Influence Of Bone Density Research Articles

Influence of bone density on the accuracy of artificial intelligence–guided implant surgery: An in vitro study

Statement of problemArtificial intelligence (AI) has been found to be applicable in medical tests and diagnostics. However, studies on the application of AI technology in oral implantology are lacking. In addition, whether bone density affects the accuracy of guided implant surgery has not been determined. PurposeThe purpose of this in vitro study was to determine the clinical reliability of an AI-assisted implant planning software program with an in vitro model. An additional goal was to determine the effect of bone density on the accuracy of static computer-assisted implant surgery (CAIS). Material and methodsTen participants with missing mandibular left first molars were selected for analysis, and surgical fully guided templates were designed by using an AI implant planning software program. Jaw models were produced in 3 filling rate groups (group L: 25%; group M: 40%; group H: 55%, higher filling rate with representatives of the denser simulated bone density) by 3-dimensional (3D) printing. The preoperative and postoperative positions of the implants were compared by measuring the value of deviation through oral scanning. The mean 3D shoulder and apical and angular deviations were calculated for each group. The data were analyzed using 1-way ANOVA (α=.05 corrected for multiple testing by using Bonferroni-Holm adjustment). ResultsThe mean ±standard deviation 3D shoulder and apical and angular deviations were 0.80 ±0.32 mm, 1.43 ±0.47 mm, and 3.68 ±1.30 degrees. These values were lower than the clinical safety distance of the fully guided implant template. A significantly lower mean 3D apical deviation (1.12 ±0.33 mm, P=.023) and angular deviation (2.81 ±1.11 degrees, P=.018) were observed in group L than in group H (1.68 ±0.37 mm, 4.32 ±0.99 degrees). However, no significant differences were found among the 3 groups in 3D deviation at the shoulder (P>.05). ConclusionsAI implant planning software program could design the ideal implant position through self-learning. The accuracy of the AI-assisted designed implant template in this study indicated its clinical reliability. Higher bone density led to increased implant deviations.

Influence of bone density, drill diameter, drilling speed, and irrigation on temperature changes during implant osteotomies: an in vitro study.

The aim of this in vitro study was to evaluate the influence of bone type, drill diameter, drilling speed, and irrigation on heat generation while performing osteotomy for dental implants. Six polyurethane foam blocks simulating type I (dense) and type IV (soft) bone were selected for the study. Each block was subjected to two different experimental conditions for each drill (2- and 3.5-mm diameter): three sub-groups were created: (a) revolutions per minute (50, 100, or 800rpm) and (b) irrigation (with or without irrigation). In 2-mm drill group, maximum temperature attained was practically identical: 23.73 ± 2.28°C in the cortical bone and 23.74 ± 2.03°C in the cancellous bone. For 3.5-mm, groups showed similar results (25.01 ± 1.88°C for cortical and 24.05 ± 1.94°C for trabecular bone). In any type of bone, the presence of irrigating fluid helped to control the maximum temperature (p =0.001). When comparing the 2-mm and 3.5-mm drills, most differences were found at 100rpm without irrigation (p <0.001) and at 800rpm with irrigation (p =0.001). Maximum temperature attained was always below the critical threshold that can cause osteonecrosis, showing that both external irrigation with higher drilling speeds and no irrigation with lower speeds were effective methods to avoid excessive heat generation. Despite being always below the critical temperature, bone type, drill diameter, drilling speed, and irrigation must be considered temperature-influencing factors during implant osteotomies.

Effect of bone density and cement morphology on biomechanical stability of tibial unicompartmental knee arthroplasty

BackgroundUnicompartmental knee arthroplasty (UKA) offers good long-term survivorship and superior kinematics and function compared with total knee arthroplasty (TKA). However, revision rates are higher with aseptic loosening representing a major cause. Biomechanical stability depends on cement penetration. The goal of this study was to analyze the influence of cement morphology and bone density on primary stability of tibial UKA under physiological loading conditions in human tibiae. MethodsThirty-six tibial trays were implanted in fresh-frozen human cadaver knees and tested for primary stability using dynamic compression–shear testing. Prior to implantation, bone density had been quantified for all 18 tibiae. Postoperatively, cement penetration has been assessed on frontal cuts based on eight predefined parameters. The influence of bone density and cement morphology on biomechanical stability was determined using correlation and linear regression analysis. ResultsMean failure load was 2691 ± 832.9 N, mean total cement thickness was 2.04 ± 0.37 mm, mean cement penetration was 1.54 ± 0.33 mm and mean trabecular bone mineral density (BMD) was 107.1 ± 29.3 mg/ml. There was no significant correlation between failure load and cement morphology (P > .05). Failure load was significantly positive correlated with trabecular BMD (r = 0.843; P < .0001) and cortical BMD (r = 0.432; P = .0136). ConclusionsSimulating physiological loading conditions, the failure load of tibial UKA is linearly dependent on the trabecular BMD. The observed parameters of cementation morphology seem capable of preventing failure at the bone–cement interface before inherent bone stability is reached. Further research is required to assess the usefulness of a preoperative assessment of bone quality for patient selection in UKA.

Influence of bone density on morphologic cement penetration in minimally invasive tibial unicompartmental knee arthroplasty: an in vitro cadaver study

BackgroundUnicompartmental knee arthroplasty is an established treatment option for anteromedial osteoarthritis. However, large registry studies report higher rates of aseptic loosening compared to total knee arthroplasty. The objective of this study was to assess the impact of bone density on morphological cement penetration. Moreover, an alternative regional bone density measuring technique was validated against the established bone mineral density assessment.MethodsComponents were implanted on the medial side of 18 fresh-frozen cadaver knees using a minimally invasive approach. Bone density has been quantified prior to implantation using Hounsfield units and bone mineral density. Morphological cement penetration has been assessed in different areas and was correlated with local bone density.FindingsA highly significant correlation between Hounsfield units and trabecular bone mineral density was detected (r = 0.93; P < 0.0001), and local bone density was significantly increased in the anterior and posterior area (P = 0.0003). The mean cement penetration depth was 1.5 (SD 0.5 mm), and cement intrusion into trabecular bone was interrupted in 31.8% (SD 23.7%) of the bone-cement interface. Bone density was correlated significantly negative with penetration depth (r = − 0.31; P = 0.023) and positive with interruptions of horizontal interdigitating (r = + 0.33; P = 0.014). Cement penetration around the anchoring peg was not significantly correlated with bone density.InterpretationAreas with high bone density were characterized by significantly lower penetration depths and significantly higher areas without cement penetration. Anchoring pegs facilitate cement intrusion mechanically. Regional quantification of bone density using Hounsfield units is a simple but valuable extension to the established determination of bone mineral density.

Comparison of the periimplant bone stress distribution on three fixed partial supported prosthesis designs under different loading. A 3D finite element analysis

ABSTRACTDespite high success and survival rates of implant-supported prosthesis therapy, biomechanical complications such as periimplant bone resorption continue to exist due to occlusal overloading. The purpose of this article is to analyse and compare the influence of bone density, direction and distribution of the occlusal load and the design of three-unit implant-supported prostheses. Three-dimensional finite element analysis study was developed to evaluate the influence on the periimplant bone stress distribution of three different designs of a 3-unit bridge supported by two implants (intermediate pontic, tilted implant, cantilever pontic), two different bone qualities (D3 and D4), and different loading directions (axial and non-axial) and distributions (uniform and non-uniform). Bridge configuration with intermediate pontic and parallel implants presents the lowest periimplant stress, whereas the highest stress was found on the tilted implant bridge. Bone D3 is biomechanically more favourable than D4. Non-axial and uniform loading conditions produce more periimplant stress. Distal cantilever and 45° convergent distal tilted implant are the second and third treatment options on a posterior three-unit rehabilitation. Lightening occlusal contacts on the pontic and avoiding non-axial loading, reduce periimplant bone stress. Bone D4 increases periimplant bone strain.

The influence of bone density and anisotropy in finite element models of distal radius fracture osteosynthesis: Evaluations and comparison to experiments

Continuum-level finite element (FE) models can be used to analyze and improve osteosynthesis procedures for distal radius fractures (DRF) from a biomechanical point of view. However, previous models oversimplified the bone material and lacked thorough experimental validation. The goal of this study was to assess the influence of local bone density and anisotropy in FE models of DRF osteosynthesis for predictions of axial stiffness, implant plate stresses, and screw loads. Experiments and FE analysis were conducted in 25 fresh frozen cadaveric radii with DRFs treated by volar locking plate osteosynthesis. Specimen specific geometries were captured using clinical quantitative CT (QCT) scans of the prepared samples. Local bone material properties were computed based on high resolution CT (HR-pQCT) scans of the intact radii. The axial stiffness and individual screw loads were evaluated in FE models, with (1) orthotropic inhomogeneous (OrthoInhom), (2) isotropic inhomogeneous (IsoInhom), and (3) isotropic homogeneous (IsoHom) bone material and compared to the experimental axial stiffness and screw–plate interface failures. FE simulated and experimental axial stiffness correlated significantly (p<0.0001) for all three model types. The coefficient of determination was similar for OrthoInhom (R2=0.807) and IsoInhom (R2=0.816) models but considerably lower for IsoHom models (R2=0.500). The peak screw loads were in qualitative agreement with experimental screw–plate interface failure. Individual loads and implant plate stresses of IsoHom models differed significantly (p<0.05) from OrthoInhom and IsoInhom models. In conclusion, including local bone density in FE models of DRF osteosynthesis is essential whereas local bone anisotropy hardly effects the models׳ predictive abilities.

Influence of bone density on peri-implant bone strain distribution in an immediately loaded implant

Influence of bone density on peri-implant bone strain distribution in an immediately loaded implant

The influence of bone density on the radiotherapy of cervix cancer

Abstract Until the 1970s the irradiated region of a patient undergoing external beam radiotherapy was considered a homogeneous volume and a regular surface, with physical characteristics similar to water. With the improvement of medical imaging equipment, it has become possible to conduct planning in radiotherapy treatment that considers the heterogeneities and irregularities of a patient's anatomy. Consequently, such technological resources have brought greater accuracy to radiotherapy. In this study, we determined the variation in the average amount of absorbed dose on the target volume and at the point of prescription treatment by comparing the doses which were calculated in a planning system considering the patient both as a homogeneous, and as a heterogeneous medium. The results showed that when we take into account the volume of the upper vagina and cervix, and consider the pelvis as a heterogeneous medium, the calculated dose was under-estimated at some points in the studied volume with respect to the dose when this region was considered homogeneous.

Influence of bone density on the cement fixation of femoral hip resurfacing components

In clinical outcome studies, small component sizes, female gender, femoral shape, focal bone defects, bad bone quality, and biomechanics have been associated with failures of resurfacing arthroplasties. We used a well-established experimental setup and human bone specimens to analyze the effects of bone density on cement fixation of femoral hip resurfacing components. Thirty-one fresh frozen femora were prepared for resurfacing using the original instruments. ASR resurfacing prostheses were implanted after dual-energy X-ray densitometer scans. Real-time measurements of pressure and temperature during implantation, analyses of cement penetration, and measurements of micro motions under torque application were performed. The associations of bone density and measurement data were examined calculating regression lines and multiple correlation coefficients; acceptability was tested with ANOVA. We found significant relations between bone density and micro motion, cement penetration, cement mantle thickness, cement pressure, and interface temperature. Mean bone density of the femora was 0.82 +/- 0.13 g/cm(2), t-score was -0.7 +/- 1.0, and mean micro motion between bone and femoral resurfacing component was 17.5 +/- 9.1 microm/Nm. The regression line between bone density and micro motion was equal to -56.7 x bone density + 63.8, R = 0.815 (p < 0.001). Bone density scans are most helpful for patient selection in hip resurfacing, and a better bone quality leads to higher initial component stability. A sophisticated cementing technique is recommended to avoid vigorous impaction and incomplete seating, since increasing bone density also results in higher cement pressures, lower cement penetration, lower interface temperatures, and thicker cement mantles.

Influence of bone density on total hip resurfacing arthroplasty in patients with osteonecrosis of the femoral head – A radiological analysis

Osteonecrosis of the femoral head is a more progressive disease for which many patients will eventually require total hip arthroplasty. With the advent of improved metal-on-metal prostheses, total hip resurfacing arthroplasty has emerged as a viable treatment option. However, it remains controversial whether this procedure should be used in patients with osteonecrosis when the femoral resurfacing component is implanted onto non-vital bone. In this study the bone mineral density (BMD) of osteonecrotic femoral heads were compared with the BMD of osteoarthrotic femoral heads. The purpose of this study was to analyse the differences between these two groups to gather information that may be useful in predicting the outcome of total hip resurfacing arthroplasty in cases of severe osteonecrosis of the femoral head. The femoral heads were classified according to the ARCO classification using MRI. For DEXA analysis the femoral heads were subdivided into three regions: the cranial femoral head (R1), the caudal femoral head (R2), and the proximal femoral neck (R3). In R3, BMD in osteonecrotic femoral heads was significantly lower than in those with osteoarthrosis and in R2 it was significantly higher. It can be assumed that a higher BMD in the caudal femoral head (R2) is caused by a "reactive interface" that occurred in this region especially in ARCO IV femoral heads. This fact, the lower BMD in the proximal femoral neck (R3) and the individual expansion of the osteonecrotic region should be considered when planning resurfacing arthroplasty for femoral head necrosis.

Load distribution and the predictive power of morphological indices in the distal radius and tibia by high resolution peripheral quantitative computed tomography

A 3D high resolution peripheral quantitative computed tomography scanner (HR-pQCT) (XtremeCT, Scanco Medical, voxel size 82 μm) has been recently developed that can perform in vivo human measurements on peripheral sites, including the wrist and tibia. The goals of this study were to use HR-pQCT measurements to determine the ability of morphological and density measurements to predict bone apparent stiffness and apparent Young's modulus in the distal radius and tibia, to determine the relative importance of cortical and trabecular bone in carrying load in the human distal radius and tibia. Furthermore, the ability of a sub-volume of trabecular bone apparent Young's modulus to predict the Young's modulus of a whole radius and tibia section was determined. A total of 25 measurements of the radius and 12 measurements of the tibia were used for morphological and finite element analyses of sections, and sub-volume cubes of trabecular bone from the distal radius and tibia. The subjects were chosen to obtain a large variation in age ranges and bone architecture and density. By combining multiple measurements, a strong ability to predict bone apparent stiffness and apparent Young's modulus was found for morphological and density measurements in the radius and tibia ( R 2 > 0.80). The relative importance of the trabecular and cortical bone in carrying load was also found to vary consistently with location in the sample for both the radius and the tibia. This indicates that measurements of the cortical and trabecular bone are required for assessing fracture risk. A cubic section of trabecular bone was found to be insufficient to accurately represent the apparent bone Young's modulus of a radius or tibia section. Morphological and density measurements of the distal radius and tibia have been shown in this study to predict bone apparent Young's modulus and apparent stiffness, and may indicate when a more time consuming finite element analysis is warranted. It should be noted that these results may be an overestimation of the predictive ability of structural parameters, as the influence of bone density is removed from the finite element analyses, and the results were only influenced by bone structure. A measurement of bone apparent Young's modulus is independent of subject size (as opposed to reaction force), and may provide the ability to distinguish between two patients that have similar mean morphological and density measurements; but different overall structures, and therefore, different fracture risk.

The Influence of Bone Density on the Osseointegration of Dental Implants Prior to and at Second-Stage Surgery

Laucillo, F; Morris, H F; Ochi, S; Weir, D J; Stoffer, W; Gillette, W; Glasscock, W; Lambert, P Author Information