The current contribution investigates the effect of some relevant microstructural parameters (specifically, morphological and crystallographic textures) on the ductility limits of polycrystalline aggregates using the Crystal Plasticity Finite Element Method (CPFEM). The polycrystalline aggregates are assumed to be representative of thin metal sheets and their macroscopic behavior is determined from that of their constituent single crystals on the basis of the periodic homogenization technique. The single crystal behavior is described by a finite strain elastoplastic framework in which the plastic flow rule obeys the classical Schmid law and plastic deformation is solely attributed to the slip on the crystallographic slip systems. The CPFEM is implemented within and in connection with ABAQUS/Standard finite element code. The ductility limits are predicted by the Rice bifurcation theory where strain localization is detected when the macroscopic acoustic tensor becomes singular. Three grain morphologies (namely, cube, random, and elongated morphology) and three initial crystallographic textures (namely, cube, random, and copper orientation) are considered to investigate the effect of morphological and crystallographic textures on the onset of plastic strain localization. The numerical results indicate that the effect of initial crystallographic texture is much more pronounced than that of grain morphology on the predicted ductility limits. In addition, the impact of grain size and sheet thickness are thoroughly analyzed. The research reveals that the trends of the predicted ductility limits are strongly dependent on the size effects.