeine consumers reported higher levels of pain severity. Conclusion: Mastalgia is frequently associated with modifiable lifestyle factors such as smoking and caffeine intake, as well as psychological factors like depression. Addressing these factors may help manage and reduce the severity of mastalgia in affected patients.

Caffeine intake, chronotype, and student sleep quality at Polytechnic of Leiria

Abstract Introduction Higher education students ingest very high doses of caffeine, on average twice the recommended safe dose. This excessive consumption can become problematic, ultimately affecting sleep quality and, consequently, academic performance. The aim of this work is to describe caffeine consumption, sleep quality and to characterize the chronotype and academic performance of students at Polytechnic of Leiria. Methods An online self-completion questionnaire was developed, consisting of several instruments: The Caffeine Consumption Questionnaire; Horne and Ostberg morningness-eveningness Questionnaire; Pittsburgh Sleep Quality Index (PSQI), to describe caffeine consumption, characterize chronotype and assess sleep quality, respectively. The mean, standard deviation, minimum and maximum values were calculated for the quantitative variables. Absolute and relative frequencies were calculated for the qualitative variables. Parametric tests were used to compare groups; when this was not possible, non-parametric tests were used. P &amp;lt; 0.05 was considered statistically significant. Results Of the 261 students (mean age: 23.26 ± 6.60 years), 64.2% had poor sleep quality and 45.3% reported an afternoon chronotype. It was found that men consumed more coffee and energy drinks than women, although women consumed more caffeine-containing food products. The average academic score was 14.56 ± 1.61. There was a statistically significant association (p &amp;lt; 0.01) between the afternoon chronotype and poor sleep quality and between the consumption of coffee and chocolate drinks and poor sleep quality. Conclusions Students at Polytechnic of Leiria tend to have poor sleep quality and an intermediate chronotype. Those with an afternoon chronotype or who drink coffee and chocolate drinks have poor sleep quality. Key messages • Accurately assessing the situation is essential for crafting suitable solutions. • Higher students should adjust their coffee consumption to achieve better sleep quality.

Caffeine optimizes Zumba training benefits on functional performances in middle-aged women: a randomized trial study

The current study aimed to explore the effect of daily caffeine supplementation (100 mg/day) and 12-week of Zumba training on functional performances in middle-aged women. Eighty-five middle-aged women were randomized into 4 groups including control, Zumba training (ZT), caffeine supplementation (Ca) or caffeine-Zumba training (Ca + ZT) groups. Functional performances were assessed using 10 m Walk, Timed Up and Go, Functional Reach, and 30-Second Chair Stand tests. As results, ZT, Ca and Ca + ZT intervention programs showed a significant (p < 0.05) functional performances improvement. However, Ca + ZT group showed significant (p < 0.001) better scores in terms of mobility (95%CI [0.71, 1.43]), gait speed (95%CI [0.52, 1.71]) and lower body endurance strength (95%CI [-6.93, -1.92]), except for dynamic balance (95%CI [-9.41, -3.44]). In conclusion, 12-week of Zumba training improves functional performances in middle-aged women, and daily caffeine intake is an effective alternative for improving such performances. Supplementing caffeine (100 mg/day) to Zumba training was effective in boosting Zumba benefits on these functional performances.

Application of Mendelian randomization to explore the genetic association between drinking habits of different beverages and sleep disorder

IntroductionThis study aims to provide genetic evidence linking Drinking Habits of Different Beverages (DHDB) to Sleep Disorder Liability (SDL), potentially informing clinical treatments to improve lifestyle factors.Material and methodsA two-sample Mendelian randomization (MR) method was employed to explore the genetic associations between DHDB and SDL. The DHDB variables studied encompassed Alcohol Intake (ALI), Alcohol Intake Frequency (ALF), High-Frequency Drinking with Meals (HAL), Tea Intake (TEAI), Coffee Intake (COFI), and Red Wine Intake (RWI). The SDL variables analyzed were Insomnia (INS), Inhibit Excitability (IE), and Sleep Duration (SD).ResultsThe MR analysis identified genetic links between ALI and INS, ALF and IE, ALF and SD, HAL and INS, HAL and IE, HAL and SD, TEAI and IE, TEAI and SD, and COFI and IE (P(IVW)&lt;0.05). Nonetheless, no significant genetic links were detected between ALI and IE, ALI and SD, ALF and INS, TEAI and INS, COFI and INS, COFI and SD, RWI and INS, RWI and IE, or RWI and SD (P(IVW)&gt;0.05).ConclusionsAlcohol intake may elevate insomnia risk without affecting daytime sleepiness or sleep duration. Frequent alcohol consumption may lead to daytime sleepiness and reduced sleep duration but not insomnia. Alcohol with meals might reduce insomnia and daytime sleepiness while improving sleep duration. Tea appears unlinked to insomnia and may reduce daytime drowsiness. Coffee may alleviate daytime drowsiness without causing insomnia, and red wine shows no significant association with sleep disorders. Reverse MR suggests potential links between sleep disorders and alcohol or caffeine intake.

The Effect of Pre-Exercise Caffeine and Glucose Ingestion on Endurance Capacity in Hypoxia: A Double-Blind Crossover Trial.

The impact of caffeine and glucose supplementation in a hypoxic environment on endurance exercise performance remains inconclusive. The current study examined the effect of pre-exercise carbohydrate and caffeine supplementation on endurance exercise performance in an acute hypoxic environment. Eight healthy active young males participated in this double-blind, within-subjects crossover study. Participants ingested the test drink 60 min before exercising at 50% Wmax for 90 min on a cycle ergometer (fatiguing preload); there followed an endurance performance test at 85% Wmax until exhaustion in a hypoxic chamber (~15%O2). Participants completed four experimental trials in a randomized order: caffeine (6 mg·kg-1; Caff), glucose (1 g·kg-1; CHO), caffeine (6 mg·kg-1) + glucose (1 g·kg-1; Caff-CHO), and taste- and color-matched placebo with no caffeine or CHO (PLA). Blood samples were collected during fasting, pre-exercise, every 30 min throughout the exercise, and immediately after exhaustion. The caffeine and glucose trials significantly enhanced endurance capacity in hypoxic conditions by Caff, 44% (68.8-31.5%, 95% confidence interval), CHO, 31% (44.7-15.6%), and Caff-CHO, 46% (79.1-13.2%). Plasma-free fatty-acid and glycerol concentrations were higher in Caff and PLA than in CHO and Caff-CHO (p < 0.05). The estimated rate of fat oxidation was higher in Caff and PLA than in CHO and Caff-CHO (p < 0.05). There were no significant differences in ratings of perceived exertion between trials. In conclusion, the ingestion of caffeine, glucose, or caffeine + glucose one hour before exercising in hypoxic conditions significantly improved 85% Wmax endurance performance after prolonged exercise.

Modification of the association between coffee consumption and constipation by alcohol drinking: A cross-sectional analysis of NHANES 2007-2010.

The association between coffee consumption and constipation remains unclear. This study aimed to examine the relationship of coffee consumption with the risk of constipation, while also investigating potential effect modifiers. This cross-sectional study included 7844 participants from the National Health and Nutrition Examination Survey (NHANES) 2007-2010. Coffee consumption was extracted from the 24-hour dietary recall. Constipation was assessed using the Bristol Stool Form Scale. The association between coffee consumption and constipation was assessed using multivariable restricted cubic spline and logistic regression with odds ratio (OR) and 95% confidence interval (CI). There was a J-shaped relationship between total coffee consumption and the risk of constipation in the whole population (p for nonlinearity = 0.049), with 1-2 cups/day of total coffee potentially reducing the risk of constipation by 39% (OR 0.61, 95% CI 0.35-1.06, p = 0.07). As for caffeinated coffee, a J-shaped association between its consumption and the risk of constipation was also observed in the whole population (p for nonlinearity = 0.008), with 1-2 cups/day being significantly associated with a reduced risk (OR 0.57, 95% CI 0.35-0.95, p = 0.03). When restricting to never drinkers of alcohol, the associations between total and caffeinated coffee consumption and constipation shifted to inverse linear trends, where at least 3 cups/day was significantly associated with an 88% reduction in constipation risk (total coffee: OR 0.12, 95% CI 0.02-0.68, p = 0.02; caffeinated coffee: OR 0.12, 95% CI 0.02-0.70, p = 0.02). Decaffeinated coffee showed no association with constipation. Consuming 1-2 cups of caffeinated coffee daily was associated with a reduced risk of constipation in the general population. Among never drinkers of alcohol, a linear protective effect was observed, with a notable 88% reduction in constipation risk for those consuming at least 3 cups per day. Moderate caffeinated coffee intake may therefore be a viable dietary strategy for managing constipation in the general population.

Caffeine and Vision: Effects on the Eye.

Caffeine, commonly found in coffee and tea, affects various aspects of eye health as it blocks adenosine receptors, impacting tear production, intraocular pressure, macular perfusion, and choroidal thickness. However, its connection with eye conditions like glaucoma and cataracts remains uncertain due to conflicting research findings. Some studies suggest potential benefits for cataracts, while others warn against frequent caffeine intake in glaucoma and surgical scenarios due to possible increases in intraocular pressure. Conflicting evidence also exists regarding its effects on dry eye, macular degeneration, myopia/hyperopia, diabetic retinopathy, retinopathy of prematurity, and central serous retinopathy. Caffeine does not seem to be a risk factor for dry eye, although studies have shown that caffeine may offer protection against wet age-related macular degeneration, and the metabolite 7-methylxanthine could be a more promising treatment for myopia. Moreover, caffeine can potentially cause tremors and might hinder surgical performance, especially in less experienced surgeons. Recommendations from experts vary, highlighting the need for further research to fully understand how caffeine affects the eye. Individuals genetically predisposed to glaucoma should be cautious due to the possibility of clinically significant elevations in intraocular pressure with caffeine consumption. For delicate procedures like microsurgery, where tremors can be detrimental, caution should be exercised with caffeine. This review underscores the importance of additional studies to provide clearer insights and prudent recommendations regarding caffeine's impact on eye health.

Caffeine Use in Huntington's Disease: A Single Center Survey.

Anecdotal evidence suggests paradoxical caffeine overuse in individuals with Huntington's disease (HD). A small retrospective study associated caffeine intake over 190 grams daily to earlier onset of HD symptoms. However, specific data on consumption habits is limited. This study aims to gather pilot data on caffeine use in people with HD, exploring motivations and consequences. Thirty adults with HD completed a survey on daily caffeine intake, its impact on symptoms, and consumption motivations through multiple-choice and open-ended questions. Descriptive statistics were used to analyze findings and compare them to general population data. Caffeine intake ranged from 0 to 1400.4 mg/day, with a median of 273.2 mg/day and a mean of 382.5 mg/day. Seventy percent of participants with HD consumed more caffeine than the average for their age group in the general population. Additionally, 20% of participants and 38% of family members believed caffeine influenced HD symptoms, primarily anxiety. People with HD typically consume more caffeine than the general U.S. population. Contrary to the hypothesis, higher caffeine intake was not associated with significant subjective worsening of HD symptoms. Further research with objective measures and multiple HD centers is necessary to guide screening and counseling on caffeine use in this population. Participants with Huntington's disease (HD) had increased caffeine intake compared to the general population, supporting previous anecdotal observations. Anxiety was the most affected HD symptom. Further research using objective measures of symptom burden and including multiple HD centers can help inform screening and counseling regarding caffeine use in this population.

Caffeine Intake Alters Recovery Sleep after Sleep Deprivation.

Caffeine is a well-known psychostimulant reputed to alleviate the deleterious effects of sleep deprivation. Nevertheless, caffeine can alter sleep duration and quality, particularly during recovery sleep. We evaluated the effects of acute caffeine intake on the duration and quality of recovery sleep following total sleep deprivation (TSD), taking into account daily caffeine consumption. Forty-one participants performed a double-blind, crossover TSD protocol (38 h of continuous wakefulness) with acute caffeine or placebo. Caffeine (2.5 mg/kg) or placebo was administered twice during continuous wakefulness (last treatment 6.5 h before bedtime for the recovery night). Polysomnographic measurements were recorded using a connected headband. TSD was associated with a rebound in total sleep time (TST) on the recovery night (+110.2 ± 23.2 min, p < 0.001). Caffeine intake decreased this recovery TST (-30.2 ± 8.2 min p = 0.02) and the N3 sleep stage duration (-35.6 ± 23.2 min, p < 0.01). Caffeine intake altered recovery sleep continuity (increased number of long awakenings), stability (higher stage transition frequency), and organization (less time spent in complete sleep cycle) and decreased the delta power spectral density during NREM sleep. On the recovery night, habitual daily caffeine consumption was negatively correlated with TST in caffeine and placebo conditions and positively correlated with wake after sleep onset (WASO) duration and with the frequency of long (>2 min) awakenings in the caffeine condition only. Acute caffeine intake during TSD affects nighttime recovery sleep, with an interaction with daily consumption. These results may influence advice on caffeine intake for night-shift workers. (NCT03859882).

The Short-term Effect of Caffeine Consumption on Reading Performance

Objective: Caffeine, a widely consumed psychoactive substance, is recognized for its cognitive-enhancing effects, notably enhancing performance on tasks requiring narrative comprehension, where it has been shown to boost both acuity and speed. This study investigates the impact of caffeine intake on reading acuity and evaluates changes in reading speed post-caffeine consumption. Material and Methods: Employing a cross-sectional design, nineteen participants with distance best-corrected vision of 6/6 or better (equivalent to logMAR 0.00 or better) (mean age=22.5±1.00 years old) and near vision of 0.1 logMAR (N5) were recruited. Baseline measurements of reading acuity and speed were taken using the article sourced from Perpustakaan Tun Abdul Razak (PTAR) and Buari-Chen Malay Reading Chart (BCMRC) before coffee consumption, respectively. Participants consumed 200 mg of Nescafe Gold (caffeine) before the subsequent assessment. The time taken to read the reading materials was recorded, alongside any errors. Results: While reading speed significantly increased post-caffeine consumption (t=-7.536, p-value&lt;0.001), reading acuity remained unaffected (t=-0.378, p-value=0.705). These results suggest a moderate dose of 200 mg of caffeine can enhance reading speed without compromising acuity in young adults.Conclusion: This indicates that caffeine mainly affects the rate of reading, while it does not alter the reading acuity of individuals.

Caffeine improves systemic lupus erythematosus endothelial dysfunction by promoting endothelial progenitor cells survival.

We studied the role of caffeine intake on endothelial function in SLE by assessing its effect on circulating endothelial progenitor cells (EPCs) both ex vivo in SLE patients and in vitro in healthy donors (HD) treated with SLE sera. We enrolled SLE patients without traditional cardiovascular risks factors. Caffeine intake was evaluated with a 7-day food frequency questionnaire. EPCs percentage was assessed by flow cytometry analysis and, subsequently, EPCs pooled from six HD were co-cultured with caffeine with and without SLE sera. After 7 days, we evaluated cells' morphology and ability to form colonies, the percentage of apoptotic cells by flow cytometry analysis and the levels of autophagy and apoptotic markers by western blot. Finally, we performed a western blot analysis to assess the A2AR/SIRT3/AMPK pathway. We enrolled 31 SLE patients, and observed a positive correlation between caffeine intake and circulating EPCs percentage. HD EPCs treated with SLE sera and caffeine showed an improvement in morphology and in number of EPCs colony-forming units in comparison with those incubated without caffeine. Caffeine was able to restore autophagy and apoptotic markers in HD EPCs as before SLE sera treatment. Finally, caffeine treatment was able to significantly reduce A2AR levels, leading to an increase in protein levels of SIRT3 and subsequently AMPK phosphorylation. Caffeine intake positively correlated with the percentage of circulating EPCs in SLE patients; moreover, caffeine in vitro treatment was able to improve EPC survival and vitality through the inhibition of apoptosis and the promotion of autophagy via A2AR/SIRT3/AMPK pathway.

Comparative study of Saudi and Turkish coffee consumption in Saudi Arabia: insights into sociodemographic factors and caffeine intake.

Saudi and Turkish coffee consumption in Saudi Arabia is increasing considerably, and the nationwide consumption patterns need elucidation to determine the contributions of Saudi and Turkish coffee toward nutrition and health. To describe the frequency and quantity of Saudi and Turkish coffee consumption and assess their association with sociodemographic factors. This cross-sectional study included 1,030 participants (Saudi Arabia) recruited via an online questionnaire study that collected information on general characteristics and coffee consumption. The caffeine content in Saudi and Turkish coffees was quantified using a standard laboratory technique. The total caffeine intake and exposure were calculated. Associations between the different parameters were assessed. Significant differences were observed in several demographic and sociodemographic factors according to the frequency of coffee intake. Specifically, individuals who consumed Saudi coffee almost every day (approximately 40% of respondents) were more likely to differ in age, body mass index, marital status, work status, monthly income, and region compared to those who consumed it less frequently. Additionally, one-third of the respondents consumed Turkish coffee, and the frequency of its consumption showed significant differences according to age, nationality, marital status, educational level, and region. Notably, the highest caffeine exposures were 0.95 mg/kg/d for Saudi coffee, 1.31 mg/kg/d for Turkish coffee, and 2.07 mg/kg/d for both coffees combined. The mean contribution to the 400 mg daily caffeine intake limit was significantly higher for Saudi coffee compared to Turkish coffee (p < 0.05). Saudi and Turkish coffee consumption patterns vary across sociodemographic characteristics, where Saudi coffee is generally more consumed. Our study may form a basis for nutrient education in terms of coffee consumption to promote a healthy lifestyle.

Dose and timing effects of caffeine on subsequent sleep: A randomised clinical crossover trial.

To investigate the effect of a typical dose of caffeine and a high dose of caffeine consumed in the morning, afternoon, and evening on subsequent sleep. Using a placebo-controlled, double-blind, randomised crossover design, 23 males (25.3±5.0 years) with a moderate habitual caffeine intake (<300mg∙day-1) completed seven conditions: placebo, and 100 and 400mg of caffeine consumed 12, eight, and four hours prior to bedtime, with a 48-hour washout. In-home partial polysomnography and sleep diaries were used to assess sleep. Linear mixed models estimated the effect of each condition. No significant effect on objective or subjective sleep occurred with the 100mg dose of caffeine compared to the placebo (p>0.05) but significant effects occurred with the 400mg dose (p<0.05). Significant delays in sleep initiation and alterations to sleep architecture were observed when 400mg was consumed within 12 hours of bedtime (p<0.05), and significantly greater sleep fragmentation occurred when 400mg was consumed within eight hours of bedtime (p<0.05). Additionally, perceived sleep quality was significantly reduced when 400mg was consumed four hours prior to bedtime (-34.02%, p=.006) but not at eight or 12 hours. A 100mg dose of caffeine can be consumed up to four hours prior to bedtime, but 400mg may negatively impact sleep when consumed as one dose within 12 hours of bedtime, with the adverse influence on sleep increasing the closer consumption occurs to bedtime. The discrepancy between objective and subjective sleep quality suggests individuals may have difficulty accurately perceiving the influence of caffeine on sleep quality.

Prevalence and Correlations of Premenstrual Dysphoric Disorder: A Sample of Adult Working Women.

Premenstrual dysphoric disorder (PMDD) represents a significant psychiatric condition affecting women of reproductive age. It is characterized by cyclical emotional and physical symptoms that considerably impair psychosocial functioning. This study aims to investigate the prevalence of PMDD among adult working women and identify associated etiological factors. From January 2022 to March 2022, a cross-sectional study utilizing cluster sampling methodology was conducted to investigate the prevalence of PMDD among adult working women in six communities in Hangzhou (China). A total of 1710 participants were selected for research through a questionnaire-based survey. To elucidate the factors associated with PMDD, logistic regression analysis was employed. Among 1710 working women, 52 had PMDD, representing an incidence of 3.04%. Age (odds ratio (OR) = 3.196, p = 0.002), age at menarche (OR = 0.362, p = 0.011), income (OR = 0.449, p = 0.043), menstrual cycle (OR = 2.352, p = 0.022), menstrual symptoms (OR = 0.317, p = 0.003), physical activity (OR = 2.234, p = 0.028), and caffeine intake (OR = 2.318, p = 0.022) were independent influencing factors of PMDD in adult working women. The study highlights that PMDD, which has a prevalence of 3.04% in the surveyed population, is a notable concern among adult working women. Key factors, such as age, age at menarche, income level, menstrual cycle characteristics, menstrual symptom presence, physical activity, and caffeine intake, significantly contribute to the likelihood of developing PMDD. These findings underscore the importance of recognizing and monitoring the above risk factors by clinicians to identify and manage PMDD in working women.

Caffeine intake from foods and beverages and trends among Chinese children and adolescents: 2004–2018

BackgroundThe popularity of caffeinated foods and beverages poses risks of high caffeine exposure among Chinese children and adolescents. Nevertheless, there is a lack of national assessments on their caffeine consumption. ObjectiveTo estimate daily caffeine intake and analyze time trends among Chinese children and adolescents. MethodsThe study subjects were participants of the China Health and Nutrition Survey in 2004, 2006, 2009 and 2011, and the National Food and Beverage Consumption Survey in 2014 and 2018. Caffeine content was determined using chromatographic instrument. The Monte Carlo simulation was utilized to estimate daily caffeine intake and the Kruskal-Wallis test was used to analyze differences between population characteristics. To examine yearly trends in caffeine intake from 2004 to 2018, the partial Mann-Kendall test was applied. ResultsThe median daily caffeine intake of Chinese children and adolescents was 0.17 (95%CI: 0.15–0.20) mg/kg BW/day. Main contributors were tea (55.52%), sodas (19.52%) and tea beverages (10.37%). Approximately 4.68% of individuals consumed caffeine exceeding 2.5 mg/kg BW/day. Higher caffeine intake was observed in adolescents aged 12–17 years, males, and consumers residing in northeastern China. While no significant overall yearly trends in caffeine intake were detected from 2004 to 2018, there was an increase in intake driven by beverage consumption between 2006 and 2014. ConclusionThis study provided a national assessment of caffeine consumption among Chinese children and adolescents. Caffeinated beverages like tea, soda, and tea beverages emerged as major contributors to caffeine intake. These findings could contribute to the regulation of caffeine consumption and the promotion of healthy habits among children and adolescents.

Maternal low-dose caffeine intake during the perinatal period promotes short- and long-term sex-dependent hormonal and behavior changes in the offspring.

Maternal caffeine crosses the placenta and mammary barriers, reaching the baby and, because his/her caffeine metabolism is immature, our hypothesis is that even a low caffeine intake (250 mg/day), lower than the dose limit recommended by the World Health Organization, can promote caffeine overexposure in the offspring, leading to short- and long-term changes. Pregnant Wistar rats received intragastric caffeine (CAF) (25 mg/Kg/day) or vehicle during the gestation and lactation periods. We evaluated morphometrical, metabolic, hormonal, and behavioral parameters of male and female offspring at different ages. Even a low caffeine intake promoted lower maternal body mass and adiposity, higher plasma cholesterol and lower plasma T3, without changes in plasma corticosterone. Female CAF offspring exhibited lower birth weight, body mass gain and food intake throughout life, and hyperinsulinemia at weaning, while male CAF offspring showed reduced food intake and lower plasma T3 at weaning. At puberty and adulthood, male CAF showed higher preference for palatable food, aversion to caffeine intake and higher locomotor activity, while female CAF only showed lower preference for high fat diet (HFD) and lower anxiety-like behavior. At adulthood, both male and female offspring showed higher plasma T3. Male CAF showed hypertestosteronemia, while female CAF showed hypoinsulinemia without effect on glucose tolerance. A low caffeine intake during the perinatal period affects rat's offspring development, promoting sex-dependent hormonal and behavior changes. Current data suggest the need to review caffeine recommendations during the perinatal period.

Acute Caffeine Intake And Muscle Performance In Young Female Football Players: A Controlled Trial.

Acute Caffeine Intake And Muscle Performance In Young Female Football Players: A Controlled Trial.

Association between dietary caffeine intake and cognitive functioning and sleep quality in university students

Association between dietary caffeine intake and cognitive functioning and sleep quality in university students