The hormonal restructuring of a woman’s body is essential in the development of perimenopausal osteoporosis. Perimenopause is characterized by a decreased osteoprotective action of estrogens, increased severity of insulin resistance, chronic inflammation, and the negative impact of these factors on bone structure (suppression of osteoblast function, activation of osteoclasts). This article presents the results of a systematic literature review on the effects of B8 vitamers (myoinositol, D-chiroinositol) and their synergists (manganese, folate) on bone tissue. Phospho-derivatives of inositols may influence bone repair process through (1) activity of inositol-dependent proteins (Inpp4b, IP6K1, SHIP1), NFATc1 protein, and the RANKL/NF-kB cascade, (2) participation in the signaling cascade of calcium-sensing receptor (CASR) and in the mechanisms of realization of antiresorptive properties of strontium, (3) participation in the realization of biological effects of parathyroid hormone (PTH), (4) estrogen-dependent regulation of osteoblast apoptosis. The supplemental administration of myoinositol, D-chiroinositol, manganese, and folate in the perimenopausal period may have a positive effect on bone metabolism in women. Key words: osteopenia, hypoestrogenism, polycystic ovary syndrome, Dikirogen, myoinositol, D-chiroinositol, manganese pyroglutamate, folic acid, nutrient deficiencies