Initial List Research Articles

Unlocking Continuous Improvement in Heart Failure Remote Monitoring: A Participatory Approach to Unveil Value Dimensions and Performance Indicators.

Introduction: Heart failure (HF) constitutes a public health concern affecting quality of life, survival, and costs. Remote patient monitoring (RPM) can enhance HF management, involving patients actively and improving follow-up. While current HF RPM assessments emphasise cost-effectiveness analysis, there is a need to consider wider RPM impacts and integrate stakeholders' perspectives into assessments for better comprehensiveness. Methods: We developed a four-stage participatory approach to select value dimensions and indicators for continuous HF RPM assessment: Stage 1 involved building a literature-informed initial list; Stage 2 utilized expert interviews for validation and list expansion; Stage 3 involved a web-Delphi process with Portuguese stakeholders and experts for agreement assessment; and Stage 4 included a conclusive expert interview. Results: A literature review identified fourteen studies on telehealth, RPM, and HF, informing an initial list of four value dimensions (Access, Clinical aspects, Acceptability, and Costs) and 22 indicators. Seven semistructured interviews validated and further adjusted the list to 38 indicators. Subsequently, the web-Delphi process engaged 29 stakeholders, giving their opinions regarding assessment aspects' relevance and proposing additional elements - 1 dimension and 12 indicators. Five value dimensions and 38 indicators (76.0%) reached group agreement for selection, while 12 did not reach an agreement. Upon expert appreciation, 5 dimensions, 43 indicators, and 6 case-mix parameters were considered relevant. Discussion: This comprehensive social approach captured diverse stakeholder perspectives, achieving agreement on pertinent HF RPM monitoring and evaluation indicators. Findings can inform visualization and management tool development, aiding day-to-day RPM evaluation and identification of improvement opportunities.

Development of the China’s list of ambulatory care sensitive conditions (ACSCs): a study protocol

BackgroundThe hospitalization rate of ambulatory care sensitive conditions (ACSCs) has been recognized as an essential indicator reflective of the overall performance of healthcare system. At present, ACSCs has been widely used in practice and research to evaluate health service quality and efficiency worldwide. The definition of ACSCs varies across countries due to different challenges posed on healthcare systems. However, China does not have its own list of ACSCs. The study aims to develop a list to meet health system monitoring, reporting and evaluation needs in China.MethodsTo develop the list, we will combine the best methodological evidence available with real-world evidence, adopt a systematic and rigorous process and absorb multidisciplinary expertise. Specific steps include: (1) establishment of working groups; (2) generations of the initial list (review of already published lists, semi-structured interviews, calculations of hospitalization rate); (3) optimization of the list (evidence evaluation, Delphi consensus survey); and (4) approval of a final version of China’s ACSCs list. Within each step of the process, we will calculate frequencies and proportions, use descriptive analysis to summarize and draw conclusions, discuss the results, draft a report, and refine the list.DiscussionOnce completed, China’s list of ACSCs can be used to comprehensively evaluate the current situation and performance of health services, identify flaws and deficiencies embedded in the healthcare system to provide evidence-based implications to inform decision-makings towards the optimization of China’s healthcare system. The experiences might be broadly applicable and serve the purpose of being a prime example for nations with similar conditions.

Working Paper 50: Seedlings of hope: Addressing corruption linked to crimes that impact the environment in line with UNCAC Resolution 8/12

At the 8th session of the Conference of the States Parties to the United Nations Convention against Corruption (UNCAC), in December 2019, States parties adopted a resolution recognising the relationship between corruption and environmental crimes. 
 Resolution 8/12 – Preventing and combating corruption as it relates to crimes that have an impact on the environment – is a landmark Resolution. With its 23 operative paragraphs (OPs), it underlies the importance of addressing corruption linked to crimes that have an impact on the environment. It urges States parties to prevent, investigate and prosecute corruption offences where they may be linked to crimes that have an impact on the environment. 
 This Working Paper report presents a concise overview of prevention and enforcement actions, initiatives and measures implemented by UNCAC States parties between 2019 and 2023 to combat corruption as it pertains to crimes that have an impact on the environment. Section 2 focuses on prevention and Section 3 on enforcement actions.
 Section 4 underscores the valuable contributions made by non-state actors, in particular civil society, academia and the media in this collective endeavour.
 The conclusion includes a list of promising initiatives for corruption prevention and enforcement.

Nonconcatenative Morphology of MSA as Represented by Deverbal Verbs

The present paper considers how the derivation of deverbal verbs occurs in Arabic, a language with nonconcatenative morphology. As Arabic linguists have carefully investigated Arabic deverbal verbs, English literature lacks such investigations. Demonstrating how a word modifies meaning while explaining the intriguing nonconcatenative morphology of Arabic are reasons for considering deverbal verbs. To illustrate the hierarchical structure of Arabic deverbal verbs efficiently, autosegmental analysis was used. Arabic manuscripts and Modern Standard Arabic (MSA) dictionaries, using the Alshamela search engine and the Almaany search engine, were consulted to create a list of deverbal verbs. The manuscripts were utilized to find the initial lists, while the dictionaries were used to filter the list to only include the current deverbal verbs. The author found MSA deverbal verbs are derived through nonconcatenative morphology. The meanings of deverbal verb particles were concluded to belong to an additional autosegmental tier that is distinct from the tier of the root meaning. Notice how the meaning of the deverbal verb تضرّب [taDar:aba] ‘hit oneself’ as an intransitive verb retains the root meaning of ضرب [Daraba] ‘hit’ and adds the deverbal meaning indicating the action happening to oneself. It had been expected that all the verb roots would interact with the deverbal verb templates; however, this was not the case. These morphological gaps were attributed to violations of MSA phonotactics or semantic oddities. Further investigation of the deverbal verbs, considering other languages with nonconcatenative morphology, while investigating the deverbal verb meanings from an Optimality Theory perspective, presents promising plans for future research.

Direct-Acting Antivirals Remain Cost-Effective Treatments for Chronic Hepatitis C in Australia Despite Changes to the Treated Population and the Availability of Retreatment: The Glecaprevir/Pibrentasvir (Maviret®) Example.

The first direct-acting antiviral (DAA) therapies for chronic hepatitis C virus (HCV) infection were reimbursed via Australia's Pharmaceutical Benefits Scheme (PBS) in March 2016. This was based on the recommendation from the Pharmaceutical Benefits Advisory Committee (PBAC) that the regimens would be acceptably cost-effective at an incremental cost-effectiveness ratio (ICER) no greater than $15,000/quality-adjusted life-year (QALY). Since the initial PBS listings for DAA therapies and subsequent listings of newer DAA treatments such as glecaprevir/pibrentasvir (Maviret®), the demographics and some of the disease characteristics of currently treated patients have markedly changed. This analysis aims to reassess the cost-effectiveness of glecaprevir/pibrentasvir, accounting for the changes to the HCV population currently seeking treatment and incorporating retreatment in first-line failures and the treatment of new infections in previously treated individuals. To assess the cost-effectiveness 7years after initial listing of DAAs, an update was made to the Markov model used to achieve PBS reimbursement for Viekira-Pak® in May 2016. Amendments to the Viekira-Pak® model include: changes to baseline age and fibrosis distribution of treated patients, and inclusion of retreatment of first-line failures [those not achieving a sustained virologic response (SVR12)] and reinfected individuals. Treatment-related inputs including SVR12 response rates, adverse events, treatment-related disutility, and discontinuations were sourced from pivotal glecaprevir/pibrentasvir clinical trials. Using the published price of glecaprevir/pibrentasvir, the ICER is below $15,000/QALY. Despite changes in demographics and disease characteristics of treated patients, and changes to the model structure to reflect retreatment in clinical practice in Australia, DAAs remain cost-effective in 2023.

Developing consensus-based clinical competencies to guide stroke clinicians in the implementation of psychological care in aphasia rehabilitation.

Background People with aphasia experience depression and anxiety associated with negative outcomes across a range of time post-stroke. Stroke clinicians are well-positioned to facilitate low-intensity psychotherapeutic interventions after aphasia (e.g. mood screening, behavioural activation, problem-solving therapy, relaxation therapy); however, they self-report a lack of knowledge, skills and confidence to do so. The Theoretical Domains Framework (TDF) provides a lens through which to view and target clinician behaviours and training needs in this area of practice. The aim of this study was to develop and gain consensus on items for a rating scale of clinical competencies in facilitating individual-based, low-intensity psychotherapeutic interventions for people with aphasia. Methods An e-Delphi methodology using focus groups and survey rounds was used to gain consensus on clinical competencies considered important. Results Eight stroke clinicians (speech pathologists and psychologists), two people with aphasia and three family members participated in one of four focus groups. Four themes were derived from the data: (1) Communication support, (2) Assessment and therapy structure, (3) Interpersonal skills, and (4) Needs of the significant other (family or friend). Themes informed an initial list of 23 self-rated and observer-rated competency items. Following two rounds of e-Delphi surveys, 11 stroke clinicians (six speech pathologists and five psychologists) reached consensus (80-100%) for 19 competencies. Conclusions The Psychological Care in Aphasia Rehabilitation Competency scale offers a preliminary list of items to guide and train clinicians to implement low-intensity psychotherapeutic interventions for people with aphasia.

Sharing Economy Development: Empirical Analysis of Technological Factors

The development of the sharing economy is accelerated using digital technologies. Such a topic is not widely discussed in the literature and requires knowledge to fill the existing gaps. The authors analyzed technology-driven variables which have the highest impact on expanding sharing activities. The research helps to examine the degree of integration of society into the process of sharing economy development. This paper aims to create a methodology that helps to evaluate the development of sharing platforms dependent on technological variables such as society’s access to digital services. Two activities are foreseen to achieve the goal. The first activity includes the steps necessary for revising technological variables (the compilation of an initial list of variables, the selection of variables, normalization, and the formation of correlation matrix). The second activity is designed to form a panel regression model using several sharing platform cases. Using the developed methodology, the revision of technological variables is carried out to expand the knowledge of economic science about the intensifying processes of the digitization of society, the resulting changes in consumption, and the redistribution of conventional economic solutions in the markets for goods and services. The authors compared the technological variables which had the highest impact on sharing platforms. The study results demonstrated that among ten sharing platforms, the highest dependence on technological variables is evident in the number of visitors visiting the Uber sharing platform.

Towards a core outcome set for dysarthria after stroke: What should we measure?

To identify and agree on what outcome domains should be measured in research and clinical practice when working with stroke survivors who have dysarthria. Delphi process, two rounds of an online survey followed by two online consensus meetings. UK and Australia. Stroke survivors with experience of dysarthria, speech and language therapists/pathologists working in stroke and communication researchers. Initial list of outcome domains generated from existing literature and with our patient and public involvement group to develop the survey. Participants completed two rounds of this survey to rate importance. Outcomes were identified as 'in', 'unclear' or 'out' from the second survey. All participants were invited to two consensus meetings to discuss these results followed by voting to identify critically important outcome domains for a future Core Outcome Set. All outcomes were voted on in the consensus meetings and included if 70% of meeting participants voted 'yes' for critically important. In total, 148 surveys were fully completed, and 28 participants attended the consensus meetings. A core outcome set for dysarthria after stroke should include four outcome domains: (a) intelligibility of speech, (b) ability to participate in conversations, (c) living well with dysarthria, (d) skills and knowledge of communication partners (where relevant). We describe the consensus of 'what' speech outcomes after stroke are valued by all stakeholders including those with lived experience. We share these findings to encourage the measurement of these domains in clinical practice and research and for future research to identify 'how' best to measure these outcomes.

How is Portugal addressing disinformation? Results of a mapping of initiatives (2010-2023)

The brisky transformation of the internet and the rise of digital technologies have been causing a deep impact on the media and in the ways audiences access, consume and participate. Although in this era information is closer and more available to citizens, concerns have been raised regarding 1) the quality of the information disseminated by digital platforms, 2) the impacts it may have on democracies and 3) the urgency of promoting citizens' MIL competencies. Disseminating unverified content can pose threats towards the status of the Internet as a space for free and informative debate, and as a tool for social inclusion. Portugal is pointed out as the second European country where citizens are most concerned about authenticity and validity of information (Newman et al., 2020). However data also shows that mechanisms of disinformation are quite participated by them. In this way, it becomes relevant to understand how the various sectors of society have been promoting the empowerment of citizens, and their resilience and competence toward information disorder.
 Within the scope of the project Read Twice, the team carried out a mapping of initiatives focused on tackling disinformation. The aim was to identify good practices and outline Portugal’s experience concerning this issue. After an initial listing of activities (N=20) promoted over the last 13 years, the team identified 3 Top Initiatives and eleven Best Practices. Overall results suggest that media literacy has been in the spotlight in the Portuguese context since the 1980s. There is also a tendency for media literacy initiatives to engage target audiences through active, participatory and creative approaches. However, and although the longest-running activity dates from the late 1980s, the initiatives identified are limited to a specific timeframe, suggesting that there is a lack of continuity repeatedly emphasised in the research.

PHANGS Hubble Space Telescope Treasury Survey: Globular Cluster Systems in 17 Nearby Spiral Galaxies

We present new catalogs of likely globular clusters (GCs) in 17 nearby spiral galaxies studied as part of the PHANGS Hubble Space Telescope (HST) Treasury Survey. The galaxies were imaged in five broadband filters from the near-ultraviolet through the I band. PHANGS-HST has produced catalogs of stellar clusters of all ages by selecting extended sources (from multiple concentration index measurements) followed by morphological classification (centrally concentrated and symmetric or asymmetric, multiple peaks, and contaminants) by visually examining the V-band images and separately by a machine-learning algorithm which classified larger samples to reach fainter limits. From both cluster catalogs, we select an initial list of candidate GCs which have B − V ≥ 0.5 and V − I ≥ 0.73 mag, then remove likely contaminants (including reddened young clusters, background galaxies misclassified by the neural network, and chance superpositions/blends of stars) after a careful visual inspection. We find that ≈86% of the color-selected candidates classified as spherically symmetric and 68% of those classified as centrally concentrated but asymmetric are likely to be GCs. The luminosity functions of the GC candidates in two of our 17 galaxies, NGC 628 and NGC 3627, are atypical, and continue to rise at least 1 mag fainter than the expected turnover near M V ∼ −7.4. These faint candidate GCs have more extended spatial distributions than their bright counterparts, and may reside in the disk rather than the bulge/halo, similar to faint GCs previously discovered in M101. These faint clusters may be somewhat younger since the age–metallicity degeneracy makes it difficult to determine precise cluster ages from integrated colors once they reach ≈1 Gyr.

Exosomes in the Real World of Medical Aesthetics: A Review.

Exosomes are cell-derived nanovesicles that transport proteins, nucleic acids, and lipids and play a significant role in almost every physiological process in the human body. They have generated great interest, especially in the field of tissue regeneration. Studies in the last decade support their great regenerating and rejuvenating potential. However, the lack of standardized procedures, limited knowledge regarding their action mechanism, and little clinical evidence impair their implementation and approval in the medical setting. This review aimed to identify published studies and clinical trials using exosomes in human patients for clinical treatments in aesthetic medicine. A systematic search was conducted in the PubMed database using the search term "exosomes" and 25 terms related to aesthetic medicine treatments in human patients. Additionally, a search was conducted in the ClinicalTrials.gov database for interventional clinical trials using exosomes for aesthetic treatments in adults 18 to ≥ 65 years of age. Nine articles were selected after debugging the initial list of published articles in which exosomes were related to Aesthetic Medicine (633 articles). Nine studies were identified from the initial search on ClinicalTrial.gov (104 trials with exosomes). There is no doubt about the scientific basis of exosome regenerative potential and the growing interest in exosomes in Aesthetic Medicine. However, companies must spend more on research to develop standardized and reliable procedures to obtain exosomes for their approval and application in clinical practice. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 . This review highlights the large amount of published research on exosomes related to aesthetic medicine and, at the same time, the lack of products approved by regulatory agencies. Several issues have been suggested to elucidate a response, such as the need for standardized protocols and more knowledge to ensure safe treatments. It also highlights the few clinical trials conducted to evaluate exosome properties in aesthetic medicine treatments.

Biodegradation of 17α-Ethinylestradiol by Strains of Aeromonas Genus Isolated from Acid Mine Drainage

17α-ethinylestradiol (EE2), a synthetically derived analogue of endogenous estrogen, is widely employed as a hormonal contraceptive and is recognized as a highly hazardous emerging pollutant, causing acute and chronic toxic effects on both aquatic and terrestrial organisms. It has been included in the initial Water Watch List. The aim of this study was to isolate bacteria from consortia recovered from mine sediments and acid mine drainage samples, both considered extreme environments, with the ability to degrade EE2. From the most promising consortia, isolates affiliated with the Aeromonas, Rhizobium, and Paraburkholderia genera were obtained, demonstrating the capability of growing at 50 mg/L EE2. Subsequently, these isolates were tested with 9 mg/L of EE2 as the sole carbon source. Among the isolated strains, Aeromonas salmonicida MLN-TP7 exhibited the best performance, efficiently degrading EE2 (95 ± 8%) and reaching concentrations of this compound below the limits of detection within 7 and 9 days. The final metabolites obtained are in accordance with those of the TCA cycle; this may indicate EE2 mineralization. As far as is known, Aeromonas salmonicida was isolated for the first time and identified in acid mine drainage, demonstrating its capacity to degrade EE2, making it a promising candidate for bioaugmentation and suggesting its possible applicability in low pH environments.

Selection, optimization and validation of ten chronic disease polygenic risk scores for clinical implementation in diverse US populations

Polygenic risk scores (PRSs) have improved in predictive performance, but several challenges remain to be addressed before PRSs can be implemented in the clinic, including reduced predictive performance of PRSs in diverse populations, and the interpretation and communication of genetic results to both providers and patients. To address these challenges, the National Human Genome Research Institute-funded Electronic Medical Records and Genomics (eMERGE) Network has developed a framework and pipeline for return of a PRS-based genome-informed risk assessment to 25,000 diverse adults and children as part of a clinical study. From an initial list of 23 conditions, ten were selected for implementation based on PRS performance, medical actionability and potential clinical utility, including cardiometabolic diseases and cancer. Standardized metrics were considered in the selection process, with additional consideration given to strength of evidence in African and Hispanic populations. We then developed a pipeline for clinical PRS implementation (score transfer to a clinical laboratory, validation and verification of score performance), and used genetic ancestry to calibrate PRS mean and variance, utilizing genetically diverse data from 13,475 participants of the All of Us Research Program cohort to train and test model parameters. Finally, we created a framework for regulatory compliance and developed a PRS clinical report for return to providers and for inclusion in an additional genome-informed risk assessment. The initial experience from eMERGE can inform the approach needed to implement PRS-based testing in diverse clinical settings.

Compositional characterization of a primordial S-type asteroid family of the inner main belt

Context. Recently, a primordial family of moderate-albedo asteroid fragments was discovered in the inner main belt. Its age was estimated to be 4.4 ± 1.7 Gyr. However, there is a lack of compositional characterization, which is important to the study of the earliest collisions in the main belt. Aims. In addition to the previously identified members and the parameters that define the family’s borders (V shape), we expanded the list of family members to include asteroids located within the central region of the V shape. These additional potential members were selected based on their diameter (larger than 7 km) and their geometric visible albedo (greater than or equal to 12%). Subsequently, we conducted a spectroscopic survey to determine the dominant taxonomy and composition of this family. This allowed us to further refine the list of family members by removing interlopers. Methods. From an initial list of 263 asteroids that are considered to be potential members of the aforementioned primordial family, we retrieved their spectra in the visible and near-infrared range from the literature and from the Gala DR3 spectral catalog of Solar System objects. For asteroids with no or poor signal-to-noise ratio spectra in the literature, we carried out new ground-based observations. We obtained new spectra for 33 members of the family using the 1.82 m Asiago Telescope for the visible spectroscopy, while for near-infrared spectroscopy, we used the 3.58 m Telescopio Nazionale Galileo (TNG) and the 4.30 m Lowell Discovery Telescope (LDT). Results. In total, we collected spectra for 261 potential members of the primordial S-type family out of 263. We determined their spectral taxonomy and properties, such as spectral slopes and absorption band parameters, when existing. Using the taxonomical characterization and the orbital space parameters, we identified and removed 71 interlopers from the potential members list. The final list of the primordial S-type family members includes 190 asteroids. The family is dominated by S-complex (~71%) asteroids with a mineralogy similar to ordinary chondrites and pyroxene-rich minerals. The family also contains members classified as L-types and V-types. (~15% and ~9%, respectively). Conclusions. The mean albedo of the family is ~23%, and its largest probable remnant is the asteroid (30) Urania. The estimated size of the family parent body ranges between 110 and 210 km. This size range is compatible with the progenitor of H and L chondrites.

Development of a Taxonomy for Causes of Changes in Construction Projects

Contracting parties in construction projects confront significant challenges due to changes. This is an inherent industry characteristic. Managing changes properly with the help of a taxonomy encompassing many of the causes of changes can have a longitudinal and positive effect on project performance, knowledge management, and stakeholder management. However, studies to date have failed to propose an in-depth taxonomy for change causes in construction projects. Therefore, a taxonomy for change causes that can be applied to different construction projects has been developed. First, a systematic literature review and desk study sessions were conducted to identify the initial list of the taxonomy components. Six case studies were then analyzed to reveal the change causes of these cases. Based on the extracted change causes from the literature review and case studies, a taxonomy was developed by conducting focus group discussions with six experts. In the next step, the applicability and validity of the refined taxonomy were evaluated through face-to-face interviews. As a result, a taxonomy with a three-level hierarchy was proposed. This taxonomy is divided into three levels with 13 main categories, 50 subcategories, and 52 change causes. The proposed taxonomy is expected to contribute to practice by reducing the frequency of changes through proactive management of potential changes and standardizing knowledge management practices for managing change.

To what extent do we learn from past epidemics: a mobile phone survey of selected villages in Liberia

Background Epidemics remain a major threat, impacting lives around the globe. We ask whether and to what extent individuals learn from past epidemics in Liberia, a country affected by both the 2014-2016 Ebola Virus Disease and COVID-19. Methods We explored the association between being exposed to the 2014–2016 Ebola epidemic and measures of beliefs, intentions, and behavior during COVID-19. We interviewed 600 respondents three times over seven years, sampled by an initial list of 2,265 respondents in 571 villages across all of Liberia selected through Random Digit Dialing (RDD) in 2015-2016. We used an Ordinary Least Square (OLS) model, controlling for county fixed effects and a set of socio-demographic and economic covariates. Results Because of the selection among individuals with mobile phones, most respondents were male, educated, and were more likely to be from urban areas and wealthy. They were, on average, 33.9 (SD=10.4) years old, 66% were Catholic, and only 23% were unemployed. 22.8% of respondents reported that they knew someone in their community who got or was suspected of having Ebola; 13.7% were exposed to COVID-19, while 4.5% were exposed to both epidemics. We found that those exposed to Ebola were less likely to have wrong beliefs about the virus and how to cure it; they were also more likely to state that they would go to the health facility for important needs such as birth delivery and child routine vaccination; and, they were more likely to get vaccinated during COVID-19. The findings are primarily driven by individuals with low trust in the government. Conclusions This research suggests that individuals who experience a previous epidemic learned from it and might be more responsive to correct information and better respond to a future one. This has policy implications for patient education and awareness campaigns during the next epidemic.

Development and pilot testing of a patient-reported outcome measure to assess symptoms of parastomal hernia.

The aim was to develop and pilot a patient-reported outcome measure (PROM) to assess symptoms of parastomal hernia (PSH). Standard questionnaire development was undertaken (phases 1-3). An initial list of questionnaire domains was identified from validated colorectal cancer PROMs and from semi-structured interviews with patients with a PSH and health professionals (phase 1). Domains were operationalized into items in a provisional questionnaire, and 'think-aloud' patient interviews explored face validity and acceptability (phase 2). The updated questionnaire was piloted in patients with a stoma who had undergone colorectal surgery and had a computed tomography scan available for review. Patient-reported symptoms were examined in relation to PSH (phase 3). Three sources determined PSH presence: (i) data about PSH presence recorded in hospital notes, (ii) independent expert review of the computed tomography scan and (iii) patient report of being informed of a PSH by a health professional. For phase 1, 169 and 127 domains were identified from 70 PROMs and 29 interviews respectively. In phase 2, 14 domains specific to PSH were identified and operationalized into questionnaire items. Think-aloud interviews led to three minor modifications. In phase 3, 44 completed questionnaires were obtained. Missing data were few: 5/660 items. PSH symptom scores associated with PSH presence varied between different data sources. The scale with the most consistent differences between PSH presence and absence and all data sources was the stoma appearance scale. A PROM to examine the symptoms of PSH has been developed from the literature and views of key informants. Although preliminary testing shows it to be understandable and acceptable it is uncertain if it is sensitive to PSH-specific symptoms and further psychometric testing is needed.

Placemaking strategies in greening Universiti Malaya Main Library

<abstract> <p>Libraries are vital for learning, literacy, and fostering innovation. Emphasizing green and sustainable practices is crucial to conserve resources. This research focused on transforming the Universiti Malaya (UM) Main Library into a greener space through placemaking and green initiatives. To assess the greening potential of the library, a systematic review was conducted to establish a list of green library initiatives. Eighteen distinctive themes or categories of green library initiatives were identified. Ten categories deemed of critical importance, including indoor air quality, water quality and management, energy consumption, noise control, policies, waste management, interior design, ecological environment, services and facilities, and library sources, were selected for inclusion in a comprehensive user survey. The survey encompassed five sections, namely: (A) Demographic information, (B) Users' satisfaction with the UM Main Library, (C) Users' knowledges of the green libraries and practices, (D) Users' perceptions towards greening UM Main Library, and (E) Users' additional aspects which include Likert-scale questions and open-ended question soliciting users' opinions on additional green initiatives or improvements. A total of 407 respondents completed the survey, offering valuable insights into their perspectives. Overall, most of respondents revealed a prevailing inclination among library users toward endorsing and adopting green library practices in alignment with those categories. A total of 12 categories and 67 initiatives and strategies were listed based on both article reviews and users' suggestions. This study underscores the significance of integrating greening strategies within the UM Main Library to enhance its environmental quality and user experience by incorporating user feedback.</p> </abstract>

Undertaking Studies Within A Trial to evaluate recruitment and retention strategies for randomised controlled trials: lessons learnt from the PROMETHEUS research programme.

Randomised controlled trials ('trials') are susceptible to poor participant recruitment and retention. Studies Within A Trial are the strongest methods for testing the effectiveness of strategies to improve recruitment and retention. However, relatively few of these have been conducted. PROMoting THE Use of Studies Within A Trial aimed to facilitate at least 25 Studies Within A Trial evaluating recruitment or retention strategies. We share our experience of delivering the PROMoting THE Use of Studies Within A Trial programme, and the lessons learnt for undertaking randomised Studies Within A Trial. A network of 10 Clinical Trials Units and 1 primary care research centre committed to conducting randomised controlled Studies Within A Trial of recruitment and/or retention strategies was established. Promising recruitment and retention strategies were identified from various sources including Cochrane systematic reviews, the Study Within A Trial Repository, and existing prioritisation exercises, which were reviewed by patient and public members to create an initial priority list of seven recruitment and eight retention interventions. Host trial teams could apply for funding and receive support from the PROMoting THE Use of Studies Within A Trial team to undertake Studies Within A Trial. We also tested the feasibility of undertaking co-ordinated Studies Within A Trial, across multiple host trials simultaneously. Clinical trials unit-based trials recruiting or following up participants in any setting in the United Kingdom were eligible. Clinical trials unit-based teams undertaking trials in any clinical context in the United Kingdom. Funding of up to £5000 and support from the PROMoting THE Use of Studies Within A Trial team to design, implement and report Studies Within A Trial. Number of host trials funded. Forty-two Studies Within A Trial were funded (31 host trials), across 12 Clinical Trials Units. The mean cost of a Study Within A Trial was £3535. Twelve Studies Within A Trial tested the same strategy across multiple host trials using a co-ordinated Study Within A Trial design, and four used a factorial design. Two recruitment and five retention strategies were evaluated in more than one host trial. PROMoting THE Use of Studies Within A Trial will add 18% more Studies Within A Trial to the Cochrane systematic review of recruitment strategies, and 79% more Studies Within A Trial to the Cochrane review of retention strategies. For retention, we found that pre-notifying participants by card, letter or e-mail before sending questionnaires was effective, as was the use of pens, and sending personalised text messages to improve questionnaire response. We highlight key lessons learnt to guide others planning Studies Within A Trial, including involving patient and public involvement partners; prioritising and selecting strategies to evaluate and elements to consider when designing a Study Within A Trial; obtaining governance approvals; implementing Studies Within A Trial, including individual and co-ordinated Studies Within A Trials; and reporting Study Within A Trials. The COVID-19 pandemic negatively impacted five Studies Within A Trial, being either delayed (n = 2) or prematurely terminated (n = 3). PROMoting THE Use of Studies Within A Trial significantly increased the evidence base for recruitment and retention strategies. When provided with both funding and practical support, host trial teams successfully implemented Studies Within A Trial. Future research should identify and target gaps in the evidence base, including widening Study Within A Trial uptake, undertaking more complex Studies Within A Trial and translating Study Within A Trial evidence into practice. All Studies Within A Trial in the PROMoting THE Use of Studies Within A Trial programme had to be registered with the Northern Ireland Network for Trials Methodology Research Study Within A Trial Repository. This award was funded by the National Institute for Health and Care Research (NIHR) Health Technology Assessment programme (NIHR award ref: 13/55/80) and is published in full in Health Technology Assessment; Vol. 28, No. 2. See the NIHR Funding and Awards website for further award information.

Knowledge Management Systems Evaluation in Food Industry: A Multicriteria Decision-Making Approach

Knowledge is a valuable intangible asset for companies that should be acquired, stored, shared, and applied to support decision making processes. Knowledge management systems (KMSs) integrate technology-based systems and organizational practices that enable organizations to manage their knowledge and improve their performance. Nowadays, several KMSs emerged, and it is not possible for organizations to use all of them at the same time. In this article, a multicriteria decision-making approach including fuzzy Delphi method (FDM), best worst method (BWM), and fuzzy technique for order preference by similarity to ideal solution (FTOPSIS) was proposed to determine the most appropriate KMSs. A comprehensive literature review allowed us to identify a list of KMSs and related evaluation criteria and subcriteria. Using FDM, the initial list of KMSs was identified, then BWM was adopted to calculate the weights of each criterion and subcriterion. Successively, the KMSs were ranked using FTOPSIS. In order to investigate the robustness of the model, sensitivity analysis was performed. The findings highlight that social media are providing a fast, widespread, and convenient infrastructure to share organizational knowledge. Consequently, organizations should pay more attention to their social channels to gain competitive advantages.