Instantaneous Rate Research Articles

Association Between Finger Plethysmographic Features and Impedance-Based Thoracic Fluid Content Measurement in a Lower Body Negative Pressure Model of Hemorrhagic Shock.

Timely identification of the need for lifesaving intervention in battlefield conditions may be improved through automated monitoring of the injured warfighter. Technologies that combine maximal noninvasive insight with minimal equipment footprint give the greatest opportunity for deployment at scale with inexperienced providers in forward areas. Finger photoplethysmography (PPG) signatures are associated with impending hemorrhagic shock but may be insufficient alone. Transthoracic impedance (TTI) monitoring is a complementary modality to PPG and able to identify volume loss and estimate functional cardiovascular parameters. We sought to understand how PPG features correlate with volume loss estimation from TTI during lower body negative pressure (LBNP) challenge. We hypothesized that features of the PPG waveform would correlate with thoracic fluid content (TFC) as measured by TTI. We obtained physiologic monitoring data from healthy adult subjects in LBNP hemorrhagic shock models after local Institutional Review Board and DoD Human Research Protection Office approval. Subjects were excluded for pregnancy, age >45 years, and conditions prohibitive of LBNP exposure. Subjects were instrumented with noninvasive sensors, including a finger PPG sensor and a TTI monitor. Subjects underwent a stepwise LBNP exposure program of -10 mmHg every 10 minutes and notified laboratory staff at first sign of near syncope, terminating the sequential program. TTI data were continuously streamed to a custom program written in MATLAB and time synchronized. To calculate PPG measures, we downsampled data to 250 Hz, screened, and parsed each beat. We featurized each beat to include a systolic, diastolic, and dicrotic notch peak, beat length and area under the curve (AUC), peak-to-peak systolic/diastolic interval, and leading/trailing slopes, all normalized to instantaneous heart rate. Thoracic fluid content was normalized to subjects' pre-LBNP baselines. We summarized all PPG features and the TFC using means (SD) generated as a subject average for each step. We used generalized estimating equation models to examine the relationship between TFC and PPG features while controlling for LBNP stage and subject. Thirty-two subjects were enrolled; 4 participants were excluded because of sensor malfunction. Twenty-eight subjects had a mean (SD) age of 25.11 (6.66) years. A total of 35.7% of subjects were female. Photoplethysmography analysis demonstrated a decreased systolic-diastolic peak interval, diastolic peak height, and beat AUC with decreased LBNP pressure. End-stage baseline normalized TFC showed an average decrease of 14.68% (±4.98%) (range: 7.54% to 27.69%). The strongest average correlations between stage TFC and PPG occurred in beat length (0.68) and normalized AUC (0.69). In generalized estimating equation models incorporating all stages, beat length, normalized AUC, and the systolic-diastolic interval were all significantly associated with time as a function of LBNP level (P < .001). Thoracic fluid content began decreasing at 12.8 (4.7) minutes, the normalized AUC decreased at 20.7 (7.2) minutes, the beat length decreased at 20.9 (7.0) minutes, and the systolic-diastolic time interval decreased at 30.6 (16.7) minutes. While both PPG features and impedance-based TFC trend congruently in the perishock state following LBNP exposure, peripheral pulse wave signals lag redistribution of thoracic fluid volume. Photoplethysmography features of beat length and normalized AUC may serve as a surrogate for TFC when direct thoracic sensing is not available.

Advanced design strategies and applications for enhanced higher-order multisegment denatured Pascal curve gears

The existing Pascal curve gears are limited by inflexible pitch curves and constrained transmission ratio changes, which hinders the application in a range of mechanical systems that require more adaptable gear solutions. To address this, a design procedure for higher-order multisegment denatured Pascal curve gear is proposed. A unified mathematical expression for the Pascal curve gear family is derived, enabling the construction of non-circular gears with free-form pitch curves by adjusting key parameters and offering more flexible pitch curve and a wider range of transmission ratios. Compared with elliptical gears and eccentric circular gears, its transmission ratio range can be expanded by up to 35%. Then the transmission characteristics of these gears are analyzed in detail. To validate the design, the visual analysis and design software of the gear is compiled based on Visual Basic, and is verified with the example. The novelty Pascal curve gears is applied to drive the differential velocity vane pump. The displacement, instantaneous flow rate, and pulsation rate of the differential velocity vane pump are calculated. The comparison with the differential pumps driven by eccentric non-circular gears and Fourier non-circular gears shows that when the pitch curves are not concave, the displacement driven by Pascal curve circular gears is the highest (compared to differential pumps driven by eccentric non-circular gears, and Fourier non-circular gears, their flow rates increased by 50.6%, and 175.7%, respectively), and the instantaneous flow pulsation rate of single pump is the smallest.This study shows that the higher-order multisegment denatured Pascal curve gear provides a viable solution for systems requiring flexible transmission mechanisms and improved operational performance.

An Analysis of Vertical Infiltration Responses in Unsaturated Soil Columns from Permafrost Regions

Rainfall infiltration affects permafrost-related slope stability by changing the pore water pressure in soil. In this study, the infiltration responses under rainfall conditions were elucidated. The instantaneous profile method and filter paper method were used to obtain the soil–water characteristic curve (SWCC) and hydraulic conductivity function (HCF). During the rainfall infiltration test, the vertical patters of volumetric moisture contents, total hydraulic head or suction and wetting front were recorded. Advancing displacement and rate of the wetting front, the cumulative infiltration, the instantaneous infiltration rate, and the average infiltration rate were determined to comprehensively assess the rainfall infiltration process, along with SWCC and HCF. Additionally, the effects of dry density and runoff on the one-dimensional vertical infiltration process of soil columns were evaluated. The results showed that the variation curve of wetting front displacement versus time obeys a power function relationship. In addition, the infiltration rate–time relationship curve and the unsaturated permeability curve could be roughly divided into three stages, and the SWCC and HCF calculated by volumetric moisture content are more sensitive to changes in dry density than to changes in runoff or hydraulic head height.

Monte Carlo modeling of a commercial machine and experimental setup for FLASH‐minibeam irradiations with electrons

BackgroundUltra‐high dose rate (UHDR/FLASH) irradiations, along with particle minibeam therapy (PMBT) are both emerging as promising alternatives to current radiotherapy techniques thanks to their improved healthy tissue sparing and similar tumor control.PurposeMonte Carlo (MC) modeling of a commercial machine delivering 5–7 MeV electrons at UHDR. This model was used afterward to compare measurements against simulations for an experimental setup combining both FLASH and PMBT modalities.MethodsWe modeled the main accelerator elements with TOPAS3.8/Geant4.10.07.p03, optimized the electron source parameters, and subsequently benchmarked this geometry against measurements. Minibeam experiments were performed by delivering 7 MeV electrons at UHDR on three different 65‐mm thick brass collimators as manufactured for protons with a 400‐µm slit width: single slit, 5 slits with a center‐to‐center (CTC) distance of 4 mm and 9 slits with CTC of 2 mm. Finally, complementary simulations were run by changing critical PMBT collimator parameters to assess their specific impact on peak‐to‐valley dose ratio (PVDR) as well as on the Bremsstrahlung photon contribution to the total dose.ResultsPercentage depth dose (PDD) distributions and lateral dose profiles showed a good agreement between simulations and measurements, with a maximum discrepancy of less than 4%. With the PMBT collimators in place, discrepancies between simulated and measured dose profiles, lateral and in‐depth in peaks and valleys, were within 3%. High PVDR between 5 and 26 were observed until 4 mm in the phantom. During the experiments, a mean dose rate of 167 Gy/s and an instantaneous dose rate of 1.2 × 105 Gy/s were obtained for the FLASH‐minibeam setup. PMBT collimator parameters need to be optimized to maximize PVDR while limiting Bremsstrahlung photon contribution to the total dose.ConclusionsThe validation of the MC model and the configuration of an electron FLASH‐minibeam setup were successfully completed, paving the way for future radiobiological investigations.

The alteration of interspecific interaction responded to various relative sowing time in wheat/maize intercropping

IntroductionAn interspecific interaction is an important reason for the yield advantage of interspecific cropping compared with sole cropping, and the relative sowing time of species is an important factor affecting interspecific competitiveness. Our purpose was to explore the effects of different relative sowing times on the interspecific competition-recovery phenomenon in wheat and maize intercropping systems.MethodsThree planting methods (wheat/maize intercropping, wheat and maize sole cropping) and different relative sowing times of wheat were used to carry out field experiments over two years. Sequential harvest of subplots was performed between 3 and 6 times, and the biomass data were fitted to logistic growth model.ResultsDelaying the sowing time of wheat reduced the wheat yield, biomass and nutrient acquisition and increased those of maize, but wheat still had an intercropping advantage during the co-growth period. At the same time, the nutrient acquisition of maize was still inhibited, but its recovery growth advanced. Changing the relative sowing time of wheat significantly changed the maximum instantaneous growth rates of wheat and maize. Delaying the relative sowing time of wheat significantly reduced its maximum instantaneous growth rate, while enhancing that of maize, leading to a balanced mutual benefit.ConclusionsDelaying the sowing time of wheat to the same sowing time as maize will change wheat/maize intercropping from asymmetrical interspecific facilitation to symmetrical interspecific facilitation. However, in this case, intercropped wheat still had an interspecific competitive advantage in the co-growth stage, and intercropped maize still underwent a competition-recovery process.

Growth, mortality, exploitation, and recruitment patterns of Labeobarbus altianalis (Boulenger, 1900) in River Kuja-Migori, Kenya

The Ripon barbel, Labeobarbus altianalis, a riverine fish found in the Lake Victoria Basin is regarded as species of less concern, but it is vulnerable to overfishing and population decline. This study aimed at determining growth, mortality, exploitation rate, and recruitment patterns of L. altianalis (Boulenger, 1900) in River Kuja-Migori. A total of 1,217 specimens with overall total lengths ranging from 9.5-41.5 cm (mean 28.5 ± 2.7) were collected monthly from January to December 2021. The fish were caught using an electrofisher in wadable areas and monofilament nets in deeper areas. Electronic length frequency analysis (ELEFAN) software in Fish Stock Assessment Tools (FiSAT II) program was used to analyze data. Natural mortality (M) Fishing mortality (F) and total mortality (Z) coefficients were 0.15 year-1, 0.52 year-1 and 0.67 year-1 respectively. The asymptotic length (L∞) was 44.94 cm TL while the instantaneous growth rate (K) was 0.15 year-1. The exploitation rate was 0.44 year-1 and the length-based growth performance index (Ø’) was 3.03. Results indicated that the longevity of L. altianalis was 9 years. Recruitment occurs throughout the year with bimodal annual recruitment peaks coinciding with the two rainy seasons in the region. This study provides important information for developing management advice for the L. altianalis riverine fishery.

Motion process and failure mode of Pusa landslide, China based on dense optical flow method

ABSTRACT Unmanned aerial vehicle (UAV) is widely applied in geohazard monitoring with its high resolution and feasibility features, where UAV videos can record the whole landslide failure process. Previous studies can only provide the qualitative depiction of the landslide failure process, rather than the quantitative motion process, which makes it difficult to analyse the landslide dynamic characteristics and failure mode. In this letter, we take UAV video of Pusa landslide, China obtained on 28 August 2017 to retrieve the landslide motion process by using the dense optical flow method. Firstly, the landslide boundary can be clearly depicted by the cumulative landslide motion time series maps. Secondly, the maximum cumulative motion distance of the Pusa landslide was located in the middle of the slope body, with the maximum distance as 79 m, while the maximum instantaneous motion rate was around 42 m/s in the middle and lower part of the slope body. Finally, the failure mode of Pusa landslide can be characterized as ‘fissure zone in the middle, fissure extension to the top, rock bulges outward in the middle and landslide failure to high-speed runout debris flow’.

Pulling Back the Curtain on Shocks and Star Formation in NGC 1266 with Gemini-NIFS

We present Gemini near-infrared integral field spectrograph K-band observations of the central 400 pc of NGC 1266, a nearby (D ≈ 30 Mpc) post-starburst galaxy with a powerful multiphase outflow and a shocked interstellar medium. We detect seven H2 rovibrational emission lines excited thermally to T ∼ 2000 K, and weak Brγ emission, consistent with a fast continuous shock (or C-shock). With these bright H2 lines, we observe the spatial structure of the shock with an unambiguous tracer for the first time. The Brγ emission is concentrated in the central ≲100 pc, indicating that any remaining star formation in NGC 1266 is in the nucleus, while the surrounding cold molecular gas has little ongoing star formation. Though it is unclear what fraction of this Brγ emission is from star formation or the active galactic nuclei (AGN), assuming it is entirely due to star formation we measure an instantaneous star formation rate of 0.7 M ⊙ yr−1, though the star formation rate may be significantly higher in the presence of additional extinction. NGC 1266 provides a unique laboratory to study the complex interactions between AGN, outflows, shocks, and star formation, all of which are necessary to unravel the evolution of the post-starburst phase.

On the acceptance, commissioning, and quality assurance of electron FLASH units.

FLASH or ultra-high dose rate (UHDR) radiation therapy (RT) has gained attention in recent years for its ability to spare normal tissues relative to conventional dose rate (CDR) RT in various preclinical trials. However, clinical implementation of this promising treatment option has been limited because of the lack of availability of accelerators capable of delivering UHDR RT. Commercial options are finally reaching the market that produce electron beams with average dose rates of up to 1000Gy/s. We established a framework for the acceptance, commissioning, and periodic quality assurance (QA) of electron FLASH units and present an example of commissioning. A protocol for acceptance, commissioning, and QA of UHDR linear accelerators was established by combining and adapting standards and professional recommendations for standard linear accelerators based on the experience with UHDR at four clinical centers that use different UHDR devices. Non-standard dosimetric beam parameters considered included pulse width, pulse repetition frequency, dose per pulse, and instantaneous dose rate, together with recommendations on how to acquire these measurements. The 6- and 9-MeV beams of an UHDR electron device were commissioned by using this developed protocol. Measurements were acquired with a combination of ion chambers, beam current transformers (BCTs), and dose-rate-independent passive dosimeters. The unit was calibrated according to the concept of redundant dosimetry using a reference setup. This study provides detailed recommendations for the acceptance testing, commissioning, and routine QA of low-energy electron UHDR linear accelerators. The proposed framework is not limited to any specific unit, making it applicable to all existing eFLASH units in the market. Through practical insights and theoretical discourse, this document establishes a benchmark for the commissioning of UHDR devices for clinical use.

Design of a compact beam transport system for laser-driven proton therapy

Abstract We put forward a new design of a compact beam transport system for intense laser-driven proton therapy, where instead of using conventional pulsed solenoids, our design relies on a helical coil irradiated by a nanosecond laser pulse to generate strong magnetic fields for focusing protons. A pair of dipole magnets and apertures are employed to further filter protons with large divergences and low energies. Our numerical studies combine particle-in-cell simulations for laser-plasma interaction to generate high-energy monoenergetic proton beams, finite element analysis for evaluating the magnetic field distribution inside the coil, and Monte-Carlo simulations for beam transport and energy deposition. Our results show that with this design, a spread-out Bragg peak in a range of several centimeters to a deep-seated tumor with a dose of approximately 16.5 cGy and fluctuation around 2% can be achieved. The instantaneous dose rate reaches up to 109 Gy/s, holding the potential for future FLASH radiotherapy research.

The efficiency of synchronization dynamics and the role of network syncreactivity

Synchronization of coupled oscillators is a fundamental process in both natural and artificial networks. While much work has investigated the asymptotic stability of the synchronous solution, the fundamental question of the transient behavior toward synchronization has received far less attention. In this work, we present the transverse reactivity as a metric to quantify the instantaneous rate of growth or decay of desynchronizing perturbations. We first use the transverse reactivity to design a coupling-efficient and energy-efficient synchronization strategy that involves varying the coupling strength dynamically according to the current state of the system. We find that our synchronization strategy is able to synchronize networks in both simulation and experiment over a significantly larger (often by orders of magnitude) range of coupling strengths than is possible when the coupling strength is constant. Then, we characterize the effects of network topology on the transient dynamics towards synchronization by introducing the concept of network syncreactivity: A network with a larger syncreactivity has a larger transverse reactivity at every point on the synchronization manifold, independent of the oscillator dynamics. We classify real-world examples of complex networks in terms of their syncreactivity.

Development and Validation of a Portable EIT System for Real-Time Respiratory Monitoring.

This work contributes to the improvement of novel medical technologies for the prevention and treatment of diseases. Electrical impedance tomography (EIT) has gained attention as a valuable tool for non-invasive monitoring providing real-time insights. The purpose of this work is to develop and validate a novel portable EIT system with a small form factor for respiratory monitoring. The device uses a 16-electrode architecture with adjacent stimulation and measurement patterns, an integrated circuit current source and a single high-speed ADC operating with multiplexers to stimulate and measure across all electrodes. Tests were conducted on 25 healthy subjects who performed a pulmonary function test with a flowmeter while using the EIT device. The results showed a good performance of the device, which was able to recognize all respirations correctly, and from the EIT signals and images, correlations of 96.7% were obtained for instantaneous respiratory rate and 96.1% for tidal volume prediction. These results validate the preliminary technical feasibility of the EIT system and demonstrates its potential as a reliable tool for non-invasive respiratory assessment. The significance of this work lies in its potential to democratize advanced respiratory monitoring technologies, making them accessible to a wider population, including those in remote or underserved areas.

Phylogeographic Analysis for Understanding Origin, Speciation, and Biogeographic Expansion of Invasive Asian Hornet, Vespa velutina Lepeletier, 1836 (Hymenoptera, Vespidae)

The Asian hornet, Vespa velutina, is an invasive species that has not only expanded its range in Asia but has also invaded European countries, and it incurs significant costs on local apiculture. This phylogeographic study aims to trace the evolutionary trajectory of V. velutina and its close relatives; it aims to identify features that characterize an invasive species. The last successful invasion of Vespa velutina into France occurred in late May, 2002, and into South Korea in early October, 2002, which were estimated by fitting a logistic equation to the number of observations over time. The instantaneous rate of increase is 1.3667 for V. velutina in France and 0.2812 in South Korea, which are consistent with the interpretation of little competition in France and strong competition from local hornet species in South Korea. The invasive potential of two sister lineages can be compared by their distribution area when proper statistical adjustments are made to account for differences in sample size. V. velutina has a greater invasive potential than its sister lineage. The ancestor of V. velutina split into two lineages, one found in Indonesia/Malaysia and the other colonizing the Asian continent. The second lineage split into a sedentary clade inhabiting Pakistan and India and an invasive lineage colonizing much of Southeast Asia. This latter lineage gave rise to the subspecies V. v. nigrithorax, which invaded France, South Korea, and Japan. My software PGT version 1.5, which generates geophylogenies and computes geographic areas for individual taxa, is useful for understanding biogeography in general and invasive species in particular. I discussed the conceptual formulation of an index of invasiveness for a comparison between sister lineages.

Dynamics of cardio-muscular networks in exercise and fatigue.

A fundamental question in cardiovascular and muscle physiology is how the heart operates in synchrony with distinct muscles to regulate homeostasis, enable movement and adapt to exercise demands and fatigue. Here we investigate how autonomic regulation of cardiac function synchronizes and integrates as a network with the activity of distinct muscles during exercise. Further, weestablish how the network of cardio-muscular interactions reorganizes with fatigue. Thirty healthy young adults performed two body weight squat tests until exhaustion. Simultaneous recordings were taken of a 3-lead electrocardiogram (EKG) along with electromyography (EMG) signals from the left and right vastus lateralis, and left and right erector spinae. We first obtained instantaneous heart rate (HR) derived from the EKG signal and decomposed the EMG recordings in 10 frequency bands (F1-F10). We next quantified pair-wise coupling (cross-correlation) between the time series for HR and all EMG spectral power frequency bands in each leg and back muscle. We uncovered the first profiles of cardio-muscular network interactions, which depend on the role muscles play during exercise and muscle fibre histochemical characteristics. Additionally, we observed a significant decline in the degree of cardio-muscular coupling with fatigue, characterized by complex transitions from synchronous to asynchronous behaviour across a range of timescales. The network approach we utilized introduces new avenues for the development of novel network-based markers, with the potential to characterize multilevel cardio-muscular interactions to assess global health, levels of fatigue, fitness status or the effectiveness of cardiovascular and muscle injury rehabilitation programmes. KEY POINTS: The heart operates in synchrony with muscles to regulate homeostasis, enable movement, and adapt to exercise demands and fatigue. However, the precise mechanisms regulating cardio-muscular coupling remain unknown. This study introduces a pioneering approach to assess cardio-muscular network interactions by examining the synchronization of cardiac function with muscle activity during exercise and fatigue. We uncover the first profiles of cardio-muscular interactions characterized by specific hierarchical organization of link strength. We observe a significant decline in the degree of cardio-muscular coupling with fatigue, marked by complex transitions from synchronous to asynchronous behaviour. This network approach offers new network-based markers to characterize multilevel cardio-muscular interactions to assess global health, levels of fatigue, fitness status or the effectiveness of cardiovascular and muscle injury rehabilitation programmes.

Comparing the differing effects of host species richness on metrics of disease

AbstractChanges in host species richness can alter infection risk and disease levels in multi‐host communities. I review theoretical predictions for direct and environmental transmission pathogens about the effects of host additions (or removals) on three commonly used disease metrics: the pathogen community reproduction number and infection prevalence and infected density in a focal host. To extend this prior work and explain why predictions differ between metrics, I analyze Susceptible Infected‐Recovered‐type models of an environmentally transmitted pathogen and multiple host species that compete for resources. Using local sensitivity analysis, I show how trait‐mediated and density‐mediated indirect effects drive each metric's response to variation in an added host's ability to transmit a pathogen, the added host's density, and the pathogen transmission mechanism. For each disease metric, the responses are typically predicted by the added host's ability to transmit the pathogen when interspecific competition is weak whereas the responses can be altered by shifts in host densities when interspecific competition is strong. In addition, the three metrics often respond in the same direction. However, the metrics can respond in different directions for three reasons: (1) differences between the ability of exposed individuals to transmit the pathogen over the length of time the individuals are infected (i.e., host competence) and a host population's instantaneous net rate of production of infectious propagules; (2) strong density‐mediated feedbacks driven by disease‐induced mortality; and (3) host additions or removals cause large changes in focal host density via competition or disease‐induced mortality. This study extends and unifies prior theoretical studies, and helps identify the rules governing the context‐dependent relationships between host species richness and the three metrics of disease.

(In)stability of de Sitter quasinormal mode spectra

We consider how the quasinormal spectrum for the conformal wave operator on the static patch of de Sitter changes in response to the addition of a small potential. Since the quasinormal modes and co-modes are explicitly known, we are able to give explicit formulae for the instantaneous rate of change of each frequency in terms of the perturbing potential. We verify these exact computations numerically using a novel technique extending the spectral hyperboloidal approach of Jaramillo et al. (2021). We propose a definition for a family of pseudospectra that we show capture the instability properties of the quasinormal frequencies.

Speckle Vibrometry for Contactless Instantaneous Heart Rate and Respiration Rate Monitoring on Mechanically Ventilated Patients.

Objective: Contactless monitoring of instantaneous heart rate and respiration rate has a significant clinical relevance. This work aims to use Speckle Vibrometry (i.e., based on the secondary laser speckle effect) to contactlessly measure these two vital signs in an intensive care unit. Methods: In this work, we propose an algorithm for the estimation of instantaneous heart rate and respiration rate from mechanically ventilated patients. The algorithm uses multiple regions, principal component analysis, and dominant angle analysis. A semi-automated peak detection method is implemented to precisely label the aortic valve opening peak within the cardiac waveform. Results: Compared with electrocardiography, the present work achieves limits of agreement of [-2.19, 1.73] beats per minute of instantaneous heart rate. The measurement spot is on the chest covered with two to three layers of duvet blankets. Compared with the airway flow signal measured by the mechanical ventilator, the present work achieves limits of agreement of [-0.68, 0.46] respirations per minute of instantaneous respiration rate. Conclusions: These results showcased Speckle Vibrometry's potential in vital sign monitoring in a clinical setting. Significance: This is the first human clinical study for Speckle Vibrometry.

Supercritical carbon dioxide as solvent for manufacturing of ibuprofen loaded gelatine sponges with enhanced performance

Supercritical carbon dioxide was used as the solvent for manufacturing of ibuprofen loaded gelatine sponges with high loading capacity and fast release performance toward healthcare materials in the treatment of postoperative dental pain. The solubility of ibuprofen in supercritical CO2 was first determined at 313 K under different pressure conditions. The micronisation of ibuprofen drugs were successfully adsorbed onto the surface of network pore system of gelatine sponges via supercritical CO₂ processing. The loading capacity of ibuprofen in gelatine sponges obtained by using supercritical CO₂ as the solvent can be up to 19.86 wt%, which was double that of the sample prepared by direct soaking in ethanol. The dissolution of ibuprofen was determined and higher instantaneous dissolution rate was observed for the ibuprofen loaded gelatine sponges synthesized by supercritical CO₂ processing.

Event-triggered nonlinear state estimation with quantized innovations

This paper proposes an event-triggered (ET) estimator with quantization mechanism to relieve the bandwidth and energy limitations of wireless sensors, where the ET strategy reduces the overall communication rate of the system, and the quantization mechanism mitigates the instantaneous bit rate constraint. Then, Gaussian approximation is applied to derive the analytical form of the minimum mean squared error (MMSE) estimator under the event-triggered strategy and quantization mechanism. Furthermore, the relationship between event-triggered parameter and communication rate is explicitly established. Finally, theoretical results are validated through some simulations on a target tracking system.

High-Precision Analysis Using μPMU Data for Smart Substations

This paper proposes a correction technique for bad data and high-precision analysis based on micro-phasor measurement unit (μPMU) data for a stable and reliable smart substation. First, a high-precision wide-area monitoring system (WAMS) with 35 μPMUs installed at Korea’s Yeonggwang substation, which is connected to renewable energy sources (RESs), is introduced. Time-synchronized μPMU data are collected through the phasor data concentrator (PDC). A pre-processing program is implemented and utilized to integrate the raw data of each μPMU into a single comma-separated values (CSV) snapshot file based on the Timetag. After presenting the technique for identification and correction of event, duplicate, and spike bad data of μPMU, causal relationships are confirmed through the voltage and current fluctuations for a total of five states, such as T/L fault, tap-up, tap-down, generation, and generation shutdown. Additionally, the difference in active power between the T/L and the secondary side of the M.Tr is compared, and the fault ride through (FRT) regulations, when the fault in wind power generation (WP), etc., occurred, is analyzed. Finally, a statistical analysis, such as boxplot and kernel density, based on the instantaneous voltage fluctuation rate (IVFR) is conducted. As a result of the simulation evaluation, the proposed correction technique and precise analysis can accurately identify various phenomena in substations and reliably estimate causal relationships.