Innovative Design Research Articles

Implementation of design approach in traditional attire Bodo Dokhona for the sustainability of apparel culture

Purpose The purpose of this study is to empower a tradition Bodo attire Dokhona skilled artisan for their livelihoods and preserve cultural and historical legacy by using new themes influenced by Bodo items. Design/methodology/approach To revive the traditional Bodo artefacts by adapting a varied form of motifs inspired from Bodo artefacts which showcases Bodo identity. Findings Motifs implemented in apparel (e.g. Dokhona) inspired from Bodo traditional tools and musical instruments, signifying Bodo identity. Such apparels could be purchased by Bodo consumers as they are very keen to sustain their culture and heritage through motifs weaved in their traditional apparel. This study also proves that Dokhona designed with novel motifs developed from traditional artefacts are better than currently available designs of Dokhona as these were more aesthetic and contemporary in look. Social implications The motif adapted from traditional artefacts would motivate the weavers to weave innovative motif designs in their apparel bringing some newness in the Bodo traditional attire Dokhona, leads to business and women empowerment. Originality/value This study showed the way to create innovative ideas for designing apparel (e.g. Dokhona) from cultural artefacts and helps prospective textile and apparel designers to design sustainable Dokhona.

Ultrasensitive Graphene Field-Effect Biosensors Based on Ferroelectric Polarization of Lithium Niobate for Breast Cancer Marker Detection.

Herein, we present a novel ultrasensitive graphene field-effect transistor (GFET) biosensor based on lithium niobate (LiNbO3) ferroelectric substrate for the application of breast cancer marker detection. The electrical properties of graphene are varied under the electrostatic field, which is generated through the spontaneous polarization of the ferroelectric substrate. It is demonstrated that the properties of interface between graphene and solution are also altered due to the interaction between the electrostatic field and ions. Compared with the graphene field-effect biosensor based on the conventional Si/SiO2 gate structure, our biosensor achieves a higher sensitivity to 64.7 mV/decade and shows a limit of detection down to 1.7 fM (equivalent to 12 fg·mL-1) on the detection of microRNA21 (a breast cancer marker). This innovative design combining GFETs with ferroelectric substrates holds great promise for developing an ultrahigh-sensitivity biosensing platform based on graphene that enables rapid and early disease diagnosis.

Building an Elastic Mechanical Network for Highly Efficient Silicon‐Based Anodes

AbstractSilicon (Si), known for its high theoretical capacity, holds promise for developing high‐energy‐density lithium‐ion batteries (LIBs). However, the intrinsic low conductivity and substantial volume expansion limit its commercial application. Developing a binder that can suppress the massive volume expansion while improving Si conductivity is particularly important for LIBs based on Si anode. Here, grafting natural adhesive cationic guar gum (CGG) with small molecular acrylamide (AM) is proposed and applied it to the Si‐based anode. The rigid guar gum main chain and the elastic polymerized acrylamide (pAM) side chain forms a 3D network that completely encapsulated Si nanoparticles and cross‐linked with the natural hydroxyl groups on the surface of Si particles through abundant functional groups. Numerous link anchors and robust mechanical networks facilitate lithium‐ion transport and effectively mitigated the significant stress generated by silicon during charge and discharge cycles. Based on this innovative design, the Si@CGG@pAM@SP (Super P) electrode demonstrates excellent long‐term cycle stability and rate performance. The Si@CGG@pAM@SP electrode preserves 2086 mAh g−1 discharge capacity after 100 cycles (corresponding to 91.5% capacity retention). Physical characterization and electrochemical tests confirm the rationality of the polymer binder design, serving as a valuable reference for the material design of lithium‐ion batteries.

Current Perspectives on the Development of Food Packaging in Local Agri-Food Systems: an Integrative Review

Objective: This study aims to consolidate a theoretical framework on the development of food packaging within the context of family farming and local agri-food systems, focusing on a critical analysis of the existing literature. Theoretical Framework: The study addresses active and intelligent packaging, new bioactive materials, and biopolymers, focusing on food quality and safety. It also explores strategic design, environmental impact, food waste, emerging trends, consumer behavior, circular economy, and the role of packaging in territorial sustainability and local food entrepreneurship. Method: The methodology consisted of applied, exploratory, and descriptive research, using longitudinal and cross-sectional studies. An integrative review was conducted, initially including 755 articles indexed in databases such as "Periódicos CAPES", "Web of Science", "Scopus", and "Science Direct", of which 47 texts were selected based on the "PRISMA 2020" protocol. The analysis of the selected articles was supported by the "Parsifal" tool, generative artificial intelligence solutions "SciSpace-Copilot" and "ChatGPT-4", and the "VOSviewer" software for graphical-bibliometric analyses. Results and Discussion: The importance of technological innovations in packaging was identified, highlighting sustainable practices and the challenges to increase the competitiveness and sustainability of agri-food products. Research Implications: The study emphasizes the need for innovations in packaging design to enhance competitiveness, as well as the importance of interdisciplinary approaches that integrate technical, environmental, and consumer aspects. Originality/Value: It contributes to the literature by mapping technological innovations in packaging and their applications in local agri-food systems, providing insights into the integration between technology, sustainability, and food systems.

Effect of Platform Configurations and Environmental Conditions on the Performance of Floating Solar Photovoltaic Structures

The growth and development of floating solar photovoltaic (FPV) power plants is a prominent topic within renewable energy technology. One reason contributing to this desired technology design concept is the possibility of land acquisition issues, whereas the usage of the ocean provides a greater technical alternative area. The objective of the research is to present an innovative design for a floating structure, focusing on investigating and comparing the seakeeping performance of several hull configurations: catamaran, trimaran, quadrimaran and pentamaran. The final computational simulation results indicate a linear negative trend in the motion response graphs, particularly in specific significant response values for heave (Global Z), roll (Global RX), and pitch (Global RY), as the hull configuration increases.

α-Fe2O3 nanorods on CoFe-LDH@MX via interfacial interactions for Congo red removal: Experimental and mechanistic studies

Developing a 3D material to support α-Fe2O3 nanorods to improve their adsorption performance for Congo Red (CR) is a major challenge. Herein, a novel 3D composite adsorbent was designed, where 2D material Ti3C2 MX and CoFe-LDH stacked on top of each other as the support material of α-Fe2O3 nanorods (α-Fe2O3@LDH@MX). The specific surface area of the α-Fe2O3@LDH@MX was increased by 2 times (101.28 m2/g) than original CoFe-LDH@MX, thus more favorable for capturing CR (698.25 mg/g). The results of kinetic studies demonstrate that the effective 3D composite structure enables unhindered movement of CR within the α-Fe2O3@LDH@MX. The Langmuir model can accurately describe the adsorption process of CR on the α-Fe2O3@LDH@MX, which means that the process belongs to monomolecular layer chemisorption. Molecular dynamics simulations revealed that the α-Fe2O3 interface primarily interacts with oxygen within the -SO3 group, achieving an adsorption energy up to Einteraction= −20,375.89 kcal/mol. The results of XPS analysis further revealed that interaction between Fe and O achieved the removal of CR. In this paper, the enhancement of α-Fe2O3 adsorption performance has been successfully achieved through innovative structural design. This significantly advances its potential applications and offers new insights for future material design.

No Peace Without Punishment? Reintegrating Islamic State “Collaborators” in Iraq

Abstract How does variation in the severity of punishment affect public opinion toward the reintegration of former enemy “collaborators” after war? We study this question in the context of Iraq where the Islamic State, an armed rebel group, captured and governed a population of more than five million Iraqi citizens between 2014 and 2017. Building upon extensive fieldwork and interviews in Iraq, we designed a survey experiment that randomly varied the severity of sentences in hypothetical scenarios of civilians who supported the Islamic State in non-violent roles (e.g., cleaners, cooks, and wives of fighters). The experiment allows us to estimate the causal effects of punishment on attitudes toward reintegration. We find that a long prison sentence (fifteen years) does not increase the likelihood of participants’ willingness to allow the reintegration of former collaborators; instead, a noncarceral punishment (community service) has a small but statistically significant positive effect. Our most striking findings show that noncarceral and community-based justice mechanisms can significantly increase the likelihood of successful reintegration after punishment. Fifteen percent of respondents who were initially opposed to the return of former collaborators into their communities said that they would be willing to change their judgment and support reintegration if they were asked to do so by a tribal or religious leader, or if the offender completes a noncarceral rehabilitation program. These findings suggest that noncarceral, restorative, and community-based justice mechanisms may be equally or potentially more effective than long-term incarceration for achieving the objectives of rehabilitation and eventual reintegration of former nonviolent offenders. This Article advances the field of comparative empirical legal scholarship by providing an innovative experimental research design that can be replicated by scholars studying other contexts to help answer important questions about the causal effects of criminal justice policies.

Antiepileptic drug-loaded and multifunctional iron oxide@silica@gelatin nanoparticles for acid-triggered drug delivery

The current study developed an innovative design for the production of smart multifunctional core-double shell superparamagnetic nanoparticles (NPs) with a focus on the development of a pH-responsive drug delivery system tailored for the controlled release of Phenytoin, accompanied by real-time monitoring capabilities. In this regard, the ultra-small superparamagnetic iron oxide@silica NPs (IO@Si MNPs) were synthesized and then coated with a layer of gelatin containing Phenytoin as an antiepileptic drug. The precise saturation magnetization value for the resultant NPs was established at 26 emu g-1. The polymeric shell showed a pH-sensitive behavior with the capacity to regulate the release of encapsulated drug under neutral pH conditions, simultaneously, releasing more amount of the drug in a simulated tumorous-epileptic acidic condition. The NPs showed an average size of 41.04 nm, which is in the desired size range facilitating entry through the blood–brain barrier. The values of drug loading and encapsulation efficiency were determined to be 2.01 and 10.05%, respectively. Moreover, kinetic studies revealed a Fickian diffusion process of Phenytoin release, and diffusional exponent values based on the Korsmeyer-Peppas equation were achieved at pH 7.4 and pH 6.3. The synthesized NPs did not show any cytotoxicity. Consequently, this new design offers a faster release of PHT at the site of a tumor in response to a change in pH, which is essential to prevent epileptic attacks.

Multi-scale Quaternion CNN and BiGRU with Cross Self-attention Feature Fusion for Fault Diagnosis of Bearing

Abstract In recent years, deep learning has led to significant advances in bearing fault diagnosis (FD). Most techniques aim to achieve greater accuracy. However, they are sensitive to noise and lack robustness, resulting in insufficient domain adaptation and anti-noise ability. The comparison of studies reveals that giving equal attention to all features does not differentiate their significance. In this work, we propose a novel FD model by integrating multi-scale quaternion convolutional neural network (MQCNN), bidirectional gated recurrent unit (BiGRU), and cross self-attention feature fusion (CSAFF). We have developed innovative designs in two modules, namely MQCNN and CSAFF. Firstly, MQCNN applies quaternion convolution to multi-scale architecture for the first time, aiming to extract the rich hidden features of the original signal from multiple scales. Then, the extracted multi-scale information is input into CSAFF for feature fusion, where CSAFF innovatively incorporates cross self-attention mechanism to enhance discriminative interaction representation within features. Finally, BiGRU captures temporal dependencies while a softmax layer is employed for fault classification, achieving accurate FD. To assess the efficacy of our approach, we experiment on three public datasets (CWRU, MFPT, and Ottawa) and compare it with other excellent methods. The results confirm its state-of-the-art, which the average accuracies can achieve up to 99.99%, 100%, and 99.21% on CWRU, MFPT, and Ottawa datasets. Moreover, we perform practical tests and ablation experiments to validate the efficacy and robustness of the proposed approach.

Exploring Design Literacy in Socially Responsible Design Education

Students majoring in design have the important responsibility of implementing the Chinese national rural revitalisation strategy in their future careers. The Rural Planning and Design course at Shandong University of Art & Design (SUAD) is a contributes to the cultivation of students' quality of responsibility. The design of this course adheres to the national strategy and closely focuses on the cultivation of these responsibilities, which are integrated into the course syllabus and activities. Students in this course are required to go into the countryside, conduct in-depth investigations to determine what social problems the people face and then think independently, cooperate with each other, create and propose innovative design strategies to solve the problems. Multidisciplinary theoretical knowledge is integrated into the course to promote students’ design literacy, including collaborative innovation, critical thinking, communication and research skills. This article introduces this course in detail and uses it as a practical case through which to explore what kind of design literacy is needed, how to cultivate design literacy and its impacts on various practical challenges.

Effect of assembled H-shaped steel struts with servo system on the safe excavation of a subway station

An innovative design of assembled H-shaped steel struts (AHSS) with servo system is introduced for the deep excavation of a T-shaped subway interchange station in soft soil. Analysis of the field monitored axial force of the strut, horizontal displacement of retaining wall, ground surface settlement and displacement of the nearby existing tunnel showed that the servo system could provide a convincing stable axial force for each level of AHSS. When a new level of AHSS with servo system was put into operation, the axial force of the closest level of concrete strut above tended to be more greatly affected than the other levels of strut. The first level of concrete strut contributed much less to resisting horizontal displacement of the diaphragm wall than the other levels of strut, and was under tension during the later stage of excavation. The maximum horizontal displacement of diaphragm wall, displacement of the existing tunnel and ground surface settlement were all controlled well with the operation of AHSS with servo system. Meanwhile, stricter control of the horizontal displacement of the diaphragm wall in the early stage is considered to be beneficial to the control of further deformation of the excavation at a later stage.

Abundant Edge Active Sites-Modified High-Crystalline g-C3N5 for Hydrogen Peroxide Production from Pure-Water via a Quasi-Homogeneous Photocatalytic Process.

Ultrathin carbon nitride pioneered a paradigm that facilitates effective charge separation and acceleration of rapid charge migration. Nevertheless, the dissociation process confronts a disruption owing to the proclivity of carbon nitride to reaggregate, thereby impeding the optimal utilization of active sites. In response to this exigency, the adoption of a synthesis methodology featuring alkaline potassium salt-assisted molten salt synthesis is advocated in this work, aiming to craft a nitrogenated graphitic carbon nitride (g-C3N5) photocatalyst characterized by thin layer and hydrophilicity, which not only amplifies the degree of crystallization of g-C3N5 but also introduces a plethora of abundant edge active sites, engendering a quasi-homogeneous photocatalytic system. Under visible light irradiation, the ultra-high H2O2 production rate of this modified high-crystalline g-C3N5 in pure water attains 151.14µmh-1. This groundbreaking study offers a novel perspective for the innovative design of highly efficient photocatalysts with a quasi-homogeneous photocatalytic system.

Technologies in Teaching and Learning at Fine Art Studios

Creativity is the essence of the arts, and it is the place where students interact to apply knowledge and create artworks and innovative designs in fine art studios. Arts and technology are to create creativity. Hence, the research demonstrates that the strategies and results of using technology have had a significant impact on the fields of art, design, and education. The experience can be inspiring and magical for students when art and technology combine to create complementary elements. The research follows a descriptive-analytical approach in analyzing the elements of creating a richer educational environment using technology in fine arts studios. Besides, the research sets out methodologies and rules for technology that can transform the spaces of the artistic studio in the digital age into stimulating environments. Therefore, this leads to transforming the learning environment into a creative environment full of excitement and curiosity to motivate students and increase academic achievement. In conclusion, the research concluded that artistic creativity comes from generating, visualizing, organizing, and developing ideas and artistic works to design artistic studio spaces that enhance technology to develop students’ creative skills.

Transformative pedagogy and visual Literacy: reframing art and design student perspectives on sustainability with illustrated infographics

This study explores the integration of key Transformative Learning Theory (TLT) principles into design education to foster Visual Literacy (VL) and promote awareness of environmental issues among undergraduate students. Through thematic analysis of 22 illustrated infographics, ideation sketches and supporting textual data created by art and design students, the study examines patterns and insights related to perspective transformation, critical reflection, and visual writing skills. Findings reveal pedagogical efficacy when prompting students to explore counter-narratives to the prevailing negative zeitgeist, resulting in perspective transformation and critical reflection of the design process. In turn, this perspective shift and critical reflection fostered the development of students’ abilities to convey complex ideas visually, thus broadening their visual vocabulary to advocate for positive change. Three main categories were considered: Critical Reflection, Perspective Transformation, and Visual Writing Skills, and six sub-categories were identified: Implicit Reflection, Paradigm Shift, Alternative Narratives, Rhetorical Concepts, Intentional Visual-Verbal Communication, and Emotional Visual Language. Implications for scholars include insights into curriculum development and the promotion of ethical and sustainable design practices, while pragmatic applications for faculty offer actionable recommendations for enhancing teaching practices. The study underscores the importance of ethical considerations, diverse perspectives, and real-world applications in nurturing students’ growth as innovative, ethical and sustainable designers.

Utilizing a structure-based virtual screening approach to discover potential LSD1 inhibitors

BackgroundLysine-specific demethylase 1 (LSD1) is highly expressed in a variety of malignant tumors, rendering it a crucial epigenetic target for anti-tumor therapy. Therefore, the inhibition of LSD1 activity has emerged as a promising innovative therapeutic approach for targeted cancer treatment.MethodsIn our study, we employed innovative structure-based drug design methods to meticulously select compounds from the ZINC15 database. Utilizing virtual docking, we evaluated docking scores and binding modes to identify potential inhibitors. To further validate our findings, we harnessed molecular dynamic simulations and conducted meticulous biochemical experiments to deeply analyze the binding interactions between the protein and compounds.ResultsOur results showcased that ZINC10039815 exhibits an exquisite binding mode with LSD1, fitting perfectly into the active pocket and forming robust interactions with multiple critical residues of the protein.ConclusionsWith its significant inhibitory effect on LSD1 activity, ZINC10039815 emerges as a highly promising candidate for the development of novel LSD1 inhibitors.

Improved Fog Collection on a Hybrid Surface with Acylated Cellulose Coating.

Fog collection serves as an efficient method to alleviate water scarcity in foggy, water-stressed regions. Recent research has focused on constructing a hybrid surface to enhance fog collection efficiency, with one approach being the prevention of liquid film formation at hydrophilic sites. Inspired by the desert beetle, a coating (10-MCC) made by partially acylating microcrystalline cellulose (MCC) exhibits hydrophilic sites alongside a hydrophobic skeleton enabling rapid droplet capture despite its overall hydrophobicity. The captured droplets quickly coalesce into a large droplet driven by the wetting gradient created by the hydrophobic backbone and hydrophilic sites. To achieve greater fog collection efficiency, a hydrophobic-superhydrophobic hybrid surface is formed by combining a coating of 10-MCC with a superhydrophobic surface. The construction of superhydrophobic surfaces typically involves creating a rough surface with a distinctive structure produced by the anodization technique and modifying it with stearic acid. The superhydrophobic surface exhibits excellent corrosion resistance and mechanical stability. Moreover, the hybrid surface shows high efficiency in fog collection, with a tested maximum efficiency of approximately 1.5092 g/cm2/h, 1.77 times that of the original Al sheets. The results demonstrate a remarkable enhancement in fog collection capacity. Furthermore, this work serves as an inspiration for the low-cost and innovative design of engineered surfaces for efficient fog collection.

Innovative Design of Marketing Ecosystems

This study is devoted to the issues of ecosystems and the ecosystem approach. The formation and use of marketing ecosystems can simplify both the processes of transformation of technological patterns and the interaction of different types of business models of enterprises. A separate focus is on marketing ecosystems as one of the important innovations of Industry 5.0. The transition from Industry 4.0 to Industry 5.0 is accompanied by the creation of the necessary software and algorithmic base of quantum computing, introduction of technologies for visualisation of management decisions, development of neuromorphic models of enterprise architecture, digital twins of business processes.The purpose of the study is to develop approaches to designing a marketing ecosystem within the framework of Industry 5.0 and Industry 4.0, which is necessary for building effective interactions between innovative enterprises of different business spheres. The article considers the stages of innovative design of new marketing ecosystems, the result of which is the end-to-end integration of information resources of their member enterprises, which is necessary for the consolidation and synchronisation of structured and unstructured data on different business models of companies and the organisation of predictive analytics mechanisms. In the course of the work, the method of scientific analysis of literature on the research problem was applied, and the empirical experience of the authors of the article was used. The results of the study will be useful to all managers of innovative companies as well as the heads and employees of marketing departments of these companies.

Research on key technology of cooled infrared bionic compound eye camera based on small lens array

Traditional 2D imaging technologies are limited by the need for a large field of view and their sensitivity to small target motion. Inspired by the characteristics of insect compound eye structure, we propose an infrared bionic compound eye camera based on a small lens array. The camera is composed of 61 small lens arrays mounted on a curved spherical shell and a relay optical system. The imaging device is a high-performance cooled mid-wave infrared detector. This is an innovative design for an infrared biomimetic compound eye camera system that provides a wide field of view and all-day detection capability. Aimed to meet the specified requirements. The optical system achieves a 100% cold-membrane match between the infrared optical system and the cooled detector, and the relay optical system optimizes the large-field aberration by introducing a higher-order aspheric surface and modifying the geometric surface of the lenses. Our entire system enables an observation field angle of 108∘×108∘\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$108^\\circ \ imes 108^\\circ$$\\end{document}. The experiments showed that the image quality of the system is high, each ommatidium was effective within the imaging range of the compound eye camera, resulting in an improved signal-to-noise ratio in various scenes.

Protecting digital rights of India: planning for succession at Internet Freedom Foundation (IFF)

Learning outcomes The learning objectives of this case study are based on Bloom’s taxonomy. Upon completion of the case study discussion and exercises, successful students will be able to design a leadership transition and succession plan for non-profit organisations; identify and evaluate critical skills and competencies required in leadership positions; and frame expectations and responsibilities for new and departing executives. Case overview/synopsis Apar Gupta co-founded Internet Freedom Foundation (IFF), a digital rights organisation born out of SaveTheInternet – Net Neutrality movement of 2015, credited for urging the Telecom Regulatory Authority of India to uphold net neutrality in India. And ban zero-cost internet services that promoted data discrimination in the country. After working on and winning the net neutrality movement, Gupta identified many areas in technology where democratic rights had not been identified or were yet to be clearly defined (like in the case of net neutrality). There was also a service gap between the existing internet volunteer groups and digital rights organisations, which could IFF fill. This was to provide objective clarity, stakeholder identification, handle policy discussions and, most importantly, arrange resources to support movements over the long term. This prompted him to co-found IFF in 2017, which he later joined as a full-time executive director in 2018. IFF worked at the intersection of technology, democratic rights and government policies and was comparable to some global organisations, such as the Electronic Frontier Foundation in the USA and the Open Rights Group in the UK. Still, none existed in India at the time. After four years as a full-time executive director in 2022, he was convinced that it was finally time for him to act on the pre-defined strategic departure plan and work towards succession for the executive director position. While there were visible gaps in the system, Gupta’s leadership design and plans had helped IFF overcome existential challenges in the past. Also, while digital rights were still at a nascent stage in emerging economies, under Gupta’s leadership, IFF had delivered unmatched value to its beneficiaries in the world’s biggest digital consumer market. However, constant changes in regulations and continuing financial constraints made him nervous about the outcomes of the succession and the overall sustainability of IFF. Gupta wanted to ensure that this phased transition from executive director after two years and then trustee manager after the next four years are carefully communicated to reduce the likelihood of attrition and loss of trust. Being the co-founder and the first and only executive director IFF had seen, the organisation would also require significant skill and competency mapping to identify the new executive leadership. But with no clear internal successor in sight, the non-profit trust would also need a successor who not only was competent but also would share a passion for the type of work done by IFF, its unique delivery mode, and also would openly inherit its position in society. The other alternative strategic routes present were to look for dual leadership or interim leadership, but then there could be concerns about Gupta’s influence overshadowing any such alternative. In the case scenario, IFF is planning for succession while navigating the organisation through financial constraints and constant regulatory changes to ensure long- and short-term sustainability. Complexity academic level The case study has been written to gain insights into departure-defined successive planning in non-profit organisations. The case study can also be used to gain insights into innovative start-ups and innovative non-profit start-ups, as digital rights are still at nascent stages in emerging markets. The case study will be valuable for courses such as human resource management, strategic human resource management, social entrepreneurial leadership, leadership development, start-up environment, innovation and entrepreneurship, public policy, development studies, cyber security and information technology. The case study also allows students and young professionals to take the perspective of an innovative start-up founder and design a departure-defined succession plan. The case study can also be useful for senior students wanting to undertake an entrepreneurial career by starting or joining a non-profit organisation. While the case study is suitable for postgraduate- and executive-level courses, it can also be used for conducting entrepreneurial workshops and skill training. Supplementary materials Teaching notes are available for educators only. Subject code CSS 3: Entrepreneurship.

NF-κB-Signaling-Targeted Immunomodulatory Nanoparticle with Photothermal and Quorum-Sensing Inhibition Effects for Efficient Healing of Biofilm-Infected Wounds.

The development of therapeutics with high antimicrobial activity and immunomodulatory effects is urgently needed for the treatment of infected wounds due to the increasing danger posed by recalcitrant-infected wounds. In this study, we developed light-controlled antibacterial, photothermal, and immunomodulatory biomimetic N/hPDA@M nanoparticles (NPs). This nanoplatform was developed by loading flavonoid naringenin onto hollow mesoporous polydopamine NPs in a π-π-stacked configuration and encasing them with macrophage membranes. First, our N/hPDA@M NPs efficiently neutralized inflammatory factors present within the wound microenvironment by the integration of macrophage membranes. Afterward, the N/hPDA@M NPs effectively dismantled bacterial biofilms through a combination of the photothermal properties of PDA and the quorum sensing inhibitory effects of naringenin. It is worth noting that N/hPDA@M NPs near-infrared-enhanced release of naringenin exhibited specificity toward the NF-κB-signaling pathway, effectively mitigating the inflammatory response. This innovative design not only conferred remarkable antibacterial properties upon the N/hPDA@M NPs but also endowed them with the capacity to modulate inflammatory responses, curbing excessive inflammation and steering macrophage polarization toward the M2 phenotype. As a result, this multifaceted approach significantly contributes to expediting the healing process of infected skin wounds.