Influence Of Enteral Nutrition Research Articles

Influence of Enteral Nutrition on Quality of Life in Head and Neck Cancer and Upper Gastrointestinal Tract Cancer Patients within a Pair-Matched Sample

Patients with cancers of the head and neck and upper gastrointestinal tract are particularly susceptible to malnutrition, which worsens both their prognosis and quality of life and may result in the need for enteral or parenteral nutrition. The aim of this study was to investigate the impact of enteral nutrition on the quality of life in a paired sample. This study included 50 patients with cancer in two paired subgroups: with enteral nutrition (studied group) and without enteral nutrition (matched group). This study was based on self-reports collected with the EORTC QLQ C30 questionnaire and retrospective analysis of medical records. The analysis revealed that weight loss, group type, and age were the primary factors influencing patients’ quality of life. Compared with all cancer patients and the general Polish population, the scores of patients in both groups were below reference values for functional scales and exceeded reference values or were similar for fatigue and vomiting/nausea. Patients who received enteral nutrition more frequently scored lower on the functional scales and higher on the symptomatic scales than the control group. These findings emphasize the complex relationship between cancer, nutritional status, and quality of life.

Quality of Life of Cancer Patients Receiving Enteral Nutrition: A Systematic Review of Randomized Controlled Trials.

Most studies confirm the beneficial effects of enteral nutrition on the quality of life, but some studies indicate an inverse association and its detrimental impacts. However, there are insufficient data on the effects of enteral nutrition on the quality of life of cancer patients. This systematic review aimed to describe the influence of applied enteral nutrition on the quality of life of cancer patients, based on the results of randomized controlled trials. It was registered in the PROSPERO database (CRD42021261226) and conducted based on the PRISMA guidelines. The searching procedure was conducted using the PubMed and Web of Science databases, as well as Cochrane Library, and it included studies published until June 2021. It was conducted to select randomized controlled trials assessing the influence of enteral nutrition (compared with the other model of nutrition) on the quality of life of cancer patients. A general number of 761 records were screened and a final number of 16 studies were included in the systematic review. The studies were included and assessed by two independent researchers, while the risk of bias was analyzed using the Newcastle–Ottawa Scale (NOS). Studies compared patients treated with and without enteral nutrition, patients treated with various methods of enteral nutrition or with enteral diets of various content, as well as patients treated with enteral and parenteral nutrition. Within the included studies, the majority were conducted in patients with cancers located in various parts of the body, or diverse areas within the gastrointestinal system, while some studies were conducted in specific populations of patients with a defined cancer location—esophagus, stomach, or ovary. The duration of applied enteral nutrition within the included studies was diversified—from two weeks or less to half a year or even more. The vast majority of studies used well-known and validated tools to assess the quality of life, either developed for a specific group of head/neck, esophagus/stomach, and ovary cancer patients or developed for more general patient populations. Most studies concerning patients treated with and without enteral nutrition supported applying enteral nutrition, which was concluded in seven studies out of ten (including four studies with a low risk of bias). The other important observations to be emphasized—formulated based on the studies with a low risk of bias—presented the role of oral supportive nutrition guided by a dietitian, as well as the beneficial role of enteral and parenteral nutrition, combined. In spite of a relatively low number of randomized controlled trials assessing the influence of enteral nutrition on the quality of life of cancer patients, which should be considered as a limitation, the results were promising. Most studies supported the positive influence of enteral nutrition on the quality of life, either assessed based on the psychological measures of the quality of life or by considering the other potential determinants (e.g., malnutrition, complications, etc.). Taking this into account, enteral nutrition should be applied whenever possible, both to prevent and treat malnutrition in cancer patients. However, considering the limited number of studies conducted so far, further research conducted in homogenic populations of patients is necessary.

The influence of enteral nutrition on language abilities in malnourished cancer patients

Rationale: Cancer patients are exposed to many complications related to anti-cancer treatment and the ongoing disease process. Malnutrition accompanying cancer generates the risk of severe nutritional deficiencies and may affect up to 75% of patients. The life expectancy of patients after anticancer therapy elongated, which increased the percentage of patients manifesting long-term complications, including cognitive disorders. Currently, it is assumed that rehabilitation of the nutritional status may have a positive effect on the cognitive functioning in cancer patients.

Influence of enteral nutrition on gut microbiota in patients using proton pump inhibitors: A prospective observational study in acute stroke patients

Influence of enteral nutrition on gut microbiota in patients using proton pump inhibitors: A prospective observational study in acute stroke patients

620PD - Influence of enteral nutrition on nutritional status, treatment toxicities, and short-term outcomes in esophageal carcinoma patients treated with concurrent chemoradiotherapy: A prospective, multicenter, randomized controlled study

620PD - Influence of enteral nutrition on nutritional status, treatment toxicities, and short-term outcomes in esophageal carcinoma patients treated with concurrent chemoradiotherapy: A prospective, multicenter, randomized controlled study

Influence of Enteral Nutrition on Occurrences of Necrotizing Enterocolitis in Very-Low-Birth-Weight Infants.

The aim of the present study was to investigate the influence of enteral feeding management on occurrences of necrotizing enterocolitis (NEC) in very-low-birth-weight (VLBW) infants. This was a case-control study conducted in a sample of 1028 VLBW infants (750 to 1499 g) admitted to a neonatal intensive care unit between January 2003 and May 2008. "Cases" were infants born with VLBW and diagnosed with NEC within the first 30 days of life, and "controls" were VLBW infants who did not develop NEC during this period. Occurrences of NEC were defined using the modified Bell criteria (stage ≥2). Among the 1028 VLBW infants, 55 (5.4%) developed NEC within the first month of life. Logistic regression analysis showed that breast milk given exclusively for <7 days (odds ratio [OR] = 4.02), never achieving full enteral feeding during the first month (OR = 3.50), and parenteral nutrition (OR = 2.70) were factors that increased the chances of NEC occurrence. The use of vasoactive drugs was associated with a lower risk of NEC (OR = 0.15). Breast milk should be recommended as a priority for the enteral nutrition of VLBW infants for no <7 days. Enteral nutrition should start early and progress quickly to achieve full enteral feeding; these procedures may help reduce the occurrence of NEC.

PS-181 Probiotics (infloran®) For Nec Prevention: Influence Of Enteral Nutrition

Background Probiotics may protect from necrotizing enterocolitis (NEC). Former studies in Asian populations have shown that Infloran® - a mixture of Lactobacillus acidophilus and Bifidobacterium infantis - decreases NEC by 80% in very low birth weight (VLBW) infants. Therefore, we implemented Infloran® at our department in 2010. The objectives of our study were to determine the influence of the probiotic Infloran® on NEC incidence, NEC severity and the influence of enteral nutrition in a Caucasian population compared to a historic control group. Material and methods Since 2010, VLBW infants born Results 230 infants were included (mean gestational age: 27+2, birth weight: 900g) and compared with 233 controls (28+5, 980g). After implementation of Infloran® NEC decreased by 32% (10.3% before vs. 7% after implementation of probiotics, p = 0.092 – corrected for confounding variables birth weight and gestational age). Probiotics had no influence on NEC severity. A NEC reduction was shown in breast fed infants only and not in formula fed infants. Discussion The effect of Infloran® was less effective in our Caucasian population than expected. Interestingly, NEC incidence was not reduced in exclusively formula fed infants. The inefficacy in this subgroup is alarming. Therefore, the impact of enteral nutrition on probiotic effects should be explored in further prospective randomised controlled trials.

Influence of enteral nutrition on intestinal mucosal barrier function and dopamine receptors in rats with traumatic brain injury

Objective To investigate the effect of glutamine and probiotics on intestinal mucosal barrier function and expression of dopamine receptor D1 and D2 (DRD1 and DRD2) in rats with traumatic brain injury (TBI). Methods Animal model was established by Feeney free fall TBI device. Thirty rats were randomly divided into three groups: control group, glutamine group (Gln), probiotics group (PB). The ratio of lactulose and mannitol (L/M) in urine was determined by high performance liquid chromatography (HPLC). Bacterial translocation and intestinal mucosal morphology were evaluated by eosin methylene blue (EMB) culturing and hematoxylin-eosin (HE) staining, respectively. Expression of DRD1 and DRD2 in intestinal mucosal were evaluated by immunohistochemistry, real-time PCR and western blot. Results After TBI, the weight of rats in the Gln and the PB group were (184.38±11.49) g and (185.22±8.46) g, respectively. Compared with the control group, the weight loss was significantly different (t=4.408, 5.305, respectively; P<0.05). The intestinal mucosal morphology was better in the Gln and the PB group, and reduced expression of DRD1 and DRD2 and bacterial translocation were observed in these groups. The L/M in urine were (0.051±0.010) and (0.038±0.009) in the Gln and the PB group. There were significant differences (t=26.48, 29.46, respectively; P<0.05). Conclusions Enteral nutrition with glutamine and probiotics can significantly improve intestinal mucosal barrier function in rats with TBI, which may be related to expression of DRD1 and DRD2 in intestinal mucosal. Key words: Enteral nutrition; Traumatic brain injury; Intestinal mucosal barrier function; Dopamine receptor

The influence of enteral nutrition on body composition measured by bioimpedance analysis (BIA) : Waldemar Pawlowski, Andrzej Kos, Krystyna Majewska

The influence of enteral nutrition on body composition measured by bioimpedance analysis (BIA) : Waldemar Pawlowski, Andrzej Kos, Krystyna Majewska

Plasma concentrations of vasoactive intestinal polypeptide in severely burned patients: Influence of enteral nutrition

Plasma vasoactive intestinal polypeptide (VIP) concentrations were measured at different days after burn injury. A significant decrease in VIP levels was observed on days 7 and 10. The influence of enteral nutrition was also investigated: a rise in plasma polypeptide levels was found at 60 min after nutrition restart on days 4 and 7 after injury. In burn patients, VIP may be involved in the multiple metabolic and hormonal responses which lead to an increase in the hypercatabolic state. The decrease in these polypeptide values should reflect enhanced utilisation or complex hormonal regulation. After enteral nutrition, the stimulation of VIP secretion disappeared after day 7 after burn injury. This phenomenon is probably mediated by a process of adaptation to continuous enteral nutrition.

Influence of enteral nutrition by an artificial oligopeptide diet on CCK- and neurotensin-cells in the small bowel mucosa : [formula omitted], H.Gebhardt, B.Lünstedt, M.L.Hansmann, E.Kaiserling (Dept. of General Surgery and Dept. of Pathology, University of Kiel, FRG)

Influence of enteral nutrition by an artificial oligopeptide diet on CCK- and neurotensin-cells in the small bowel mucosa : [formula omitted], H.Gebhardt, B.Lünstedt, M.L.Hansmann, E.Kaiserling (Dept. of General Surgery and Dept. of Pathology, University of Kiel, FRG)