This paper introduces AVATAR (adversarial self-supervised domain adaptation network for target domain), a novel unsupervised domain adaptation method designed to address the challenge of transferring knowledge from a well-labeled source domain to an unlabeled target domain. AVATAR’s key contributions lie in its unique combination of adversarial learning and self-supervised learning techniques, which enhance the model’s adaptability and accuracy in new, unlabeled environments. The technical innovations of AVATAR include a domain adversarial learning component that reduces domain discrepancy by aligning source and target domain features in a shared feature space, a self-supervised learning module that leverages pseudo-labels and instance weights to refine target domain discrimination boundaries, and a sample selection strategy guided by within-cluster distances to focus on aligning informative samples while mitigating the impact of outliers. By integrating these components, AVATAR provides a comprehensive framework for tackling complex unsupervised domain adaptation tasks, particularly when the domain gap is significant. The method balances domain-invariant feature learning with domain-specific adjustments, enabling effective adaptation to dynamically changing environments. Extensive experiments on multiple benchmark datasets demonstrate AVATAR’s superior performance compared to existing domain adaptation methods, especially in scenarios with limited labeled target domain data. These results highlight AVATAR’s potential as a versatile and robust solution for domain adaptation challenges in various real-world applications.