Microsphere-based colon-specific medication delivery devices should improve bioactive chemical administration and residence periods. In the first step, insulin microspheres were made using Eudragit RL 100 and L-100 by quasi-emulsion solvent diffusion. Microspheres were made since prior research showed that colon tissue macrophages could take up drug carrier systems with a molecular weight of 956 m or less. The uptake process allows accurate medication delivery to the specified site. Microspheres’ longer residence time than conventional drug delivery methods may allow dosage reduction and therapeutic efficacy. Because microspheres are permeable, they may be compacted and used to make stronger tablets. Thus, the CPDRS1 formulation performs well, enabling insulin delivery via an anti-diabetic microsphere. Drug-polymer ratio affects microsphere size and form. Variations in emulsifying agent amounts affect microsphere sizes and manufacturing yield. Using appropriate polymer and emulsification agent concentrations improves insulin-loaded Eudrajit L microsphere (Eudrajit RL) formulation and manufacturing yield