Influence Of Different Dosages Research Articles

Research on the Preparation and Mechanical Properties of Solidified 3D Printed Concrete Materials

Three-dimensional (3D) printing is an innovative manufacturing process based on 3D digital models that involves layer-by-layer addition of materials. In recent years, 3D printing has made good progress in the field of construction, thereby leading to more stringent requirements for materials. In this study, we first compare different equipment and materials used for 3D printing concrete. Subsequently, the mix ratio of extruded and cured 3D printed concrete is studied by using flow and slump as the main evaluation indexes. Through a universal test, the influence of different dosages of water reducer, retarder, and latex powder on the performance of 3D printed concrete (compression resistance strength) is studied. Furthermore, the optimum mix ratio for fiber reinforced concrete is determined, based on which axial pull-out, axial compression, and three-point bending tests are performed to elucidate the peak compressive strength, load–displacement curve, and mechanical properties of 3D printed concrete. By employing the ABAQUS finite element software, the shaft pulling force and axial compression of 3D printed concrete are simulated and analyzed to determine the parameters influencing the bonding performance of different 3D printed concrete layers. Moreover, the influence of water reducer and sand–glue ratio is observed to be greater than that of water gel ratio and sodium gluconate. The testing results showed that the mechanical strength of 3D printed concrete is lower than that of poured concrete. Meanwhile, bending and compressive strengths of 3D printed concrete and poured concrete are quite different.

A novel strategy for efficient capture of intact harmful algal cells using Zinc oxide modified carbon nitride composites

The development of safe and efficient materials to remove harmful algae is continuing to be a major challenge in controlling cyanobacterial blooms in eutrophication waters. Herein, we present a novel strategy that combines Zinc oxide (ZnO) with carbon nitride composites to efficiently collect the intact Microcystis aeruginosa cells. The influence of different dosages of g-C3N4 precursors were assessed and the synthesized catalysts were characterized. The results revealed that 93.0 % of algae cells were removed by the ZnO/CN (2:1) system within 10 min at a dose of 4.0 g L−1. Regardless of the variation in initial cell density, the final removal efficiency reached >90.0 %. The integrity of the algal cell membrane was observed by K+ release and intracellular organic matter such as MC-LR during the removal process, which were further verified by SEM images. The Zeta potential values indicated that the improved effectiveness may be attributed to the electrostatic attraction and coagulation by ZnO/CN. The removal mechanism of ZnO/CN was revealed through charge neutralizing flocculation and the different types of flocculants were compared. The present work provides a new insight in using ZnO nanoparticles modified carbon-based composites in treating cyanobacterial blooms.

Influence of different dosages of feed additive "AktivSorbent" in the diets of piglets on the morphological and biochemical status of blood

The article presents data from experimental studies on the effect of new feed additives of mycotoxin adsorbents "AktivSorbent" in the diets of growing piglets on hematological parameters. It has been established that the use of feed additives "AktivSorbent" in the feeding of young pigs on rearing at a dose of 1.750 kg / t of compound feed improves the morphological and biochemical parameters of blood.

Influence of different dosage and frequency of liquid jeevamrutha application on leaf nutrient status of guava (Psidium guajava) cv. L-49 under Northern Transition Zone of Karnataka

The present field experiment was conducted at Regional Horticultural Research and Extension Center, Kumbapur, Dharwad during 2019-20 and 2020-2021. The objective of the study was to study the influence of application of liquid jeevamrutha at different dosage and frequency on leaf nutrient status (N, P, K, Ca, Mg & S) of guava cv. L-49. The experiment was designed in two factorial randomized block design with each factor having three levels. Three different levels of liquid jeevamrutha viz., 500 l/ha, 750 l/ha and 1000 l/ha at different frequencies like 15 days, 21 days and 30 days was applied to guava trees in the effective root zone area. The combination effect of dosage and frequency of application was compared with recommended package of practice (RPP). The results showed that application of higher dosage of liquid jeevamrutha i.e., 1000 l/ha at an interval of 15 days recorded significantly higher leaf nutrient status. Similarly in interactions also D3F1 (Application of liquid jeevamrutha @ 1000 l/ha at 15 days interval) recorded significantly highest nitrogen (1.79 % and 1.56 %), phosphorous (0.30 % and 0.23 %), potassium (0.73 and 0.68 %), Sulphur (0.54 % and 0.49 %), calcium (2.30 % and 2.09 %) and magnesium (0.68 % and 0.50 %) at flowering and after harvest respectively.

A prominent dual heterojunction framed CuWO4/Bi2WO6/MnS ternary NCs for para-chlorophenol degradation, Cr(VI) reduction & toxicity studies.

In account of environmental remediation, an ideal photocatalyst was fabricated for the effective treatment of water systems. Herein, dual heterojunctions framed CuWO4/Bi2WO6/MnS nanocomposite (NCs) was synthesized via simple co-precipitation method followed by ultra-sonicated assisted route. The prepared NCs were investigated its photocatalytic degradation performance using para-chlorophenol (4-CP) and reduction of chromium VI (Cr (VI)) under visible light irradiation. The photocatalyst were characterized by various analytical techniques including XRD, HR-TEM, XPS, UV-vis DRS, FE-SEM, EIS, PL, ESR, Raman and N2 adsorption and desorption studies. The excellent photodegradation of 4-CP was observed within 180min by the NCs. Similarly, the Cr (VI) reduction was about 97% within 140min. The effect of pH and influence of different dosage of NCs and 4-CP on the photodegradation efficiency was investigated. The reusability and stability of the NCs was examined over 6 consecutive runs where the XRD and XPS confirm the structural stability of the prepared NCs. The scavenging experiment were carried out to elucidate the mechanism and the active species involved were O2-• and OH• radicals. The TOC analysis affirmed the complete mineralization of the prepared NCs. The ecotoxicity analysis was carried out to determine the toxicity effect of intermediates using ECOSAR software and the end product toxicity was also evaluated against E. coli and S. epidermis. The end product toxicity study also confirmed that the degraded product was less toxic compared to parent compound. Further, the genotoxicity study was done to understand the environmental impact using allium cepa and results confirms that there are no causes of cytotoxicity & genotoxicity by the prepared NCs. Therefore, the prepared NCs can be economical, efficient with excellent photocatalytic performance and environment friendly.

Synergistic self-healing effect of fiber and bio-capsule on mortar cracks

Self-healing is an effective technique to prolong the service life of cement-based materials. In this study, the porous volcanic rock was used as the carrier to prepare the bio-capsules, and the waterproofness and storage stability of the bio-capsules were studied by weighing method. The influence of different dosage of bio-capsules on mortar strength was studied by three-point bending and uniaxial compression. Then, PVA and sisal fibers containing a large amount of –OH and bio-capsules were placed in cement mortar, and the self-healing effect of mortar cracks, as well as the synergistic heal mechanisms of both fibers and bio-capsules on the formation of cracks were studied by using water permeability, gas permeability, crack healing width and healing area. The results show that the bio-capsules have good waterproofness and storage stability. When the content of bio-capsules was 12%, the compressive and flexural strengths of the mortar could be increased by 32.01% and 14.39%, respectively. The water permeability of the mortar was reduced by two orders of magnitude (from 1.63 × 10−4 to 7.55 × 10−6 cm s−1) after crack healing. At the end of testing (28 days), most cracks with widths of 0–600 μm were completely healed, leading to an area healing rate of 100% for sample C–BH. The presence of large amounts of –OH in the fiber could keep the crack area in the water environment, as well as accelerate the rate of bacterial mineralization and the fiber as the nucleation site can make the mineralization product form three-dimensional networking structures in the cracked areas.

Influence of feed sorbents on the productive and reproductive traits of cows of Black-and-White breed

In the composition of feed for cattle, the presence of toxins that are formed as a result of violations of the technology of harvesting and storage of feed is recorded. Aflatoxins, ochratoxins, zearalenone, T-2 toxin, DON (deoxynivalenol), fumonisin are isolated. Mycotoxins entering the blood have a rather negative effect on the body of cows, reducing their productivity and fertilizing ability. Under conditions of intensive milk production technology, the determination of toxins in feed when feeding highly productive cows is of particular importance. The purpose of the research was to establish the degree of influence of different dosages of feed sorbents on the productive and reproductive traits of cows. The research was carried out under the conditions of the breeding farm of Black-and-White breed in OOO “Barmino” in the Nizhny Novgorod region. The objects of research were cows of the first lactation of Black-and-White breed, and the subject of research was the dairy productivity of cows and their reproductive traits. The objectives of the research included a comparative study of the influence of feed additives “Provitol” and “Vetosporin-active” on the productivity and reproductive traits of cows. In the concentrate part of the feed, the excess of the permissible norm of the mycotoxins zearalenone by 2,5 times and ochratoxin by 4,2 times was revealed. It was found that the dairy productivity of cows and higher indicators of reproductive abilities were animals in the 4th experimental group, who have been received the largest amount of the feed sorbent “Vetosporin-active” 2 kg per ton of concentrated feed. In comparison with the analogues of other experimental groups, they have the best ease of calving, the absence of problems with the separation of the afterbirth and endometriosis, the optimal duration of the open days period and the minimum expenditures of sperm doses for effective insemination. It was recommended to use the feed sorbent “Vetosporin-active” at the dose of 2,0 kg per ton of feed as a feed additive in the main ration of highly productive cows to improve their reproductive and productive traits.

Effects of subanesthesia dose S-ketamine induction on postoperative psychiatric complications after gynecological surgery.

Ketamine may become an important drug for multimodal analgesia regime again because of its strong analgesic effects and retaining the advantage of spontaneous breathing. The present study was designed to explore the influences of different dosages of S-ketamine anesthesia induction regimes on psychiatric complications and postoperative prognosis in patients undergoing gynecological operations. In this prospective, triple-blinded, randomized, controlled study, patients undergoing elective gynecological surgery were randomized to one of three treatment groups: low-dose S-ketamine (LDSK) group (a 0.3 mg/kg bolus for anesthesia induction), minimal-dose S-ketamine (MDSK) group (a 0.2 mg/kg bolus for anesthesia induction), and placebo (CON) group (a saline bolus for anesthesia induction). The main outcome measures were as follows: intraoperative vital signs, extubation time, anesthesia recovery time and postanesthesia care unit (PACU) stay duration, incidence of psychiatric complications, Ramsay sedation scale (RSS) 1, 2, 24, and 48 h, postoperatively, and overall prognosis. One hundred and eightyfemale participants were finally included in this study from April 2021 to December 2021. Significant differences were not observed in age, height, weight, American Society of Anesthesiologists physical status classification, or history of mental illness between the groups. No statistically significant differences were discovered with regard to intraoperative vital signs, extubation time and PACU stay duration, incidence of psychiatric complications, andRSS scores at 1, 2, 24, and 48 h postoperatively in thethree groups. However, the visual analog scale (VAS) scores of the CON group at 10 min after extubation and at the time point leaving PACU were much higher than that of the LDSK and MDSK groups. The VAS scores at 48 h after surgery in the MDSK group were also lower than that of the CON group and the CON group had received more analgesic drug treatment in the surgical wards consequently. Postoperative nausea and vomiting (PONV) occurrence at 24and 48 h, postoperatively, increased sharply in the CON group than in the other two experimental groups, which led to an increase in the use of postoperative antiemetic drugs in this group. According to the postoperative satisfaction survey, patients in theCON group had lower medical satisfaction. Our data demonstrate that a small dosage of S-ketamine anesthesia induction can reduce postoperative pain and the incidence of PONV without increasing hemodynamic fluctuations or psychiatric complications.

Towards the low-energy usage of high viscosity asphalt in porous asphalt pavements: A case study of warm-mix asphalt additives

The problems of energy waste and pollutant gas emissions caused by the high-temperature construction of high viscosity asphalt (HVA) for porous pavements may be effectively solved by the warm-mix asphalt (WMA) additives. In this paper, the rheological properties of HVA with WMA additives were investigated considering the application in porous pavement. First, the influences of different dosages of Sasobit, EC120, Evotherm, foaming water on the conventional properties of HVA were investigated by rotational viscosity, absolute viscosity (60 °C), toughness and tenacity, penetration, softening point, and ductility (5 °C). The four optimum dosages of Sasobit (3%), EC120 (3%), Evotherm (1%), and foaming water (4%) were determined. Second, the rheological properties at the high-temperature, intermediate-temperature, and low-temperature of HVA with the four optimum dosages of WMA additives were studied by dynamic shear rheometer (DSR) test and bending beam rheometer (BBR) test. The result showed that the rotational viscosity (135 °C) of HVA was significantly reduced by the WMA additives, thereby improving the workability of the HVA. Meanwhile, the WMA additives at optimum dosage can improve the high-temperature rheological properties of HVA except for foaming water. However, Sasobit, EC120, and foaming water have adverse effects on the intermediate-temperature fatigue performance and low-temperature crack resistance of HVA. By comprehensive comparison, it is suggested that HVA with 1% Evotherm is more suitable for the construction in porous asphalt pavements.

Use of the feed additive “Toxinon” in feeding of replacement young chickens and laying hens

At the present time of the development of industrial poultry farming, the main tasks are to increase the productivity of poultry, reduce production costs and improve its quality. Under practical conditions, there is a shortage of minerals in compound feed for poultry, which leads to a violation of metabolism in the body, slowing down growth and development, deterioration of the work of organs and systems, a decrease in productivity and its quality, and an increase in the prime-cost of production. The purpose of the research was to study the effectiveness of the use of the feed additive “Toxinon” in feeding of replacement young chickens and laying hens. The research has been carried out under the conditions of OOO “Bogotolskaya Poultry Farm” in the Bogotolsky area in the Krasnoyarsk Territory. Comprehensive studies have been conducted to study the effect of the feed additive “Toxinon” on the growth and development, productivity and metabolism of replacement young chickens and laying hens of the industrial herd of the cross “Haysex brown”. The influence of different dosages of the feed additive “Toxinon” on the growth rate, livestock livability, digestibility and use of feed nutrients, egg productivity, egg quality, hematological and biochemical blood parameters of replacement young chickens and laying hens has been studied. The laying hens of the 3rd experimental group were distinguished by the highest egg productivity during the experiment period, which exceeded the control group in terms of the gross number of eggs by 6,4 %, the intensity of egg production by 5,02 abs.%, egg weight by 3,0 % (P > 0,95), the yield of egg mass on the average laying hen by 9,12 %. At the same time, expenditures of feed in the 3rd experimental group have decreased compared to the control group by 7,3 % for 10 eggs, by 9,2 % for 1 kg of egg mass. It has been found that in feeding replacement young chickens and laying hens, the most effective use of the feed additive “Toxinon” in the dosage of 0,25 % of the weight of the feed mixture (2,5 kg/ton of feed).

Rheological properties of composite mixtures from wheat and amaranth flour

The lack of essential nutrients in the population’s diet contributes to the expansion of the range of traditional products through the production of fortified products. Enrichment is often carried out by adjusting the traditional recipe by introducing unconventional raw materials, characterized by an increased content of deficient substances, primarily protein, alimentary fiber, minerals and vitamins. Changes in the properties of the dough lead to a change in the characteristics of the finished bakery. The influence of different dosages of unconventional raw materials (in the article - flour from extrudate amaranth grain, from 10 to 20 %) on the rheological properties of the dough was investigated using Brabender instruments.

The effect of prebiotic with bifidogenic properties on morphometric parameters of rabbits

The research was aimed at study of the potential and effectiveness of lactulose use in rabbit breeding. Lactulose is an isomer of milk sugar (disaccharide), it serves as a nutrient substrate for saccharolytic bacteria. The latter decompose it into short-chain fatty acids - lactic, acetic, propionic, butyric. At that time, the pH of the contents of the colon decreases. The microbiocenosis uses lactulose as a source of carbohydrates and energy. In this work, the optimal dosage and method of introducing lactulose into the diet of young rabbits of the California breed are calculated and determined experimentally. The experiment (2013-2016) involved male rabbits at the age of 45 days. The duration of the experiment was 60 days. The control group and two experimental groups of 20 heads each were formed by the method of analog pairs. The dry type of feeding was used using full-grain granular compound feed KK-92. Lactulose concentrate "Lactusan" was used, being added to drinking water. As the basic value of the norm for the introduction of lactulose into the diet of rabbits for further planned experiments, 0.06 g/kg of live weight per day was taken. As a result of the conducted studies, some responses of the rabbit body were revealed when they were raised using the lactulose prebiotic, which has bifidogenic properties. The influence of different dosages of lactulose on some morphological parameters and meat productivity of rabbits was established. The mass of the examined internal organs did not undergo critical changes. The introduction of lactulose into the diet of California rabbits for 60 days at a dosage of 0.06 g/kg of live weight per day increased the slaughter yield by 3.1 %, and at a dosage of 0.12 g/kg ‒by 0.5 %.

Study on Strength, Water Stability, Shrinkage, and Microstructure of CFB Slag Modified Cement Stabilized Clay.

Circulating fluidized bed slag (CFBS) is an industrial waste produced by coal combustion in power plants. To explore the application of CFB slag in cement-stabilized bases, this paper studies the influence of different dosage of CFBS on the mechanics, water stability, and shrinkage of cement-stabilized soil using laboratory experiments. The hydration activity and interface morphology of CFBS in cement-stabilized clay were observed using XRD and SEM. The improvement mechanism of CFBS on the performance of cement-stabilized clay was revealed. The results indicated that, compared with cement-stabilized clay, cement–CFBS-stabilized clay exhibited better mechanical and water stability, and significantly inhibited the shrinkage deformation of cement-stabilized clay. When the addition of CFBS was 70%, cement–CFBS-stabilized clay had the best mechanics and durability. Microscopic tests show that CFBS contains more active silicon aluminum oxide, which is easily dissolved and the hydration of which produces more gel products, so the mixture structure is denser, the strength is improved, and water does not easily evaporate; it has the characteristics of micro expansion which compensates for dry shrinkage deformation.

Effect of nano-silica as cementitious materials-reducing admixtures on the workability, mechanical properties and durability of concrete

Abstract Nano-silica (NS) is one of the most important nanomaterials in recent years. It is used as a new cement-based composite reinforcement in building materials because of its high volcanic ash activity. In order to achieve the goal of carbon peaking and carbon neutralization, combined with the research idea of cementitious materials-reducing admixture for concrete, under the condition of reducing the amount of cement in concrete by 20%, the influence of different dosages of NS on the setting time and mechanical properties of concrete was analyzed. In addition, the shrinkage performance, impermeability, and resistance to chloride-ion permeability of concrete were also studied. The results show that under the same curing conditions and ages, when the NS dosage is 2.5%, the compressive strength and splitting tensile strength of the specimen after 28 days of curing are the highest, reaching 40.87 and 3.8 MPa, which show an increase by 6.6 and 15.15%. The shrinkage performance of concrete increases with the increase in NS dosage. In addition, when the NS dosage is 2.0%, the durability of concrete has also been greatly improved. The impermeability of concrete increased by 18.7% and the resistance to chloride-ion permeability increased by 14.7%. Through microscopic analysis it was found that NS can promote the hydration reaction, generate more hydration products such as calcium silicate hydrate (C–S–H), enhance the interfacial adhesion between the matrix and the aggregate, and form a closer interfacial transition zone. Moreover, the addition of NS also reduces the cumulative pore volume in concrete, refines the pore size, and makes the internal structure of concrete denser.

Influence of Different Dosages of Limestone Dust and Charcoal on the Properties of Lightweight Cement Composites

This paper presents the characterization of new lightweight cement composites incorporating limestone dust and charcoal. The charcoal is used not only to make the composite lighter in weight but also to improve its hygrothermal performance. Additionally, limestone dust, a waste material, is used instead of sand in the mixtures to improve their sustainability. Results show that the limestone-charcoal-cement composites have low thermal conductivity, while retaining good mechanical strength, high water vapor permeability, and low flammability. It was also found that these composites do not release dangerous substances in concentrations that jeopardize the safety of the environment or human health. Overall, the results suggest that the new limestone-charcoal-cement composites can be applied as lightweight screeds and other construction solutions, such as mortars or plasters that do not require high mechanical strength.

Performance analysis of steel slag powder-coal gangue grouting material

In this paper, coal gangue soil, steel slag powder and polycarboxylic acid superplasticizer with different dosages were combined into ordinary Portland cement. Grouting solution was prepared according to different water-cement ratios and solidified under standard conditions. Through orthogonal experiments, the influence of different dosages on the rate of grout stones and the compressive strength of stones in different ages was studied. The experimental results show that the increase in the amount of coal gangue will lead to the decrease of the slurry stone first and then increase, and the compressive strength will decrease. The increase in the amount of steel slag powder reduces the stone rate and compressive strength of the slurry.

Experimental Study on Axial Tensile Stress-Strain Relationship of High Crack Resistance Concrete

For demand of high crack resistance of concrete, the calcium-magnesium expansion agents and basalt fiber are chosen. The study of the full stress-strain curve of concrete under uniaxial tensile can comprehensively reflect its mechanical properties. The uniaxial stretch tests are used to study the concrete axial tensile constitutive model, and then the corresponding curve and formula are obtained in this paper. The influence of different dosages and water-binder ratio on the characteristic points of the curve is studied, and a suitable mathematical expression for the axial tensile stress-strain curve is proposed. Studies have shown that by adopting the method of dual admixture of expansive agent and basalt fiber, the toughness, tensile strength, ductility, and even other properties of concrete can be significantly improved. This shows that the dual admixture of the two materials has a strong toughening effect on concrete. With the amount of fiber content, the amount of expansion agent and the water-binder ratio is respectively 1%, 7% and 0.42, the performance of concrete shows the best state. The proposed calculation formula is in good agreement with the experimental results, which can provide a theoretical basis for the design and nonlinear analysis of concrete structures.

Dynamics of biochemical indicators in blood of replacement heifers of black and military breed during use of selenorganic preparations

The results of the influence of different dosages of organoselenium preparations on the blood biochemical parameters of replacement heifers in different age periods are presented. It was found that the inclusion of organic selenium preparations Sel-Plex and DAFS-25 in the diet of replacement heifers up to 18 months of age at the rate of selenium 0.20–0.36 mg / kg of dry matter of the diet contributed to an increase in protein metabolism.

Effect of 2 Different Dosages of Rosuvastatin on Prognosis of Acute Myocardial Infarction Patients with New-Onset Atrial Fibrillation in Jinan, China.

BackgroundAtrial fibrillation (AF) often occurs in patients with acute myocardial infarction (AMI). This study aimed to observe the influence of different dosages of rosuvastatin on the prognosis of AMI patients with AF.Material/MethodsWe performed an observational, retrospective cohort study in Jinan, China, in which 323 AMI patients were recruited. All patients were randomized to receive optimal medication treatment and 10 mg or 20 mg of rosuvastatin. Holter monitor results, serum lipid levels, and heart function were recorded. We used multivariate Cox and Kaplan-Meier analyses to assess the independent factors and differences in AF and ischemia events and safety of rosuvastatin administered at different dosages.ResultsTC, LDL-C, and TG at 1 and 12 months were significantly lower compared with those observed prior to treatment in both groups. The heart function of both groups was significantly improved after 12 months of treatment, especially in the 20 mg group. Multivariate Cox analysis showed that different dosages of rosuvastatin, age, smoking, drinking alcohol, and diabetes are independent factors related to the occurrence of AF and ischemic events. In addition, according to Kaplan-Meier analysis, no significant difference in adverse clinical events existed at different dosages of rosuvastatin.ConclusionsTreatment with rosuvastatin can reduce the serum lipid level and improve cardiac function. Different dosages of rosuvastatin, age, smoking, drinking alcohol, and diabetes are independent risk factors for AF and ischemia events. The results suggested it is safe to use 20 mg rosuvastatin in the 12 months after hospital admission.

PECULIARITIES OF UNITIOL INFLUENCE ON THE KIDNEY FUNCTIONING IN RATS OF THE JUVENILE AGE

This investigation shows an influence of different dosages of unitiol (sodium2,3-dimercaptopropanesulfonate) on the kidney functioning in juvenile rats.Purpose of the work is to study unitiol influence upon the kidney excretion function insexually mature rats at single and repeated injections.Material and methods. This investigation was performed on the juvenile male rats withthe body weight 95.0±8.5 g. The kidney functioning was determined for the single andrepeated (10, 20 and 30 days) injections of 5 % unitiol solution (50 mg/kg, subcutaneously)against a background of the additional water load realized through introduction of warmwater into the stomach in the volume of 5 % of the animal’s body weight. The concentrationOriginal research53Клінічна та експериментальна патологія. 2020. Т.19, №1(71) ISSN 1727-4338 https://www.bsmu.edu.uaof sodium, potassium ions, creatinine, proteins, ammonium, titratable acids and pH weredetermined in the rat’s urine and then compared with the corresponding values obtainedfrom the control and previous groups under study.Results. No significant changes were determined in the excretion and acid-regulationfunctions of the rat’s kidney in 2.5 hours after unitiol single injection against a backgroundof the water load. However, the concentration of sodium increased 1.7 times as large andthe concentration of potassium decreased correspondingly. No changes were registeredin diuresis while excretion of sodium increased 1.9 times as large, kaliuresis decreased1.6 times, sodium/potassium urine coefficient increased 2.6 times.After daily untiol injection during 10 days, concentration of sodium in the urine became3.2 times less in comparison with animal’s reaction to the single injection of the drugand 1.9 times less than that in the control group. Against a background of the 20 and30 days of the drug injection, the concentration of sodium has decreased almost thricecomparing to the control group value. Natriuresis decreased by 4 times comparing tothe value achieved after a single drug injection, decreased twice in comparison withthe control group and then it remained unchanged throughout the following 20- or 30-days long injections. No significant deviations from the control value were found in thepotassium concentration after the repeated injections of the drug. Kaliuresis decreasedafter the single injection but then it increased to its control value following the injection ofthe drug during 20 days. The urine sodium/potassium coefficient decreased 1.7-2.5 timescomparing to the control value after the repeated injections. No significant changes wereregistered throughout the entire experiment in the endogenous creatinine excretion andconcentration. The protein concentration decreased by 2.2 times comparing to its controllevel after unitiol application during 10 days and then it remained unchanged after 20-or 30-days long courses of injections. The indices of titratable acids and ammoniumexcretion became in 1.8 times less than those in the control group, then they increasedafter the 20th day and on the 30th day of injection they didn’t significantly differ fromthe control indices. The hydrogen excretion increased 2.4 and 2.8 times as large after20 and 30 days of the drug injection respectively at urine pH decrease. Unlike the singleinjection, the repeated unitiol injections significantly decrease natriuresis and the proteinexcretion with urine. Some age-related features of unitiol influence on the kidneys can beaccounted at different types of its administration as a chemical antidote.Conclusions. 1. Unitiol influence on the kidney functioning combined with the water loadin juvenile rats depends on the duration of application.2. The natriuretic effect increases and the kaliuretic effect decreases after a singleinjection of the drug when there is no significant influence on diuresis, excretion andacid-regulating parameters of the kidney. 3. A prolonged (10, 20, 30 days) application ofunitiol causes some intensification of sodium-retaining and hypoproteinuretic activitiescombined with some increase in the urine pH.