Types Of Innovation Research Articles

Current Implementation of Digital Health in Chronic Disease Management: Scoping Review.

Approximately 1 in 3 adults live with multiple chronic diseases. Digital health is being harnessed to improve continuity of care and management of chronic diseases. However, meaningful uptake of digital health for chronic disease management remains low. It is unclear how these innovations have been implemented and evaluated. This scoping review aims to identify how digital health innovations for chronic disease management have been implemented and evaluated: what implementation frameworks, methods, and strategies were used; how successful these strategies were; key barriers and enablers to implementation; and lessons learned and recommendations shared by study authors. We used the Joanna Briggs Institute methodology for scoping reviews. Five databases were searched for studies published between January 2015 and March 2023: PubMed, Scopus, CINAHL, PsycINFO, and IEEE Xplore. We included primary studies of any study design with any type of digital health innovations for chronic diseases that benefit patients, caregivers, or health care professionals. We extracted study characteristics; type of digital health innovation; implementation frameworks, strategies, and outcome measures used; barriers and enablers to implementation; lessons learned; and recommendations reported by study authors. We used established taxonomies to synthesize extracted data. Extracted barriers and enablers were grouped into categories for reporting. Descriptive statistics were used to consolidate extracted data. A total of 252 studies were included, comprising mainly mobile health (107/252, 42.5%), eHealth (61/252, 24.2%), and telehealth (97/252, 38.5%), with some studies involving more than 1 innovation. Only 23 studies (23/252, 9.1%) reported using an implementation science theory, model, or framework; the most common were implementation theories, classic theories, and determinant frameworks, with 7 studies each. Of 252 studies, 144 (57.1%) used 2 to 5 implementation strategies. Frequently used strategies were "obtain and use patient or consumer feedback" (196/252, 77.8%); "audit and provide feedback" (106/252, 42.1%); and piloting before implementation or "stage implementation scale-up" (85/252, 33.7%). Commonly measured implementation outcomes were acceptability, feasibility, and adoption of the digital innovation. Of 252 studies, 247 studies (98%) did not measure service outcomes, while patient health outcomes were measured in 89 studies (35.3%). The main method used to assess outcomes was surveys (173/252, 68.7%), followed by interviews (95/252, 37.7%). Key barriers impacting implementation were data privacy concerns and patient preference for in-person consultations. Key enablers were training for health care workers and personalization of digital health features to patient needs. This review generated a summary of how digital health in chronic disease management is currently implemented and evaluated and serves as a useful resource for clinicians, researchers, health system managers, and policy makers planning real-world implementation. Future studies should investigate whether using implementation science frameworks, including how well they are used, would yield better outcomes compared to not using them.

Insurtech strategies: a comparison of incumbent insurance firms with new entrants

AbstractInsurtech is closely associated with digital transformation by new entrants that seek to disrupt insurance markets. However, the insurtech concept also includes its use by incumbent insurance companies, which are actively deploying a wide variety of insurtech applications to protect their market positions through innovation of their existing business models, e.g. through improved business processes or new insurance services. A theoretical insurtech business innovation model is developed that captures the effects of digital technology in insurance markets by considering innovation as a multi-dimensional concept that encompasses business processes, novel insurance products and changes to the insurance value chain. This framework is applied to an empirical sample of digital leaders: three incumbents and four new entrants. The results illustrate a variety of insurtech applications that include the transformation of business processes, products and new types of value chain configuration, as well as relatively minor enhancements to existing systems and business practices. It is shown that all the new entrants exploit artificial intelligence, big data and digital technology to build brand-new insurance services that emphasise innovative product features, high customer value and a delightful customer experience. In contrast, the legacy insurance firms tend to use digital technology in a defensive manner, e.g. the enhancement of existing insurance services, distribution channels and market positions. The exception is the launch of a telematics insurance service by an incumbent firm, where the telematics insurance effectively operates as a standalone business within a legacy insurance firm. The theory model is effective at analysing and evaluating both the type and magnitude of innovation. The case studies make an empirical contribution by illustrating state-of-the-art innovation by insurance disruptors and contrasts this with the defensive and sometimes novel digital strategies of incumbent firms. Future trends and research opportunities are outlined.

Digital Capabilities and Ambidextrous Innovation: Evidence from Chinese Technology-Based SMEs

Ambidextrous innovation is key to the high-quality and sustainable development of enterprises, but it remains unclear how digital capabilities affect knowledge management and ambidextrous innovation in the digital economy era. Based on organizational learning theory, this paper explores the impact pathways of digital capabilities on knowledge management and ambidextrous innovation, while also analyzing the moderating effect of knowledge inertia. Empirical research on 253 technology-based small and medium-sized enterprises (SMEs) demonstrates that digital capabilities have a significant positive effect on both exploitative and exploratory innovation, and they influence both types of innovation through the mediating role of knowledge management. Furthermore, knowledge inertia negatively moderates the impact of digital capabilities on knowledge management and exploratory innovation. This study reveals the internal mechanism by which digital capabilities drive ambidextrous innovation through knowledge management, providing theoretical support for enterprises to deepen digitalization and carry out ambidextrous innovation.

Does digital platform capability enable Chinese SMEs’ business model innovation? The role of complementary assets and entrepreneurial orientation

ABSTRACT In the digital economy, many small and medium-sized enterprises (SMEs) establish digital platforms early in their operations to drive business model innovation. However, effectively utilizing diverse complementary assets through digital platform capability to achieve the intended business model design remains a significant challenge. This study classifies business model innovation into two types: novelty-oriented and efficiency-oriented. It constructs a theoretical framework grounded in digital platform capability and empirically tests it using data from 328 Chinese SMEs. The findings demonstrate that digital platform capability positively influences both innovation types, with generic and specialised complementary assets serving as mediators. Moreover, entrepreneurial orientation strengthens the relationship between digital platform capability and business model innovation. This research advances theoretical insights into digital platform capability and its role in fostering business model innovation, while providing valuable insights for building a business model innovation ecosystem specifically tailored to SMEs.

Identification of tanshinone I as a natural Cu(II) ionophore

The development of Cu(II) ionophores for targeted disruption of aberrant redox homeostasis in cancer cells has been considered an appealing strategy in the field of anticancer research. This study presents the first identification of tanshinone I (Ts1), a natural o-quinone, as a Cu(II) ionophore. Structure-activity relationship studies on tanshinones and mechanistic investigations reveal that the presence of Cu(II) effectively promotes the tautomerization of Ts1 from its diketo to keto-enol forms, thereby facilitating its sequential proton-loss Cu(II) chelation, and enabling it to function as a Cu(II) ionophore due to its structural features including the presence of an o-quinone moiety, a benzyl hydrogen, and a large conjugated system. The unique property allows Ts1 to preferentially induce copper accumulation in human hepatoma HepG2 cells over human umbilical vein endothelial cells, by releasing copper driven by reduced glutathione (GSH). This copper accumulation leads to a reduction in the GSH-to-oxidized glutathione ratio and the generation of reactive oxygen species, ultimately triggering apoptosis of HepG2 cells. The findings not only provide support for o-quinones as innovative types of anticancer Cu(II) ionophores, but also shed light on the previously unrecognized role of Ts1 as a potent Cu(II) ionophore for eradicating cancer cells by selectively disrupting their redox regulation programs, resembling a "Trojan horse".

Drivers of Advanced Digital Technologies

Advancements in digital technologies, especially computer and information systems, force firms to adopt them in their production processes. Artificial intelligence, cloud computing, big data analytics, robotics, smart devices, and blockchain are the leading advanced technologies. This study explores the drivers of firms’ adoption of these technologies by estimating a multivariate probit model utilizing a Eurobarometer dataset. A statistically significant and positive correlation between the error terms of all models indicates that investigating the adoption of all advanced digital technologies together is more appropriate than independent analyses. Drivers of advanced digital technologies appear similar with decisive factors in using new technologies, and implementation of any type of innovation significantly increases the probability of adoption. The other determinants are the firm size, interaction with international markets, and the network structure of the market in which firms operate. Furthermore, location positively impacts the adoption of cloud computing and big data analytics, while it exerts no significant influence on the adoption of other types of advanced digital technologies.

Unveiling Critical Innovation Factors in Sustainable Coffee Production: A Colombian Perspective

Abstract The coffee sector stands as a cornerstone of Colombia’s economy, ranking third in the nation’s export portfolio. Despite the Colombian coffee esteemed global reputation, it has yet to fully exploit its potential for diversification into differentiated products. Present agro-industrial paradigms emphasize trade and sustainable, efficient agricultural practices, underscoring the imperative for innovation across production, marketing, and distribution channels. This study aims to pinpoint the pivotal innovation factors within coffee farm production processes. To this end, a sample of 66 coffee farms was selected through simple random sampling. Drawing from the 2018 Oslo model, innovation types associated with sustainable specialty coffee certifications were delineated. Within this framework, seven fundamental factors emerged for investigation: economic, social, environmental, production, knowledge, technology, and change management. Through cluster analysis, it became evident that economic, environmental, knowledge, technological, and change management factors are indispensable for fortifying the coffee industry.

Sustainable innovation: Case studies from product development

AbstractAttempts to implement sustainable development in industry are hampered by the fact that production processes are often not environmentally sound. Therefore, there is a need for innovation processes that are sustainable. This means that they need to be durable on the one hand, but also with reduced materials consumption and a low carbon footprint, on the other. Current trends suggest that much could be gained, by undertaking research that may lead to more sustainable industrial production and processes. Against this background, this paper describes the characteristics of sustainable innovation, discusses what makes innovation sustainable, and introduces a set of case studies where different types of innovation in product development are described, drawing the lessons learned. The paper concludes by describing the items, which need to be considered in the future, to make a greater use of sustainable innovation principles in product development, as part of a systemic transformation.

Unlocking Nonprofit Innovation for Growth: Director Insights from Australia

ABSTRACT Our research unlocks the new construct of “innovation for growth” in nonprofits, defined as “innovation activities undertaken in the pursuit of revenue growth.” By interpreting rich quantitative and qualitative data from a survey of 101 directors of mid-to-large, mainly Australian nonprofits, it advances nonprofit-innovation and -governance scholarship, and reveals perceived organizational strategies and returns for nonprofit marketing leaders and boards seeking to pursue this innovation type. The research can also be drawn on to inform innovation policy for nonprofits, thus supporting the development of a thriving, impactful sector and providing flow-on benefits for society.

Two dimensions of product modularity and innovation: the case of R&D teams

Abstract This study investigates the relationship between product modularity and innovation in 101 research and development (R&D) teams. The key contribution and the departure from prior empirical work consists in bringing into relation multidimensional operationalizations of these two concepts. Product modularity is composed of standardization and reconfigurability and innovation of novelty and efficiency. The literature provides arguments for both negative and positive relationships between standardization and the two types of innovation, while positive relationships are argued for product reconfigurability. The empirical findings corroborate most of the theorizing, although negative relationships are found for standardization. This study contributes to the literature by unpacking the understanding of the concept of product modularity in R&D organizations since the multidimensional approach resolves some of the ambiguity from previous studies. The modularity literature long called for studies to empirically investigate product modularity in more than one dimension implying a number of theoretical implications discussed here.

Assessing the Drivers of Corporate Sustainability Performance Disclosures Using the Global Reporting Initiative (GRI) G4 Framework

The primary objective of this study is to analyze the factors influencing the corporate sustainability performance disclosures of companies listed on the Bombay Stock Exchange (BSE) using the Global Reporting Initiative (GRI) G4 framework. This research is based on a sample of 434 firms listed on the BSE from 2017 to 2022. According to the content analysis method, the disclosure score of 434 non-financial companies is 79% (approximately), suggesting that, on an average, the sample companies have revealed 79% of the GRI-specified elements in their sustainability reports. The outcomes of the regression models indicate that profitability, firm size, innovation, board size, gender diversity, sustainability committee, and industry type are major drivers of corporate sustainability performance disclosure. Furthermore, research identified significant differences in the determinants of such practices between high-polluting and low-polluting companies. This research aims to elucidate the intricate dynamics affecting corporate sustainability performance by examining a diverse array of concerns. It employs meticulous data analysis to identify critical elements influencing sustainability disclosure. These findings may assist corporate managers, investors, policymakers, and stakeholders in comprehending the critical aspects to consider when formulating strategies that promote sustainability and enhance long-term value maximization.

RESEARCH ON THE ISSUES OF DIGITAL TRANSFORMATION: BIBLIOMETRIC ANALYSIS

Due to the capabilities offered by automation of management processes, the scope of application for information systems and technologies (IST) as a research subject is expanding exponentially, covering a wide range of related topics, fields of knowledge, and areas of activity. This expansion highlights the importance of studying the conceptual framework and trends in digital transformation. The purpose of this article is to examine the quantitative and qualitative structure of scientific publications on digitalization, key research directions, and to identify prospects for further developments in digital transformation. The article presents results of a bibliometric analysis of scientific publications on digitalization issues indexed in the SCOPUS scientometric database. The embedded analytical tools in SCOPUS were used to analyze the selected publications sample. Bibliometric indicators included: annual publication dynamics and the structure of scientific fields associated with these publications. An important part of the study is an analysis of the content of the most-cited publications in the sample. Keyword analysis revealed that the most commonly used keywords by authors are "digitalization," "transformation," and "innovation." It was found that digital transformation in scholarly work generally focuses on two areas: (1) digitalization as a product and outcome of IST application, aimed at meeting the needs of various stakeholders, and (2) digitalization as the process of IST creation. This result confirms the close link between digital transformation and innovative activities, highlighting two types of innovations: product-innovation and process-innovation. It was found that the relevance and continuous development of IST research are influenced by highly cited publications from researchers primarily affiliated with universities in developed countries. Bibliometric analysis of publications related to digital transformation has demonstrated a growing interest among researchers in this topic. Over the past decade, there has been a steady increase in the number of scientific articles dedicated to this issue, and the context in which the topic of digitalization is considered has proven to be quite diverse. Researchers from various countries are studying the impact of digitalization on the economy and social processes as a whole. Conclusions are drawn regarding the identified trends, and the potential for future research topics is summarized.

Incremental and Radical Innovations that Contribute to the Survival of Small Businesses in Environments of Crisis

This paper examines the influence of incremental and radical innovations on the survival capacity of micro and small companies (MSE) in contexts of economic crisis.State of the art on innovation points to a lack of a specific methodology to segregate incremental and radical innovation in MSEs. Identifying such a method allows for action to promote innovation in such more assertive companies, contributing to the survival of companies in the most adverse moments, such as crises.In this sense, a methodology was developed to identify the type and degree of innovation based on the level of innovation in the sector of activity and was applied to a sample of 60 companies in the textile retail sector. The dependent variable was business survival, measured by the continuity or cessation of activity in 2020. The estimate of the probability of survival was carried out using a binary logistic regression model.The dimensions of incremental innovation, which are the most common in the business environment, did not significantly affect survival. The dimensions of radical innovation, which imply deeper and more disruptive changes in the business model, had a positive impact. significant impact on survival in all cases. The most complex actions in the Solutions dimension increased the chances of survival by 42%; improving Processes by 39%; and innovation in the Square by 38%. These findings suggest that small businesses that adopt radical innovations have greater adaptability and resilience to adverse situations.

Implementing Innovations That Provide Sustainable Solutions in the Tourism Sector

Objective: The purpose of this development is to present the relationship between the implementation of innovations in the tourism business and its sustainable development. Theoretical Framework: In this topic, presents the main concepts and theories for the scope of innovation activity in the tourism sector. The main types of economic and non-economic innovations related to the sustainable management of the tourism business are highlighted. Method: Qualitative methods, including interviews and observations, were used in this study. Owners and managers of tourist organizations who are familiar with the innovative activities of the represented enterprises and can indicate the effect of their implementation were surveyed. Results and Discussion: The findings of the study highlight the importance of synergy between innovation and sustainable management of the tourism business. The study of the experience of the Bulgarian tourist enterprises proves that the implementation of innovations provides competitive advantages to the tourist enterprises and contributes to their sustainable development. Research Implications: A practical study is carried out, which presents the spread of innovations in the tourism sector in Bulgaria and proves that they lead to both economic and non-economic effects related to the sustainable development of the enterprise's activities. Originality/Value: This study contributes to the literature by presenting the scope of innovation activity in the tourism enterprise and outlines the relationship between economic and non-economic innovations. The relevance and value of this research is demonstrated by addressing the specific topic of innovation in the tourism industry, which is an important area of inquiry given the dynamic nature of the sector and its significance for economic development.

Technology Complexity And Utilization Of Alternative Banking Channels

Alternative Banking Channels have been found to have positive benefits for financial institutions. Financial institutions such as commercial banks and insurance companies have employed alternative banking channels to a great extent but SACCOs which are an important part of the financial system have been left behind in this respect. Technology complexity plays a role in the utilization of any type of IT innovation including alternative banking channels. The current study therefore sought to determine the effect of technology complexity on utilization of alternative banking channels among deposit-taking SACCOs in Nyeri County in Kenya. This research used a descriptive cross-sectional survey approach. Deposit-taking SACCOS in Nyeri county were the unit of analysis while managers are the unit of observation. Information was gathered via the use of a questionnaire. Descriptive and correlation analysis was used to analyse data with the help of Statistical Package for the Social Sciences. The study found that technology complexity in the alternative banking channels among deposit-taking SACCOS was average. Technology complexity was significantly associated utilisation of alternative banking channels. The study showed that technology posed a significant barrier to the adoption and utilization of ABCs, especially among older, less literate, and rural members who may lack access to necessary gadgets. SACCOs should therefore organize training sessions and educational workshops for members, particularly targeting older, less literate, and rural members to teach basic digital literacy skills and how to use ABCs effectively

Innovative fuzzy logic type 3 controller for transient and maximum power point tracking in hydrogen fuel cells

This study introduces an advanced Fuzzy Logic Type 3 (FLT3) controller for Proton Exchange Membrane Fuel Cells (PEMFCs), aiming to optimize Maximum Power Point Tracking (MPPT) under dynamically varying temperature conditions. The FLT3 controller advances fuzzy logic control by incorporating an additional layer of uncertainty modelling, which enhances its ability to manage the inherent nonlinearities in PEMFC systems, such as temperature fluctuations and gas pressure variations. The controller is developed and validated through MATLAB/Simulink simulations, using a refined rule based on mechanism with finely tuned membership functions for precise adaptation to changing conditions. When compared to traditional Perturb and Observe (P&O) and Fuzzy Logic Type 2 (FLT2) controllers, the FLT3 controller demonstrates superior performance by achieving faster sitting times, minimizing power fluctuations, and maintaining operation closer to the nominal power point, particularly under transient conditions for hydrogen-based fuel cell. This innovative approach significantly improves the efficiency and stability of PEMFC systems, marking a substantial advancement in their operational management.

Human and canine osteosarcoma cell lines: How do they react upon incubation with calcium phosphate-coated lipid nanoparticles carrying doxorubicin and curcumin?

Osteosarcoma (OSA) is a bone cancer that affects both humans and animals, with dogs being particularly vulnerable. Standard therapy is often limited by multidrug resistance (MDR), primarily due to the overexpression of P-glycoprotein (P-gp), which expels drugs from the cells, reducing their efficacy. To overcome this challenge, drug delivery systems (DDS) and P-gp modulators have been explored. However, developing DDS that selectively target cancer cells remains difficult, with many current options lacking efficiency. Our research group has recently developed an innovative type of nanoparticle with a lipid core and a calcium phosphate shell (CaP-NPs), which enhances the uptake of doxorubicin (DOXO) in OSA cells. In this study, we loaded a lipophilic ester of doxorubicin (C12DOXO) and curcumin (CURC), a natural P-gp modulator, into CaP-NPs and co-incubated them into human and canine OSA cell lines, including DOXO-resistant cells. The results demonstrated a significant reduction in viability in human OSA cells. Additionally, the combination treatment led to a further increase in C12DOXO retention when cells were also treated with the P-gp inhibitor verapamil, indicating enhanced efficacy against MDR mechanisms. Notably, canine OSA cells exhibited a distinct response pattern, suggesting the presence of species-specific differences that warrant further investigation.

IMPLEMENTATION OF THE PRINCIPLES OF SUSTAINABLE DEVELOPMENT IN FOOD ENTERPRISES OF UKRAINE IN THE CONTEXT OF INDUSTRY 4.0

The paper discusses the problems and opportunities of implementing sustainable development in the context of Industry 4.0. It analyzes the difficulties associated with outdated technologies and the challenges of developing resilience strategies. The types of innovations in this field, their advantages, and disadvantages are described. A comparative analysis of the world and Ukrainian experience in implementing sustainable development in companies such as Danone, Nestlé, Unilever, Beyond Meat, Impossible Foods, BrewDog, LLC «Organic Milk», LLC SP «Nibulon», PJSC «Ternopil Dairy Plant» (Molokia), LLC «Ukrprodukt Group», PJSC «Kyiv Confectionery Factory «Roshen», PJSC «Chumak», PJSC «Оbolon is conducted. Strategies for successful implementation of sustainable development in the conditions of Industry 4.0 are proposed. The research results emphasize the need for an innovative approach to sustainable development and key principles for achieving success in this field.

Enhancing SME performance through innovation: evidence from a transition economy – Kosovo

Purpose – What are the effects of implementing various types of innovation, including product, process, and technological innovations, on the performance of SMEs in the manufacturing sector? This is a question that preoccupies us a lot. This study seeks to examine the individual and integrated effects of these innovations. Indeed, we examine the impact of three categories of innovation – product, process, and technological innovation – on the performance of SMEs in the manufacturing industry. Research methodology – We used a quantitative approach to execute this research, selecting SMEs at random using self-administered questionnaires. The data collected from 153 manufacturing SMEs was analyzed using hierarchical linear regression to investigate, evaluate, and refine the relation among product, process, and technological innovation and SME performance. Findings – This study’s findings reveal a clear and direct relationship between these three forms of innovation and SMEs’ performance. This study also provides empirical evidence that various forms of innovation, either examined individually or as integrated, exert a positive effect on the performance of SMEs in the manufacturing industry. Limitations – This study focuses on Kosovo-based SMEs, with the assumption of an upright connection between variables. Future studies can examine the existence of reverse causality in a variety of regional, cultural, and industrial settings. Originality/Value – This study significantly advances existing knowledge by providing useful insights into the complex interplay among product, process, and technological innovation (examined from both individual and integrated perspectives) as well as the performance of SMEs in the manufacturing industry.

Innovation challenges and benefits in high-tech start-ups: A quantitative analysis of university student entrepreneurs in Romania

This article analyses the entrepreneurial students’ attitudes towards innovations developed in high-tech industries, with the aim of identifying the benefits brought to the entrepreneurial ecosystem. It also identifies the main challenges that entrepreneurial students are faced with when developing innovations in high-tech start-ups. The empirical study used the quantitative methodology with the hypotheses tested with the independence tests for a sample of 98 students (n=98) from Romanian universities. The results confirm that students would start-up a new business in the activity fields connected to their studies whereas an association between their start-up idea and innovation in high-tech businesses was identified, with the need of proper managerial education. Hence, our findings demonstrate that there are variances between genders with regard to the challenges of implementing innovations in high-tech start-ups. They also show that the start-up ideas, according to their innovation type (application, platform or device with software), bring different benefits to entrepreneurs, within the three business fields they belong to: Earth problem-solving, business engineering and human and animal welfare. In this respect, our conclusions have significant implications for both the literature and practice of entrepreneurship.