The optimum control methods for the epidemiology of the COVID-19 model are acknowledged using a novel advanced intelligent computing infrastructure that joins artificial neural networks with unsupervised learning-based optimizers i.e., Genetic Algorithms (GA) and sequential quadratic programming (SQP). Unsupervised learning strategy is provided which depends on the wavelet basis's sequential deconstruction of stochastic data. The weights or selection values of neural networks are utilizing cumulative algorithms of Meyer wavelet artificial neural networks (MWANNs) optimized with global search Genetic Algorithms (GAs) and Sequential Quadratic Programming (SQP), referred to as MWANNs-GA-SQP and the design technique is utilized to determine the COVID-19 model for five different scenarios employing different step sizes and input intervals. The findings of this research article examined that in order to minimize the total disease transmission at the lowest cost and complexity, safety, focused medical care, and exterior sterilization methods applicability. The provided data is validated through various graphical simulations, which surely authenticate the effectiveness and robustness of the proposed solver. The suggested solver, MWANNs-GA-SQP, is tested in a variety of circumstances to examine that how reliable, safe, and tolerant. Using the proposed MWANNs hubristic intelligent approach, an objective optimization function is created in feed forward neural networking to minimize the mean square error. An investigation of the hybrid GA-SQP is used to confirm the accuracy and dependability of the MWANNs model results. Mean absolute graphs have been constructed to assess the integrity and efficiency of the proposed methodology. The accuracy and reliability of the suggested method are demonstrated by constantly achieving maximum variables of analytical assessment criteria computed for a large appropriate variety of distinct trials.