Instrument Analysis Research Articles

A Newly Developed Compressed Air Cannon Test Bench Designed for Multi-Impact Analysis of Composite Structures

Understanding the response and damage evolution of structures subjected to multiple impact events is essential for designing resilient structures capable of withstanding complex loading scenarios, such as impacts from hail, gravel or foreign object debris. This article presents the development and characterization of a novel test bench, the “Compressed air multi-cannon”, designed specifically for studying the multi-impact behavior of composite materials. This test bench offers advantages over traditional impact testing methods by enabling controlled and adjustable impact parameters, including number of impacts, spatial and temporal lag, energy, angle and impactor dimensions. The primary objective of this work is to provide a detailed description of the test bench design, construction, and validation procedures. Key components such as the pressurized air system, projectile launch mechanism, target mounting arrangement, and data acquisition system are discussed. Experimental methodologies for assessing multi-impact response, specimen preparation, instrumentation, and data analysis techniques are outlined. Through a series of single-impact and multi-impact tests, distinctive damage mechanisms and energy absorption characteristics were observed in composite structures, revealing significant differences in how composites respond under single- and multi-impact conditions. It was found that the single-impact configuration remains particularly critical compared to multi-impact configurations with a high number of impacts. However, further testing is required to determine whether this result holds true under varying impact parameters, highlighting the unique value of this machine for exploring new, realistic questions in the literature.

Development and application of a LC-HRMS method for simultaneous determination of ten illicit antifungal drugs in herbal bacteriostatic products.

The widespread use of sub-therapeutic antibiotics may lead to treatment failures, increased resistance to antibiotics, and even the encouragement of the formation of superbugs. Fraudulent herbal medicines that actually contain unlabeled active ingredients are a global problem. Therefore, streamlined and accurate analytical techniques that can identify and quantify a variety of antimicrobials in suspected illegal products are required. In the present work, we developed a sensitive, robust, and accurate method that involves multi-step extraction, EMR-lipid-based pass-through cleanup, and UHPLC-Q/HRMS with an orbital ion trap instrument analysis for the simultaneous detection of ten illicit antifungal drugs (flucytosine, fluconazole, ketoconazole, naftifine hydrochloride, griseofulvin, bifonazole, econazole nitrate, elubiol, clotrimazole, and miconazole nitrate) in herbal disinfection products. This validated method was then applied to 210 authentic samples, resulting in 25% of the samples being positive for the drugs. The results suggested the need to strengthen controls in this field to detect illicit antifungal drugs in herbal bacteriostatic products, which represents a potential health risk for the consumer. On a global scale, more and more frequent routine monitoring is being carried out in this area. This study provides valuable insights into large-scale complex sample chemical profiling, and the method developed appears to be promising and applicable for high-throughput routine multiple antibiotic analysis in a complex sample matrix.

Metabolite profile analysis of methanol extract of belulang grass (Eleusine indica (L.) GAERTN) leaves by gas chromatography-mass spectrophotometry (GC-MS) method

Leaf of belulang grass (Eleusine indica (L.) Gaertn) is one of the wild plants that is used as herbal medicine by the community because of its many health benefits for the treatment of certain diseases such as diabetes, high blood pressure, and cholesterol. A materil is said to have potential as a medicine because the composition of the chemical compounds contained in a plant is not always the same and requires further testing. Differences in chemical compound content can be influenced by environmental factors and plant metabolism. The aim of this research is to analyze the metabolite profile and abundance of metabolite compounds using the GC-MS instrument analysis approach. Sampling was conducted in Sidomulyo Village, Air Kumbang District, Banyuasin Regency, South Sumatra. Samples of belulang grass leaves obtained were dried, pulverized, and extracted with methanol solvent. The methanol extract was analyzed using GC-MS. The results showed that the highest 20 compound peaks were obtained based on the relative area percent of the 69 compounds obtained with an abundance of compounds amounting to 80.86%. At the highest peak, the compounds n-hexadecanoic acid, I-(+)-ascorbic acid 2, 6- dihexadecanoate, and pentadecanoic acid were found with a percent area of 31.25%.

Validación de una escala de innovación en marketing en consumidores de pequeños y medianos restaurantes

Marketing innovation contributes to commercial and organizational success; therefore, it is important to have a scale that measures such construct comprehensively. Hence, this research aimed at developing and validating a scale to measure the perception of marketing innovation from consumers of small and medium-sized restaurants’ point of view. The process was carried out in five stages: design of the instrument, content validity, pilot test and exploratory analysis of the scale (with 52 diners), confirmatory factor analysis (with 286 diners), and verification of the scale through a structural model. Results show a high-order scale with five dimensions: technology, management, market research, competitiveness and marketing mix; and sixteen items.

Advancements in mass spectrometry-based proteomics: anew era in pathology research and diagnostics.

Mass spectrometry (MS)-based proteomics is rapidly transforming pathology research and diagnostics by enabling comprehensive studies of protein expression and post-translational modifications (PTMs). This article discusses recent advancements in MS-based proteomics, focusing on emerging technologies in sample preparation, MS instrumentation, and data analysis. These developments are scrutinized for their applications in clinical cohort studies and molecular pathology diagnostics. The article reviews innovations in automated sample preparation, chromatography systems, advanced MS technologies, and proteomic data analysis in the context of pathology. Specific applications such as liquid biopsy, spike-in heavy peptide panels, immunopeptidomics, and PTM screening are highlighted alongside opportunities for data integration. Recent technological improvements have significantly increased the throughput, precision, and scope of proteomic studies, enabling the analysis of large clinical cohorts and small specimens with unprecedented sensitivity. Advanced MS techniques have broadened applications, opening new avenues for discovery and diagnosis of marker proteins and therapeutic targets. Advancements in MS-based proteomics have created new opportunities in clinical research and diagnostics. By facilitating more comprehensive and integrated analyses of proteomes, these technologies are set to play apivotal role in the future of personalized medicine and pathology research.

The Mediating Impact of Service Quality Towards Improving Sustainable Organizational Performance Private University in Indonesia

This study aims to determine the challenges of dynamics in the turmoil of sustainable transitions in the context of Organizational Performance at LLDIKTI 3 Jakarta Private University The independent variables used in this research are Organizational Change, Risk Management, Good University Governance, and ICT Competencies while the dependent variable used is Organizational Performance and also the mediating variable used is Service Quality. The methodology used in this study uses quantitative methods, implementation questionnaires via Google form, then the output data is collected for further protection. The population in this study is Private University with a total of 283 institutions, in the context of the University cluster there are 68 institutions. The sample in this study were 376 respondents. Instrument analysis applied to SmartPLS 3.0 with stratified random sampling method technique. .In order for higher education institutions to be managed effectively, openly, accountably, and able to implement their learning and research objectives, good university governance is very important. Here are some suggestions for effective Good University Governance such as continuous improvement is necessary for good governance, and this requires regular assessment of policies, practices, and procedures to ensure they remain relevant, efficient, and aligned with the agency's mission and goals.

Pengaruh Promosi dan Citra Merek Terhadap Keputusan Pembelian pada Bengkel Mobil Garasi-In

The purpose of the study was to determine the extent to which the promotion and brand image of the car repair shop influence purchasing decisions. The study used a quantitative method by distributing questionnaires to 97 respondents via Google Form. Data includes instrument analysis to assess validity and reliability, classical assumption tests such as normality tests, heteroscedasticity tests, and multicollinearity tests, hypothesis tests such as t-tests and F-tests, multiple linear regression analysis, and calculating the coefficient of determination. This provides results that promotion and brand image have a significant influence on purchasing decisions. Producing a contribution value of promotion variables and brand image variables to purchasing decisions of 68.8% to purchasing decisions..

Recent Advancements in Proteomic Sample Preparation from Recombinant Chinese Hamster Ovary Cells.

Chinese hamster ovary (CHO) cells are the most commonly used mammalian host cell line for biopharmaceutical production because of their ability to correctly fold and post-translationally modify recombinant proteins that are compatible with human use. Proteomics, along with other "omic platforms," are being used to understand the biology of CHO cells with the ultimate aim to enhance CHO cell factories for more efficient production of biopharmaceuticals. Liquid chromatography-mass spectrometry (LC-MS) for proteomic analysis has become the standard technique for profiling proteomes. There are three stages to a typical bottom-up approach, namely, sample preparation, LC-MS/MS, and data analysis. Although there have been major advances in LC-MS/MS instrumentation and data analysis tools, sample preparation is still the crucial stage that affects the overall efficiency of any proteomic study. In this chapter, we present a comparison of a number of widely used sample preparation methods for proteomic applications, including in-solution digestion and commercially available device-based kits. All methods performed well; however, each method has inherent advantages and disadvantages.

Design, Implementation, and Analysis of an Assessment and Accreditation Model to Evaluate a Digital Competence Framework for Health Professionals: Mixed Methods Study.

Although digital health is essential for improving health care, its adoption remains slow due to the lack of literacy in this area. Therefore, it is crucial for health professionals to acquire digital skills and for a digital competence assessment and accreditation model to be implemented to make advances in this field. This study had two objectives: (1) to create a specific map of digital competences for health professionals and (2) to define and test a digital competence assessment and accreditation model for health professionals. We took an iterative mixed methods approach, which included a review of the gray literature and consultation with local experts. We used the arithmetic mean and SD in descriptive statistics, P values in hypothesis testing and subgroup comparisons, the greatest lower bound in test diagnosis, and the discrimination index in study instrument analysis. The assessment model designed in accordance with the competence content defined in the map of digital competences and based on scenarios had excellent internal consistency overall (greatest lower bound=0.91). Although most study participants (110/122, 90.2%) reported an intermediate self-perceived digital competence level, we found that the vast majority would not attain a level-2 Accreditation of Competence in Information and Communication Technologies. Knowing the digital competence level of health professionals based on a defined competence framework should enable such professionals to be trained and updated to meet real needs in their specific professional contexts and, consequently, take full advantage of the potential of digital technologies. These results have informed the Health Plan for Catalonia 2021-2025, thus laying the foundations for creating and offering specific training to assess and certify the digital competence of such professionals.

Developing Models for Measuring and Evaluating Success in Vocational and Professional Education and Training. An Empirical Study

This study aimed to evaluate the performance of vocational high schools by developing and applying a comprehensive assessment instrument. The focus was on the actual processes occurring within these institutions, rather than solely relying on document-based evaluations. By analyzing factors affecting school performance, constructing a valid instrument, and conducting a thorough evaluation, the study found that the investigated vocational high schools demonstrated satisfactory performance in general management and academic management. Most of the evaluations of education, training and performance carried out in vocational high schools focus on documents or passive data, rather than on the processes taking place in the secondary schools themselves. Recognizing the need to study precisely these processes, this study focuses on the performance evaluation of secondary schools. The study begins with the identification of constructs and the development of instruments to assess the performance of vocational high schools. Based on the problems found in the field, before conducting the evaluation, the researcher must first develop the evaluation tool through three stages of development. The first one is to analyze the concepts related to evaluation by examining the factors affecting the performance of vocational high schools. In the second, instrument development and instrument analysis (content validation of selected criteria) are conducted with the help of experts. The third one, entailed a rigorous evaluation of the effectiveness of vocational secondary schools. Based on the evaluation findings, the investigated vocational high schools demonstrated commendable performance in both general management and academic management.

Analysis and monitoring of the behavior of a rock fill dam ten years after construction: a case study of the Iran-Madani Dam

AbstractIn this study we compared dam monitoring results with those of numerical analysis to propose a plan for the first reservoir impounding of the Iran-Madani Rock fill dam, ten years after the completion of its construction. The stability of the dam body has been assessed using numerical analysis and data obtained from sensors installed in the dam. The correctness and accuracy of the geotechnical parameters of the dam body materials were confirmed by comparing the results of numerical analysis and monitoring through back analysis. The linear correlation coefficients between the experimental data and the numerical results for settlement, pore water pressure, and total stress are 84%, 67%, and 99%, respectively. In addition, the agreement between the design assumptions with both the numerical analysis results and instrumentation data was examined. The arching ratio values obtained from instrumentation and numerical analysis in the core of the dam are 0.47 and 0.35, respectively, indicating the safety of the dam. Finally, a numerical sensitivity analysis was conducted to present a special impounding program for the dam, with a focus on controlling simultaneous changes in pore water pressure and effective stress in the clay core, ten years after the completion of the dam body construction.

Improving digital storybook story comprehension in kindergartners with developmental delays using peer-assisted learning strategies

This study evaluated the effect of peer-assisted learning strategies (PALS) intervention on the language and story comprehension skills of two kindergartners with developmental delays from a special education class while reading a digital storybook. The study was conducted in Taiwan with participants who spoke Mandarin Chinese. This study was a single-subject A-B1-C1-B2-C2-M study. The study compared the effects of conventional teaching methods with those of the modified PALS intervention. A standardized instrument and visual analysis were used to assess changes in language and story comprehension skills. After the intervention, the teacher and parents of the study participants were interviewed to evaluate changes in language skills of the participants at home and at school. The qualitative and quantitative results showed that this strategy effectively improved story comprehension skills. The teacher and parents all had positive views on this teaching strategy. Based on the findings, practical and future research suggestions are proposed.

Pengaruh Peran Koperasi Dalam Menumbuhkan Jiwa Kewirausahaan Pada Pengurus Dan Anggota Koperasi Sekolah SMAN Banjarmasin

This study aims to analyze the influence of the role of cooperatives in fostering the entrepreneurial spirit, especially in the administrators and members of school cooperatives in SMAN Banjarmasin City. The research method used is descriptive research with a quantitative approach. Samples were taken using purposive sampling technique as many as 163 people consisting of administrators and members of school cooperatives. Data collection techniques through observation, interviews and questionnaires to administrators and members of school cooperatives and by taking references from journals, books and other relevant sources. Instrument analysis in this study used the Rasch Model. Data analysis in this study was conducted using descriptive statistical analysis, classical assumption analysis, simple regression analysis and partial test (t-test). The results showed that there was a positive influence between the role of cooperatives on the entrepreneurial spirit of the administrators and members of school cooperatives in Banjarmasin City High School.

Structure and anticoagulant activity of a galactoarabinan sulfate polysaccharide and its oligosaccharide from the green algae, Codium fragile

A polysaccharide, CZS-0-1, was obtained from the marine green algae Codium fragile using ion-exchange and size-exclusion chromatography. Composition and characteristics analyses showed CZS-0-1 was a sulfated galactoarabinan consisting of arabinose, galactose and a small amount of glucose in a ratio of 9:2:1 with 21% sulfate content and a molecular weight of 810 kDa. Structural properties were determined using desulfation and methylation analyses combined with instrument analysis. The results showed that the backbone of CZS-0-1 was (1 → 3)-β-L-Arap. Its O-4 and/or O-2 positions showed sulfate modification; additionally, it had 10% of (1 → 3)-β-D-Galp branches at the O-4 position of the (1 → 3)-β-L-Arap. The galactose side chains also had sulfate modification at the O-4 or O-6 position. The structure of CZS-0-1 was further confirmed by Top-down analysis of the oligosaccharides after oxidated hydrolysis by mass spectrometry. CZS-0-1 exhibited significant heparin-like anticoagulant activity. It exerted anticoagulant effects by inhibiting FIIa and FXa activities with the presence of heparin cofactors. The anticoagulant activity of CSZ-0-1 was closely related to the molecular weight, and the reduction of molecular weight may lead to a significant decrease in the anticoagulant activity. This study demonstrated that the green algae, Codium fragile can be considered as a useful resource for bioactive polysaccharides.

Pengaruh Pengetahuan Investasi, Persepsi Return dan Persepsi Risiko Terhadap Minat Berinvestasi di Platform Bibit: Studi pada Mahasiswa UBP Karawang

This research aims to find out the influence of investment knowledge, perception of return and risk perception on the investment interest of students of Buana University of Karawang Struggle in the Plant Platform partially and simultaneously. The population includes the entire UBP Karawang student recorded on the 2023 forlap with a sample of 100 respondents, and the sample is calculated using the Slovin formula. Purposive sampling is used as a sampling technique. The Likert scale is used as a measurement scale on questionnaires in data collection. For instrument analysis, validity and reliability tests are used. The data analysis method applied is the double regression analysis, which is supported by the classical assumption test as well as the hypothesis test of the t test, the f test and the R2 test using the SPSS 26 program. This research results in whether investment knowledge, perception of return and risk perception significantly influence the investment interest of UBP Karawang students in the Bibit platform partially and simultaneously. Three free variables in this study influenced the interest of UBP Karawang students in investing in Bibit platforms (only 55,%) that means, many other free variable that can affect the interest investing UBP karawang students on Bibit Platform.

Pengaruh Customer Experience, Keamanan, dan Ketepatan Waktu Terhadap Kepuasan Pelanggan Shopee Express di Kota Bandung

Indonesia is the country with the fourth largest number of internet users in the world, after the United States, with 212.9 million users in 2023. The development of technology and the internet has had a significant impact on people's lives, especially in terms of online shopping. E-commerce users in Indonesia have increased significantly in recent years. Shopee is one of the platforms that is often used by Indonesians to shop online easily, safely, and quickly. This platform supports customers with strong payments and logistics services, and can be easily accessed via smartphones. Shopee Express, as part of Shopee's e-commerce service, has advantages over other platforms because of the various offers provided. However, a number of Shopee consumers have complained about the delivery service, ranging from damaged goods to packages that arrive late. This study aims to determine the effect of Customer Experience, Security, and Punctuality on Shopee Express Customer Satisfaction in Bandung City. This study uses a descriptive and verification approach with quantitative methods, and data collection techniques using questionnaires. Respondents' answers to the questionnaires distributed were then analyzed using research instrument analysis, classical assumption tests, and multiple linear regression. The statistical analysis tool used in this study is the Statistical Package for the Social Science (SPSS) software. The number of samples in this study was 385 people, selected through simple random sampling techniques. The results of multiple linear regression analysis show that partially, Customer Experience has an effect of 11.953, Security of 5.466, and Punctuality of 8.647, which have a positive and significant effect on Customer Satisfaction. Simultaneously, Customer Experience, Security, and Punctuality have a positive and significant effect on Customer Satisfaction of 389.559, with a coefficient of determination of 75.2%.

ANALYSIS OF METANIL YELLOW IN PACKAGED JAMU BY UV-VIS SPECTROPHOTOMETRIC METHOD

Introduction. Metanil yellow is a synthetic coloring material used for textile products, wood paint, painting paint, and fur. Despite its use having been banned in the Regulation of the Minister of Health of Indonesia No. 239/MENKES/PER/V/1985, metanil yellow is still commonly found in the local community. In Indonesia, this coloring material is often misused to color various types of food, including herbs, crackers, noodles, tofu, and yellow snacks. The purpose of this research is to validate the analytical method for determining metanil yellow levels in herbal medicine of jamu using the UV-Vis spectrophotometric method. Method. In this research, the determination of metanil yellow levels was carried out by instrument analysis using the UV-Vis Sectrophotometric method. Result & Analysis. In the linearity validation parameter, the regression equation y = 0.0548x-0.01398 is obtained with an r² value of 0.9999, the LOD parameter is 0.11686 ppm, LOQ is 0.5620 ppm, the precision parameter RSD value obtained is 0.87% which meets the requirements of ≤ 4%. Furthermore, the results on the determination of metanil yellow levels in each sample A obtained a percentage of 0.00006755% ± 3.9260; sample B obtained a percentage of 0.000110% ± 10.5309; and sample C obtained a percentage of 0.0001023% ± 9.2998. Discussion. Given the very low concentration, it is possible that the yellow color in the herbal medicine samples is not completely caused by metanil yellow, but it might also be influenced by other natural ingredients with yellow pigments.

Pengaruh Product Ingredients, Brand Ambassador dan Social Media Marketing terhadap Keputusan Pembelian Produk Viva Cosmetics di Kota Bandung

Cosmetic products have recently become very close to the community and have even become a major need for most women. The magnitude of this cosmetic need causes competition between cosmetic manufacturers. The purpose of this study was to determine the effect of Product Ingredients, Brand Ambassadors, and Social Media Marketing on Purchasing Decisions for Viva Cosmetics Products in Bandung City. The type of research used is descriptive and verification with an approach using quantitative methods, with data distribution techniques using a questionnaire. The results of respondents' answers to the questionnaires distributed, then the research instrument analysis, clasi assumption test, and multiple linear regression will be carried out. Statistical analysis tools in this study used Statistical Package for the Social Science (SPSS) software. The number of samples in this study were 385 people, by determining the sample using simple random sampling. Based on the results of the t test in this study, it shows that partially Product Ingredients, Brand Ambassadors, and Social Media Marketing have a positive and significant influence on Purchasing Decisions. Simultaneously Product Ingredients, Brand Ambassadors, and Social Media Marketing have a positive and significant influence on Purchasing Decisions. The results showed that Product Ingredients, Brand Ambassadors, and Social Media Marketing had an influence of 39.1% on Purchasing Decisions while the remaining 60.9% was influenced by other variables not examined in this study.

Phenolic Content and Functional Groups of Green Tea Kombucha, Telang Flower Kombucha, Rosella Flower Kombucha, Chamomile Flower Kombucha, and Lavender Flower Kombucha

Kombucha is a fermentation product between green tea and microorganisms. The basic ingredients for kombucha can be obtained from plants that contain high antioxidants, such as green tea, butterfly pea flowers, rosella flowers, chamomile flowers and lavender flowers. The aim of this research was to determine the phenolic content and functional groups in green tea kombucha, telang flower kombucha, rosella flower kombucha, chamomile flower kombucha and lavender flower kombucha. This research uses experimental research by testing phenolic content using a UV-Vis Spectrophotometer instrument and functional group analysis using Fourier Transform Infrared (FTIR). The results showed that the phenolic content of green tea kombucha was 162.35 mg/L GAE, butterfly pea flower kombucha was 124.46 mg/L GAE, rosella flower kombucha was 101.30 mg/L GAE, chamomile flower kombucha was 35.41 mg/L GAE and lavender flower kombucha was 136.43 mg/L GAE. The highest phenolic content is found in green tea kombucha. The spectra resulting from the identification of telang flower kombucha tea samples contain alcohol functional groups, amines, nitro compounds, and the broad peaks indicate the stretching vibration of OH monometric alcohol. In green tea kombucha, alkenes, alkynes and monometric alcohol groups are found. In rosella flower kombucha, the functional groups alcohol, alkene, alkyne, nitrile and phenol are found. In chamomile flower kombucha, the functional groups ether, amine, alkene, alkyne, ester and alcohol are found. In lavender flower kombucha, the functional groups alcohol, alkene, alkyne and alkane are found. It can be concluded that kombucha contains secondary metabolite compounds including flavonoids, phenolics, saponins, tannins, steroids and triterpenoids.

Pengaruh Harga Dan Diferensiasi Produk Terhadap Keputusan Pembelian Pada Rumah Makan Sagala Sunda

The aim of this research is to determine the partial and simultaneous influence of price and product differences on purchasing choices at the Sagala Sunda Restaurant. This research method uses quantitative, which is based on certain groups or samples based on the principles of positivism. The research population consisted of customers who ate at the Sagala Sunda Restaurant, resulting in a sample size of 150 people. Data examination includes instrument analysis to assess validity and reliability, classical assumption tests such as normality tests, heteroscedasticity tests, and multicollinearity tests, hypothesis tests such as t tests and F tests, multiple linear regression analysis, and calculating the coefficient of determination. The findings from this research show that price and product differentiation have a positive and significant effect on purchasing decisions at the Sagala Sunda Restaurant. In addition, it is shown that these two variables together contribute 78.5% of the impact on purchasing decisions.