Inhibition Efficiency Research Articles

Synergistic effect of ZnO nanocomposite of Dodonea viscosa for corrosion inhibition in saline media

Abstract Dodonea viscosa-zinc oxide (DV-ZnO) nanocomposite was synthesized and characterized using Fourier transform infrared (FTIR), thermal gravimetric method (TGA), X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy dispersive X-ray spectroscopy (EDS). The most abundant compounds in the plant extract were explored using gas chromatography-mass spectrometry (GC-MS). FTIR indicated the existence of the different functional groups, XRD showed that the nanocomposite has the hexagonal wurtzite shape of ZnO nanoparticles, SEM-EDS showed a size of 50 nm, and elemental analysis depicts the existence of the different elements in the extract, which confirms, along with TGA results, the formation of DV-ZnO nanocomposite. The nanocomposite synergistic effect was examined for anticorrosion capabilities using gravimetric, electrochemical, and surface analysis methods. Both the plant extract and the nanocomposite exhibited corrosion inhibition abilities. However, the incorporation of the plant extract with ZnO increased the inhibition efficiency by 20 %. Weight loss and electrochemical methods concluded an inhibition efficiency of 80 % for DV-ZnO nanocomposite. The inhibition of the nanocomposite is due to the adsorption of the inhibitor on the carbon steel surface, which was verified using X-ray photoelectron spectroscopy and scanning electron microscopy (SEM). The adsorption was found to follow both Langmuir and Temkin isotherms. Surface examination using atomic force microscopy (AFM) found that the carbon steel surface roughness was decreased from the sample submerged in an uninhibited medium (Sa = 121.20 nm) when adding DV-ZnO nanocomposite (Sa = 22.95 nm) and DV plant extract inhibitor (Sa = 54.73 nm).

Batatas lam leaf extract as a biodegradable corrosion inhibitor for copper in 0.5 M H2SO4 solution

In this study, the Ipomoea Batatas Lam Leaf Extract (IBLE) was obtained through a pure water decoction process. To investigate the corrosion inhibition capabilities of Ipomoea Batatas Lam Leaf Extract (IBLE), a comprehensive approach encompassing electrochemical techniques, X-ray Photoelectron Spectroscopy (XPS), Atomic Force Microscopy (AFM), Scanning Electron Microscopy (SEM), and theoretical calculations has been employed. The electrochemical test results demonstrate a remarkable corrosion inhibition efficiency of up to 96.7% when utilizing an 800 mg/L concentration of IBLE. As the temperature increases, IBLE can still maintain a high standard of anti-corrosion performance and the corrosion inhibition performance can even maintain more than 95% at a temperature of 315 K. Polarization curve test results demonstrate that IBLE belongs to the mixed corrosion inhibitor, which restrains both anode and cathode reactions of copper electrodes in 0.5 M H2SO4 medium. The EIS test shows that the effective inhibition of the charge transfer process by the adsorption of IBLE onto the interface of copper, as the concentration of IBLE increases, there is a notable and significant rise in it, thus showing a great corrosion inhibition property. The surface morphology test shows that the erosion of the copper surface is significantly suppressed after IBLE adsorbing on the copper surface. XPS test reveals that the active ingredients in IBLE can generate Cu–N bonds on the copper surface, producing chemisorption. Theoretical calculation results reveal that the active ingredients of IBLE have great corrosion suppression property.

Synthesis and study of the inhibitory properties of a new Schiff base for C45 carbon steel in 1 M HCl

A newly Schiff base 1, 13-bis-[(4-dimethylamino) benzaldehyde 4, 7, 10-trioxatridecane-diimine] (DABT) was synthesized and characterized on the basis of the results of FT-IR, mass spectroscopy (MS), 1HNMR and 13CNMR. The desired performance of the organic compound DABT which is easy, inexpensive to prepare and eco-friendly, as a corrosion inhibitor for C45 carbon steel in 1 M HCl medium was evaluated using weight loss, potentiodynamic polarization, electrochemical impedance spectroscopy (EIS) measurements. The results suggest that the corrosion inhibition effectiveness increases with increasing inhibitor concentration and decreases with increasing temperature. The polarization experiments demonstrate that DABT exhibits the characteristics of a mixed-type inhibitor and follows the Langmuir isotherm in its adsorption behavior. Contact angle measurement revealed that the inhibitor on the surface of the carbon steel is hydrophobic. The synergistic effect of DABT has been investigated; inhibitory efficiency rises with increasing concentration of KI by competitive adsorption to form a layer of protection on the metal surface. Energy dispersive X-ray spectroscopy (EDS) combined with scanning electron microscope (SEM) was utilized to interpret the morphological study of the carbon steel surface. A good correlation was found between theoretical [Density functional theory (DFT), molecular dynamics simulation (MDS)] and experimental findings.

Hydrogel Nanoparticles Enable Nucleation Barrier Regulation and Ion Anchoring as an Alternative Pathway for Monosodium Urate Monohydrate Crystallization Control.

Gout flare-up, commonly resulting from monosodium urate monohydrate (MSUM) crystallization, has led to painful inflammatory arthritis among hundreds of millions of people. Herein, a kind of hydrogel nanoparticles (HNPs) with specific properties was developed, aimed at providing a promising pathway for MSUM crystallization control. The experimental and molecular dynamics simulation results synchronously indicate that the fabricated HNPs achieve efficient inhibition of MSUM crystallization governed by the mechanism of "host-guest interaction" even under very low-dose administration. HNPs as the host dispersed in the hyperuricemic model effectively lift the relative heterogeneous nucleation barrier of the MSUM crystal and hinder solute aggregation with strong electronegativity and hydrophobicity. The initial appearance of MSUM crystals was then delayed from 94 to 334 h. HNPs as the guest on the surface of the formed crystal can decelerate the growth rate by anchoring ions and occupying the active sites on the surface, and the terminal yield of the MSUM crystal declined to less than 1% of the control group. The good biocompatibility of HNPs (cell viability > 94%) renders it possible for future clinical applications. This study can guide the rational design of inhibitory nanomaterials and the development of their application in the control of relevant pathological crystallization.

Study the Effect of “Di-dodecyl amine” as a Corrosion Inhibitor for Carbon Steel in HCl Medium

Numerous organic compounds have been investigated for their potential to reduce corrosion under various circumstances. This study investigated the effects of di-dodecyl amine, an organic chemical, on carbon steel metal corrosion at different temperatures while HCl acid was present. The examination was carried out using accepted methods for polarization, weight loss, and corrosion process testing. The obtained findings demonstrated that the corrosion rate reduces with increasing inhibitor concentration, leading to increased inhibition efficiency. Furthermore, as shown in the weight loss technique, the corrosion rate lowers with increasing surface coverage with organic inhibitor at 313 °C. In the anodic and cathodic polarization methods, as well as in the inhibition efficiency, it is observed to see the cathodic and anodic curves through which the occurrence of the potential and corrosion current is known. The current and corrosion potential decreases with increasing inhibitor concentration. The amines and methyl motiveless in this inhibitor's composition give it their efficacy since they may coat the metal surface and stop corrosion

In Situ Polymerized Self-Healing Microcapsules as Multifunctional Fillers toward Phosphate Ceramic Coatings.

The protective efficacy of chemically bonded phosphate ceramic coatings (CBPC) is notably diminished owing to the presence of micropores and inadequate self-healing capacity in prolonged corrosive environments. Consequently, it is imperative to augment the corrosion and wear resistance of phosphate ceramic coatings while imbuing them with self-healing capabilities. In this work, a novel self-healing phosphate ceramic coating (MC-PTx@CBPC, x = 0.5, 1.0, 1.5) is designed by urea-formaldehyde (UF) in situ polymerization of nanoscale microcapsules encapsulated with 1H,1H,2H,2H-perfluorodecyltriethoxysilane (PFDTES) and evaluated in detail for corrosion and wear resistance. The corrosion inhibition efficiencies of all formulated MC-PTx@CBPC (x = 0.5, 1.0, 1.5) coatings exceed 90%, with the impedance modulus at the lowest frequency (|Z|f=0.01) showing enhancements of 1-2 orders of magnitude compared to pure CBPC. Moreover, the self-healing function becomes active during prolonged immersion. This can be primarily ascribed to the formation of a unique micronanostructure facilitated by nanoscale microcapsules and micrometer-sized alumina ceramics, bonded via the AlPO4 phase. This structure enhances both the hydrophobicity and the bonding strength of the coating. Specifically, following prolonged immersion, the encapsulated PFDTES is liberated from the microcapsules, undergoing hydrolysis and subsequent polymerization upon contact with the electrolyte to form a protective thin film. This film efficiently obstructs the ingress of corrosive agents. Furthermore, the special micronanostructure enhances the hardness of the coating and the releasing PFDTES can form a lubricating film at the interface of abrasion, thus reducing the wear rate and friction coefficient of the MC-PTx@CBPC (x = 0.5, 1.0, 1.5). Therefore, MC-PTx@CBPC (x = 0.5, 1.0, 1.5) possesses excellent corrosion protection, tribological properties, and self-healing capabilities, which provide thought-provoking ideas for phosphate ceramic coatings to protect metals in harsh environments.

Microbial Biofilm Inhibition Using Magnetic Cross-Linked Polyphenol Oxidase Aggregates.

Microbial biofilm accumulation poses a serious threat to the environment, presents significant challenges to different industries, and exhibits a large impact on public health. Since there has not been a conclusive answer found despite various efforts, the potential green and economical methods are being focused on, particularly the innovative approaches that employ biochemical agents. In the present study, we propose a bio-nanotechnological method using magnetic cross-linked polyphenol oxidase aggregates (PPO m-CLEA) for inhibition of microbial biofilm including multidrug resistant bacteria. Free PPO solution showed only 55-60% biofilm inhibition, whereas m-CLEA showed 70-75% inhibition, as confirmed through microscopic techniques. The carbohydrate and protein contents in biofilm extracellular polymeric substances (EPSs) were reduced significantly. The m-CLEA demonstrated reusability up to 5 cycles with consistent efficiency in biofilm inhibition. Computational work was also done where molecular docking of PPO with microbial proteins associated with biofilm formation was conducted, resulting in favorable binding scores and inter-residual interactions. Overall, both in vitro and in silico results suggest that PPO interferes with microbial cell attachment and EPS formation, thereby preventing biofilm colonization.

Coarse grained MD simulation of bulk and interfacial behavior of mixture of CTAB/SDS surfactants.

This study involves simulating the process of inhibiting corrosion through the formation of micelles by surfactants and their deposition on iron (Fe) surfaces. The primary focus is on examining CTAB/SDS mixtures in aqueous solutions with different concentrations. Micelle properties, including size, shape, aggregation number, cluster size, and surfactant diffusion, were calculated and validated with experimental data. The coarse-grained Fe surface was modeled and validated against experimental water contact-angle data. Subsequently, the deposition of CTAB/SDS mixtures on the Fe surface and air-water interface was studied systematically. We found that the relative ratio of CTAB/SDS in the solution directly influences surfactant deposition behavior, which might impact the corrosion inhibition efficiency. All the MD simulations were performed using the GROMACS software with MARTINI2 force field and Martini polar water. The molecules are packed using PACKMOL software. Both NVT and NPT simulations are caried out at temperature and pressure of 303 K and 1 bar respectively, with a nonbonded interaction cut-off (rcut) of 1.1 nm. The LJ potential was shifted from 0.9 nm to rcut, while the electrostatic potential was shifted from 0.0 nm to rcut. For electrostatics, reaction-field coulomb type is used, relative dielectric constant (epsilon-r) and the reaction field dielectric constant (epsilon-rf) are equal to 2.5 and infinity respectively. The dielectric constant below rcut is epsilon-r, and beyond the cut-off is epsilon-rf. Coulomb-modifier used as potential-shift which leads to shift in the coulomb potential by a constant such that it is zero at the rcut. This makes the potential of the integral of the force . The neighbor list was updated every 10 steps, employing a neighbor list cut-off equal to rcut. Using a polar water model, we used a constant time step of 0.02 ps throughout the simulation. The used epsilon-r = 2.5, is recommended for polar water.

Study on thermal runaway propagation inhibition of battery module by flame-retardant phase change material combined with aerogel felt

Phase change materials (PCMs) are susceptible to fire and may accelerate heat transfer when thermal runaway propagation (TRP) in lithium-ion battery (LIB) modules, requiring the design and safe use of insulation structures with excellent flame-retardant properties. In this work, the sandwich structure composed of flame-retardant phase change material (FRPCM) combined with aerogel felt (AEGF) is used to study the inhibitory effect on TRP of pouch battery modules (BMs). The structural materials are applied between cells, and the changes of temperature, voltage, mass and other parameters in the TRP process are analyzed by changing the thickness of FRPCMs and AEGFs, and the changes of heat flux of materials were also qualitatively analyzed. The results show that the increase of FRPCM and AEGF thickness can increase the interval time of TRP and reduce the overall thermal risk of the BMs. Compared to Test-1, the increase in TRP time between cells 1 and 2 in Test-2 to Test-5 ranged from 52.7% to 358.7%, and the longest thermal runaway interval reached 844 s. Both the structural materials in Test-6 and Test-7 block the TRP. Combining the thermal conductivity of PCMs and the thermal insulation properties of AEGFs, this work can effectively conduct heat to the environment and block the TRP when applied to BMs, which provides a valuable reference for efficient inhibition and blocking of TRP.

A General Molecular Structural Design for Highly Efficient Photopyroptosis that can be Activated within 10 s Irradiation.

Photopyroptosis is an emerging research branch of photodynamic therapy (PDT), whereas there remains a lack of molecular structural principles to fabricate photosensitizers for triggering a highly efficient pyroptosis. Herein, a general and rational structural design principle to implement this hypothesis, is proposed. The principle relies on the clamping of cationic moieties (e.g., pyridinium, imidazolium) onto one photosensitive core to facilitate a considerable mitochondrial targeting (both of the inner and the outer membranes) of the molecules, thus maximizing the photogenerated reactive oxygen species (ROS) at the specific site to trigger the gasdermin E-mediated pyroptosis. Through this design, the pyroptotic trigger can be achieved in a minimum of 10 s of irradiation with a substantially low light dosage (0.4 Jcm⁻2), compared to relevant work reported (up to 60 Jcm⁻2). Moreover, immunotherapy with high tumor inhibition efficiency is realized by applying the synthetic molecules alone. This structural paradigm is valuable for deepening the understanding of PDT (especially the mitochondrial-targeted PDT) from the perspective of pyroptosis, toward the future development of the state-of-the-art form of PDT.

Corrosion Inhibition Performance of Brachystegia eurycoma Leaf Extract on Mild Steel in Acid Media

The aim of this work is to investigate the corrosion inhibition of B. eurycoma leaves extract as a natural inhibitor for mild steel corrosion in 3 M H2SO4 solution. The corrosion inhibitory activity was analyzed by electrochemical impedance spectroscopy (EIS) and potentiodynamic polarization. The surface roughness and its properties through scanning electron microscopy (SEM). The obtained result from EIS divulges that the gradual increase in inhibitor concentration and time of immersion leads to progressive increase in inhibition efficiency. At the end of 8 hours immersion time and inhibitor concentration of 1000 mg/l the highest inhibition efficiency of (88%) was obtained. The potentiodynamic polarization results indicated that addition of B. eurycoma leaves extracts hindered the reaction rates of anodic and cathodic reactions thereby performing as mixed- type inhibitor. The corrosion current density also revealed that in the presence of B. eurycoma leaves extracts the value of corrosion density reduced considerably from 265.2 \(\mu\) A/cm2 for sample without inhibitor to 67.8 \(\mu\) A/cm2 for sample with inhibitor. Again, it was observed that in the presence B. eurycoma leaves extracts the mechanism of hydrogen (effervescence) evolution was unique whereas the anodic dissolution of iron mechanism experienced the impact of the inhibitor. SEM inspection revealed that the mild steel surface showed smoother and lower damage in the presence of inhibitor. Obvious correlations were found between corrosion inhibition efficiency and some quantum chemical parameters such as energy of highest occupied molecular orbital (EHOMO), energy of lowest unoccupied molecular orbital (ELUMO), energy gap (EL–H) and electronic density etc. The obtained results were further elucidated with frontier molecular orbital theory.

Constructing multiple active sites of Bi2WO6 for efficient photocatalytic NO removal and NO2 inhibition

Insufficient photocatalytic NOx oxidation capacity will lead to excessive toxic by-products (NO2), which still seriously restrict its practical application. Herein, the multiple active sites (Cl, Bi0 and OVs) modified Bi2WO6 has been established by in-situ synthesis method. The synergistic effect of multiple active sites greatly increased the photo-electric properties of the Bi2WO6, resulting in the boosting photocatalytic NOx deep oxidation to nitrate. The visible light driven OVs-Bi@BWO-Cl catalyst exhibited a highest NO conversion efficiency (67.3 %) with extremely low NO2 concentration (17.9 ppb). The synergism of structural regulation from the OVs with Cl-doping and surface plasmon resonance of Bi0 significantly enhanced light absorption and provided a fast charge transport channel, improving the separation efficiency of photo-generated carriers. The in-situ DRIFTS and density functional theory (DFT) results shown that the synergistic effect by multiple active sites could enhance the adsorption and activation of reactants to accelerate the processes of H2O/O2-to-ROS and decrease the energy barrier of NO removal to promote deep oxidation of NO-to-NO3−. This work can provide ideas for the design and preparation of the catalyst for safe photocatalytic environment purification.

Synthesis, kinetic studies, and QSAR of dinucleoside polyphosphate derivatives as human AK1 inhibitors

Adenylate kinase (AK) plays a crucial role in the metabolic monitoring of cellular adenine nucleotide homeostasis by catalyzing the reversible transfer of a phosphate group between ATP and AMP, yielding two ADP molecules. By regulating the nucleotide levels and energy metabolism, the enzyme is considered a disease modifier and potential therapeutic target for various human diseases, including malignancies and inflammatory and neurodegenerative disorders. However, lacking approved drugs targeting AK hinders broad studies on this enzyme's pathological importance and therapeutic potential.In this work, we determined the effect of a series of dinucleoside polyphosphate derivatives, commercially available (11 compounds) and newly synthesized (8 compounds), on the catalytic activity of human adenylate kinase isoenzyme 1 (hAK1). The tested compounds belonged to the following groups: (1) diadenosine polyphosphates with different phosphate chain lengths, (2) base-modified derivatives, and (3) phosphate-modified derivatives. We found that all the investigated compounds inhibited the catalytic activity of hAK1, yet with different efficiencies. Three dinucleoside polyphosphates showed IC50 values below 1 µM, and the most significant inhibitory effect was observed for P1-(5′-adenosyl) P5-(5′-adenosyl) pentaphosphate (Ap5A). To understand the observed differences in the inhibition efficiency of the tested dinucleoside polyphosphates, the molecular docking of these compounds to hAK1 was performed. Finally, we conducted a quantitative structure–activity relationship (QSAR) analysis to establish a computational prediction model for hAK1 modulators. Two PLS-regression-based models were built using kinetic data obtained from the AK1 activity analysis performed in both directions of the enzymatic reaction. Model 1 (AMP and ATP synthesis) had a good prediction power (R2 = 0.931, Q2 = 0.854, and MAE = 0.286), while Model 2 (ADP synthesis) exhibited a moderate quality (R2 = 0.913, Q2 = 0.848, and MAE = 0.370). These studies can help better understand the interactions between dinucleoside polyphosphates and adenylate kinase to attain more effective and selective inhibitors in the future.

Rust Prevention Property of a New Organic Inhibitor under Different Conditions.

The corrosion resistance properties of a new type of environmentally-friendly organic inhibitor containing amino ketone molecules are presented in this paper. To evaluate the prevention effect of the inhibitor on corrosion of reinforcement, the electrochemical characteristics of steels in the simulated concrete pore solution (SPS) were investigated under varied conditions of the relevant parameters, including concentrations of the inhibitor and NaCl, pH value, and temperature. The inhibition efficiency of the material was characterized through electrochemical impedance spectroscopy (EIS), potentiodynamic polarization, and the weight loss of steels. The results reveal a significant improvement in the corrosion resistance of steels with the inhibitor. A maximum resistance value of 89.07% was achieved at an inhibitor concentration of 4%. Moreover, the new organic inhibitor exhibited good corrosion protection capability for steels under different NaCl concentrations. Its inhibition efficiency was determined to be 65.62, 80.06, and 66.30% at NaCl concentrations of 2, 3.5 and 5%, respectively. On the other hand, it was found that an alkaline environment was favorable for an enhanced corrosion prevention effect, and an optimal pH value of 11.3 was observed in this work. Besides, the inhibition efficiencies at different temperatures showed a trend of 25 > 35 > 40 > 20 > 30 °C, with a maximum value of 81.32% at 25 °C. The above results suggest that the new organic material has high potential to be used as an eco-friendly and long-term durable inhibitor for steel corrosion prevention under complex conditions.

In-situ biosynthesized plant exudate gums‑silver nanocomposites as corrosion inhibitors for mild steel in hydrochloric acid medium

Natural gums due to availability, multifunctionality, and nontoxicity are multifaceted in application. In corrosion inhibition applications, their performance, in unmodified form is unsatisfactory because of high hydration rate, solubility issues, algal and microbial contamination, as well as thermal instability. This work attempts to enhance the inhibitive performance of Berlinia grandiflora (BEG) and cashew (CEG) exudate gums through various modification approaches. The potential of biogenic BEG and CEG gums−silver (Ag) nanocomposites (NCPs) for corrosion inhibition of mild steel in 1 M HCl is studied. The nanocomposites were characterized using the FTIR, UV–vis, and TEM techniques. The corrosion studies through the gravimetric and electrochemical (PDP, EIS, LPR, and EFM) analyses reveal moderate inhibition performance by the nanocomposites. Furthermore, the PDP results reveal that both inhibitors are mixed-type with maximum corrosion inhibition efficiencies (IEs) of 61.2 % and 54.2 % for BEG-Ag NCP and CEG-Ag NCP, respectively at an optimum concentration of 1.0 %. Modification of these inhibitors with iodide ion (KI) significantly increased the IE values to 90.1 % and 88.5 % for BEG-Ag NCP and CEG-Ag NCP at the same concentration. Surface observation of the uninhibited and inhibited steel samples using SEM/EDAX, 3D Surface profilometer, and AFM affirm that the modified nanocomposites are highly effective.

Synthesis and characterization of selenium-polyvinyl alcohol nanoparticles as eco-friendly corrosion inhibitor for carbon steel in 1.0 M H2SO4

Selenium nanoparticles capped with polyvinyl alcohol (Se-PVA NPs) have been synthesized by chemical reduction using ascorbic acid as a reducing agent. The synthesized nanoparticles were characterized using XRD, DLS, zeta potential, FT-IR, and TEM analysis and found to be stable. The solution of Se-PVA NPs was used as a carbon steel corrosion inhibitor in 1.0 M H2SO4. The effect of the presence of Se-PVA NPs in the corrosion medium was studied by potentiodynamic polarization and gravimetric analyses In the presence of Se-PVA NPs with a concentration of 600 ppm at 303 K, corrosion inhibition efficiency values of 92.86 % and 92.3 % were recorded by potentiodynamic polarization and gravimetric analysis methods, respectively. Over the Se-PVA NPs concentration range 100–600 ppm, it was found that increasing the concentration increases the inhibition efficiency, while the temperature has an adverse effect, inhibition efficiency values of 80.0 % was recorded at 323 K for the 600 ppm Se-PVA NPs solution. The potentiodynamic polarization measurements suggested that Se-PVA NPs work as a mixed-type inhibitor. The corrosion inhibition process was confirmed by testing the used specimens’ metal surface using SEM and AFM techniques, which showed that the acidic medium’s negative impact (distortion and roughness) on the carbon steel surface was reduced significantly in the presence of Se-PVA NPs. The inhibitor’s adsorption on the metal surface was studied. It obeys the Langmuir isotherm with a mixed-type adsorption process. The related kinetic and thermodynamic parameters were investigated.

Synthesis, scale and corrosion inhibition evaluation and mechanism of 2-aminobenzimidazole modified polyaspartic acid

With the growing public concern for environmental preservation, this work employs environmentally friendly polyaspartic acid (PASP) as the main chain, to develop a green and efficient dual-function inhibitor with scale and corrosion inhibition. The new inhibitor PASP-2-A was synthesized by grafting 2-amino-benzimidazole (2-A) containing nitrogen heterocyclic into polysuccinimide under alkaline conditions. The corrosion inhibition of carbon steel and brass was determined by static test, polarization curve and electrochemical impedance spectroscopy (EIS). It can be found that PASP-2-A had better scale inhibition performance than PASP under different conditions. The addition of 5 mg·L−1 PASP-2-A can almost 100% prevent the formation of CaCO3 scale. Molecular dynamics simulation results showed that PASP-2-A significantly destroys the crystal structure of CaCO3 scale due to the coordination between PASP-2-A and Ca2+ groups. The modified PASP scale inhibitor can prevent the growth of calcite (110) and (104) crystal faces, regulate the transformation of CaCO3 from stable calcite to more soluble spherical vaterite, making it less deposit. The electrochemical test results showed that the corrosion inhibition of PASP-2-A is greatly improved compared with PASP, and the corrosion inhibition of Q235 carbon steel increased about 40% at the dosage of 200 ppm. The corrosion inhibition efficiency of H62 brass in 3.5 wt% NaCl was 97.97% with 300 ppm PASP-2-A. Notably, due to its degradable nature, low toxicity, and affordability, PASP-2-A serves as an excellent inhibitor, exhibiting remarkable performance in both scale inhibition and corrosion inhibition. Consequently, it presents a promising avenue for further advancements in modified PASP.

Cancer–stromal cell interactions in breast cancer brain metastases induce glycocalyx-mediated resistance to HER2-targeting therapies

Brain metastatic breast cancer is particularly lethal largely due to therapeutic resistance. Almost half of the patients with metastatic HER2-positive breast cancer develop brain metastases, representing a major clinical challenge. We previously described that cancer-associated fibroblasts are an important source of resistance in primary tumors. Here, we report that breast cancer brain metastasis stromal cell interactions in 3D cocultures induce therapeutic resistance to HER2-targeting agents, particularly to the small molecule inhibitor of HER2/EGFR neratinib. We investigated the underlying mechanisms using a synthetic Notch reporter system enabling the sorting of cancer cells that directly interact with stromal cells. We identified mucins and bulky glycoprotein synthesis as top-up-regulated genes and pathways by comparing the gene expression and chromatin profiles of stroma-contact and no-contact cancer cells before and after neratinib treatment. Glycoprotein gene signatures were also enriched in human brain metastases compared to primary tumors. We confirmed increased glycocalyx surrounding cocultures by immunofluorescence and showed that mucinase treatment increased sensitivity to neratinib by enabling a more efficient inhibition of EGFR/HER2 signaling in cancer cells. Overexpression of truncated MUC1 lacking the intracellular domain as a model of increased glycocalyx-induced resistance to neratinib both in cell culture and in experimental brain metastases in immunodeficient mice. Our results highlight the importance of glycoproteins as a resistance mechanism to HER2-targeting therapies in breast cancer brain metastases.

Grape Leaves and Ziziphus Spina-Christi, Extracts as a Green Inhibitors Corrosion for The Carbon Steel and Oil Pipelines in 1M H2SO4

Metals suffer from corrosion by the surrounding fluids, which causes great economic losses and bad environmental effects, especially in oil pipelines or reservoirs. The extract of grape leaves (GL) and Sidr leaves, (Ziziphus spina-christi), (Zizi) were used as green corrosion inhibitors (CI) for carbon steel (CS), and Oil Pipelines in 1M H2SO4, these extracts showed varying capabilities in resisting corrosion. Corrosion rate was decreased with increase in inhibitor dose which could be due to enhanced surface coverage, as well as the effect of increasing the temperature on the percentage of the efficiency of inhibition, are decrease, and drawing the curves for that, as well as studying some physical properties related to the process of adsorption of extracts on the surface of (CS), such as the activation energy and entropy of the process of adsorption of the extracts on the surface of (CS), and calculating those values, and the extracts showed an efficiency that exceeded 90% at concentrations up to 400 ppm and a temperature of 313-343K. The activation energy associated with this process indicated surface interaction as the main mechanism and positive values of enthalpy change confirmed the endothermic nature. The potentiometric method showed the extent of voltage change with time for each concentration of extract of grape leaves for immersion time (2–24 h), and that the voltage increases with increasing concentration, which indicates a high ability of the inhibitor to adsorb to the metal..

Preparation of magnetic core-shell Fe3O4@MBT-LDH composite and its application as an effective inhibitor for carbon steel

The core-shell structural Fe3O4@MBT-LDH was synthesized via the ion exchange method, with MBT (2-mercaptobenzothiazole) inhibitor ions intercalated lamellar ZnAlCe-LDH attaching closely to the Fe3O4 microspheres surface. The morphology, composition, structure, and magnetic properties of the composite were measured by transmission electron microscope, X-ray diffraction, Fourier transform infrared spectra, and vibrating sample magnetometer. The release behavior of MBT ions and corrosion inhibition performance of the Fe3O4@MBT-LDH under “no MF” (without an external magnetic field) and “MF ON” modes (under an external magnetic field) were measured by UV–vis spectroscopy, electrochemical tests, scanning electron microscopy, and X-ray photoelectron spectrometer (XPS). Calcinating the composite after the release test and redispersing the sintered products in MBT ions-containing solution, the composite was reestablished. Results showed that the Fe3O4@MBT-LDH possessed moderate MBT loadings amount (12.0%) and presented strong superparamagnetic properties with saturation magnetization (Ms) of 27.6 emu⋅g−1. The release behavior of the MBT− from the composite was sustainable and could be further slowed down by using an external magnetic field with changing the release mechanism. The release curve reached equilibrium with a longer time of 48 h and a lower release amount of 57.0% under MF ON mode than that of no MF mode with a time of 7 h and a release amount of 74.7%. The Fe3O4@MBT-LDH owned a good and long-term protection performance for Q235 carbon steel with maximum corrosion inhibition efficiency (ηe) of up to 93.30%. As a promising controlled-release inhibitor, it could be recycled and regenerated by simple treatment, still having high ηe higher than 80% and excellent magnetic properties with Ms of 21.47 emu⋅g−1 after five cycles. The corrosion mechanism for carbon steel was further analyzed by quantum chemical calculations and molecular dynamics simulation.