Influence Of Psychological Stress Research Articles

The influence of psychological stress and stress-related disorders in treatment outcome of periodontitis: A systematic review and meta-analysis

The influence of psychological stress and stress-related disorders in treatment outcome of periodontitis: A systematic review and meta-analysis

Чем опасен психологический стресс для беременных и как снизить его влияние на течение беременности и перинатальные исходы

Aim: assess the impact of psycho-emotional stress on the course of pregnancy at various times, as well as consider the possibility of reducing it with the help of vitamin-mineral complexes. Key Points. Pregnant women, like all others, are influenced by a variety of stress factors, and about 30% of them at different stages of gestation realize clinical manifestations of psychological stress. The article considers issue related to the causes of psychological stress before and during pregnancy, identifies the most vulnerable categories of women. Data on the influence of psychological stress on pregnancy outcomes and postnatal development are presented. Attention is paid to modern ideas about the pathogenesis of the damaging effect of psychological stress on various body systems, including the microbiome. Emphasis is placed on the role of an obstetrician-gynecologist as an attending physician in the timely identification of women with signs of psychological stress, in the organization of non-drug care and rational pharmacological support. Pathogenetically justified possibilities of using vitamin and mineral complexes to compensate for the negative effects of psychological stress at the preconception stage and during pregnancy were discussed. Conclusion. Stress before and during pregnancy affects the offspring in the long term, disrupting their physical condition, negatively affecting the functions of the central nervous system. In modern obstetric practice, medical alertness, timely consultation with specialists and the full use of all the possibilities of non-drug and pharmacological support aimed at overcoming anxiety and stress at each stage of gestation will be relevant. Key words: psychological stress, pregnancy, perinatal complications, anemia, vitamin and mineral complexes.

Assessment of ergonomics to study the correlation between physical and psychological factors with prevalence of musculoskeletal disorders in practicing dentists.

Musculoskeletal disorders are very commonly seen in dentists. These disorders can hinder their clinical practice and at times results in severe complications leading to an early retirement. The aim of this study is to find a correlation between physical and psychological factors with the prevalence of musculoskeletal disorders in practicing dentists. This study is a culmination of two fields of medicine, physiotherapy and dentistry, thus proving to be of significant value in terms of interdisciplinary approach to healthcare. The sample size consisted of 50 dentists. It was an observational cross-sectional study with a questionnaire divided into three sections. Inclusion and exclusion criteria includes Section 1 - Demographic data and basic questions related to the aim of the study. Section 2 - Cornell Musculoskeletal Disorder Questionnaire. Section 3 - General Health Questionnaire-12 for assessment of psychological stress. Wrong posture, existing physical illness, lack of exercise and increases levels of psychological stress increase the prevalence of musculoskeletal disorders.This study could be used to implement better treatment options to dentists suffering from musculoskeletal disorders considering both physical and mental factors. It is very important to increase the awareness of ergonomics and the influence of psychological stress in practicing dentists so that they can avoid these disorders and provide a high-quality treatment to their patients without any hindrance in their professional careers due to these disorders.

Moderate Weight Loss is associated with Reductions in LH Pulse Frequency and Increases in 24-hour Cortisol with no change in Perceived Stress in Young Ovulatory Women

ObjectiveDetermine the potential role of cortisol as an indicator of both metabolic and psychosocial stress and its relation to LH pulse dynamics during a three-month diet and exercise intervention causing moderate weight loss. MethodsSecondary analysis of a randomized controlled trial that demonstrated the causal role of low energy availability in the disruption of the menstrual cycle. Twenty-one women aged 18-24 yrs (BMI 21.7± 1.9 kg·m−2), completed a baseline menstrual cycle and three intervention menstrual cycles of a controlled diet and supervised exercise program. Twenty-four-hour LH pulse dynamics (q10 min) and diurnal patterns of cortisol (q60 min) as well as Perceived Stress Scale scores were determined in the early follicular phase prior to the intervention and in the post intervention cycle. Pre to post comparisons were determined with paired t-tests, and Pearson bivariate correlations assessed associations. ResultsSubjects lost weight (-2.8±1.97 kg) and LH pulse frequency declined pre=0.79±0.23 pulses·hr−1 to post=0.60±0.29 pulses·hr−1 (p=0.014). Weight loss was associated with an increase in cortisol AUC R= -0.473, (p=0.03) and the decline in LH pulse frequency R= 0.523; (p=0.026). Increases in cortisol AUC were associated with declines in LH pulse frequency R= -0.472; (p=0.048). The morning cortisol rise AUC increased from pre=2140±878 µg·dL−1 · day to post=2556±1067 µg·dL−1 · day (p=0.034). Changes in PSS were not associated with changes in LH or cortisol. ConclusionThe initial perturbation of LH pulsatility with moderate diet and exercise is associated with metabolically driven increases in cortisol AUC with no influence of psychological stress.

Stress and aging perspectives. Psychological and neuro-psychological interventions

"Aging is partially modulated by the interactions between genes and the environment, but an important part of aging and longevity comes from the psychological area. Chronic (traumatic) psychological stress has multiple effects on health (Vasile & Albu, 2011) and, implicitly, on longevity. Several hormones (cortisol, glucocorticoids, CRH, ACTH), genetic expressions (ANK3), or reactions (inflammation, upper respiratory symptoms) are activated under the influence of psychological stress and cause major disorders of the body, premature aging, culminating in serious illness and even the death. Chronic psychological stress is present in many people in today's society, and its appearance is accompanied by various epigenetic elements. Studies to date suggest effective ways to reduce stress and prevent premature aging: psychotherapy and personal development (Vasile, 2012), transcranial magnetic stimulation (TMS) – from a neuropsychology view, traditional Chinese medicine (TCM), forest therapy - forest bath, diet, fitness, music therapy and physical therapy. At the same time, however, a multiaxial psychological evaluation is needed, as well as medical evaluation, which will make the intervention more efficient for rebalancing and regaining health. "

Analysis of the Influence of Psychological Stress on Glucose Metabolism of Coronary Heart Disease Patients with Type 2 Diabetes Mellitus after PCI

Analysis of the Influence of Psychological Stress on Glucose Metabolism of Coronary Heart Disease Patients with Type 2 Diabetes Mellitus after PCI

The influence of psychological stress on the cardiovascular system of students in interaction with orthostatic test

The article is devoted to the study of the cardiovascular systemindicators in students under the conditions of exam stress. Asa result we have found that students have experienced severestress before the examination and after it that has negativelyaffected their hemodynamic parameters, which have shownhigh values indicating overstrain of the adaptation mechanisms.

The influence of psychological stress on the cardiovascular system of students of the Faculty of Biology and Chemistry in interaction with the orthostatic test

The scientific article is devoted to the study of indicators of the cardiovascular system in students under examination stress. As a result of our research, we recorded that before the start of the exam and after its completion, the students experienced severe stress, which negatively affected the results of the hemodynamic parameters study that showed high values indicating an overstrain of the adaptive mechanisms.

The Influence of Psychological Stress on HPV Infection Manifestations and Carcinogenesis

Psychological stress is an important factor involved in disease manifestations of human papillomavirus (HPV) infection, and it can participate in HPV-associated carcinogenesis. The impact or effect which stress can have (exert) depends on a person's genetic pool, experiences and behaviors. Due to inconsistencies in some study results, this issue remains a subject of research. Concerning the course of HPV manifestations, it has been observed that a higher number of life stressors in at least the previous 6 months, the absence of social support and the types of personal coping mechanisms employed, all influence HPV progression. In women with cervical dysplasia, a connection between greater stress experiences and dysregulation of specific immune responses has been observed. Once HPV enters a cell via the α6 integrin there are three possible sequences: latent infection, subclinical infection, and clinically manifest disease. HPV proliferation in differentiated epithelial cells induces morphologically cytopathic changes (koilocytosis, epidermal thickening, hyperplasia, hyperkeratosis). Oncogenic transformation requires the integration of the virus genome into the host genome. In doing so, DNA in the E1 region of E2 breaks down, leading to transcription disorders of E6 and E7. For the formation of irreversible malignancy, the following sequence is necessary: initial expression of E6 and E7 genes followed by suppression of apoptosis and the stabile expression of E6 and E7 proteins that protect transformed cells from apoptosis. A successful immune response is characterized by a strong, local cell-mediated immune response. Several factors are important for the regression of HPV manifestation/infection, among which is psychological stress which can prolong the duration and severity of HPV disease. Stress hormones may reactivate latent tumor viruses, stimulate viral oncogene expression, and inhibit antiviral host responses. In the regression of HPV infection, increased activity of Th1 cells was observed. However, during psychosocial stress, a decrease in the Th1 type of immune response is seen, and there is a shift towards a Th2 response. Understanding perceived stress and biological changes in stress, as well as the evaluation of immune parameters, gives researchers a better picture of how stress influences HPV infections and how to improve disease management and outcomes.

Influence of psychological stress and coping styles in the professional identity of undergraduate nursing students after the outbreak of COVID-19: A cross-sectional study in China.

AimTo investigate the influencing factors in professional identity of undergraduate nursing students after the outbreak of COVID‐19.DesignCross‐sectional study.MethodsThe study covered 2,999 nursing students in six undergraduate nursing schools. Several self‐report questionnaires were used to collect the general information, psychological stress, coping styles and professional identity of the undergraduate nursing students.ResultsThe overall average score of the professional identity of nursing students (3.67 ± 0.51) has increased significantly after the outbreak of COVID‐19. The professional identity of the undergraduate nursing students was negatively correlated with psychological stress (r = −0.23, p < .001), expectation (r = −0.12, p < .001) and avoidance (r = −0.16, p < .001), but was positively correlated with solving problems (r = 0.18, p < .001) and seeking support (r = 0.12, p < .001). Academic performance, positions, grades, reasons for choosing a nursing profession, parents or relatives engaged in nursing work and the risk degree of residence were the factors influencing the professional identity score of undergraduate nursing students' (p < .001).

Evaluation of copeptin and psychological stress among healthcare providers during COVID-19 pandemic

ABSTRACT Background: The COVID-19 pandemic created a remarkable impact on healthcare providers (HCP) both physically and psychologically. Perceived psychological stress (PSS) influences the homeostatic equilibrium, involving activation of the sympathetic nervous system and hypothalamus pituitary adrenal (HPA) axis. Copeptin, C-terminal portion of Vasopressin (AVP) precursor is stable; however, evidence about impact of PSS on copeptin levels is limited. Aim: The aim of this study was to estimate the influence of psychological stress on copeptin levels among HCP working in intensive care unit (ICU). Methods: A total of 70 HCP served in quarantine ICU participated in this prospective study; 35 physicians (28 males and 7 females) and 35 nurses (10 males and 25 females). A control group of 40 HCP matched age, BMI and specialty in non- quarantine hospitals. Fasting morning blood samples were withdrawn for determination of copeptin, cortisol, insulin at three points; pre-quarantine at ICU. Second point at end of first week and third point was two weeks’ post quarantine. A questionnaire was conducted to all participants to assess stress (PSS). Cortisol was determined by a chemiluminescence immunoassay while insulin and Copeptin were measured by ELISA. Results: Baseline plasma copeptin level pre-quarantine was significantly increased 15.76 ± 8.6 pmol/l (P = 0.001*) and was positively correlated with high stress PSS score mean 66.9 ± 18.3. Post-quarantine copeptin was markedly reduced 3.98 ± 1.28 pmol/l and mean PSS was 23.0 ± 7.95 (P = 0.001*). Also, there was positive correlation between plasma copeptin and PSS, systolic blood pressure and serum insulin. On the other hand, there was no correlation between copeptin and serum cortisol. Conclusion: Our finding suggested that copeptin may be used a potential biomarker for physiological strain during work in a stressful environment.

Psychological Stress, Intestinal Barrier Dysfunctions, and Autoimmune Disorders: An Overview.

Autoimmune disorders (ADs) are multifactorial diseases involving, genetic, epigenetic, and environmental factors characterized by an inappropriate immune response toward self-antigens. In the past decades, there has been a continuous rise in the incidence of ADs, which cannot be explained by genetic factors alone. Influence of psychological stress on the development or the course of autoimmune disorders has been discussed for a long time. Indeed, based on epidemiological studies, stress has been suggested to precede AD occurrence and to exacerbate symptoms. Furthermore, compiling data showed that most of ADs are associated with gastrointestinal symptoms, that is, microbiota dysbiosis, intestinal hyperpermeability, and intestinal inflammation. Interestingly, social stress (acute or chronic, in adult or in neonate) is a well-described intestinal disrupting factor. Taken together, those observations question a potential role of stress-induced defect of the intestinal barrier in the onset and/or the course of ADs. In this review, we aim to present evidences supporting the hypothesis for a role of stress-induced intestinal barrier disruption in the onset and/or the course of ADs. We will mainly focus on autoimmune type 1 diabetes, multiple sclerosis and systemic lupus erythematosus, ADs for which we could find sufficient circumstantial data to support this hypothesis. We excluded gastrointestinal (GI) ADs like coeliac disease to privilege ADs not focused on intestinal disorders to avoid confounding factors. Indeed, GIADs are characterized by antibodies directed against intestinal barrier actors.

Psychological stress creates an immune-suppressive environment that increases the susceptibility of aged mice to Mycobacterium tuberculosis infection

Abstract Age is a risk factor for chronic infections, including tuberculosis (TB). A second compounding factor of TB susceptibility is psychological stress, which is particularly acute in older individuals. While the influence of psychological stress in TB is well documented, the mechanisms by which stress influences M.tb susceptibility in the elderly are almost completely unknown. To study the effects of chronic psychological stress on M.tb infection in old mice, we employed a mouse social stressor model (called social disruption stress or SDR) which involves repeated social defeat in subordinate mice. Young (3 month) and old (18 month) C57BL/6 mice were subjected to SDR and bronchial fluid (BF) and alveolar macrophages (AMs) were isolated by lung lavage. Our studies showed that SDR created an immune-suppressive lung environment in old mice, based on lower levels of pro-inflammatory cytokines and chemokines in bronchial fluid (BF) or their mRNA expression by AMs. AMs from old SDR mice compared to non-stressed mice were also deficient in their ability to mount an inflammatory cytokine response or induce MHC class II mRNA expression. To determine the effect of SDR on M.tb growth, young and old mice were subjected to SDR and infected with M.tb. At 30 days, SDR in both young and old mice reduced M.tb burden. However, this was transient as at 60 days M.tb burden was higher in old mice compared to young mice and SDR further significantly increased M.tb burden in old mice. Also we found that SDR at 60 days in old mice induced significantly higher levels of IL-10 and IL-17 mRNA in the lung, which favors growth of M.tb. In conclusion, our studies suggest that psychological stress during the initial stage of Mtb infection has long-term impact on the control of the infection.

Maternal and Neonatal Hair Cortisol Levels and Psychological Stress Are Associated With Onset of Secretory Activation of Human Milk Production.

Several factors can influence the production of mothers' own milk. To assess the influence of maternal psychological stress, maternal cortisol levels, and neonatal hair cortisol levels on timing of secretory activation. A prospective study was conducted at 2 public health centers in Andalusia, Spain. Participants were 60 pregnant women and their 60 neonates. Hair cortisol levels and psychological stress (pregnancy-specific stress [Prenatal Distress Questionnaire, PDQ] and perceived stress [Perceived Stress Scale, PSS]) were evaluated during the third trimester and the postpartum period. This study was part of the GESTASTRESS cohort study on the effects of stress during pregnancy. Higher PDQ and PSS scores (P < .05) in the third trimester were associated with later onset of secretory activation. Higher postpartum maternal hair cortisol levels were associated with a delayed secretory activation of mother's own milk (P < .05). Future studies should look at the influence of psychological stress and cortisol levels on hormones involved in mother's own milk production. Neonatal nurses and other healthcare providers should be familiar with levels of neonates' exposure to maternal prenatal stress prior to birth.

The role of parental acute psychological distress in paediatric burn re-epithelialization.

Following a paediatric burn, parents commonly experience high levels of acute psychological distress, which has been shown to increase child psychological distress as well as child procedural distress. The influence of psychological stress and perceived pain on wound healing has been demonstrated in several laboratory and medical populations. This paper investigates the influence of parental acute psychological distress and procedural behaviour on the child's rate of re-epithelialization, after controlling for child procedural distress. A prospective observational study with longitudinal outcome. Eighty-three parents of children 1-6years old reported acute psychological distress (post-traumatic stress symptoms [PTSS], guilt, pre-procedural fear, general anxiety/depression symptoms) in relation to their child's burn. A researcher observed parent-child behaviour at the first dressing change, and parents and nurses reported child procedural distress (pre-, peak-, and post-procedural pain and fear). These variables, along with demographic and injury information, were tested for predicting time to re-epithelialization. Date of re-epithelialization was determined by the treating consultant. Days to re-epithelialization ranged from 3 to 35days post-injury. A hierarchical multiple regression analysis found wound depth and size significantly accounted for 28% of the variance in time to re-epithelialization. In Block 2, child peak-procedural pain significantly accounted for 6% additional variance. In Block 3, parental PTSS significantly accounted for 5% additional variance. Parental PTSS appears to be an important but under-recognized factor that may influence their child's burn re-epithelialization. Further investigation is required to understand the mechanisms contributing to this association. Statement of contribution What is already known on this subject? Psychological stress delays wound healing, and this relationship has been found in paediatric burn populations with procedural pain. Parental psychological stress is often present after a child's burn and is related to the child's procedural coping and distress. What does this study add? Parental post-traumatic stress is related to delayed child burn re-epithelialization. This association is in addition to procedural pain delaying re-epithelialization.

Stress Levels Escalate When Repeatedly Performing Tasks Involving Threats.

Police work may include performing repeated tasks under the influence of psychological stress, which can affect perceptual, cognitive and motor performance. However, it is largely unknown how repeatedly performing stressful tasks physically affect police officers in terms of heart rate and pupil diameter properties. Psychological stress is commonly assessed by monitoring the changes in these biomarkers. Heart rate and pupil diameter was measured in 12 male police officers when performing a sequence of four stressful tasks, each lasting between 20 and 130 s. The participants were first placed in a dimly illuminated anteroom before allowed to enter a brightly lit room where a scenario was played out. After each task was performed, the participants returned to the anteroom for about 30 s before performing the next sequential task. Performing a repeated sequence of stressful tasks caused a significant increase in heart rate (p = 0.005). The heart rate started to increase already before entering the scenario room and was significantly larger just after starting the task than just before starting the task (p < 0.001). This pattern was more marked during the first tasks (p < 0.001). Issuance of a verbal “abort” command which terminated the tasks led to a significant increase of heart rate (p = 0.002), especially when performing the first tasks (p = 0.002). The pupil diameter changed significantly during the repeated tasks during all phases but in a complex pattern where the pupil diameter reached a minimum during task 2 followed by an increase during tasks 3 and 4 (p ≤ 0.020). During the initial tasks, the pupil size (p = 0.014) increased significantly. The results suggest that being repeatedly exposed to stressful tasks can produce in itself an escalation of psychological stress, this even prior to being exposed to the task. However, the characteristics of both the heart rate and pupil diameter were complex, thus, the findings highlight the importance of studying the effects and dynamics of different stress-generating factors. Monitoring heart rate was found useful to screen for stress responses, and thus, to be a vehicle for indication if and when rotation of deployed personnel is necessary to avoid sustained high stress exposures.

The Influence of Psychological Stress on the Initiation and Progression of Diabetes and Cancer.

ContextPsychological stress can be considered a risk factor for the initiation and progression of many pathological conditions, including type 1 and 2 diabetes mellitus and cancer.ObjectivesThe aim of this review article was to evaluate the molecular and cellular mechanisms linking psychological stress to the onset and progression of diabetes and cancer.Evidence AcquisitionThe current review was conducted to survey and analyze studies related to the effects of psychological stress on diabetes and cancer.ResultsPsychological stress may make individuals prone to the development of diabetes through the impairment of the hypothalamic–pituitary–adrenal (HPA) axis function, sympathetic nerves system (SNS), lipid profile, cytokines balance, renin-angiotensin system (RAS), and insulin signaling pathway. Additionally, psychological stress can contribute to the development of cancer through the perturbation in the HPA axis, SNS function, and cytokines balance. Psychological stress is also capable of decreasing the levels of oxytocin and dopamine, leading to an increased risk of cancer in susceptible individuals.ConclusionsIt seems that psychological stress plays a significant role in the onset and progression of diabetes and cancer. The identification of the pathways triggered by psychological stress would open up a new avenue for the understanding of molecular mechanisms by which diabetes and cancer could be managed or even prevented.

Exposure to an enriched environment promotes the terminal maturation and proliferation of natural killer cells in mice

The maturation of natural killer (NK) cells is critical for the acquisition of robust effector functions and the immune response to tumors. However, the influence of psychological stress on NK-cell maturation remains unknown. In this study, we investigated the alteration of NK-cell maturation in response to enriched environment (EE) exposure, which induced eustress, or positive stress, in mice. Analysis of markers representing distinct mature stages revealed that EE promoted the terminal maturation of NK cells both centrally in the bone marrow and peripherally in the spleen and blood. Additionally, EE increased CD27+ immature and intermediate-mature NK cell proliferation in the bone marrow. Furthermore, EE exposure brought about a similar promoting effect on NK-cell maturation in tumor-bearing mice. In tumor-bearing mice, EE substantially enhanced the proliferative potential of splenic CD27+ NK cells compared to those in the bone marrow. EE-housed mice displayed a tumor-resistant phenotype and an increased proportion of intratumoral NK cells, especially CD11b+ CD27− mature NK cells, while splenectomy abolished the tumor-retardant effect caused by EE and EE-induced NK-cell infiltration into tumors. Given that our previous study demonstrated an important role for NK cells in EE-induced tumor inhibition, the findings of this study further indicate that the enhanced maturation and proliferation of splenic NK cells may contribute to EE-induced tumor inhibition to some extent. Taken together, the results of this study suggest a positive modulating effect of environment-induced eustress on NK-cell maturation, with potential implications for understanding how eustress boosts NK-cell antitumor immunity.

Perceived stress, illness invalidation, and symptom severity in myalgic encephalomyelitis/chronic fatigue syndrome

ABSTRACT Background: Qualitative studies indicate that individuals with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) commonly experience illness invalidation from medical professionals that is often experienced as stressful and may contribute to strained patient–provider relationships, transfers of care, and/or decreased treatment adherence. Purpose: To examine the impact of perceived stress and illness invalidation from medical professionals on ME/CFS symptom severity. Methods: Adults with ME/CFS (N = 266) participated in an online survey, where they completed the Illness Invalidation Inventory (I*3) [Kool MB, van Middendorp H, Lumley MA, et al. Lack of understanding in fibromyalgia and rheumatoid arthritis: the Illness Invalidation Inventory (3*I). Ann Rheum Dis. 2010;69:1990–1995.], the Perceived Stress Scale (PSS) [Cohen S, Kamarck T, Mermelstein R. A global measure of perceived stress. J Health Soc Behav. 1983;24:385–396.], and the CDC Symptom Inventory for Assessment of CFS. Results were evaluated via hierarchical regression. Results: Neither perceived stress nor illness invalidation from medical professionals were significant predictors of ME/CFS symptom severity. Illness invalidation from medical professionals was positively correlated with illness invalidation from family, work colleagues, and social service workers. Conclusions: Results called into question the influence of psychological stress in ME/CFS symptom exacerbation, thus contributing additional information to the body of literature exploring the underlying mechanisms of ME/CFS. Additionally, this study suggested the particular importance of medical providers striving to create a validating relationship with patients who have ME/CFS.

The influence of psychological stress on arginine vasopressin concentration in the human plasma and cerebrospinal fluid

Psychological stress is strain affecting the intangible self, caused by problems in adaptation, perception, and emotions. Previous studies have demonstrated that arginine vasopressin (AVP) plays an important role in psychological stress. The goal of present study was to investigate the interaction between AVP release and cardiovascular functions by measuring AVP concentration and recording blood pressure or heart rate during psychological stress in human. The results showed that (1) psychological stress not only increased the systolic blood pressure, diastolic blood pressure and heart rate, but also elevated the cortisol and AVP concentration in both plasma and CSF in a stress level-dependent manner; (2) there was a positive relationship between plasma AVP concentration and systolic blood pressure, diastolic blood pressure, heart rate or plasma cortisol concentration; (3) there was also a positive relationship between AVP concentrations in plasma and CSF AVP. The data suggested that plasma AVP, which might come from the central nervous system, might influence the cardiovascular functions during psychological stress in human.