A hydrogen liquefaction process is proposed with the liquid natural gas utilization, binary refrigerant precooling and helium cryogenic cycles combined, and a general model is built for analyzing the variation of hot and cold composite curves and heat transfer temperature difference (HTTD) along with refrigerant parameters. The relationship between temperature and enthalpy of the precooling cycle and the variation of HTTD are deduced. Based on this, the composite curves and HTTD curves are constructed, and the influence of refrigerant on the HTTD and the refrigerant outlet temperature is analyzed. The optimization procedure of refrigerant is proposed based on the temperature-enthalpy relationship and HTTD considering the temperature glide. For the proposed hydrogen liquefaction system, the optimal binary refrigerant includes 60.21 % nitrogen and 39.79 % propane (mass fraction), and its mass flow rate and inlet temperature are 23,821.96 kg/h and −199.72 °C, respectively. The corresponding specific energy consumption (SEC) of the hydrogen liquefaction system is 4.44 kWh/kgLH2, reduced by 10.30 %, and the coefficient of performance (COP) and exergy efficiency are 27.10 % and 28.26 %, increased by 11.34 % and 17.80 %, respectively.