This work presents new geological, geochemical, and geochronological data of Paleoproterozoic granites located in the south-central sector of the Amazonian Craton. This region falls within the Peixoto de Azevedo Domain in the southern Tapajós-Parima Tectonic Province. The results here presented are of the utmost importance in advancing geological knowledge of the Alta Floresta Gold Province. The study area encompasses granitic rocks of the Matupá Intrusive Suite, and of the newly individualized Teles Pires Intrusive Suite. The latter includes two granitic bodies that have been previously ascribed to the Matupá Intrusive Suite. The Matupá Intrusive Suite was divided into two facies: Facies 1, composed of syenogranites and monzogranites, and Facies 2, composed of granodiorites. Granodiorites of Facies 2 have chemical characteristics similar to that of magnesian and metaluminous granites, while syenogranites and monzogranites of Facies 1 are ferrous and slightly peraluminous. Petrographic and geochemical features demonstrate the calc-alkaline nature of the Matupá Intrusive Suite which is typical for I-type granites from of volcanic arc settings. Magmatic zircon crystals yielded U–Pb LA-ICP-MS ages at 1864 ± 19 Ma and 1859 ± 8 Ma for syenogranite and monzogranite of Facies 1, respectively, and an age of 1881 ± 5 Ma for granodiorite of Facies 2. These are the crystallization ages for intrusive bodies of the Matupá Intrusive Suite. The Teles Pires Intrusive Suite varies from syenogranite to monzogranite whose calc-alkaline signature can be linked to the setting of a mature magmatic arc. U–Pb zircon in situ dating with LA-ICP-MS yielded upper intercept ages at 1790 ± 6 Ma and 1793 ± 7 Ma which are interpreted as its magmatic crystallization. Besides these crystallization ages, inherited zircon crystals also provided an older intercept age of 1870 ± 14 Ma, which is correlatable with the Matupá Intrusive Suite. Crustal assimilation and/or contamination are suggested for both the Matupá and Teles Pires intrusive suites due to the presence of inherited zircon populations of ca. 1960 Ma and 1900 Ma, and ca 1896 Ma and 1880 Ma, respectively. These ages are coherent with the Creporizão (Creporizão orogenic) Intrusive Suite, Tropas Intrusive Suite (Tropas orogenic), and Parauari Intrusive Suite (Parauari orogenic), which are all part of the Tapajós Domain. The two intrusive suites outcropping in the study area are therefore attributed to the Matupá Intrusive Suite, Peixoto de Azevedo Domain, and to the Teles Pires Intrusive Suite, Juruena Domain, which in turn is part of the Rondônia-Juruena Tectonic Province.