Set Of Instruments Research Articles

The Frequency of Health Anxiety, Coronavirus Anxiety and Anxiety Disorder in Patients With Tinnitus During the COVID-19 Pandemic and the Impact of Pandemic on Tinnitus.

This study aimed to examine the frequency of anxiety disorder, coronavirus anxiety and health anxiety in tinnitus patients during the pandemic and also, determined the psychophysiological impact of COVID-19 on tinnitus. This cross-sectional study was conducted in a tertiary central pandemic hospital from 15 July 2021 to 15 December 2022. In total, 124 patients with tinnitus and 77 healthy controls participated in the study. The sociodemographic data, a set of valid and reliable assessment instruments were used to measure outcomes of anxiety disorder, coronavirus anxiety, health anxiety and severity of tinnitus. Patients with tinnitus were found to experience higher levels of coronavirus anxiety, health anxiety and anxiety disorder than controls (p < 0.05). In tinnitus patients, the frequency of coronavirus anxiety was 22.6% and anxiety disorder was 18.5%. Notably, the levels of tinnitus severity were moderate to severe in more than half of the patients (51.6%) and also most of them (81.3%) reported that the severity of tinnitus during the pandemic was higher compared with the pre-pandemic. Tinnitus patients had high levels of anxiety disorder, coronavirus anxiety and health anxiety. In line with these findings, it was evaluated that there was a relationship between the COVID-19 pandemic with psychological problems and tinnitus. Therefore, the predominance of tinnitus symptoms at presentation should not lead the clinician to neglect the underlying psychopathological problems in these patients.

The M-POHL Health Literacy Population Survey 2024-2026 (HLS24)

Abstract Background Inspired by the first European Health Literacy Survey (HLS-EU) and its policy impact, the WHO Action Network on Measuring Population and Organizational Health Literacy (M-POHL) was established in 2018 under the auspices of WHO Europe to monitor and strengthen health literacy (HL) in Europe. The Health Literacy Survey 2019-2021 (HLS19) was the first project of M-POHL, focusing on both general and specific aspects of HL. The follow-up survey (HLS24) builds on this work and will provide even more comprehensive data on HL by including more countries and new aspects of HL. By also focusing on NCDs and prevention, HLS24 is a key partner in the European Joint Action PreventNCD. Methods The HLS24 is a cross-sectional study based on nationally representative samples of the adult population (18+) in more than 20 participating countries. The HLS24 core questionnaire includes items on general HL, sociodemographics, health behavior, health status, and health care utilization. Some countries also include questions on prevention and early detection of chronic diseases and health problems. Five optional packages (OPs) enable countries to focus on specific aspects of HL, namely digital, communicative, navigational, vaccination and mental HL. Results HLS24 uses a harmonized set of HL instruments that provide a solid database for health policy decisions to strengthen HL and health equity in Europe. In addition to the three OPs on digital, communicative and navigational HL discussed in the following presentations, an 11-item set on vaccination literacy and a 21-item set on mental HL are provided. Conclusions Covering NCDs, prevention, digital health, immunization, and mental health, the HLS24 provides important data on current health challenges and highlights the needs of the European population regarding health information and services upon which policy and action interventions can be based.

Construction of Virtual Experiment Teaching Platform based on 5E Teaching Mode and VI Technology

Virtual instruments have many advantages such as low cost, comprehensive functionality, easy scalability, and easy replication. At the same time, they can also meet the special requirements of time and space for remote experiments. Based on Web technology and virtual instrument technology, a virtual experiment system is constructed, which combines data sharing, remote control, and real-time operation. More conducive to utilizing experimental and scientific research resources. At the same time, virtual instruments have high flexibility and are no longer limited by traditional experimental teaching modes, which can save a lot of repeated investment costs. They can also keep the teaching equipment in the laboratory up-to-date and closely follow the development trend of science and technology. As a compulsory course for mechanical engineering majors, although the existing experimental system has achieved certain results, there are still limitations to 'Mechanical Engineering Testing Technology'. This article aims to address the problems of insufficient instrument sets and outdated equipment in the experimental teaching of "Mechanical Engineering Testing Technology", as well as students' poor ability to apply theory to practice and insufficient innovation ability. By integrating the 5E teaching mode, a virtual experimental teaching platform based on VI (Virtual Instrument) technology is established. Students can break through traditional experimental methods and conduct various experiments through the network, obtaining experimental experiences that are very similar to real experiments. At the same time, it can deepen their understanding and recognition of experiments, and better grasp theoretical knowledge.

KELOMPOK MUSIK CV. BINTANG GRUP: MEDIA MERAWAT IDENTITAS ADAT BATAK MELALUI MUSIK DI SOLO RAYA

Migration is an activity that has become a tradition for the Batak people. The migration destinations extend beyond the island, one of which is in the Solo Raya area. The identity of the Batak community remains preserved during migration because their original customs and culture continue to be an integral part of their daily lives. The purpose of this journal is to explore the cultural life of the Batak community and the steps they have taken to preserve their traditional identity through music, specifically through CV. Bintang Group. The research method used in this journal is qualitative, collecting data through observation, interviews, literature studies, and several other methods. The findings indicate that the Batak community, represented by CV. Bintang Group, has successfully preserved their traditional identity through various means. These include teaching Batak music to their children, participat ing in cultural events outside of traditional Batak ceremonies, possessing a complete set of traditional Batak instruments, and being active on social media. The conclusion of this research is that the Batakcommunity has successfully maintained their traditional identity even while living in distant lands.

Development and validation of an ICP-MS method and its application in assessing heavy metals in whole blood samples among occupationally exposed lead smelting plant workers.

Occupational exposure to heavy metals affects various organ systems and poses a significant health risk to workers. Consequently, its precise estimation is of clinical concern and warrants the need for an analytical method with reliable precision and accuracy. The current study aimed to develop an analytical method using inductively coupled plasma‒mass spectrometry (ICP-MS) to detect trace to elevated levels of potentially toxic elements in human blood. The sample preparation was optimized using a two-step ramp temperature microwave acid digestion program. The toxic elements were quantified using ICP-MS operating in kinetic energy discrimination (KED) mode, adjusting the data acquisition parameters and instrumental settings. The analytical method was validated using standard performance parameters. Each validation parameter was aligned with the acceptable criteria outlined in standard guidelines. The method achieved optimal linearity (r2 > 0.99), recovery (85.60-112.00%), and precision (1.35-7.03%), was capable of detecting the lowest concentrations of 0.32, 0.28, 0.28, and 0.19µg/L, and was capable of quantifying trace levels of 1.01, 0.88, 0.90, and 0.62µg/L for arsenic (As), cadmium (Cd), mercury (Hg), and lead (Pb), respectively. Post-validation, the method was applied to estimate heavy metals in blood samples from 250 Pb-smelting plant workers, revealing potential health implications of occupational exposure. The cohort analysis revealed that demographic and employment factors were associated with elevated blood Pb levels, leading to symptoms and health risks. Clinical analysis revealed that 33.6% of the participants experienced hypertension. These findings highlight the significant health risks associated with elevated blood Pb levels. The weak but significant correlation with systolic blood pressure underscores the need for improved monitoring and workplace safety. This emphasizes the importance of continuous monitoring, targeted interventions, and enhanced occupational hygiene to protect workers' well-being.

A Mendelian randomization study of the association between serum uric acid and osteoporosis risk.

The relationship between serum uric acid (SUA) and osteoporosis (OP) has yielded conflicting results in observational studies. This Mendelian randomization (MR) study aims to elucidate the causal association between SUA and OP. A two-sample MR analysis was conducted using summary-level data from genome-wide association studies (GWAS). Two sets of polygenic instruments strongly associated (p < 5 × 10-8) with SUA were extracted from the CKDGen consortium and UK biobank. Polygenic instruments associated with OP (p < 5 × 10-8) were derived from FinnGen biobank and UK biobank. Inverse variance weighting (IVW) was employed as the primary analysis method. Additionally, we utilized MR-Egger, weighted median, the simple mode method, and the weighted mode as complementary analyses. Cochran's Q statistics were used to assess heterogeneity, with MR-Egger intercept testing and MR pleiotropy residual sum and outlier (MR-PRESSO) to examine horizontal pleiotropy. Sensitivity analysis was performed using the leave-one-out method. The IVW analysis conducted across four groups confirms no significant causal relationship between SUA concentration and OP: UKB-UKB (OR: 1.001, 95% CI: 0.999-1.003, p=0.464), CKD-UKB (OR: 1.001, 95% CI: 0.999-1.003, p=0.349), UKB-Fin (OR: 0.934, 95% CI: 0.747-1.168, p=0.549), CKD-Fin (OR: 1.041, 95%CI: 0.934-1.161, p=0.470). Furthermore, additional four MR analyses corroborated these findings. Upon excluding all outliers identified by the MR-PRESSO test, no significant directional pleiotropy was observed, except for some data heterogeneity noted in the UKB-UKB group (Q=50.65, P=0.002). Additionally, a leave-one-out analysis indicated that no single SNP exerted undue influence on the results. This MR analysis provides convincing genetic evidence that there is no causal association between SUA and OP, SUA is unlikely to increase or reduce the risk of OP.

Identifying and tracking climate change mitigation strategies with a cluster-based assessment

To guide climate change mitigation efforts, we identify and characterize the different types of mitigation strategies countries adopted over the last two decades. The analysis exploits the novel and rich policy repository of the OECD’s Climate Actions and Policies Measurement Framework (CAPMF), covering more than 120 policy variables and 50 countries over 2000–2020. All countries in the dataset increased the number of climate policy instruments and their stringency over the past two decades, but at a different pace and using different policy instruments. Using statistical cluster analysis, we identify four distinct types of mitigation strategies, which differ in the composition and stringency of mitigation policies. Regression results show that emissions are negatively associated with the overall stringency of the country’s mitigation strategies. Evidence also supports the hypothesis that this relationship is stronger for mitigation strategies comprising a more diverse set of instruments, pointing to possible policy synergies.

Поэма Абу Бакра Каландара Руми «Каландар-наме» как источник сведений по суфийской ритуальной музыке

This paper is devoted to analyze the text of Abu Bakr Qalandar Rumi’s poem “Qalandar-name” from the point of view of describing the Sufi ritual of listening to sama`. As it is known, Sufi zikr can be two types – “loud”, with singing, dancing movements and playing musical instruments, and “quiet” without any musical part. Research materials: The statement of the author of the poem is of scholarly interest because the author welcomes both two types of zikr, as his Ushshaki group used singing, dancing and musical instruments. All these activities were used for the sole purpose of unity with the divine. The text of the poem is a source on Sufi rituals and their musical peculiarities in different tariqats. The poet also provides theoretical justifications for the permissibility of music in Sufi rituals, based on famous Sufi sheikhs of the earlier centuries. Also the author of the poem displays a deep knowledge of the general Sufi Islamic culture of his time, often referring to poetic images of famous Sufi poets of different countries. The musical instruments presented in the poem give a deep insight into the fact that each group of dervishes may have had their own set of instruments and their own dances. A common genre for all Sufi groups in the world is the genre of munajat, which appears four times in the poem as a separate prayer chapter. Results and novelty of the study: In this paper much attention is paid to the analysis of Sufi musical genres and instruments which were typical of that era. Also a number of the most favorite musical instruments are identified, which were widely used during the Sufi ritual of listening to sama`. The differences between the terms sama` (Sufi listening ritual) and the dance genre of Crimean Tatars “sema” and Tajik “samo” are explained separately. The musical instruments, such as arganun and organ, as well as musikar / musigar, which have different descriptions in historical and modern scientific literature, are also studied separately. The description of the organ in the context of the poem together with the image of the immortal bird Kuknus / Phoenix gives the readers the poem the image about two variants of the wind instrument – the Pan flute type and the keyboard type with mechas. Since we have not found a precise description of the organ and the arganun / musikar in the poem itself, this question remains open for future research. The poem “Kalandar-nameh” will no doubt be useful as a source on Sufi culture of different tariqats of the Middle Ages.

Political Economy of Agriculture and Food Policy in Africa

This article reviews the literature on the political economy of agricultural and food policy in sub-Saharan Africa. In doing so, it first presents a conceptual framework highlighting that agricultural and food policy decisions are contingent on the intersection between governance structures, the preferences and pressures from societal interest groups, and international dynamics. The interrelations among these three factors are then examined across several different sets of policy instruments that have been the focus of traditional political economy research in the region: trade, tax, and marketing policies; public investments and regulations; input and food subsidies; and cross-cutting policies for value chain development. Recognizing several broader demographic, technology, and governance transitions in the region, the article also highlights key areas for future analysis that examine the role of cities in food policy, the possibilities presented by expanded mobile phone and Internet access, and the efficacy of new public administration modalities for policy implementation.

Contribution of machine learning and physics-based sound simulations for the optimization of brass instruments

Sound simulations by physical model are interesting to transcribe the physics underlying the functioning of a musical instrument. These simulations make it possible to create virtual sounds with a mode of operation representative of the interaction musician/instrument (driving a sound by the causes that create it). The work consists in studying the contribution of machine learning (ML) methods in the optimization of a musical instrument. The application concerns the brass instruments (trumpets). From a training set of virtual instruments, ML methods are trained to model the intonation (represented by the equivalent fundamental pitch) and the ease of emission (represented by the threshold pressure obtained by linear stability analysis) of sounds, according to the modal parameters of the input impedance. With the ML models, an optimization with genetic algorithms is next carried out to improve the intonation and the ease of emission. The last stage of the approach consists in the optimization of the bore of the instrument (optimization of the shape of the leadpipe). The results show that the approach gives promising results: optimal instruments are actually efficient when re-simulated with the physical model. The manufacturing of an optimal instrument is in progress to confirm the validity of the approach

Optimising the acquisition conditions of high information quality low-field NMR signals based on a cutting-edge approach applying information theory and Taguchi's experimental designs – Virgin olive oil as an application example

BackgroundDeveloping a new spectrometric analytical method based on a fingerprinting approach requires optimization of the experimental stage, particularly with novel instruments like benchtop low-field NMR spectrometers. To ensure high-quality LF-NMR spectra before developing the multivariate model, an experimental design to optimize instrument conditions is essential. However, difficult-to-control factors may be critical for optimization. Taguchi methodology addresses these factors to obtain a system robust to variation. This study uses the Taguchi methodology to optimize instrument settings for acquiring high-quality 1H and 13C LF-NMR signals in a short time from virgin olive oil (VOO). ResultsTwo experimental trials (for 1H and 13C signals, respectively) were carried out and analysed to find an optimal and robust combination of instrument settings against changes in two difficult-to-control factors: ambient temperature and small deviations of the NMR tube volume (700 ± 50 μL). The responses to be optimised, run time and spectral information quality, were analysed separately and jointly, as some factors showed opposite behaviour in the effect on the responses. Multiple response analysis based on suitable desirability functions yielded a combination of factors resulting in desirability values above 0.8 for 1H LF-NMR signals and almost 1.0 for 13C LF-NMR signals.In addition, a novel approach to assess the information quality of an analytical signal was proposed, addressing a major challenge in analytical chemistry. By applying information theory and calculating information entropy, this approach demonstrated its potential for selecting the highest quality (i.e. most informative) analytical signals. SignificanceThe acquisition instrument conditions of LF-NMR were successfully optimised using Taguchi methodology to acquire highly informative 1H and 13C spectra in a minimum run time. The importance lies in the future development of non-targeted analytical applications for VOO quality control. In addition, the innovative use of information entropy to a priori assess the signal quality represents a significant advance and proposes a solution to a long-standing challenge in analytical chemistry.

Case Report: When Arteries Betray: Massive Post-transplantation Hemorrhage

Hepatic artery pseudoaneurysm is a rare complication that may occur in the setting of liver transplantation and other traumatic instrumentation of the hepatobiliary system. This condition poses a significant morbidity and mortality risk and must be diagnosed and intervened upon emergently. Herein we present a case of hepatic artery pseudoaneurysm complicated by hemorrhagic shock in the setting of a post-liver transplant biliary leak. In this case, the patient was ultimately diagnosed via hepatic angiogram, treated with hepatic artery embolization, and required subsequent retransplantation. The objective of this case was to demonstrate the importance of maintaining a high clinical suspicion for hepatic artery pseudoaneurysm in the post-transplant setting, emphasize the use of computed tomography angiography as a primary diagnostic tool, and involving interventional radiology early in the treatment course.

Probing the Impact of Radio-mode Feedback on the Properties of the Cool Circumgalactic Medium

We explore the influence of radio-mode feedback on the properties of the cool circumgalactic medium (CGM). To this end, we assemble a statistical sample of approximately 30,000 radio galaxies with background quasars by combining optical spectroscopic measurements of luminous red galaxies and quasars from the year 1 data set of the Dark Energy Spectroscopic Instrument and radio sources from the LOw-Frequency ARray Two-metre Sky Survey (LoTSS) DR2 catalog and the Very Large Array Sky Survey (VLASS) quick-look catalog. Galaxies with similar optical properties but with no radio counterparts in LoTSS and VLASS are selected as the control group. We measure the cool CGM properties of radio galaxies and their control samples traced by Mg ii absorption lines, including covering fraction, rest equivalent width, and gas kinematics. Our results show no significant difference in the properties of gas around radio galaxies and their control sample, indicating that the operating radio-mode feedback of massive galaxies does not produce detectable effects on the properties of the cool CGM. Finally, we show that the CGM of radio galaxies contains a nonnegligible amount of cool gas with approximately 1010 M ⊙. This abundance can place a stringent constraint on the radio-mode feedback models.

The Procedure for Admitting New Members to the European Union: Legal Aspect

INTRODUCTION. The article is devoted to the process of accession of new states to the European Union (EU). The authors try to demonstrate the evolution of the procedure for admitting new members since the formation of the European Communities and identify the main subjects of this procedure.MATERIALS AND METHODS. The current research is based on various international legal documents, including the founding treaties of the European Union, as well as acts of EU institutions and doctrinal sources.RESEARCH RESULTS. The research represents a retrospective analysis of the formation of the procedure for accession of new members to the European Communities/EU. It was found out that the norms of the founding agreement set only the general legal framework of the procedure, and its specific content differed through out the existence of the European integration project. The actual content of the accession process is determined by the member states, which, through the institutions of the Communities/Union, primarily the Council and the European Council, formulate the criteria and principles of accession. The Commission also plays a significant role in the process. The role of the European Parliament in this procedure is insignificant, although this institution tries to increase its influence throughout the negotiation process. DISCUSSION AND COCLUSION. To sum up, the accession procedure is typologically close to a special legislative procedure. Since its origin the accession of new states to the EU has been transformed from a rule-making procedure enshrined in the founding treaties to a set of various instruments and practices, including non-legal (political) ones.

Dynamics of Burn Wound Healing in Children: Dependence on Anthropometric Parameters

Thermal trauma among pediatric patients has remained the leading cause of hospitalization in pediatric surgery departments in recent decades. Anthropometric parameters are often used by doctors when performing a comprehensive assessment of the child's physical development, and can also be used as essential factors in predicting the course of the disease. The aim of the study was to assess the dynamics of burn wound healing and its relationship with anthropometric parameters in individuals of the first period of childhood. Material and methods. The study involved investigation of the wound healing process in 125 male children, aged 4–6, having different levels of physical development. The patients' height, body weight (with calculation of the body mass index), head, chest and waist circumferences were measured on the day of admission using a standard set of anthropometric instruments, the WHtR index (waist to height ratio), and the head to chest ratio was calculated. Based on the BMI parameters, patients were divided into two groups: with normal weight and overweight. The wound area was measured on the 1st, 3rd, 5th, 7th and 9th days using the stereometric technique, applying a polyethylene antiseptic-processed film to the wound surface; this followed by outlining the edges of the wound defect. The results were processed using nonparametric statistics. Results It was found that in overweight patients, all the studied parameters, except for the ratio of head circumference to chest circumference, were higher than in children with the normal body weight. Correlations were detected between a number of anthropometric parameters in patients of both groups. On the 7th day, 73.9% of children with the normal body weight demonstrated epithelialization of the wound defect over the entire surface area of the wound, while in overweight children this was observed only in 34% of cases. Conclusion. As demonstrated, we obtained anthropometric measurements in boys of the first period of childhood having normal and overweight body weight. In children with the normal body weight, the process of wound epithelialization was completed mainly on the 7th day, while in patients with excess body weight, the wound defect closed by the 9th day. Excess body weight in children has a statistically significant relationship with an increased healing time of burn wounds.

Reconnoitering the Correlation between ICT Facilities’ Application and Capacity Building of Library Staff in University Libraries in South-South, Nigeria

Technology integration in library operations is fundamental to meeting information, literature and research needs of students, researchers and administrative staff of tertiary institutions. This study explored the correlation between ICT facilities application such as social media handles, internet, as well as online public access catalogue (OPAC) and capacity building of library staff in public university libraries in South-South, Nigeria. Correlational research design was used to examine the extent to which ICT facilities’ application correlate with capacity building of library staff. Three (3) each of research objectives, questions, and hypotheses were formulated to guide the study. The population was 416 library staff from six public university libraries. The total enumeration sampling technique was used. Two sets of self-structured questionnaire instruments totaling 416 copies were used for data collection, out of which, 306 were retrieved and analyzed which represented 74% response rate. Face and content validity of the instruments were done. A reliability test was conducted which yielded the coefficients of 0.89 and 0.85 respectively. The research questions were analyzed using Pearson Product Moment Correlation Coefficient (PPMC) while the hypotheses were tested at 0.05 level of significance using linear regression statistics. Findings revealed a significant positive correlation between internet, social media handles application and capacity building of library staff, while applications of OPAC showed a feeble correlation with capacity building. Hence, the level to which ICT facilities’ application correlate with capacity building of library staff in the university libraries was insignificant, which by implication had negative effects on library staff services delivery. It was therefore recommended, among other measures, the implementation of a comprehensive ICT training programme to address gaps in ICT facilities’ application by library staff for effective utilization of all relevant technologies.

Making climate finance: toward everyday, historically informed, and reparative understandings

The centering of climate finance around a narrow set of institutions, sites, instruments, practices, and technologies is an achievement made possible by the domination of finance capital and policy elites. In this intervention, we shift the spotlight away from such elite projects and practices in favor of a wider understanding of urban climate finance—one that includes a more diverse set of sites, activities and participants. A wider and more inclusive conceptualization of urban climate finance requires accounting for the historical and ongoing role of finance in the production of climate vulnerability. Reconceptualized in this way, urban climate finance expands to include everyday financial life in cities around the world. Everyday climate finance is thus generated in places where the risks and uncertainties of climate change are currently unrecognized by policy elites as such, yet are being managed through improvised repertoires of financial practices. Additionally, (re)considering past financial practices as climate finance (e.g. historical residential redlining that produces climate vulnerability today), provides a rationale for demanding that past and present financial actors account for today’s climate injustices, and contribute to future reparative and abolitionist climate action.

TOPICAL ISSUES OF DOCTRINE AND COURT PRACTICE ON THE INTERNATIONAL RESPONSIBILITY OF THE STATE FOR THE ACTIVITIES OF FOREIGN NON-STATE ARMED GROUPS

The article examines the topical issues of doctrine and international judicial practice regarding the determination of the State's responsibility for international wrongful acts, in particular, those related to the activities of foreign non-State armed groups. The authors analyse the international legal framework of State responsibility for international wrongful acts, as well as individual criminal liability of individuals. The paper substantiates a set of economic and legal instruments for the implementation of international responsibility (reparations, satisfaction, restitution, economic sanctions) as a mechanism for ensuring compliance with international law by States. The study identifies the legal positions of the International Court of Justice, the International Criminal Court, the International Criminal Tribunal for the former Yugoslavia, the European Court of Human Rights and other international judicial institutions on the application of the concepts of "effective control" and "overall control" in judicial practice, as well as problematic issues of law enforcement.

Towards a Reinvigoration of the Risk Management Framework for the Scope of Upgrading Prudential Surveillance

This article discusses financial stability related notions of risk, the issue of convergence and cross financial sector prudential intervention. It elucidates the Basel framework shortcomings and enunciates the requirement of setting a reinvigorated prudential framework before proceeding to its essentials in terms of engineering. It highlights an early warning approach dealing with the issue of time reaction mismatch of the prudential authority and the priority of setting a long run forwarded guided approach. The objective of this research is to provide a clue into enhancing prudential setting of instruments, the forwarded guided purview of surveillance as well as hedging and the Balanced Score Card.

Optimization of whole slide imaging scan settings for computer vision using human lung cancer tissue.

Digital pathology has become increasingly popular for research and clinical applications. Using high-quality microscopes to produce Whole Slide Images of tumor tissue enables the discovery of insights into biological aspects invisible to the human eye. These are acquired through downstream analyses using spatial statistics and artificial intelligence. Determination of the quality and consistency of these images is needed to ensure accurate outcomes when identifying clinical and subclinical image features. Additionally, the time-intensive process of generating high-volume images results in a trade-off that needs to be carefully balanced. This study aims to determine optimal instrument settings to generate representative images of pathological tissue using digital microscopy. Using various settings, an H&E stained sample was scanned using the ZEISS Axio Scan.Z1. Next, nucleus segmentation was performed on resulting images using StarDist. Subsequently, detections were compared between scans using a matching algorithm. Finally, nucleus-level information was compared between scans. Results indicated that while general matching percentages were high, similarity between information from replicates was relatively low. Additionally, settings resulting in longer scanning times and increased data volume did not increase similarity between replicates. In conclusion, the scan setting ultimately deemed optimal combined consistent and qualitative performance with low throughput time.