Process Information Research Articles

Hyper-binding: the surprising roles of age and affect.

When irrelevant stimuli are processed and then bound to relevant stimuli in memory, it is known as hyper-binding. Hyper-binding has been demonstrated consistently in older-aged participants, but university-aged participants do not typically show hyper-binding. This phenomenon has been attributed to older individuals having greater difficulty filtering out irrelevant information compared to younger adults. Emotions can also influence how individuals attend to and process information, and older individuals report feeling greater positive, and less negative, affect than younger adults. Low arousal positive affect is associated with greater cognitive breadth and reduced distractor suppression. Therefore, it is possible that differences in affect contribute to the differences in hyper-binding demonstrated for younger versus older adults. In four studies, we measured hyper-binding using a standard hyper-binding task and examined whether individual differences in hyper-binding could be predicted by individual differences in self-reported affect. Study 1 included an online community sample between 18 and 45years of age. Study 2 included university undergraduate students that were tested online. Study 3 participants included university undergraduate students that were tested in the lab. Study 4 participants included an older aged sample that was tested online. Overall, there were no significant relationships between affect and hyper-binding across age samples. Surprisingly, however, significant hyper-binding was observed for all age groups and was not larger for older individuals. The results suggest that individual differences in naturally occurring affect do not meaningfully predict hyper-binding, but the prevalence of hyper-binding across all studies demonstrates it may not be unique to older adults.

The moderating role of the late positive potential in the link between attachment anxiety and emotion regulation difficulties

IntroductionUnderstanding how adults experience and regulate their emotions is strongly linked to attachment orientations. Numerous studies indicate emotional regulation difficulties in both attachment avoidance and anxiety. Additionally, emotional Event-Related Potentials (ERPs), such as the Late Positive Potential (LPP), reveal the process of emotional information at the cerebral level, and thus, LPP is commonly used in studies examining emotion regulation processes. For instance, when individuals are asked to use cognitive strategies to increase, maintain, or decrease their emotional responses to stimuli, changes in LPP amplitude can reflect the effectiveness of these regulation strategies. However, little is known about the potential moderating effect of the LPP during the implementation of emotional regulation strategies in the relationship between attachment dimensions and emotional dysregulation. To address this oversight, the purpose of the present study was to examine the association between both dimensions of attachment, anxiety and avoidance, and emotional dysregulation, as well as the moderating role of the LPP during the induced implementation of cognitive reappraisal.MethodsBrain activity was recorded using EEG from n = 63 adults while they performed a task in which they were instructed to either reappraise or suppress emotions elicited by unpleasant images. To assess the associations between LPP, emotional dysregulation, and attachment orientations, the Difficulties in Emotion Regulation Scale Spanish version (DERS-E) and the Experiences in Close Relationships questionnaire (ECR-12) were used.ResultsInterestingly, we found that greater LPP amplitudes during reappraisal implementation intensified the association between attachment anxiety and emotional regulation difficulties. Conversely, this relationship was non-significant under lower levels of LPP amplitude—Providing supporting evidence for the moderating role of LPP.DiscussionOur results highlight how attachment anxiety can influence the ability to regulate emotions. This study provides new insights into how variations in LPP contribute to the effectiveness of emotion regulation strategies.

Foreground separation knowledge distillation for object detection

In recent years, deep learning models have become predominant methods for computer vision tasks, but the large computation and storage requirements of many models make them challenging to deploy on devices with limited resources. Knowledge distillation (KD) is a widely used approach for model compression. However, when applied in the object detection problems, the existing KD methods either directly applies the feature map or simply separate the foreground from the background by using a binary mask, aligning the attention between the teacher and the student models. Unfortunately, these methods either completely overlook or fail to thoroughly eliminate noise, resulting in unsatisfactory model accuracy for student models. To address this issue, we propose a foreground separation distillation (FSD) method in this paper. The FSD method enables student models to distinguish between foreground and background using Gaussian heatmaps, reducing irrelevant information in the learning process. Additionally, FSD also extracts the channel feature by converting the spatial feature maps into probabilistic forms to fully utilize the knowledge in each channel of a well-trained teacher. Experimental results demonstrate that the YOLOX detector enhanced with our distillation method achieved superior performance on both the fall detection and the VOC2007 datasets. For example, YOLOX with FSD achieved 73.1% mean average precision (mAP) on the Fall Detection dataset, which is 1.6% higher than the baseline. The code of FSD is accessible via https://doi.org/10.5281/zenodo.13829676.

Association of a non-synonymous variant of MLH3 gene involved in meiotic recombination with conception rate of Japanese Black cattle

Context Conception rate, which is an important parameter to evaluate female fertility, has been gradually decreasing in Japanese Black cattle during the past decades. Meiosis is an essential biological process in gamete formation and meiotic failure could be a cause of infertility or reduced fertility in mammals. Of note, single nucleotide polymorphisms (SNPs) in the MLH3 gene involved in meiotic recombination were reported to affect the genome-wide recombination rate of meiosis in cattle. Aims The present study was conducted to investigate the association of SNPs in the MLH3 gene with conception rate in Japanese Black cattle. Methods On the basis of the reproductive data of 2045 Japanese Black cattle born from 1990 to 2009, we selected two groups of the reproductive females with high conception rate (n = 103) and low conception rate (n = 109). Then, we genotyped the SNPs in MLH3 gene in both reproductive groups by sequencing and polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP). The significant association of SNPs with conception rate in Japanese Black cattle was estimated by Fisher’s exact test, by using R commander. Key results We found the presence of five SNPs of MLH3 gene in Japanese Black cattle, including non-synonymous variants of MLH3 N408S that has been reported to be involved in meiotic recombination rate and MLH3 S591G newly identified in the present study. Comparison of genotype distributions and allele frequencies of the MLH3 N408S between high and low conception-rate groups indicated a significant difference between these groups, suggesting that this SNP is associated with conception rate. However, there is no significant difference between MLH3 S591G with conception rate in Japanese Black cattle. Conclusions We found a significant association between a non-synonymous variant of MLH3 N408S and conception rate, suggesting that this SNP can be a potential marker for selecting the Japanese Black cattle for improving fertility. We also identified a novel non-synonymous variant of MLH3 S591G in Japanese Black cattle. Implications These findings will be informative for future marker-assisted selection to improve the fertility of Japanese Black cattle. This is the first report of a genetic variant implicated in meiotic recombination being linked to female fertility in cattle.

Less gets more attention: A novel human-centered MR remote collaboration assembly method with information recommendation and visual enhancement

Mixed reality remote collaboration assembly is a type of computer-supported collaborative assembly work that uses mixed reality technology to enable spatial information and collaboration status sharing among geographically distributed collaborators, including remote experts and local users. However, due to the abundance of mixed virtual and real-world information in the MR space and the limitations imposed by narrow field-of-view augmented reality (AR) glasses, users face challenges in effectively focusing on relevant and valuable visual information. Our research aims to enhance users' visual attention to critical guidance information in MR collaborative assembly tasks, thereby improving the clear expression of instructions and facilitating the transmission of collaborative intention. We developed the Information Recommendation and Visual Enhancement System (IRVES) through an assembly process information hierarchy division mechanism, a content-based information recommendation system, and a gesture interaction-based information visual enhancement method. IRVES can leverage the guidance expertise and preferences of remote experts to recommend information to filter out irrelevant information and present the key information that the remote expert conveys to the local user in an intuitive way through visual enhancement. We conducted a user study experiment of a collaborative assembly task of a small engine in a laboratory environment. The experimental results indicate that IRVES outperforms traditional MR remote collaborative assembly methods (VG3DV) in terms of time performance, operational errors, cognitive performance and user experience. Our research contributes a human-centered information visualization approach for remote experts and local users, providing a novel method and idea for designing visual information interfaces in MR remote collaboration assembly tasks.

Reprogramming of flagellin receptor responses with surrogate ligands.

Receptor kinase (RK) families process information from small molecules, short peptides, or glycan ligands to regulate core cellular pathways in plants. To date, whether individual plant RKs are capable of processing signals from distinct types of ligands remains largely unexplored. Addressing this requires the discovery of structurally unrelated ligands that engage the same receptor. Here, we focus on FLAGELLIN-SENSING 2 (FLS2), an RK that senses a peptide of bacterial flagellin to activate antibacterial immunity in Arabidopsis. We interrogate >20,000 potential interactions between small molecules and the sensory domain of FLS2 using a large-scale reverse chemical screen. We discover two small molecules that interact with FLS2 in atypical ways. The surrogate ligands weakly activate the receptor to drive a functional antibacterial response channeled via unusual gene expression programs. Thus, chemical probes acting as biased ligands can be exploited to discover unexpected levels of output flexibility in RKs signal transduction.

PREVALÊNCIA DOS SINTOMAS DO TDAH EM CRIANÇAS COM BAIXO RENDIMENTO ESCOLAR SUBMETIDAS AO P.A.P.E. NO ANO 2022 EM PRESIDENTE PRUDENTE

Specific learning disorder impairs the brain's ability to process information, affecting around 30-40% of students. These disorders represent 35-45% of mental health visits and 35% of visits to pediatricians. In 2018, Presidente Prudente/SP launched the Specialized Pedagogical Support Program (PAPE) to offer support to students with learning difficulties in the Municipal Network. The study, including 136 students evaluated by MTA-SNAP IV, revealed that ADHD and ODD are common in the school age group, especially in elementary school and more frequent among boys, with inattention being the main characteristic. The research highlighted the effectiveness of the questionnaire in improving intervention and support methods, improving students' quality of life and academic performance. Greater involvement of the Municipal Health Department is recommended to enhance children's care and learning, preventing future problems such as school dropout and difficulties in adult life.

Driving corporate digitization with reliable data through the A3 approach: an Italian case study

PurposePursuing digital transformation is a valuable strategy to attain companies’ operational excellence and sustainable development. However, installing digital technologies and software is insufficient for achieving a successful digital transformation. Equally vital is providing digital solutions with reliable input data, which is a hard task in companies where information is gathered through manual or non-standardized processes. The lack of reliable data prevents technologies and software from operating at their best, hindering their ability to process information and derive correct insights for improvement. To avoid this, companies should embrace structured problem-solving approaches to evaluate current data retrieval processes, identify error sources and formulate countermeasures. This paper aims to provide an empirical study to substantiate A3 as a winning approach for advancing input data acquisition in companies.Design/methodology/approachA case study research is proposed, investigating the application of A3 in an ink manufacturing company, and checking how A3 improves data collection and company performance.FindingsThe case study corroborates A3 as an effective approach, allowing the removal of inefficiencies that previously went unnoticed and reaching a 10% productivity improvement.Practical implicationsPursuing digital transformation is a valuable strategy to attain companies’ operational excellence and sustainable development. However, installing digital technologies and software is insufficient for achieving a successful digital transformation. Equally vital is providing digital solutions with reliable input data, which is a hard task in companies where information is gathered through manual or non-standardized processes.Originality/valueThe originality of this paper lies in the application scope and aim of the A3 approach. A3 is a mature paradigm but often coined for production and still endowed with unexplored potential. This paper proposes the application of A3 for improving companies’ data retrieval processes, focusing for the first time on information reliability and its importance in ensuring the functioning of digital technologies and software.

Neurodiversity Can Explain Differences in How People Experience Everyday Life

Neurodiversity means that all people’s brains process information differently from each other. In other words, people think and learn in a variety of ways. Being neurodivergent means that the way a person’s brain processes information might be quite distinctive, or even rare—and in some cases this difference might have a name, like ADHD, autism, or dyslexia. About one person in every five is neurodivergent: maybe you are neurodivergent yourself! In this article, we discuss the ways that neurodiversity can affect how people experience day-to-day life. We explain some of the research that has explored how neurodivergent people process information. We also share some on-going research that focuses on making places like schools and hospitals more comfortable for neurodivergent people. When we all understand what neurodiversity is, it is easier for everyone to be themselves, no matter how they think, feel and learn.

Heterogeneous marine environments diversify microbial-driven polymetallic nodule formation in the South China Sea

Most studies on the genesis of polymetallic nodules suggested that nodules in the South China Sea (SCS) are hydrogenetic; however, the complexity and the heterogeneity in hydrology and geochemistry of the SCS might cause different processes of nodule formation, impacting their application and economic value. Microbial-mediated ferromanganese deposition is an important process in nodule formation, but the related microbial potentials are still unclear in the SCS. In this study, we sampled in three typical regions (A, B, and C) of the SCS enriched with polymetallic nodules. Firstly, we investigated environmental and microbial characteristics of the water columns to determine the heterogeneity of upper seawater that directly influenced deep-sea environments. Then, microbial compositions and structures in sediment cores, overlying waters, and nodules (inside and outside) collected within the same region were analyzed for inferring features of nodule environments. Microbial interactions between nodules and surrounding environments were estimated with collinear network analysis. The microbial evidence indicated that geochemical characteristics in deep sea of the SCS that were key to the polymetallic nodule formation were severely affected by organic matter flux from upper water column. The sediment in region A was sub-oxic due to the large input of terrigenous and phytoplankton-derived organic matter, potentially enhancing the overflow of reduced metals from the porewater. The intense microbial interaction between nodules and surface sediment reinforced the origin of metals for the ferromanganese deposition from the sediment (diagenetic type). Contrarily, the sediments in regions B and C were relatively rich in oxygen, and metal ions could be majorly supplied from seawater (hydrogenetic type). The large discrepancy in microbial communities between nodule inside and remaining samples suggested that nodules experienced a long-term formation process, consistent with the feature of hydrogenetic nodules. Overall, distributions and interactions of microbial communities in nodules and surrounding environments significantly contributed to the nodule formation in the SCS by manipulating biogeochemical processes that eventually determined the source and the fate of metal ions.

Philosophical and Ethical Underpinnings of the Medical Decision-Making Process: A Focus on Patient Values and Preferences.

Current clinical practice is based on the principles of evidence-based medicine (EBM) with clinical practice guidelines (CPGs) often serving as a source of information for the medical decision-making process. There are philosophical and ethical tenets underlying this process including those pertaining to patient values and preferences. Despite their importance, these tenets may receive less attention than the empirically derived recommendations in CPGs based on the principles of EBM. The purpose of this article is to provide an overview of the philosophical and ethical underpinnings of the medical decision-making process with a focus on patient values and preferences so pharmacists and other clinicians can appreciate the interplay between science, philosophy and ethics when providing patient- or person-centered care. Appreciation of these discussions should help practitioners to recognize the limitations and challenges when attempting to incorporate population-based evidence into a patient-specific medical decision-making process that often necessitates reconciliation and negotiation between the clinician and patient when striving to provide optimal care.

The Hippo Signaling Pathway, Reactive Oxygen Species Production, and Oxidative Stress: A Two-Way Traffic Regulation

The Hippo signaling pathway is recognized for its significant role in cell differentiation, proliferation, survival, and tissue regeneration. Recently, the Hippo signaling pathway was also found to be associated with oxidative stress and reactive oxygen species (ROS) regulation, which are important in the regulation of cell survival. Studies indicate a correlation between components of the Hippo signaling pathway, including MST1, YAP, and TAZ, and the generation of ROS. On the other hand, ROS and oxidative stress can activate key components of the Hippo signaling pathway. For example, ROS production activates MST1, which subsequently phosphorylates FOXO3, leading to apoptotic cell death. ROS was also found to regulate YAP, in addition to MST1/2. Oxidative stress and ROS formation can impair lipids, proteins, and DNA, leading to many disorders, including aging, neurodegeneration, atherosclerosis, and diabetes. Consequently, understanding the interplay between the Hippo signaling pathway, ROS, and oxidative stress is crucial for developing future disease management strategies. This paper aimed to review the association between the Hippo signaling pathway, regulation of ROS production, and oxidative stress to provide beneficial information in understanding cell function and pathological processes.

Gene Expression Modulation of Markers Involved in Bone Formation and Resorption by Bisphenol A, Bisphenol F, Bisphenol S, and Bisphenol AF

Background: Bisphenol A (BPA) and its analogs (BPF, BPS, and BPAF) are recognized for inducing detrimental effects on various tissues, including bone. Objectives: The aim of this study is to investigate their impact on information and repair processes, specifically focusing on vascular endothelial growth factor (VEGF), transforming growth factor β1 (TGF-β1), and the receptors for transforming growth factor β (TGFR1, TGFR2, and TGFR3). Methods: Human osteoblasts isolated through primary culture from bone samples of healthy volunteers were subjected to cultivation in the presence of various dosage levels (10−5, 10−6, or 10−7 M) of BPA, BPF, BPS, or BPAF for 24 h. Gene expressions of RANKL, OPG, TGF-β1, TGFR1, TGFR2, TGFR3, and VEGF were analyzed by real-time polymerase chain reaction (RT-PCR). All experiments included untreated cells as controls. Results: Expressions of RANKL and OPG were dose-dependently downregulated by the presence of all tested bisphenols (BPs) except for BPAF, whose presence upregulated OPG expression at all three doses. TGF-β1 expression was downregulated by all BP treatments, and TGF-β1 receptor expression was also downregulated as a function of the BP and dose. VEGF expression was downregulated in the presence of BPF and BPAF at all three doses and in the presence of BPA at the two higher doses (10−5, and 10−6 M), but it was not changed by the presence of BPS at any dose. Conclusions: The inhibition of both RANKL and OPG by the BPs, with a higher %inhibition of RANKL than of OPG, appears to rule out BP-induced activation of osteoclastogenesis via RANKL/RANK/OPG. Nevertheless, the effect of the BPs on the expression by osteoblasts of TGF-β1, TGF-β receptors, and VEGF indicates that these compounds can be responsible for major molecular changes in this cell population, contributing to their adverse effects on bone tissue.

Information Training and Media Education: a Method of Solving Students' Educational and Cognitive Problems in an Integrated Information Environment

Discusses the method of solving students' educational and cognitive problems in an integrated information environment. The purpose of the study is to determine effective forms and methods of information training and media education to ensure universal access to education throughout life. The source of the study was the works of scientists who consider issues of media education and information training as an important component of the educational and cognitive tasks of students in the context of an integrated information environment. A set of pedagogical research methods, both theoretical and practical, was used. According to experts, in the field of educational resources, the total volume of knowledge doubles every year, while the degree of satisfaction of the information needs of users in the absence of an appropriate level of skill in working with information does not improve. Computer science is today defined as one of the fundamental areas of scientific knowledge that forms a system-information approach to the analysis of the surrounding world, the study of information processes, methods and means of obtaining, transforming, transmitting, storing and using information, a rapidly developing and constantly expanding area of human practical activity associated with the use of educational resources. In this regard, media education and information training of students are considered as an important part of the professional and educational skills and abilities of students in the context of an integrated information environment. The results of the study can serve as a basis for solving educational and cognitive problems of continuous education, since today no serious economic, social, technical problem can be successfully solved without processing significant amounts of information.

Roasted sesame oil: A review on production technology, flavor chemistry, and other related issues

AbstractSesame oil (SO) produced through roasting technology offers pleasant flavor, often named roasted sesame oil (RSO) in the market. During the RSO production process, roasting is an essential technology in determining the flavor of RSO, which directly influences the consumer acceptance. Therefore, the present work systematically offers current knowledge on flavors and related issues of RSO, which will focus on production technologies (i.e., roasting technology, extraction technology, subsequent processing technology), flavor characteristics and flavor compounds, formation pathways of major flavor compounds (i.e., Maillard reaction pathway, oil oxidation pathway, thermal degradation pathway), and effects of roasting on the nutrition and safety. In addition, the present work provides an outlook for the future development of RSO industry, including the establishment of a grading system for the evaluation of RSO flavors, high‐value utilization of by‐products from RSO processing, and how to improve production efficiency of RSO. This work could provide a better understanding of RSO roasting process and promising information for better production of aromatic, nutritious and safe RSO by controlling/innovating the roasting process.

Therapeutic Peptides Encapsulated into Lipid-Based Nanovesicles: Scaling from Lab to Plant

Lipid-based peptide-encapsulated nanovesicles represent a cutting-edge approach in drug delivery systems, offering enhanced stability, targeted delivery, and controlled release of therapeutic peptides. This review explores the comprehensive science and techniques behind the robust formulation and analytical methods for these nanovesicles, spanning from lab-scale research to large- scale manufacturing. Critical aspects include lipid selection, detailing how the choice of lipids impacts the stability and efficacy of the nanovesicles, and various peptide encapsulation techniques, emphasizing methods to achieve high encapsulation efficiency and controlled release. Key processes in vesicle formation, such as thin film hydration, sonication, and microfluidics, are discussed to highlight their roles in producing nanovesicles with consistent size and morphology. The importance of stability studies, including physical, chemical, and thermal assessments, is underscored. Analytical techniques such as Dynamic Light Scattering (DLS), Zeta Potential measurement, High-Performance Liquid Chromatography (HPLC), and Mass Spectrometry (MS) are detailed, showcasing their crucial roles in characterizing nanovesicles and ensuring their quality, safety, and efficacy for pharmaceutical use. The review addresses the challenges and solutions associated with scaling up production, including maintaining consistent product quality, optimizing manufacturing processes, and controlling production costs. It also navigates the regulatory landscape, discussing the stringent guidelines set by agencies such as the FDA and EMA and the necessity of strategic regulatory planning to facilitate market approval. This comprehensive review aims to serve as an in-depth resource for experts in the field, aiding in the translation of lipid-based peptide-encapsulated nanovesicle formulations from bench to bedside, ultimately enhancing therapeutic outcomes and expanding treatment options for various disease. Key Words: Peptide, Amino acid, Degradation, Pharmacokinetics, Peptide encapsulation, drug delivery systems, Peptide Characterization

ANALISIS PENYALURAN PEMBIAYAAN DAN MODEL PENGEMBANGAN KOPRASI IBNU AFFAN PATANI THAILAND

This study aims to examine the financing distribution system and the development model of the Ibnu Affan Cooperative in Thailand. A qualitative approach with descriptive methods was utilized, involving interviews and documentation as data collection techniques.Based on the analysis conducted, Koperasi Ibnu Affan applies Sharia principles with a focus on transparency. The transparency referred to involves the openness of information and decision-making processes carried out by the cooperative, where the cooperative is able to manage finances openly to both the management and all members, as well as the supervisory board. Furthermore, the welfare of the members is one of the cooperative's main programs aimed at improving the welfare of its members and the community in general. This is achieved through the use of a modern management model that focuses on the application of efficient and professional management principles while considering cooperative values based on democracy, transparency, and solidarity for operational success.

Affective Computing in Mental Health: The Role of Facial Expression Recognition

Affective computing has emerged as one of the leading interdisciplinary disciplines that utilize technology to detect and interpret human emotions, and so it provides critical information for the mental health monitoring process. The present study addresses the facial expression recognition as an important tool in the diagnosis and treatment of mental health disorders. By discussing the physiological and psychological implications that facial expressions may have, we analyze how FER systems can supplement the traditional approach to mental health evaluation by providing real-time feedback and timely intervention. Improved algorithms for machine learning and computer vision techniques in FER systems enhance the accuracy and efficiency of FER systems, thus increasing their applicability in teletherapy, clinical assessment, and personal well-being applications. This discussion paper shall also touch on the issues and ethical concerns of FER technology, such as privacy and the potential for misinterpretation. Our results indicate that FER can be a meaningful contributor to care for personal mental health by continuous monitoring and understanding of emotional well-being.

Digital and Sustainable Information Processes: a look at changing information patterns and climate adaptation

Digital and Sustainable Information Processes: a look at changing information patterns and climate adaptation

Advancements in Nanowire-Based Devices for Neuromorphic Computing: A Review.

Neuromorphic computing, inspired by the highly interconnected and energy-efficient way the human brain processes information, has emerged as a promising technology for post-Moore's law era. This emerging technology can emulate the structures and the functions of the human brain and is expected to overcome the fundamental limitation of the current von Neumann computing architecture. Neuromorphic devices stand out as the key components of future electronic systems, exhibiting potential in shaping the landscape of neuromorphic computing. Especially, nanowire (NW)-based neuromorphic devices, with their advantages of high integration, high-speed computing, and low power consumption, have recently emerged as candidates for neuromorphic computing technology. Here, a critical overview of the current development and relevant research in the field of NW-based neuromorphic devices are provided. Neuromorphic devices based on different NW materials are comprehensively discussed, including Ag NW-based, organic NW-based, metal oxide NW-based, and semiconductor NW-based devices. Finally, as a foresight perspective, the potentials and the challenges of these NW-based neuromorphic devices for use as future brain-like electronics are discussed.