Abstract Strong health information systems (HIS) are essential for robust, evidence-informed policymaking and decision making in all levels of healthcare. The COVID-19 pandemic underscored the vital importance of HIS, but also highlighted flaws and weaknesses across HIS in Europe. Common HIS challenges include limited resources and capacity; insufficient coordination and collaboration between HIS stakeholders, leading to fragmentation and problems with interoperability; lack of central governance; and limited use of health information for decision-making. Both at the level of the WHO Regional Office for Europe (WHO/Europe) and the European Commission, policies and strategies are being implemented to support Member States in strengthening their HIS, thereby improving the availability of high quality, timely data for evidence-informed decision making, both at the country and international level. Supporting the further digitalization of HIS is an important element in this. In 2023, WHO/Europe and the European Commission joined forces in the field of HIS strengthening. This workshop will inform participants about current and future capacity building tools and activities that will be implemented under the umbrella of the EU-funded action ‘Supporting Member States in the WHO European Region in strengthening HIS and boosting health data governance and interoperability’. It will explain the policy as well as situation-on-the-ground contexts in which the action will be implemented. The workshop will start with a (1) presentation by WHO/Europe on the current HIS situation in the Region and what are the main priority areas in WHO’s work for the coming years. After that, (2) the European Commission will give more information on the above-mentioned EU-funded action and the related EU policy landscape, most notably the European Health Data Space (EHDS). Next, (3) WHO/Europe will present their catalogue of capacity building tools and activities, and share experiences with implementing these. Finally, (4) HIS modernization cases with enabling factors and challenges will be presented based on different countries’ real life experiences, illustrating the impact of HIS strengthening activities at the country level. Workshop participants will get a comprehensive overview of available HIS strengthening tools and activities in the European Region. This will help them in selecting and applying tools for strengthening their own national or regional HIS, and ensuring their HIS is prepared for aligning with the EHDS and other important policies and strategies. This will contribute to sustainable and future-proof HIS across Europe. During the workshop, there will be ample time for questions and discussion. In the discussion, participants will be asked whether they have any HIS strengthening needs that are not yet covered in the current package of tools and activities. This will help WHO and the European Commission to further harmonise their efforts with what is needed on the ground. Key messages • Despite investments in HIS following the COVID-19 pandemic, many challenges remain, which are often similar across European countries. • WHO/Europe and the European Commission have joined forces to strengthen HIS and boost health data governance and interoperability, while leveraging EHDS developments.