The primary intent of this scientific research is to effectively assess and collate the inherent potentiality of the two selected investigative composite materials in effectual maintenance of their standard color following subsequent and consistent submersion in customary available pediatric liquids consumed by children. The above investigation will be effectively estimated using the Commission Internationale de I'Eclairege (CIE) L*a*b* system-based spectrophotometer. A total of 100 composites of spheroidal plates were fabricated accordingly. A total of 50 nanohybrids and microhybrids of 8 × 2 mm were fabricated and timely cured using a light cure unit for an approximated time period of 40 seconds. This was then trialled by subsequent sample submersion in the specified five immersive media, which include mineral water, tea, Mirinda, pomegranate juice, and iron syrup, respectively, for a definitive and habitual time of thrice daily up to 15 minutes for a duration of 28 experimental days. The respective marked readings were recorded on the 7th, 14th, 21st, and 28th days by utilization of a CIE L*a*b* system-based spectrophotometer. Mann-Whitney U test and Friedman's Test were utilized for statistical evaluation of the above-described experimental research. The p-value was statistically found to be significant at (p < 0.001). The conclusive findings from the above-defined experimental research were that iron syrup was found to cause the most noticeable and definitive staining in comparison to other immersive media. Nanohybrid composite restorative material was hence identified as being highly resistant to staining and possessing an undeniable ability to maintain the persistent color, unlike its microhybrid counterpart. The esthetic appearance is an important factor for both the parents and children; hence, this determines that the longevity of color stability of restorative materials is of valid significance. Thribhuvanan L, MS S, Gopalakrishnan A, et al. Comparative Spectrophotometric Assessment of Color Stability of Two Hybrid Composite Materials in an Oral Environment when Exposed to Various Liquids. Int J Clin Pediatr Dent 2024;17(2):176-183.