Innovative Strategies Research Articles

Engaging Adolescents: Innovative ESL Teaching Strategies for Teen Learners

This study investigated the effectiveness of innovative ESL teaching strategies tailored specifically for teenage learners, focusing on the integration of digital tools and culturally relevant materials. Participants aged 13 to 19 were subjected to a mixed-methods approach, combining quantitative assessments of language skills and qualitative feedback through interviews and focus groups. Results indicated significant improvements in both test scores and student engagement, highlighting the crucial role of adapting educational strategies to the developmental needs and interests of teenagers. The research confirms that interactive and relevant teaching approaches can profoundly enhance learning outcomes in ESL contexts.

МЕХАНІЗМ ФОРМУВАННЯ СТРАТЕГІЇ ІННОВАЦІЙНОГО РОЗВИТКУ БУДІВЕЛЬНИХ ПІДПРИЄМСТВ

The article identifies that as of today, Ukraine's construction industry is operating under challenging conditions during the period of the full-scale invasion of Ukraine by the Russian Federation. It was found that in 2022, the construction sector lost its position in the structure of the country's GDP by 1.6%, compared to 2020-2021, where it accounted for 2.8%. It is determined that the share of the construction industry in the GDP throughout the examined period did not exceed 3%, which is significantly lower than the corresponding period in European countries. Additionally, the article examines the mechanism for forming a strategy of innovative development for construction enterprises, which enhances their competitiveness and adaptability to market changes. The key aspects of developing an innovation strategy for construction enterprises are described: improving production efficiency; enhancing the quality and durability of structures; adapting to market conditions; ensuring competitiveness; promoting sustainable development; improving working conditions and safety on-site; attracting investment and business growth. Key steps at the main stages of developing an innovation strategy are proposed, including an analysis of the external and internal environment, the determination of strategic goals, the development of innovative solutions, investment in resources and personnel, as well as strategy monitoring and adaptation. The importance of applying various methods and tools to optimize, increase productivity, and improve enterprise adaptability was emphasized. The proposed approach allows construction companies to enhance production efficiency and achieve sustainable development in the face of modern challenges and technological changes. Keywords: innovations, innovative development, competitiveness, construction enterprise, 3D printing, modular construction.

Innovative Strategy for Rainwater Harvesting in Saline-affected Urban Areas: A Case Study of a Sports Complex in Delhi

Water scarcity remains a critical global challenge, requiring immediate, sustainable management strategies, particularly in areas with an increasing disparity between water supply and demand. In India, and especially in Delhi, this issue is acute. In response to growing environmental concerns and the urgent need for sustainable water resource management, rainwater harvesting has emerged as a practical and effective solution for water conservation. This study investigates the application of rainwater harvesting to sustainably support water needs for a sports complex located in a salinity affected region. The land, originally intended for agriculture, has been converted into a complex featuring hydro-landscape facilities, including swimming pools, water polo areas, diving pools, toddler pools, and leisure pools. These facilities require an initial water input of 6,754.5 m³ and an annual replenishment of 7,957.28 m³ due to evaporation and seepage. By calculating the total rainwater harvesting potential based on the runoff coefficient, annual rainfall intensity, and the complex's catchment area, the study reveals that 29,693.8 m³ of rainwater can be harvested annually, providing a surplus of 14,981.7 m³ of potable water. This analysis demonstrates the viability of designing sports complexes in saline areas using efficient land use and rainwater harvesting, and presenting a scalable model for sustainable water management in similar regions worldwide.

University-to-industry knowledge transfers and firms’ resilience during the great recession: evidence for Spanish firms

ABSTRACT This study examines the relationship between university-to-industry knowledge transfers and firm performance during economic downturns. Using a sample of Spanish manufacturing firms, we evaluate the performance of firms that collaborated with or acquired R&D from universities prior to the Great Recession, focusing on real sales growth relative to their peers. We find that firms that received knowledge transfers from universities outperformed their peers during the ecession, especially in the most affected sectors (as measured by export growth). Notably, the greater resilience associated with these partnerships appears to be limited to small and medium-sized firms. In addition, product differentiation and expansion into new markets appear to be potential mechanisms associated with the greater resilience of firms involved in university knowledge transfers. This is consistent with a shift in their innovation strategy towards exploration during recessions.

Abstract B028: The Role of cDC1 Gene Signatures in gastric cancer prognosis and immune microenvironment modulation

Abstract Background and Aim: Gastric cancer (GC) continues to be a major global health burden, with a growing body of evidence highlighting the critical role of conventional type 1 dendritic cells (cDC1s) within the tumor microenvironment. This study aims to elucidate the prognostic significance of cDC1-associated genes—CD141, XCR1, CLEC9A, CADM1, and BTLA—in gastric cancer, as well as to explore the biological mechanisms that underpin their effects on patient outcomes. Materials and Methods: We conducted a comprehensive analysis of RNA- seq data from The Cancer Genome Atlas (TCGA-STAD) and Gene Expression Omnibus (GEO) datasets, focusing on the expression profiles of five cDC1-related genes. Patients were stratified into high and low expression groups based on a defined cDC1 gene signature. To assess the impact of these signatures, we utilized gene set variation analysis (GSVA) to examine relevant oncogenic pathways and performed Kaplan-Meier survival analysis along with Cox proportional hazards modeling to evaluate their prognostic value. Results: Our findings demonstrate that patients exhibiting a high cDC1-related gene signature had significantly worse overall and disease-free survival within the TCGA-STAD cohort. Further analysis revealed marked differences in CD8+ T cell infiltration and cytotoxic activity between the high and low cDC1 signature groups. Additionally, the high cDC1 signature group was strongly associated with upregulated expression of immune checkpoint proteins and the activation of oncogenic pathways, indicating a highly immunosuppressive tumor microenvironment. Conclusions: This study suggests that the cDC1-related gene signature may serve as a potent prognostic biomarker in gastric cancer, offering new insights into the complex interactions between the tumor and immune microenvironment. These results could pave the way for innovative therapeutic strategies that target the immune landscape in gastric cancer, potentially improving patient outcomes. Citation Format: Song-hee han. The Role of cDC1 Gene Signatures in gastric cancer prognosis and immune microenvironment modulation [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: Tumor-body Interactions: The Roles of Micro- and Macroenvironment in Cancer; 2024 Nov 17-20; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2024;84(22_Suppl):Abstract nr B028.

3D‐Printed In Situ Growth of Bilayer MOF Hydrogels for Accelerated Osteochondral Defect Repair

AbstractRepairing osteochondral (OC) defect presents a significant challenge due to the intricate structural requirements and the unpredictable differentiation pathways of bone marrow mesenchymal stem cells (BMSCs). To address this challenge, a novel biomimetic OC hydrogel scaffold is developed that features a structure of soft and hard components. This scaffold incorporates bilayer metal–organic frameworks (MOFs), specifically ZIF‐67 in the upper layer and ZIF‐8 in the lower layer, achieved through an in situ printing process. This configuration enables the spatial and temporal modulation of BMSC differentiation by controlling the release of Co2⁺ and Zn2⁺. The results demonstrate that the bilayer MOF hydrogels significantly outperform hydrogels that either lack MOFs or contain a single type of MOF in enhancing repair outcomes in rabbit models of knee OC defects. The improved regenerative efficacy is attributed to the distinct chondrogenic and osteogenic differentiation cues provided by the bilayer MOFs, effectively guiding BMSCs toward enhanced tissue regeneration. This customizable biomimetic OC hydrogel scaffold not only opens new avenues for innovative therapeutic strategies but also holds great promise for widespread clinical applications.

Carotenoids as modulators of the PI3K/Akt/mTOR pathway: innovative strategies in cancer therapy.

Cancer progression is primarily driven by the uncontrolled activation of cellular signaling pathways, with the PI3K/Akt/mTOR (PAMT) pathway playing a central role. This pathway significantly contributes to the proliferation and survival of cancer cells, and its hyperactivity is a major challenge in managing several types of malignancies. This article delves into the promising potential of carotenoids, natural pigments found in abundance in fruits and vegetables, as a novel therapeutic strategy for cancer treatment. By specifically targeting and inhibiting the PAMT pathway, carotenoids may effectively disrupt the growth and survival of cancer cells. The article examines the complex mechanisms underlying these interactions and highlights the obstacles faced in cancer treatment. It proposes a compelling approach to developing therapies that leverage natural products to target this critical pathway, offering a fresh perspective on cancer treatment. Further research is essential to enhance the therapeutic efficacy of these compounds.

Feasibility and Impact of Community Pharmacy and Novel Pick-up Points for Antiretroviral Therapy Pre-exposure Prophylaxis Initiation and Continuation in Low and Middle-income Countries.

This review assesses recent developments in community access to pre-exposure prophylaxis (PrEP) for HIV prevention in low-and middle-income countries (LMICs). It examines literature on differentiated service delivery (DSD) and alternative delivery modes for PrEP, focusing on the role of community pharmacies and novel pick-up points. Key considerations include barriers to access, potential benefits, and strategies for implementation. Challenges to optimal HIV healthcare delivery persist globally, with LMICs facing greater barriers due to resource constraints and structural obstacles. Community pharmacies and novel pick-up points offer promising avenues to expand access to HIV medication, especially in hard-to-reach populations. However, operational complexities and regulatory frameworks present significant challenges. Recent initiatives, such as collaborative practice agreements and programmes by global health agencies, highlight efforts to integrate community pharmacies into HIV prevention and care delivery. Mobile health clinics and home delivery services have also shown promise in improving treatment coverage. Community pharmacies and novel pick-up points play a crucial role in enhancing access to HIV PrEP in LMICs. Despite challenges related to infrastructure, funding, and regulatory oversight, innovative strategies like DSD and mobile outreach offer opportunities to reach marginalized populations. Real-life examples from LMICs demonstrate the feasibility and effectiveness of leveraging community pharmacies for HIV treatment. However, addressing policy gaps, strengthening pharmacist training, and promoting patient-centred approaches are essential for scaling up access to PrEP. Collaboration between governments, health agencies, and local communities is key to realizing the full potential of community pharmacies in HIV prevention and care.

(Micro)soft power in Dutch public education: making classrooms platform-ready through partner work

ABSTRACT This article explores how the global technology company Microsoft, supported by local partners, makes Dutch classrooms platform-ready by influencing how schools approach three key public governance responsibilities in their digital transformation: developing a vision for digital education, creating strategies for educational innovation and fostering digital literacy. Using the concept of soft power and extensive empirical research, the study shows how Microsoft aligns these responsibilities with its own corporate interests. As a result, the company gains control over schools’ digital infrastructure – not only in terms of hardware and software but also in terms of its pedagogical design. The conclusion emphasises the importance of collective and collaborative national efforts to resist the global influence of platforms like Microsoft on local digital education.

Enabling Interfacial Lattice Matching by Selective Epitaxial Growth of CuS Crystals on Bi2WO6 Nanosheets for Efficient CO2 Photoreduction into Solar Fuels

AbstractPhotocatalytic CO2 reduction serves as an important technology for value‐added solar fuel production, however, it is generally limited by interfacial charge transport. To address this limitation, a two‐dimensional/two‐dimensional (2D/2D) p‐n heterojunction CuS‐Bi2WO6 (CS‐BWO) with highly connected and matched interfacial lattices was designed in this work via a two‐step hydrothermal tandem synthesis strategy. The integration of CuS with BWO created a robust interface electric field and provided fast charge transfer channels due to the work function difference, as well as highly connected and matched interfacial lattices. The p‐n heterojunction combination promoted the electron transfer from the Cu to Bi sites, leading to the coordination of Bi sites with high electronic density and low oxidation state. The Bi sites in the BWO nanosheets facilitated the adsorption and activation of CO2, and the generation of high‐coverage key intermediate b‐CO32−, while CuS (CS) acted as a broad light‐harvesting material to provide abundant photoinduced electrons that were injected into the conduction band of BWO for CO2 photoreduction reaction. Remarkably, the p‐n heterojunction CS‐BWO exhibited average CO and CH4 yields of 33.9 and 16.4 μmol g−1 h−1, respectively, which were significantly higher than those of CS, BWO, and physical mixture CS‐BWO samples. This work provided an innovative design strategy for developing high‐activity heterojunction photocatalyst for converting CO2 into value‐added solar fuels.

Contemporary review of the evolution of various treatment modalities for mitral regurgitation.

Mitral regurgitation is one of the commonest valvular heart diseases for which there have been several innovative treatment strategies that have developed over the last several decades. We describe the various treatment modalities that have been used for the last several decades. All articles in PubMed, Cochran and Embase were screened from inception to August 2024 for the following - 'Mitral valve regurgitation' 'Mitral valve repair' 'Mitral valve replacement' 'Robotic mitral surgery' 'Transcatheter mitral valve repair.' Mitral regurgitation (MR) is classified into primary and secondary MR. Causes of primary MR include degenerative disease, rheumatic heart disease, and infective endocarditis. Secondary MR is observed in the setting of left ventricle (LV) pathology, including ischemic or dilated cardiomyopathy. In secondary MR, annular dilation, papillary muscle displacement, tethering of chordae tendineae and/or mitral valve (MV) leaflets result in leaflet restriction and malcoaptation. In this review, we discuss various modalities for treatment of mitral regurgitation, as well as newer treatment options for MR including robotic MV repair and other minimally invasive procedures. Several ongoing randomized controlled trials in this topic will help shed more light and provide guidance to deliver the optimal care for our patients.

Crystallization Control of Blade‐Coated Wide Bandgap FACs‐Based Perovskite

AbstractTransforming perovskite solar cells into commercial production requires advanced scalable deposition technology. However, the deposition of high‐quality perovskite thin films using the blade coating method presents challenges, especially in controlling the nucleation and crystallization of perovskite. In this work, an effective approach is proposed for controlling nucleation and crystallization by simultaneously incorporating two kinds of ionic liquid, namely 1H‐imidazole acetate (IMAc), and 1‐buty‐3‐methylimidazolium tetrafluoroborate (BMIMBF4), into the precursor solution. This innovative strategy initiates π–π interactions between IM and BMIM cations, thereby enhancing the interaction between cations and the Pb‐I framework. The competitive mechanism of interaction with Pb‐I framework effectively suppresses the formation of unfavorable mesophase, thereby enabling a single crystallization pathway from NMP + PbI2 to α‐perovskite. Consequently, this method effectively reduces defects and enhances the crystal quality of α‐perovskite film. Based on this strategy, the power conversion efficiency of the p‐i‐n wide bandgap perovskite device prepared by the blade coating method, is increased to 21.31%, representing one of the highest efficiencies achieved with this technology for 1.68 eV bandgap FACs‐based perovskites. Thus, this approach emerges as a feasible breakthrough strategy that may unleash the full potential of perovskite solar cells.

FORTALECENDO O CONTROLE PÉLVICO PARA UMA VIDA SEM LIMITAÇÕES: UMA REVISÃO DE LITERATURA SOBRE A EFICÁCIA DA FISIOTERAPIA COM EXERCÍCIO DE KEGEL NO TRATAMENTO DA INCONTINÊNCIA URINÁRIA

The pelvic floor muscles support organs such as the bladder and uterus, and can weaken due to pregnancy and aging, which results in problems such as urinary incontinence or prolapse. The latter affects millions of women, being associated with factors such as age and number of births. Evaluation, especially through ultrasound, is crucial. Treatments include Kegel exercises, behavioral therapy, and mechanical devices. Innovative strategies, such as the gamification of Kegel exercises, have shown promise for improving adherence and treatment outcomes. The importance of pelvic floor muscles and their dysfunctions, such as urinary incontinence, was addressed, highlighting the need for effective and innovative approaches to improve patients' quality of life. An analysis of the efficacy of Kegel exercise on urinary incontinence in women was conducted, reviewing studies, synthesizing results, and offering recommendations for future research. A systematic review of the literature, conducted between February and May 2024, was adopted to analyze studies on Kegel exercise in urinary incontinence in women, searching for articles in databases such as VHL, PubMed, ScienceDirect, and JSTOR, with strict inclusion criteria. Studies on treatments for pelvic floor dysfunctions, such as prolapse and urinary incontinence, have revealed several approaches. Some have shown effectiveness in personalized training of the muscles, while others have compared methods such as electrical stimulation and active training. In addition, innovative techniques such as position detection during Kegel exercises and mechanotherapy were explored. The efficacy of simple interventions, such as Kegel exercises combined with behavioral therapy, was highlighted. These studies highlighted the complexity of pelvic floor dysfunctions and the importance of multifaceted and individualized approaches to treatment, highlighting the challenges faced and the need for more effective interventions to improve patients' health and quality of life. Authors have emphasized the importance of pelvic muscles and treatments such as training and behavioral therapy, while innovative strategies such as gamification have shown promise for promoting better physical, emotional, and social well-being and outcomes.

Harnessing the power of targeted metal nanocarriers mediated photodynamic and photothermal therapy.

The treatment of cancer has become a profoundly intricate procedure. Traditional treatment methods, including chemotherapy, surgery and radiotherapy, have been utilized, while notable progress has been achieved in recent years. Among targeted therapies for cancer, folic acid (FA) conjugated metal-based nanoparticles (NP) have emerged as an innovative strategy, namely for photodynamic therapy (PDT) and photothermal therapy (PTT). These NP exploit the strong attraction between FA and folate receptors, which are excessively produced in several cancer cells, in order to enable precise administration and improved effectiveness of treatment. During PDT, metal-based NP functionalized with FA are used as photosensitizers which are activated by light, and produce reactive oxygen species that cause cancer cells to undergo apoptosis. Within the framework of PTT, these NP effectively transform light energy into concentrated heat, specifically targeting and destroying tumor cells. This review examines the fundamental mechanisms by which these NP improve the effectiveness of PDT and PTT while simultaneously presenting important findings that demonstrate the effectiveness of FA-functionalized MNP in laboratory and animal models. In addition, the paper also discusses the problems and potential directions for their clinical translation.

ENHANCING TRANSDERMAL DELIVERY OF POORLY WATER-SOLUBLE NSAIDS: EFFECTIVE STRATEGIES

Transdermal drug delivery offers significant advantages for administering non-steroidal anti-inflammatory drugs (NSAIDs) and anti-complementary drugs, particularly those with poor water solubility. This delivery route bypasses first-pass metabolism and gastrointestinal degradation, enhancing bioavailability and patient compliance. However, the stratum corneum, the outermost layer of the skin, poses a formidable barrier to drug permeation. To address this challenge, several innovative strategies have been developed to improve the transdermal delivery of these poorly soluble drugs. Chemical enhancers, such as alcohols, fatty acids, and surfactants, can disrupt the lipid structure of the stratum corneum, increasing drug solubility and permeability. Nanoformulations, including liposomes, niosomes, solid lipid nanoparticles, and nanoemulsions, enhance drug solubility, provide protection against degradation, and facilitate controlled release with deeper skin penetration. Prodrugs, designed to convert into the active drug within the skin, can improve solubility and permeability. Physical methods like microneedles, iontophoresis, and phonophoresis create micropores or use electrical and ultrasound waves to enhance permeation without compromising skin integrity. Cyclodextrins form inclusion complexes with drugs, boosting solubility and stability. Hydrogels and polymer-based formulations create a moist environment for sustained drug release and better absorption. Co-solvents and surfactants, such as ethanol and DMSO, further enhance solubility and disrupt the stratum corneum to facilitate drug penetration. Electroporation and thermal ablation transiently disrupt the skin barrier, significantly improving drug permeation. These strategies, individually or in combination, hold promise for optimizing the transdermal delivery of poorly water-soluble NSAIDs and anticomplementary drugs, ensuring effective therapeutic outcomes and improved patient compliance.

Timing and experience in global markets: unraveling the impact of servitization on new manufacturing venture survival

AbstractThe emergence of global competition and advances in technology have prompted manufacturing firms to reshape their competitive strategies in global markets. Servitization is an innovative strategy, which integrates services into traditional products to offer both domestic and international customers greater value added. In the context of international entrepreneurship and drawing on the resource-based view and internationalization perspectives, this study investigates the relationship between servitization and the survival of new manufacturing ventures that are engaging in global markets. In addition, it further explores whether the pre-internationalization preparation and post-internationalization experience can moderate the servitization-survival relationship from the perspectives of costs, resources, and capabilities developed in different stages. Our findings support the view that, in the context of international markets, new manufacturing ventures are more vulnerable to risk and the additional costs of servitization coupled with the uncertainty of international markets. Later entry into foreign markets and greater international experience enable manufacturing ventures to resist the hazards associated with servitization and the process of internationalization. In doing so, we contribute to an understanding of the service paradox by adopting a dynamic and processual view of internationalization.

Novel Emerging Mechanisms in Acetaminophen (APAP) Hepatotoxicity.

Drug-induced liver injury represents a critical public health issue, marked by unpredictable and potentially severe adverse reactions to medications, herbal products or dietary supplements. Acetaminophen is notably a leading cause of hepatotoxicity, impacting over one million individuals worldwide. Extensive research has elucidated the intricate mechanisms driving APAP-induced liver injury, emphasising the significant roles of endoplasmic reticulum stress, oxidative stress, mitochondrial dysfunction and cell death. These insights pave the way for innovative therapeutic strategies, including the use of magnesium, bile acids, microbiota modulation and mesenchymal stem cells. This review explores into these pathological mechanisms, proposing viable therapeutic interventions for patients suffering from APAP-induced liver injury.

RNA communication between organisms inspires innovative eco-friendly strategies for disease control.

RNA communication between organisms inspires innovative eco-friendly strategies for disease control.

Excitatory amino acids as therapeutic agents: Reversing neurodegenerative trajectory by tackling excitotoxicity.

Neurodegenerative diseases pose significant challenges to healthcare systems globally due to their complex etiology and relentless progression, often rendering conventional treatments ineffective. Recent advances have spotlighted excitatory amino acids, particularly D-amino acids, once considered as products of metabolism of the microbiota or deriving from food intake. This review explores the role of D-amino acids in mitigating excitotoxicity-a process characterized by excessive calcium influx through aberrant N-methyl-D-aspartate receptor (NMDAR) activation, which is implicated in the pathogenesis of diseases like Alzheimer's disease. By providing alternative pathways for neuronal signaling and protecting against excitotoxic damage, D-amino acids offer a novel approach to reversing neurodegenerative trajectories. Future research should focus on elucidating the detailed mechanisms of action of these compounds, evaluating their therapeutic potential through rigorous preclinical and clinical trials, and developing effective delivery systems to optimize their neuroprotective effects. This emerging field holds promise for developing innovative treatment strategies that could significantly improve outcomes for patients with neurodegenerative disorders.

Hybrid package integration strategy for silicon ICs operating beyond 200 GHz

Abstract This paper proposes an innovative hybrid package integration strategy compatible with silicon-based technologies. It is evaluated beyond 200 GHz by the integration of a WR3 back-to-back waveguide-to-suspended stripline transition designed in BiCMOS technology, relying on metallic split-block package and organic laminate substrate. Simulated insertion loss below 3 dB is observed in the 220–320 GHz frequency band, competing with reported traditional solutions using III–V substrates. The achieved performances lead to promising perspectives for low-cost silicon packaging solutions beyond 200 GHz.