Influence Of Childhood Adversity Research Articles

The moderated mediating effect of community integration in depressive symptoms which are related to childhood adversity and suicide attempts by adolescents who have dropped out of school

The aim of this study was to verify the moderated mediating effect of community integration on the influence of childhood adversity on suicide attempts in adolescent who have dropped out of school and examine the mediating effect of depressive symptoms. This study used the data of the first year from a Longitudinal Survey and Support Plan for Dropouts in 2013. Among 776 respondents, 685 (mean age = 18.04, SD = 0.78) participants were included in the final analysis. The results of this study showed that both childhood adversity and depressive symptoms were positively associated with suicide attempts. Depressive symptoms mediate the relationship between childhood adversity and suicide attempts. In particular, the mediating effect of depression on the influence of childhood adversity on suicide attempts was moderated by community integration. The results of this study suggest that help from counselors and social workers at a national level is needed to strengthen social ties between out-of-school youth and community members to prevent suicide among youth who have dropped out of school.

Influence of Childhood Adversity on Students’ Delinquent Activities: Interplay with Neighborhood Context and Delinquent Peer Association

Juvenile delinquency is often linked with various proximal family and environmental factors during a child’s upbringing. Richard Jessor’s problem behavior theory (PBT) emphasizes that a combined interplay of these factors may explain this phenomenon appropriately. This study employed the PBT framework to investigate the impact of family on students’ delinquency, considering the influence of neighborhood and delinquent peer association. A model was developed for analyzing the variables by structural equation modeling (SEM). Data were collected through interviews with 1026 students aged between 12 and 18 years from a child development center and eight educational institutes in Bangladesh. The findings revealed that family-level factors (adverse childhood experiences (ACEs) and family deprivation) can significantly predict students’ delinquency directly and through the moderation effect of neighborhood-level variables (neighborhood social capital and neighborhood disorganization). Delinquent peer association exhibited a significant mediating role in the model. It could directly predict delinquency as well. The research has notable theoretical and practical implications for understanding the complex dynamics of family, neighborhood, and delinquent peer association in explaining students’ delinquency.

Does childhood trauma predict schizotypal traits? A path modelling approach in a cohort of help-seeking subjects

Schizotypy constitutes a susceptibility to beneficial and deleterious schizotypal traits, ranging from coping mechanisms to schizotypal personality disorder on a psychosis continuum. Growing evidence indicates a relationship between childhood adversity and trauma and schizotypy. However, the exact influence of childhood adversity and trauma on schizotypy and its relation to sex is not sufficiently understood. Therefore, we investigated sex-adjusted connections between childhood adversity and trauma subdomains (emotional/physical/sexual abuse, emotional/physical neglect) and positive (magical ideation, perceptual aberration) as well as negative schizotypy (physical/social anhedonia). In total, 240 outpatients of the Early Detection and Intervention Centre of the University Hospital Cologne were assessed with the Trauma and Distress Scale for childhood adversity and trauma and the Wisconsin Schizotypy Scales for schizotypy. Path analyses were performed to investigate sex-adjusted correlations. The well-fitting path model of the total sample linked emotional abuse to magical ideation (p = 0.03; SE = 0.20) and emotional neglect to social anhedonia (p = 0.01; SE = 0.26). In females, physical abuse predicted magical ideation (p = 0.01; SE = 0.33), while emotional neglect forecasted physical anhedonia (p = 0.03; SE = 0.34) and social anhedonia (p = 0.03; SE = 0.32). In males, sexual abuse predicted perceptive aberration (p = 0.04; SE = 0.19) and emotional abuse forecasted magical ideation (p = 0.03; SE = 0.27). Overall, the significance of sex-specific interrelations between trauma and schizotypy were highlighted. Magical ideation and perceptive aberration occurred prominently in the absence of negative and disorganized schizotypy, thus positive schizotypy could be discussed as a beneficial expression of coping with emotional, physical and sexual abuse. Furthermore, emotional neglect should be addressed particularly to prevent deleterious negative schizotypy in females.Trial registration number (20-1243), date of registration (May 19th 2020), retrospectively registered.

Influence of Childhood Adversity and Infection on Timing of Menarche in a Multiethnic Sample of Women.

Childhood adversities (CAs) and infections may affect the timing of reproductive development. We examined the associations of indicators of CAs and exposure to tonsillitis and infectious mononucleosis (mono) with age at menarche. A multiethnic cohort of 400 women (ages 40–64 years) reported exposure to parental maltreatment and maladjustment during childhood and any diagnosis of tonsillitis and/or mono; infections primarily acquired in early life and adolescence, respectively. We used linear and relative risk regression models to examine the associations of indicators of CAs individually and cumulatively, and history of tonsillitis/mono with an average age at menarche and early onset of menarche (<12 years of age). In multivariable models, histories of mental illness in the household (RR = 1.44, 95% CI: 1.01–2.06), and tonsillitis diagnosis (RR = 1.67, 95% CI: 1.20–2.33) were associated with early menarche (<12 years), and with an earlier average age at menarche by 7.1 months (95% CI: −1.15, −0.02) and 8.8 months (95% CI: −1.26, −0.20), respectively. Other adversities indicators, cumulative adversities, and mono were not statistically associated with menarcheal timing. These findings provided some support for the growing evidence that early life experiences may influence the reproductive development in girls.

Investigating the moderating influence of childhood adversity on the relationship between acute stress and reward learning

Investigating the moderating influence of childhood adversity on the relationship between acute stress and reward learning

Influence of childhood adversity, approach motivation traits, and depression on individual differences in brain activation during reward anticipation

Reward anticipation dysfunction is associated with major depressive disorder (MDD), but is not universally observed in individuals with MDD. Reward anticipation deficits have also been linked to childhood adversity (CA) and approach/avoidance traits. The present study evaluated whether severity of CA (as measured by the Childhood Trauma Questionnaire) and approach/avoidance traits predict individual differences in blood oxygen level dependent (BOLD) response to reward anticipation beyond MDD diagnosis alone. Participants were individuals with MDD (n = 23) and healthy controls (n = 27). Multiple regression was conducted using CTQ scores, trait approach/avoidance scores, and diagnosis to predict activation during reward anticipation in a monetary incentive delay fMRI task. Across groups, higher trait reward responsiveness predicted increased activation in the hippocampus, cingulate cortex, and medial frontal gyrus. Greater CTQ scores predicted increased reward network activation. Overall, CTQ and reward responsiveness scores predicted more variance in reward anticipation activation than diagnosis. These findings suggest that clinicians should assess history of childhood adversity and trait reward responsiveness when treating individuals with MDD.

Nonsocial and social cognition in schizophrenia: current evidence and future directions.

Cognitive impairment in schizophrenia involves a broad array of nonsocial and social cognitive domains. It is a core feature of the illness, and one with substantial implications for treatment and prognosis. Our understanding of the causes, consequences and interventions for cognitive impairment in schizophrenia has grown substantially in recent years. Here we review a range of topics, including: a) the types of nonsocial cognitive, social cognitive, and perceptual deficits in schizophrenia; b) how deficits in schizophrenia are similar or different from those in other disorders; c) cognitive impairments in the prodromal period and over the lifespan in schizophrenia; d) neuroimaging of the neural substrates of nonsocial and social cognition, and e) relationships of nonsocial and social cognition to functional outcome. The paper also reviews the considerable efforts that have been directed to improve cognitive impairments in schizophrenia through novel psychopharmacology, cognitive remediation, social cognitive training, and alternative approaches. In the final section, we consider areas that are emerging and have the potential to provide future insights, including the interface of motivation and cognition, the influence of childhood adversity, metacognition, the role of neuroinflammation, computational modelling, the application of remote digital technology, and novel methods to evaluate brain network organization. The study of cognitive impairment has provided a way to approach, examine and comprehend a wide range of features of schizophrenia, and it may ultimately affect how we define and diagnose this complex disorder.

Childhood and Adolescent Adversity and Cardiometabolic Outcomes: A Scientific Statement From the American Heart Association.

Adverse experiences in childhood and adolescence, defined as subjectively perceived threats to the safety or security of the child's bodily integrity, family, or social structures, are known to be associated with cardiometabolic outcomes over the life course into adulthood. This American Heart Association scientific statement reviews the scientific literature on the influence of childhood adversity on cardiometabolic outcomes that constitute the greatest public health burden in the United States, including obesity, hypertension, type 2 diabetes mellitus, and cardiovascular disease. This statement also conceptually outlines pathways linking adversity to cardiometabolic health, identifies evidence gaps, and provides suggestions for future research to inform practice and policy. We note that, despite a lack of objective agreement on what subjectively qualifies as exposure to childhood adversity and a dearth of prospective studies, substantial evidence documents an association between childhood adversity and cardiometabolic outcomes across the life course. Future studies that focus on mechanisms, resiliency, and vulnerability factors would further strengthen the evidence and provide much-needed information on targets for effective interventions. Given that childhood adversities affect cardiometabolic health and multiple health domains across the life course, interventions that ameliorate these initial upstream exposures may be more appropriate than interventions remediating downstream cardiovascular disease risk factor effects later in life.

Childhood Adversity, Daily Stress, and Marital Strain in Same-Sex and Different-Sex Marriages.

Childhood adversity has enduring consequences for individuals throughout life, including increased reactivity to stress that may contribute to marital strain in adulthood. Past research on gendered experiences of heterosexual spouses raises questions about how the influence of childhood adversity might differ for men and women in same-sex marriages. We analyze dyadic diary data from 756 individuals in 106 male same-sex, 157 female same-sex, and 115 different-sex marriages to consider how childhood adversity moderates the association between daily stress and marital strain. Results suggest that the negative consequences of daily stress for marital strain are amplified by past childhood adversity with variation for men and women in same- and different-sex unions, such that women and those in same-sex marriages may experience some protection from the adverse consequences of childhood adversity.

Examining Perpetration of Physical Violence by Women: The Influence of Childhood Adversity, Victimization, Mental Illness, Substance Abuse, and Anger.

Research on women's perpetration of physical violence has focused primarily on partners, often neglecting perpetration against nonpartners. This study proposes a conceptual model with direct and indirect relationships between childhood adversity and different targets of violence (partners and nonpartners), mediated by victimization experiences (by partner and nonpartners), mental illness, substance abuse, and anger. Using survey data from a random sample of incarcerated women (N = 574), structural equation modeling resulted in significant, albeit different, indirect paths from childhood adversity, through victimization, to perpetration of violence against partners (β = .20) and nonpartners (β = .19). The results indicate that prevention of women's violence requires attention to specific forms of victimization, anger expression, and targets of her aggression.

The Influence of Childhood Adversity on Rural Black Men's Sexual Risk Behavior.

Young Black men living in resource-poor rural environments are disproportionately affected by both adverse childhood experiences and HIV/STIs. The influence of childhood adversity on sexual risk behavior remains to be examined among this vulnerable population. In this study, we investigated the influence of overall adversity as well as three subcomponents, abusive parenting, parental neglect, and witnessing family violence, on men's engagement in sexual risk behavior. We hypothesized that adverse experiences would predict engagement in sexual risk behaviors including multiple sexual partnerships, inconsistent condom use, frequent sexual activity, and concurrent substance abuse and sexual activity. We tested formally the extent to which defensive relational schemas mediated these associations. Hypotheses were tested with data from 505 rural Black men (M age = 20.29, SD = 1.10) participating in the African American Men's Health Project. Participants were recruited using respondent-driven sampling. Self-report data were gathered from participants via audio computer-assisted self-interviews. Bi-factor analyses revealed that, in addition to a common adversity factor, neglect independently predicted sexual risk behavior. Men's defensive relational schemas partially mediated the influence of the common adversity factor as well as the neglect subcomponent on sexual risk behavior. The present research identified a potential risk factor for sexual risk behavior in an understudied and vulnerable population. Adverse childhood experiences in general, and neglect in particular, may place many young Black men at risk for engaging in sexual risk behavior due in part to the influence of these experiences on men's development of relational schemas characterized by defensiveness and mistrust.

120. Influence of childhood adversity and neighborhood violence on inflammatory risk in young urban African American men

Increased risk for cardiovascular disease (CVD) in African American men (AAM) may be rooted in childhood adversity. Altered stress reactivity and low grade inflammation are both risk factors for CVD. Thus, this ongoing project seeks to determine whether childhood adversity and neighborhood violence result in greater inflammatory risk and hypothalamic–pituitary–adrenocortical (HPA) dysregulation during adulthood. AAM, 18–27 years, are being enrolled from disadvantaged urban neighborhoods. Saliva and plasma levels of the proinflammatory cytokine, IL-6, and salivary cortisol are evaluated. Demographically, men were raised in low-income households and report childhood physical abuse and emotional neglect, as well as intense exposure to neighborhood violence. Results revealed that increased childhood emotional neglect was related to increased salivary cortisol levels. In contrast, direct exposure to violence was associated with decreased salivary cortisol, likely reflecting effects of allostatic load on HPA regulation. Elevations in circulating and salivary IL-6 were related to increased childhood emotional abuse and physical neglect, respectively. However, social support buffered the effects of childhood adversity, as it was associated with reduced salivary IL-6 levels. Findings indicate that early life adversity imprints long-lasting effects on stress and inflammatory response systems. Identification of aspects of early life adversity that increase inflammatory risk, as well as identification of protective factors that reduce this risk, can guide approaches that target the early-life environment and improve well-being for those raised under adverse conditions.

The influence of childhood adversity on social relations and mental health at mid-life

Childhood adversity is predictive of affective and anxiety disorders in adulthood, although there are likely to be several mediating factors. Social relations and social networks are potential mediators, and have also been linked to onset and recovery of affective and anxiety disorders in adulthood. This study explored positive and negative aspects of close relationships, their association with mid-life anxiety and affective disorders, and their mediating role in the relationship between childhood adversity and mid-life disorders. Data from the 1958 British birth cohort were analysed using measures of adversity taken during childhood, measurements of social relations at 45 years, and diagnosis of affective and anxiety disorders at 45 years of age (N=9377). Childhood adversity was associated with smaller social network size and higher negative aspects of close relationships. Smaller social network size and negative aspects of close relationships, but not emotional or practical support, were associated with higher odds of having affective or anxiety disorder. However, social relations did not mediate or moderate the pathway between childhood adversity and mid-life affective and anxiety disorders. Social relations and affective and anxiety disorders were measured cross-sectionally so direction of causation cannot be determined. Negative aspects of close relationships and social network size, rather than emotional or practical support, are associated with affective and anxiety disorders. Childhood adversity is related to later social relationships as well as mid-life affective and anxiety disorders.

The Influence of Childhood Adversity on Mothers' Behavior with Preschoolers: Role of Maternal Attachment Coherence, Dissociative Symptoms, and Marital Behaviors

Relations between mothers' experiences of childhood adversities and emotional and task-related support of their preschoolers were examined. Mothers, n = 48, were observed with their children and partners and assessed with the AAI, SCID, DES, and for marital aggression. Early adverse experiences were coded from interviews. AAI coherence mediated the link between adverse events and other variables, and was associated with secure base behaviors with children. Dissociative symptoms and marital aggression were not associated with maternal behavior, but dissociative symptoms were linked to partners' aggression. Results suggest narrative coherence is a key mechanism linking childhood adversity to later relationship variables.

The association between brain-derived neurotrophic factor polymorphism (BDNF Val66Met) and suicide

Background Brain-derived neurotrophic factor (BDNF) mediates neural plasticity, mood, different behaviours, and stress response. A functional BDNF polymorphism (BDNF Val66Met) was reported to influence the effects of stressful life events or childhood adversity on depression and suicidal behaviour in various psychopathologies. The study evaluated the association between BDNF Val66Met variants and suicide, committed with violent or non-violent methods, in victims with or without stressful childhood experience. Methods BDNF Val66Met polymorphism was genotyped on 560 DNA samples from 359 suicide victims and 201 control subjects collected on autopsy from unrelated Caucasian subjects and subdivided according to gender, method of suicide, and influence of childhood adversity. Results A similar frequency of BDNF Val66Met variants was found between all included suicide victims and the control groups, and also between the male groups. The frequency of the combined Met/Met and Met/Val genotypes and the homozygous Val/Val genotype was significantly different between the female suicide victims and female controls, between the female suicide victims who used violent suicide methods and female controls, and between all included suicide victims with or without stressful life events. The combined Met/Met and Met/Val genotypes contributed to this significance. Limitation A small group of suicide victims with available data on childhood adversity was studied. Conclusions The combined Met/Met and Met/Val genotypes of the BDNF Val66Met variant could be the risk factor for violent suicide in female subjects and for suicide in victims exposed to childhood trauma. These results confirm a major role of BDNF in increased vulnerability to suicide.

Does the Influence of Childhood Adversity on Psychopathology Persist Across the Lifecourse? A 45-Year Prospective Epidemiologic Study

Prospective evidence about whether the association of childhood adversity and psychopathology attenuates across the lifecourse and whether effects on mid-life psychopathology are mediated through adolescent and early adulthood psychopathology is limited. Data were from the 1958 British Birth Cohort, a 45-year study of 98% of births in 1 week in 1958 in England, Scotland, and Wales. Outcomes included International Statistical Classification of Diseases (ICD-10) diagnoses for affective and anxiety disorders at 45 years and psychopathology at 16 years and 23 years. Multiple multi-informant measures of childhood adversity were available at 7, 11, and 16 years, with additional retrospective measures of parental sexual and physical abuse at 45 years. Analyses were determined on the basis of N = 9377; 59% of the surviving sample. After adjustment for socioeconomic covariates, childhood adversities were associated with adolescent, early adulthood, and mid-life psychopathology: most associations did not attenuate with age. Mid-life associations were significantly fully or partially mediated by early adulthood psychopathology: cumulative adversity, illness, sexual abuse, and physical abuse remained significantly associated with mid-life psychopathology. The findings confirm the importance of preventing exposure to adversity and suggest that effects of adversity on mid-life psychopathology may operate through psychopathology in early adulthood. Future research is needed to examine other intermediary factors which may explain these associations.

Influence of childhood adversity on health among male UK military personnel

Exposure to childhood adversity may explain why only a minority of combatants exposed to trauma develop psychological problems. To examine the association between self-reported childhood vulnerability and later health outcomes in a large randomly selected male military cohort. Data are derived from the first stage of a cohort study comparing Iraq veterans and non-deployed UK military personnel. We describe data collected by questionnaire from males in the regular UK armed forces (n=7937). Pre-enlistment vulnerability is associated with being single, of lower rank, having low educational attainment and serving in the Army. Pre-enlistment vulnerability is associated with a variety of negative health outcomes. Two main factors emerge as important predictors of ill health: a 'family relationships' factor reflecting the home environment and an 'externalising behaviour' factor reflecting behavioural disturbance. Pre-enlistment vulnerability is an important individual risk factor for ill health in military men. Awareness of such factors is important in understanding post-combat psychiatric disorder.