The article is devoted to the search for opportunities for reindustrialization of depressed border ultracontinental territories in the context of the implementation of China's strategic initiative "One Belt One Road". The purpose of the study is to find ways to restore and develop economic ties between two border regions – the Altai Territory in the Russian Federation and East Kazakhstan, as the hypothesis of the study is the possibility of increasing the effectiveness of their joint activities. The object of research in the article is the cross-border area between Rubtsovsk and Semey and their adjacent territories. On the basis of a system-dialectical approach, the possibilities of creating a Rubtsovo-Semey industrial and innovative hub within the Altai Territory and the East Kazakhstan region are analyzed. The authors conclude that such cooperation can open up new opportunities for industries producing resource-intensive consumer goods, given the traditional ties and proximity of cultures of the population living here. The article defines the specialization of territories and the existing level of interaction between regions. The authors substantiate the sectors of the economy that are promising for development in the cluster. The role of Turksib for the reindustrialization of depressed cross-border territories is shown. A concept for the development of a future cross-border industrial cluster is proposed, which is one of the scientific results of the study.