Nano-delivery system of milk-derived exosomes loaded with Forsythiaside A: Studies on bovine mammary epithelial cells and mastitis induced mice.

Multi-omics analyses reveal a rhamnogalacturonan I (RG-I) from Polygonum aviculare ameliorates nephrolithiasis through regulation of the gut-kidney axis.

The brain encodes and stores information about peripheral inflammation and can directly recapitulate prior inflammatory responses. However, whether individual cytokines activate specific neural circuits to produce distinct physiological responses remains unknown. To address this fundamental question, we mapped brain-wide responses to IL-1β and found prominent engagement of the bed nucleus of the stria terminalis (BNST). Using targeted recombination in active populations, snRNA sequencing, and circuit tracing, we discovered that corticotropin-releasing hormone-expressing BNST neurons encode IL-1β signals. Chemogenetic reactivation of these neurons precisely recapitulates the physiological signatures of IL-1β exposure with increased circulating IL-6 and corticosterone and tachycardia. These responses require a defined BNST→paraventricular nucleus→rostral ventrolateral medulla→β receptor adrenergic signaling pathway. Critically, restraint stress also activates these BNST IL-1β-encoding neurons to generate the same physiological responses. Our findings establish how a single inflammatory mediator uses a precise neural circuit to activate systemic responses and provide mechanistic insight into the neuroimmune interactions underlying stress-related psychiatric and inflammatory diseases.

Anti-oxidant, anti-estrogenic and anti-inflammatory activities of the UHPLC fingerprinted Acacia seyal Delile (Mimosaceae) extracts: possible anticancer modes of action.

Acute inflammation is a complex biological response triggered by various invading agents provoking distinct immune pathways. As inter-strain variability in guinea pigs can influence inflammatory responses, ultimately affecting disease progression, understanding these strain-specific differences can improve the reliability and translational relevance of guinea pig models for studying acute inflammation. In this study, two guinea pig strains, Trik coloured and Dunkin-Hartley albino, were subjected to bacterial endotoxin lipopolysaccharide (LPS) to induce acute systemic inflammation. Specific metabolite alterations in the blood plasma and bronchoalveolar lavage fluid (BALF) were identified using hydrogen-1 nuclear magnetic resonance (¹H NMR) spectroscopy. Distinct differences in the metabolomic profiles in the blood plasma indicated significant inter-strain variability in circulating metabolites during LPS-induced acute inflammation, including those involved in amino acid transamination, ammonia transfer, and immune responses. Metabolomic analysis of BALF from guinea pigs with LPS-induced inflammation revealed decreased levels of specific metabolites. Moreover, changes in blood and BALF white blood cell counts and body weight were evaluated after LPS exposure. In BALF, LPS caused a slight, non-significant increase in total cell count and a significant neutrophil increase in the Dunkin-Hartley strain. In blood, Trik strain showed a significant increase in total count of cells and a significant neutrophil decrease. LPS induced weight loss in both strains, more pronounced in Trik. The study points out strain-specific metabolomic changes in guinea pig LPS model, highlighting the importance of strain selection in inflammation research. While descriptive, these preliminary findings provide a basis for future work to explore inflammatory mechanisms of LPS and improve translation to human disease.

Mechanisms by Which miR-584-5p Regulates Osteogenic Differentiation and Inflammation in Human Dental Pulp Stem Cells.

Chronic effects of traumatic brain injury and the impact of biperiden treatment in a male rat model.

Burkholderia pseudomallei quorum sensing molecule 3-hydroxy-C10 HSL, triggers organelle stress and inflammatory responses in A549 cell line.

Parthenolide ameliorates inflammation in sepsis via covalently targeting Trim33 and inhibiting NF-κB pathway.

Ethyl acetate fraction from Dendrobium officinale inhibits IL-17A signaling pathway to mitigate acute lung injury.

Interval appendicitis.

Nrf2: the key target for antagonizing the toxicity of deoxynivalenol.

Therapeutic application of fecal microbiota transplantation for neurological diseases: Exploring novel mechanisms and perspectives.

IL-24 regulates corneal inflammation and fibrosis in fungal keratitis via the caspase-11/gasdermin D pathway.

α7nAChR inhibits pyroptosis of rheumatoid arthritis synovial fibroblasts via the NLRP3/GSDMD pathway.

Small nucleolar RNA host gene 3 regulates sepsis-induced acute lung injury and inflammation by targeting microRNA-186-5p.

Isodeoxyelephantopin mitigates DSS-induced ulcerative colitis by suppressing IL-1β-driven inflammation via the TXNIP/NLRP3 axis.

Yu Dan Tong Formula inhibits NLRP3 inflammasome activation by suppressing Ca²⁺ influx in treating cholestatic liver disease.

Gualou Huoxue Jiedu Decoction inhibits VSMC phenotypic switching to alleviate atherosclerosis via promoting Mfap4 DNA methylation.

Hyaluronic acid engineered melanin-MOF nanoreactor synergistically remodeling redox and immune homeostasis for targeted acute lung injury therapy.