In this review paper, we discuss some of our recent results concerning the rigorous analysis of initial boundary value problems (IBVPs) and newly discovered effects for certain evolution partial differential equations (PDEs). These equations arise in the applied sciences as models of phenomena and processes pertaining, for example, to continuum mechanics, heat‐mass transfer, solid–fluid dynamics, electron physics and radiation, chemical and petroleum engineering, and nanotechnology. The mathematical problems we address include certain well‐known classical variations of the traditional heat (diffusion) equation, including (i) the Sobolev–Barenblatt pseudoparabolic PDE (or modified heat or second‐order fluid equation), (ii) a fourth‐order heat equation and the associated Cahn–Hilliard (or Kuramoto–Sivashinsky) model, and (iii) the Rubinshtein–Aifantis double‐diffusion system. Our work is based on the synergy of (i) the celebrated Fokas unified transform method (UTM) and (ii) a new approach to the rigorous analysis of this method recently introduced by one of the authors. In recent works, we considered forced versions of the aforementioned PDEs posed in a spatiotemporal quarter‐plane with arbitrary, fully non‐homogeneous initial and boundary data, and we derived formally effective solution representations, for the first time in the history of the models, justifying a posteriori their validity. This included the reconstruction of the prescribed initial and boundary conditions, which required careful analysis of the various integral terms appearing in the formulae, proving that they converge in a strictly defined sense. In each IBVP, the novel formula was utilized to rigorously deduce the solution's regularity properties near the boundaries of the spatiotemporal domain. Importantly, this analysis is indispensable for proving (non)uniqueness of solution. These works extend previous investigations. The usefulness of our closed‐form solutions will be demonstrated by studying their long‐time asymptotics. Specifically, we will briefly review some asymptotic results about Barenblatt's equation.