Influence Of Changes In Level Research Articles

Sustained IL-6 and sTNF-αR1 levels after hip fracture predict 5-year mortality: A prospective cohort study from the Baltimore Hip Studies.

Persistent inflammation is associated with adverse health outcomes, but its impact on mortality has not been investigated previously among hip fracture patients. This article aims to investigate the influence of changes in levels of cytokines in the 2 months after a hip fracture repair on 5-year mortality. This is a prospective cohort study from the Baltimore Hip Studies (BHS) with 191 community-dwelling older men and women (≥65 years) who had recently undergone surgical repair of an acute hip fracture, with recruitment from May 2006 to June 2011. Plasma interleukin-6 (IL-6), soluble tumor necrosis factor alpha receptor1 (sTNFα-R1), and interleukin-1 receptor agonist (IL-1RA) were obtained within 22 days of admission and at 2 months. All-cause mortality over 5 years was determined. Logistic regression analysis tested the associations between the cytokines' trajectories and mortality over 5 years, adjusted for covariates (age, sex, education, body mass index, lower extremity physical activities of daily living, and Charlson comorbidity index). High levels of IL-6 and sTNFα-R1 at baseline with small or no decline at 2 months were associated with higher odds of 5-year mortality compared with those with lower levels at baseline and greater decline at 2 months after adjustment for age, and other potential confounders (OR = 4.71, p = 0.01 for IL-6; OR = 15.03, p = 0.002 for sTNFα-R1). Similar results that failed to reach significance were found for IL-1RA (OR = 2.40, p = 0.18). Those with higher levels of cytokines at baseline with greater decline did not have significantly greater mortality than the reference group, those with lower levels at baseline and greater decline. Persistent elevation of plasma IL-6 and sTNFα-R1 levels within the first 2 months after hospital admission in patients with hip fracture is associated with higher 5-year mortality. These patients may benefit from enhanced care and earlier intensive interventions to reduce the risk of death.

MEASUREMENT OF WATER RETENTION OF PEAT SOIL IN CANAL BLOCKING USING PRESSURE PLATE CHAMBER

Measuring air retention in constructed canal blockage is critical for determining changes in air content after canal blocking. The purpose of this study is to assess the influence of changes in levels on air retention values measured at three depths, namely 0-20 cm, 20-40 cm, and 40-60 cm, at four transect sampling stations created at a distance of 10 m to 260 m from the canal block. Changes in bulk density, porosity, and peat volume affect groundwater. Peat soil samples were collected from burned peatlands, and canal blocks were constructed. A pressure plate chamber was used to assess air retention. The findings of the investigation revealed that the air retention pattern of peat soil at 16 test sample locations was at maximum at PF 0.2 at each depth. At higher pressures (pF 2-4.2), peat groundwater is strongly bonded by peat soil particles. The average bulk density of peat is 0.2 2 and the porosity value is 86.79%. The higher the air content at each pF value has no influence on the porosity and bulk density values. Changes in air content between pF 2.0 and 4.2 lower average peat volume by 7.4%. The size of this value is assumed to be determined by the peat's type, maturity, and decomposition value

Association of plasma omentin-1 level with insulin resistance in chronic kidney disease patients

Introduction The early prediction and prevention of cardiovascular disease risk factors is highly important in chronic kidney disease (CKD) patients. The plasma level of omentin was found to be associated with different disorders such as insulin resistance, diabetes mellitus, obesity, endothelial dysfunction, and atherosclerosis. The aim of the study was to clarify the influence of changes in levels of circulating omentin-1 on insulin resistance in CKD patients with and without type 2 diabetes mellitus. Participants and methods Seventy-eight patients were enrolled in this cross-sectional study: 23 patients with CKD on conservative treatment, 35 patients on maintenance hemodialysis, and 20 healthy volunteers. Serum concentrations of omentin-1 were determined with an enzyme-linked immunosorbent assay kit. Results Significant difference in plasma omentin-1 level was noticed between diabetic patients and nondiabetic patients in both the predialysis group and the hemodialysis (HD) group. There was also a significant difference in plasma omentin-1 level between nondiabetic patients in the predialysis group and the HD group and between diabetic patients in the predialysis group and hemodialysis group. There were significant negative correlation between plasma Omentin-1 level (ng/ml), fasting insulin level (mIU/ml), HOMA-IR and eGFR (ml/min/1.73m 2 ) while significant positive correlation with IL-6 (pg/ml) and hsCRP (mg/l). Conclusion Plasma omentin-1 concentration was higher in CKD patients. In addition, there was an association between omentin-1 and insulin resistance in hemodialysis patients, which may be considered a cardiovascular risk factor in CKD patients.

Haemostatic changes and acquired activated protein C resistance in normal pregnancy

Influence of changes in levels of coagulation factors and anticoagulants on acquired activated protein C (APC) resistance were studied in 40 healthy women during normal pregnancy. Factor VIII (FVIII), von Willebrand factor antigen (VWF:Ag), free protein S (FPS) and protein C were determined at 5-13, 14-26 and 27-40 weeks gestation and more than 6 weeks postpartum. APC anticoagulant activity was determined by measuring the activated partial thromboplastin time before and after adding human APC, expressed as the APC-sensitivity ratio (APC-SR). During the second and third gestation trimesters a significant increase (P < 0.05) in FVIII and VWF:Ag levels and a decrease in FPS levels were seen compared with the first trimester. Postpartum FVIII and VWF:Ag levels significantly decreased and FPS levels increased compared with the third trimester. Protein C levels remained unchanged during pregnancy and postpartum. Between increased FVIII and lowered APC-SR a trend of inverse correlation (r = -0.329; P = 0.076) occurred in the second trimester. No correlation was found between APC-SR and FPS or VWF:Ag levels. A remarkable finding is the strong inverse relationship between APC-SR and protein C levels (r <or= -0.392; P < 0.05) during pregnancy and postpartum. This may indicate that anticoagulant activity of added human APC measured by activated partial thromboplastin time is diminished in the presence of high endogenous protein C levels. A possible hypothesis is steric hindrance by sample protein C of APC binding sites on target activated factor V and/or cofactor protein S. The clinical significance of this finding should be determined because it complicates the interpretation of lowered APC-SR.

Influence of Changes in Level on Passenger Route Choice in Railway Stations

In assessing the design of a public transfer station, it is important to be able to predict the routes taken by passengers. Most simulation tools use simple route choice models that take into account only the shortest walking distance or walking time between a passenger's origin and destination. To improve this type of route choice model, other factors affecting passenger route choice need to be identified. Also, the way these factors influence route choice behavior needs to be determined to indicate how each factor is valued. In this research, route choice data have been collected in two Dutch train stations by following passengers through the facility from their origins to their destinations. These data have been used to estimate extended route choice models. The focus is on the influences of level changes in walking routes on passenger route choice behavior. It appears that ways of bridging level changes (ramps, stairs, escalators) each have a significant and different impact on the attractiveness of a route to a traveler.

Influence of Changes in Level on Passenger Route Choice in Railway Stations

In assessing the design of a public transfer station, it is important to be able to predict the routes taken by passengers. Most simulation tools use simple route choice models that take into account only the shortest walking distance or walking time between a passenger's origin and destination. To improve this type of route choice model, other factors affecting passenger route choice need to be identified. Also, the way these factors influence route choice behavior needs to be determined to indicate how each factor is valued. In this research, route choice data have been collected in two Dutch train stations by following passengers through the facility from their origins to their destinations. These data have been used to estimate extended route choice models. The focus is on the influences of level changes in walking routes on passenger route choice behavior. It appears that ways of bridging level changes (ramps, stairs, escalators) each have a significant and different impact on the attractiveness of a...

Influence of changes in level of feeding on milk production

The influence upon milk production of changes in level of feeding and in proportion of bulky foods has been investigated, using all available experimental material.The experimental results show that increases in level of feeding, to rates well in excess of conventional English standards, are capable of giving substantial increases in milk production (Fig. 1).It is shown that physiological efficiency falls off as food intake is increased. A curve representing physiological efficiency has been constructed by taking account of changes in live weight as well as changes in yield of milk (Fig. 4).