Inoculation Of Tubercle Bacilli Research Articles

Multifocal tuberculosis verrucosa cutis

Tuberculosis Verrucosa Cutis (TBVC), a verrucous form of cutaneous tuberculosis, occurs from inoculation of tubercle bacilli into the skin of a previously sensitized patient with moderate to high degree of immunity. This disease is now rare in western countries and in India; the incidence of cutaneous tuberculosis has fallen from 2% to 0.15%. However two recent studies from the Indian subcontinent have reported the prevalence of cutaneous tuebrculosis as 0.7% (Varshney et al) and 0.26% (Patra et al) This case is reported to demonstrate the indolent and extensive nature of tuberculosis verrucosa cutis in an immunocompetent individual and to highlight the importance of histopathology and empirical antitubercular therapy as an adjunct diagnostic tool.

Another Tattoo Risk

The process of tattooing may introduce into the skin more than pigment. Previous reports have documented inoculation of tubercle bacilli, wart viruses,

EXPERIMENTAL STUDIES OF OCULAR TUBERCULOSIS

In a previous study 1 it was noted that for an undetermined period after recovery from an attack of secondary ocular tuberculosis the previously diseased eyes were endowed with a relative immunity to reinoculation with tubercle bacilli. When such eyes were given an inoculation of tubercle bacilli which produced typical disease in the normal fellow eye, the recovered eyes showed only a transient reaction to the tuberculin in the inoculum and did not have a second attack of tuberculosis. The studies at that time indicated that this local resistance was not due either to an increase in the general systemic immunity or to an exhaustion of the reaction capacity of the eye. It appeared to be related to some local condition in the eye itself. The purpose of this paper is to report further studies on this phenomenon of increased local resistance. These studies are reported in two parts. The

EXPERIMENTAL SPOROTRICHOSIS

Following the production of tuberculides by Lewandowsky 1 by means of intracardial inoculation of tubercle bacilli, Saeves 2 produced mycotic infections on the skin of guinea-pigs by hematogenous inoculation of trichophytons ( Achorion quinckcanum and Trichophyton gypseum ). Kogoj 3 and Smolka 4 have shown that these mycotic lesions, following hematogenous infection, localize on irritated skin areas. Even earlier Calmette and Guerin, 5 as well as Prowazek and Yamamoto, 6 had made the observation, which had previously escaped attention, that after hematogenous inoculation of variola virus, lesions appeared on the epilated irritated skin. W. Jadassohn 7 observed that trichophytons enter the blood of guinea-pigs quickly after cutaneous inoculation, and thereby explained the immunity which Martenstein 8 had observed to follow the early excision of the site of cutaneous inoculation. The fact that bacteria causing skin lesions may enter the regional lymph nodes in a short time has been demonstrated by such work

Experimental Production of Tuberculous Intestinal Lesions in Guinea Pigs.

In several hundred autopsies of guinea pigs with generalized tuberculosis, produced chiefly by subcutaneous, intraocular, intratesticular and intraspinal inoculation of tubercle bacilli, we have failed to discover any true tubercle formation in the intestines, although hypertrophy of the lymph nodes, particularly those in the cecum, do occur. Similarly, feeding guinea pigs with suspensions of virulent tubercle bacilli for a long time, or with food contaminated with fly specks containing the organisms, was unsuccessful in producing intestinal lesions.On the other hand, inoculation of a virulent human strain (H 37) into the left ventricle of 23 normal pigs, either in single doses of 34,000 and upwards, or in three repeated doses of 30,000 to 5,000,000 organisms, resulted in 17 animals developing definite tubercles in the lymph follicles of the gut. The cecum is most frequently involved, and next in order the ascending colon and ileum. In a few cases, feeding contaminated sputum did not alter the typical les...

THE OCCURRENCE OF LUPUS VULGARIS IN THE WIFE AND DAUGHTER OF A TUBERCULOUS SUBJECT.

Allow me to make a quotation from Kaposi1as an excuse for the following paper: No experimental proof has been offered that characteristic lupus vulgaris can be produced by inoculation of tubercle The inoculation of lupus tissue and of the bacilli derived from it has given rise to inflammatory products, but not to lupus, nor has any clinical proof been found, unless we accept extremely careless statements. This is less true concerning a few published cases such as that of Besnier (lupus in a vaccination scar), Sachs (lupus after piercing the ear), etc. These and other similar, although less carefully observed cases, might demonstrate the occurrence of clinical lupus from inoculation of tubercle bacilli. The cases to be related are not experimental proof, but rather examples of clinical lupus from probable inoculation of the tubercular germ. There is very little, if any, reason to consider one of the