Initial Suppression Research Articles

Mechanical suppression of invasive Northern Pike in Box Canyon Reservoir, Washington

AbstractObjectiveNorthern Pike Esox lucius recently invaded Box Canyon Reservoir, Washington, expanding to over 10,000 individuals by 2011. To limit further impacts, a significant reduction in population abundance was required. Project objectives were to reduce relative abundance (catch per unit effort [CPUE]) to less than 1.7 Northern Pike/net (87% reduction) in the core area and to less than 0.5 Northern Pike/net in the northern reservoir section within 3 years and then maintain those abundance targets thereafter.MethodsUsing gill nets, we conducted intensive annual (2012–2018) suppression each spring, focusing on spawning aggregations in shallow (<2‐m), flooded habitats. To evaluate CPUE, a standardized spring pike index netting (SPIN) survey was conducted annually in May and compared to suppression netting CPUE.ResultIn total, 17,464 Northern Pike were removed in 4868 net sets, with 92.9% captured in the first 3 years, limiting future recruitment. Mean SPIN CPUE in the core area declined from a presuppression (2011) high of 13.2 Northern Pike/net to less than 1.0 Northern Pike/net by 2014. Effort was reduced by up to 80% as the project transitioned from the initial suppression phase (2012–2014) to a control phase (2015–2018), which explored the minimum effort required to maintain abundance targets. A significant rebound in CPUE occurred from 2017 to 2018, indicating that over 267 net sets annually may be required for long‐term control. Although the mean CPUE (±95% confidence interval) increased slightly in 2018 (0.6 ± 0.5 Northern Pike/net), the target abundance in the core area was achieved annually from 2013 to 2018. Changes in suppression CPUE reflected those observed in SPIN surveys, further validating the survey and corroborating abundance trends.ConclusionResults demonstrate that the suppression of Northern Pike in large, complex waters is feasible but requires a substantial long‐term commitment. We expect the suppression of this invasive species to become standard practice outside of its native range. The methodology and equipment described here could be applied directly or modified by others to suppress Northern Pike.

A sleepy cannabis constituent: cannabinol and its active metabolite influence sleep architecture in rats.

Medicinal cannabis is being used worldwide and there is increasing use of novel cannabis products in the community. Cannabis contains the major cannabinoids, Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD), but also an array of minor cannabinoids that have undergone much less pharmacological characterization. Cannabinol (CBN) is a minor cannabinoid used in the community in "isolate' products and is claimed to have pro-sleep effects comparable to conventional sleep medications. However, no study has yet examined whether it impacts sleep architecture using objective sleep measures. The effects of CBN on sleep in rats using polysomnography were therefore examined. CBN increased total sleep time, although there was evidence of biphasic effects with initial sleep suppression before a dramatic increase in sleep. CBN increased both non-rapid eye movement (NREM) and rapid eye movement (REM) sleep. The magnitude of the effect of CBN on NREM was comparable to the sleep aid zolpidem, although, unlike CBN, zolpidem did not influence REM sleep. Following CBN dosing, 11-hydroxy-CBN, a primary metabolite of CBN surprisingly attained equivalently high brain concentrations to CBN. 11-hydroxy-CBN was active at cannabinoid CB1 receptors with comparable potency and efficacy to Δ9-THC, however, CBN had much lower activity. We then discovered that the metabolite 11-hydroxy-CBN also influenced sleep architecture, albeit with some subtle differences from CBN itself. This study shows CBN affects sleep using objective sleep measures and suggests an active metabolite may contribute to its hypnotic action.

Delayed testing in directed forgetting dissociates active and passive forms of forgetting.

Across two experiments, we assessed the rates of relative forgetting following instructions to remember or forget information in an item-method directed forgetting paradigm across several retention intervals. In addition to the Forget and Remember cues, we also included Thought Substitution (TS) cues in the same design instructing participants to mentally shift to a different context on some study trials. TS cues have been shown to impair memory compared with Remember cues, but not as effectively as cues to Forget in item-method studies (Hubbard & Sahakyan, 2021). The results demonstrated that Forget cues produce accelerated rates of forgetting compared with Remember cues and showed that these differences are independent of initial learning rates, which were deliberately equated in Experiment 2. TS cued items showed faster forgetting than Remember cued items but were less effective than Forget cues and exhibited a more complex pattern likely reflecting individual differences. Thus, delayed testing demonstrated that active forgetting can have long-lasting effects on memory traces beyond initial suppression, in line with cognitive neuroscientific theory suggesting inhibition can produce lasting changes to memory traces. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Extraction and structural analysis of mannoproteins from different species of yeast: Bitter suppression and the potential mechanisms for wine

To rich the research for mannoproteins (MPs) suppressive effect on the bitterness of wine, this study distinguished bitterness into initial bitterness and bitter aftertaste. By utilizing the thermal alkali extraction method, MPs were extracted from three different yeast species: Saccharomyces cerevisiae (CECA), Lachancea thermotolerans (A38), and Torulaspora delbrueckii (2082). Their basic structures, addition concentrations, and correlation with bitter suppression ability were characterized. CECA exhibited stronger initial bitterness suppression ability, may attributed to its more branches and lack of a triple-helix structure. 2082 showed greater bitter aftertaste suppression and might due to smaller particle aggregation, fewer branches, and triple-helix structure. Additionally, it was noteworthy that due to the unique structure of 2082, it may bound more monomer and oligomeric proanthocyanidins (MOPC) on MPs surface, reducing its initial bitterness suppression ability. Concerning concentration, the increase in polysaccharide chain polymerization hindered further interaction with MOPC, leading to a decrease in its initial bitterness suppression ability. Bitter aftertaste exhibited different behaviors. As the concentration of CECA increased, there was an increase in oral adhesion instead.

Intelligent Fire Suppression Devices Based on Microcapsules Linked to Sensor Internet of Things

Most fire spread is caused by the absence of suppression means at the beginning of the fire. This results in the missed golden time. There are various factors that cause initial fires, such as electrical outlets, general distribution circuits, and oil–vapor–gas cluster spaces. In most cases, these places are out of reach of human hands or they lose the initial suppression time when a fire occurs, causing the spread of fire. This study implements an intelligent fire suppression device that connects sensor IoT based on microcapsules to secure initial fire suppression and golden time in the event of a fire in blind spots that cannot be seen by humans or at a time when it is difficult to recognize a fire. The microcapsule is a micro-collection unit that collects Novec 1230 gas generated in the semiconductor production process. The microcapsule is molded into a form with a fire suppression function and, when a fire occurs, the molded body explodes and absorbs ambient oxygen to suppress the fire. The complex-sensor IoT executes smoke and heat detection generated when a fire is suppressed within 10 s, which ensures the reliability of the detector by notifying of the fire and detecting the ignition point through communication linkages such as Ieee 485 and WiFi or LoRa.

Sleep-wake behavior and responses to sleep deprivation and immune challenge of protein kinase RNA-activated knockout mice

Protein Kinase RNA-activated (PKR) is an enzyme that plays a role in many systemic processes, including modulation of inflammation, and is implicated in neurodegenerative diseases, such as Alzheimer’s disease (AD). PKR phosphorylation results in the production of several cytokines involved in the regulation / modulation of sleep, including interleukin-1β, tumor necrosis factor-α and interferon-γ. We hypothesized targeting PKR would alter spontaneous sleep of mice, attenuate responses to sleep deprivation, and inhibit responses to immune challenge. To test these hypotheses, we determined the sleep-wake phenotype of mice lacking PKR (knockout; PKR-/-) during undisturbed baseline conditions; in responses to six hours of sleep deprivation; and after immune challenge with lipopolysaccharide (LPS). Adult male mice (C57BL/6J, n = 7; PKR-/-, n = 7) were surgically instrumented with EEG recording electrodes and an intraperitoneal microchip to record core body temperature. During undisturbed baseline conditions, PKR -/- mice spent more time in non-rapid eye movement sleep (NREMS) and rapid-eye movement sleep (REMS), and less time awake at the beginning of the dark period of the light:dark cycle. Delta power during NREMS, a measure of sleep depth, was less in PKR-/- mice during the dark period, and core body temperatures were lower during the light period. Both mouse strains responded to sleep deprivation with increased NREMS and REMS, although these changes did not differ substantively between strains. The initial increase in delta power during NREMS after sleep deprivation was greater in PKR-/- mice, suggesting a faster buildup of sleep pressure with prolonged waking. Immune challenge with LPS increased NREMS and inhibited REMS to the same extent in both mouse strains, whereas the initial LPS-induced suppression of delta power during NREMS was greater in PKR-/- mice. Because sleep regulatory and immune responsive systems in brain are redundant and overlapping, other mediators and signaling pathways in addition to PKR are involved in the responses to acute sleep deprivation and LPS immune challenge.

Hierarchical Framework for Optimizing Wildfire Surveillance and Suppression Using Human-Autonomous Teaming

The integration of manned and unmanned aircraft can help improve wildfire response. Wildfire containment failures occur when the resources available to first responders, who execute the initial stages of wildfire management referred to as the initial attack, are ineffective or insufficient. Initial attack surveillance and suppression models have linked action spaces and objectives, making their optimization computationally challenging. The initial attack may be formulated as a multi-agent partially observable Markov decision process (MPOMDP). We divide the initial attack MPOMDP into surveillance and suppression processes with their respective planners operating on different, but constant, time scales. A hierarchical framework iterates between surveillance and suppression planners while also providing collision avoidance. This framework is exemplified by a set of multirotor unmanned aircraft surveying an initial attack fire while a manned helicopter suppresses the fire with a water bucket. Wildfire-specific solver extensions are formulated to reduce the otherwise vast action spaces. The hierarchical framework outperforms firefighting techniques and a myopic baseline by up to 242% for moderate wildfires and 60% for rapid wildfires when simulated in abstracted and actual case studies. We also validate the early dispatching of additional suppression assets using regression models to ensure wildfire containment within thresholds established by wildfire agencies.

Suppression of Initial Charging Torque for Electric Drive-Reconfigured On-Board Charger

This paper presents a new electric drive-reconfigured on-board charger and initial electromagnetic torque suppression method. This proposed reconfigured on-board charger does not need many components added to the original electric drive system: only a connector is needed, which is easy to add. Specifically, the inverter for propulsion is reconfigured as a buck chopper and a conduction path to match the reconfigured windings. Two of the machine phase windings serve as inductors, while the third phase winding is reutilized as a common-mode inductor. In addition, the initial charging torque is generated at the outset of the charging process, which may cause an instant shock or even rotational movement. In order to prevent vehicle movement, the reason for the charging torque and suppression method were analyzed. Further, predictive control of the model based on mutual inductance analysis was adopted, where the charging torque was directly used as a control object in the cost function. Finally, experimental performances were applied to verify the proposed reconfigured on-board charger under constant current and constant voltage charging.

Is there a role for suppression of infection in managing fracture-related infection following intra-medullary nailing?

BackgroundThe management of fracture-related infection has undergone radical progress following the development of international guidelines. However, there is limited consideration to the realities of healthcare in low-resource environments due to a lack of available evidence in the literature from these settings. Initial antimicrobial suppression to support fracture union is frequently used in low- and middle-income countries despite the lack of published clinical evidence to support its practice. This study aimed to evaluate the outcomes following initial antimicrobial suppression to support fracture union in the management of fracture-related infection. MethodsA retrospective review of consecutive patients treated with initial antimicrobial suppression to support fracture healing followed by definitive eradication surgery to manage fracture-related infections following intramedullary fixation was performed. Indications for this approach were; a soft tissue envelope not requiring reconstructive surgery, radiographic evidence of stable fixation with adequate alignment, and progression towards fracture union. ResultsThis approach was associated with successful treatment in 51/55 (93 %) patients. Fracture union was achieved in 52/55 (95 %) patients with antimicrobial suppression alone. Remission of infection was achieved in 54/55 (98 %) patients following definitive infection eradication surgery. Following antibiotic suppression, 6/46 (13 %) pathogens isolated from intra-operative samples demonstrated multi-drug resistance. ConclusionInitial antimicrobial suppression to support fracture healing followed by definitive infection eradication surgery was associated with successful treatment in 93 % of patients. The likelihood of remission of infection increases when eradication surgery is performed in a healed bone. This approach was not associated with an increased risk of developing multi-drug-resistant infections compared to contemporary bone infection cohorts in the published literature. Level of evidenceIV

Catalyst or Obstacle? Green innovation and total factor energy efficiency

Green innovation possesses dual externalities of “innovation” and “environmental protection”, and enhancing energy efficiency serves as a crucial means to promote high-quality economic development. Building upon the energy rebound effect, we use the balanced panel data of cities at prefecture level and above in China from 2008 to 2018 to explore the impact of urban green innovation on total factor energy efficiency (TFEE). The findings of this study indicate that, firstly, the impact of green innovation on TFEE exhibits a positive U-shaped pattern, characterized by initial suppression followed by subsequent promotion. This conclusion remains robust after undergoing a series of rigorous robustness tests. Second, high-quality green innovation is found to reach the turning point more quickly, implying that substantial green innovation can cross the turning point in smaller quantities. Thirdly, on the whole, in comparison to non-resource-based cities, resource-based cities are capable of reaching the turning point at an earlier stage. Finally, the new energy demonstration cities have not yet reached the turning point, while the non-new energy demonstration cities have crossed the turning point. This study contributes novel insights into the relationship between green innovation and TFEE, which holds significant implications for the formulation and implementation of sustainable development policies.

Disputes over Burial Mountains

This article examines legal decisions in lineage property disputes from the Korean Empire period (1897–1910) to the first two decades of the Japanese colonial rule to trace the effect of Japanese efforts to implement property rights reforms in colonial Korea. Lineage properties were heavily concentrated in the mountains in the form of communal burial sites; thus, to ease acceptance of colonial rule, such Japanese objectives as forest cultivation needed to accommodate long-established Korean practices of mountain burial. In addition, Japanese perceptions of Koreans as primitively collective in their property relations led to initial suppression of the rights of heirs over lineage property. The colonial court's subsequent gradual and uneven invocation of the principle of exclusive individual property rights became a source of both legal and physical conflicts. The case of how lineage property rights were reorganized in colonial Korea shows the compromised nature of the colonial property regime as it sought to balance traditional claims and modern concepts of property ownership, with long-term consequences for property rights in Korea.

IS THERE A ROLE FOR ANTIBIOTIC SUPPRESSION IN THE MANAGEMENT OF FRACTURE-RELATED INFECTION FOLLOWING INTRAMEDULLARY NAILING?

IntroductionThe management of fracture-related infection has undergone radical progress following the development of international guidelines. However, there is limited consideration to the realities of healthcare in low-resource environments due to a lack of available evidence in the literature from these settings. Initial antimicrobial suppression to support fracture union is frequently used in low- and middle-income countries despite the lack of published clinical evidence to support its practice. This study aimed to evaluate the outcomes following initial antimicrobial suppression to support fracture union in the management of fracture-related infection.Materials & MethodsA retrospective review of consecutive patients treated with initial antimicrobial suppression to support fracture healing followed by definitive eradication surgery to manage fracture-related infections following intramedullary fixation was performed. Indications for this approach were; a soft tissue envelope not requiring reconstructive surgery, radiographic evidence of stable fixation with adequate alignment, and progression towards fracture union.ResultsThis approach was associated with successful treatment in 51/55 (93%) patients. Fracture union was achieved in 52/55 (95%) patients with antimicrobial suppression alone. Remission of infection was achieved in 54/55 (98%) patients following definitive infection eradication surgery. Following antibiotic suppression, 6/46 (13%) pathogens isolated from intra-operative samples demonstrated multi-drug resistance.ConclusionsInitial antimicrobial suppression to support fracture healing followed by definitive infection eradication surgery was associated with successful treatment in 93% of patients. The likelihood of remission of infection increases when eradication surgery is performed in a healed bone. This approach was not associated with an increased risk of developing multi-drug-resistant infections compared to contemporary bone infection cohorts in the published literature.

Analysis of mononuclear leukocyte functional activity in peripheral blood of patients with varying clinical severity of acute Lyme disease

The aim of the study is to assess spontaneous and phytohemagglutinin (PHA)-induced proliferative and cytokine secretory activity in mononuclear blood cell cultures of patients with acute Lyme borreliosis (LB) over times before and after antibiotic therapy as well as depending on clinical severity. Materials and methods. Activity of blast transformation reaction (BTR) of lymphocytes and the secretion levels of interleukins (IL)-1β, IL-2, IL-6, IL-4, IL-10, IL-8, tumor necrosis factor (TNF)-α, monocyte chemoattractant protein (MCP)-1, interferon (IFN)-γ and IFN-α were assessed twice over time in the cultures of mononuclear blood cells of 18 and 14 patients with mild and moderate severity of acute LB. Results. It was determined that the moderate clinical course of acute LB as compared with the mild course was associated with the significant suppression of BTR levels, the increases in spontaneous and/or PHA-stimulated production levels of proinflammatory cytokines IL-1β, IL-6, IL-8, TNF-α and MCP-1, which were balanced by the increases in secretion levels of anti-inflammatory cytokines IL-10 and IL-4. The initial suppression of IFN-γ secretion in this group gave way to an increase in its production over time, which generally corresponded to the formation of an immune response of the mixed Th1/Th2 type.

Abstract 7203: Anti-HDGF antibody attenuates the rise of resistance to EGFR tyrosine kinase inhibitor in NSCLC patient-derived xenograft tumors

Abstract Mutant epidermal growth factor receptor (EGFR), a major oncogenic driver in non-small cell lung cancer (NSCLC), is found in the tumors of 15% (western countries) to 50% (Asian countries) of patients. EGFR-targeted therapy using tyrosine kinase inhibitors (TKIs) is a standard of care for those patients who developed metastatic or recurrent diseases. However, despite having an 80% initial response rate, most patients had partial tumor regression and their disease would progress when acquired resistance emerges. Thus, developing more effective treatment is an unmet need. The clinical response of these patients can be recapitulated in mouse models of patient-derived xenograft (PDX) tumor bearing sensitizing EGFR mutations. In this study, treating established PDX tumors with osimertinib, a third generation EGFR TKI, induced partial tumor regression (50% to 70% size reduction from baseline) followed by progression with a median progression-free survival (PFS) of 26 to 28 days. Interestingly, co-administering an antibody against hepatoma-derived growth factor (HDGF) with osimertinib resulted in enhanced tumor regression (98% to 100% size reduction from baseline) which translated into significantly extended animal survival with a median PFS of 103 or 135 days. Immunohistochemical and western blot examination of tumors collected at different treatment timepoints indicated that AKT/mTOR and MAPK pathways were reactivated after initial suppression in TKI monotherapy arm despite persistent EGFR inhibition. Since AKT/mTOR and MAPK pathways are key survival and proliferative signaling pathways, their reactivation can promote TKI tolerance of tumor cells and the emergence of TKI resistance. However, blocking HDGF attenuated the reactivation of these pathways which could partially explain the enhanced efficacy of osimertinib plus anti-HDGF antibody combination treatment seen in this study. Our results suggest tumor-derived HDGF could play a crucial role in the rise of acquired resistance to osimertinib. Identifying the exact cells and molecular pathways utilized by HDGF to promote tumor cell tolerance to TKI will help us understand how TKI sensitive tumor cells survive EGFR blockade and emerge as resistant cells. Citation Format: Cindy Q. Zhou, Ariel Li, Kaoru Ri, Ahmed Sultan, Hening Ren. Anti-HDGF antibody attenuates the rise of resistance to EGFR tyrosine kinase inhibitor in NSCLC patient-derived xenograft tumors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 7203.

Abstract 1935: The FAK/SRC axis mediates resistance to KRAS G12C inhibitors and its blockade can overcome KRAS inhibitor resistance

Abstract Activating mutations in KRAS are found in approximately 30% of non-small cell lung cancer (NSCLC), and among all KRAS mutations, KRAS G12C is the most frequent variant in NSCLC, with a prevalence of approximately 14%. KRAS G12C inhibitors, sotorasib and adagrasib are FDA approved for locally advanced or metastatic KRAS G12C-positive NSCLC. However, clinical evidence suggests that there are various factors limiting the efficacy of KRAS G12C inhibitors in patients with KRAS G12C-positive NSCLC, highlighting the urgent need for novel treatment strategies or combinations to improve efficacy. Therefore, we sought to identify effective combinations to enhance the efficacy of KRAS G12C inhibitors using in vitro and in vivo models of KRAS G12C-positive NSCLC. Employing a high throughput in vitro drug screening effort using KRAS mutant NSCLC cell lines, we observed that Focal Adhesion Kinase (FAK) and Steroid Receptor Coactivator (SRC) inhibitors produced a synergistic effect when combined with KRAS G12C inhibitors adagrasib or sotorasib. As determined by reverse phase array and Western blotting, in H358, H23, HCC44, and H2122 cells, KRAS inhibitor treatment alone resulted in an initial suppression of RAS/MAPK and AKT pathway activation which was followed by upregulation of multiple receptor tyrosine kinases and integrins which contributed to the re-activation of the RAS/MAPK and AKT pathways after 24-48 hours. We identified FAK as a key downstream mediator of these bypass pathways. FAK/SRC inhibitors enhanced the efficacy of KRAS G12C inhibitors by preventing this feedback activation. Moreover, we observed increased FAK activation in H358 NSCLC cell lines with acquired resistance to adagrasib or sotorasib as compared to parental cells, and FAK/SRC inhibitors re-sensitized resistant cells to KRAS G12C inhibitors. Using a xenograft model of human KRAS mutant NSCLC, we determined that the combination of repotrectinib, a FAK/SRC inhibitor, and a KRAS G12C inhibitor significantly suppressed tumor growth as compared to KRAS G12C inhibitors alone, and this combination was well tolerated. Overall, our findings indicate that activation of FAK is a key mechanism of adaptive feedback and acquired resistance to KRAS G12C inhibitors in KRAS G12C-positive NSCLC and highlight the therapeutic potential of FAK/SRC inhibitors in combination with KRAS G12C inhibitors. These data support the clinical testing of the combination of FAK/SRC inhibitors and KRAS G12C inhibitors in patients with KRAS G12C-positive NSCLC. Citation Format: Yuji Shibata, Hibiki Udagawa, Monique B. Nilsson, Jacqulyne Robichaux, Ana Galan-Cobo, Marcelo Negrao, David P. Molkentine, Junqin He, Alissa Poteete, Yu Qian, Qian Huang, Ferdinandos Skoulidis, John V. Heymach. The FAK/SRC axis mediates resistance to KRAS G12C inhibitors and its blockade can overcome KRAS inhibitor resistance [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 1935.

A recursive multi-head self-attention learning for acoustic-based gear fault diagnosis in real-industrial noise condition

Acoustic-based diagnosis (ABD) is a promising method for rotating machinery fault detection in real-industrial fields due to its advantage of non-contact measurement by air-couple. However, most ABD methods, which rely on single function module of denoising or anti-noise diagnosis, lacks sufficient ability against the strong and highly non-stationary background noise interference in practical industrial application. To deal with the obstacle, a novel two-stage ABD system, which performs denoising and anti-noise diagnosis in a step-by-step fashion, is proposed in this paper. In our method, the denoising sub-system can adaptively track and suppress real-industrial background noise from collected multi-channel signal by our designed recursive multi-head self-attention (RMHSA) mechanism, which take into account the global and long-range information of signal to recursively exclude noise component at each position in signal sequence for overcoming the limitation of traditional method in balancing denoising performance and computational complexity and discontinuity in diagnosis procedure. Subsequently, a novel anti-noise method is explored to automatically track the residual noise components after initial suppression and estimating the noise interference probability within time-frequency (T-F) unit of each signal sample by our designed spatial multi-head self-attention (SMHSA) mechanism in recursive manner. Simultaneously, the anti-noise protocol interacts with diagnosis model based on estimated probability in anti-noise diagnosis sub-system to further improve the diagnosis performance of ABD system under the interference of background noise. Experiment result in both real-industrial noise condition and simulated noise conditions with extremely worse SNRs indicate that the proposed two-stage ABD system is effective in dealing with gear fault diagnosis task under noise condition.

Overlooked voices under strict lockdown: mapping humanitarian needs in 2022 Shanghai COVID-19 outbreak

ABSTRACT The COVID-19 pandemic that emerged in 2020 has caused significant health crises worldwide. Countries and regions around the globe have practiced different policies to contain the pandemic. One commonly adopted strategy is the Zero-COVID policy, comprising two phases: an initial suppression phase, typically enforced through lockdowns, followed by a sustained containment phase. However, sudden and strict lockdown policies in the suppression phase would inevitably bring unexpected challenges to vulnerable populations. There is a need to identify the emergent needs of underprepared, vulnerable populations under lockdowns to inform future pandemic management. In this study, the messages posted on an online mutual help-requesting platform during the 2022 Shanghai lockdown were leveraged as the near real-time agent to represent the side effects of the lockdown policy. This work explores the spatiotemporal correlation of the posts to their potential influencing factors and mines knowledge from the textual content of the posts. The results indicate that the help requests were clustered in downtown Shanghai. The access to profuse medical resources and public services may be hindered in districts with more stringent lockdown policies. The help requests’ content unveils a need for medication and groceries under lockdown. It also underscores that the elderly population was affected most by the lockdown. Based on these insights, policymakers can better anticipate and address the urgent residential needs that may arise in future lockdowns. This knowledge can contribute to more effective planning and preparedness efforts to mitigate the impact on vulnerable populations and ensure their well-being during similar crisis situations.

Examining the influence of location-oriented policies on green transition development of resource-based cities: evidence from China.

Assessing the impact of transforming resource-based cities (RBCs) through scientific evaluation is a crucial approach to gauge the efficacy of implementation of national locational policies. Drawing upon panel data encompassing 113 RBCs over the period 2006 to 2020, this study employs the difference-in-differences (DID) model to systematically evaluate the impact of location-oriented policies, represented by the "National Resource-Based Economic Transformation Comprehensive Supporting Reform Pilot Zone" (CRPZ), on the trajectory of green transition development (GTD) within RBCs. The results indicate, firstly, that the CRPZ has facilitated the GTD of RBCs, and a series of robustness tests confirm this conclusion, revealing a stimulating effect that evolves from initial suppression to subsequent promotion. Secondly, CRPZ can drive the GTD of RBCs by optimizing industrial structure and enhancing innovation capability, which shows that different marginal utilities are observed in its impact on the GTD of RBCs. Finally, the effectiveness of the CRPZ in promoting the GTD of RBCs is influenced by the degree of resource dependence, with a more pronounced impact on cities with higher levels of resource dependence. The conclusions of this study provide valuable insights for the ongoing evaluation of location-oriented policies and the promotion of GTD in RBCs.

산불의 초기 확산단계 전환에 영향을 미치는 인자 분석

Identifying the key factors that influence the transition from ignition to the early stage of spread is important for effective early response to forest fires. This study aimed to identify the factors influencing the stage transition of forest fires, focusing on those that occurred in five cities along the east coast of Gangwon State in South Korea from 2007 to 2019. The study analyzed the association of factors including terrain, forest characteristics, social and geographical factors of the burned areas with the transition from ignition to early stage of spread, using independence tests and logistic regression. The results showed that elevation, slope and the distance to the nearest initial firefighting resources were highly associated with the stage transition. Forest type, crown density and the number of fire monitoring resources observing burned area showed relatively low association with the stage transition. However, these factors had a relation with the frequency of forest fire occurrences. These findings are expected to be helpful in establishing strategies for early response to, and initial suppression of, forest fires.

Taste aversion learning during successive negative contrast

Previous experiments found that acceptance of saccharin by rats was reduced if they had prior experience of sucrose or some other highly palatable solution. This study tested whether such successive negative contrast (SNC) effects involve acquisition of an aversion to the new taste. In three experiments, rats were switched from sucrose exposure in Stage 1 to a less palatable solution containing a new taste in Stage 2. In Experiments 1 and 2, a novel flavor was added to a saccharin solution at the start of Stage 2. In Experiment 1, preference tests revealed a weak aversion to the added vanilla flavor in the Suc-Sacch group, while in Experiment 2 an aversion was found in the Suc-Sacch group to the salty flavor that was used, compared with controls given access either saccharin or water in Stage 1. In Experiment 3, the Suc-Quin group, given quinine solution in Stage 2, displayed a greater aversion to quinine than a Water-Quin control group. These results support the suggestion that taste aversion learning plays a role in the initial suppression of intakes in a qualitative consummatory SNC effect. However, in the light of other evidence, it seems that the unusual persistence of successive negative contrast when rats are switched from sucrose to saccharin is not due to a long-lasting reduction in the value of saccharin.