In order to improve the forming quality of largesize nickel-based alloy chemical tubes, the influence of different tube specifications and mandrel/tube clearances on the bending forming quality of largesize Hastelloy C-276 alloy tubes was studied. A finite element (FE) analysis model for NC rotary drawing bending (RDB) was established and verified. The results show that with the increasement of the clearance, the wall-thinning ratio [Formula: see text] of different tube specifications gradually decreases, and the wall-thickening ratio [Formula: see text] and ovality [Formula: see text] gradually increase. As the measuring angle increases, the [Formula: see text] of different specifications initially increases and then decreases. The [Formula: see text] exhibits a trend of initially increasing and then decreasing. It is reasonable to take about 1/8 of the wall thickness t for the mandrel/tube clearance. It is of great significance for guiding the bending forming of largesize nickel-based alloy chemical tubes and development of intelligent forming equipment.