ABSTRACT Digital communication has generated forms of written speech that may deviate from standard ones, such as Greeklish (a Latin-alphabet-based script) vs. Greek. The question of interest is how different orthographic representations of the same referent (e.g. petaloyda, “butterfly”, in Greeklish vs. πϵταλούδα “butterfly” in Greek) may influence word processing, particularly visual word recognition and access to affective connotations. 120 Greek native speakers were tested on a lexical decision task, in which script (Greeklish vs. Greek) and valence (positive vs. negative vs. neutral) were manipulated within participants. Words were matched for word class, frequency, concreteness, length, number of syllables and orthographic neighbourhood. Emotional words differed from neutral ones in valence and arousal. Results yielded faster response times for words written in the standard script (Greek) than the non-standard script (Greeklish). Moreover, regardless of script, response times were negatively correlated with the words’ valence, with slowest responses for negative words and fastest for positive ones, suggesting that positive content accelerates lexical access, whereas negative content slows it down. To sum up, although script type was found to affect word recognition, activation of and access to emotional content seemed to resist non-standard characteristics of visual word processing.