Introduction: Pancreatic pseudocysts are known complications of acute and chronic pancreatitis. However, subsequent infection of pseudocyst is uncommon. We present a rare case of chronic pancreatitis with pancreatic pseudocyst complicated by a candida infection. Case report: A 42-year old African American female with alcoholic chronic pancreatitis, presented with complaints of abdominal pain, nausea and vomiting over 2 weeks. Computed tomography (CT) scan of abdomen revealed an acute on chronic pancreatitis with a large (91x48 mm) multiloculated pancreatic pseudocyst involving body and tail of the pancreas without signs of necrotizing pancreatitis. Initially she was managed conservatively, she began to spike fevers with worsening abdominal pain. She was therefore started on IV Meropenem but showed no clinical improvement. Given the lack of an endoscopic ultrasound in our institution, she underwent CT guided percutaneous drainage and aspirate cultures grew Candida albicans and antibiotics were switched to IV Fluconazole. Her fevers and poor appetite persisted. Repeat CT abdomen showed no change in the size of her pseudocyst. Subsequently, she again underwent percutaneous drainage; this time, a drainage catheter was left in place, and again, the fluid cultures grew C. albicans. Meropenem was resumed to cover for common pathogens. Despite all this, her condition did not improve. She therefore underwent exploratory laparotomy and several pockets of pus with significant amount of necrotic tissue were found. These pockets were debrided and her abdomen was left open with wound-vac drainage. Meropenem and Fluconazole were continued and underwent several peritoneal washings until eventually her abdomen was closed. She was later discharged with close outpatient follow up. Conclusion: Although most pancreactic pseudocysts are managed expectantly and resolve on their own, 10% of pseudocysts can get infected and carry a high morbidity and mortality. The most common pathogens isolated from pancreatic pseudocysts are bacterial including Escherichia coli, Klebsiella pneumonia, Enterococcus faecalis, Staphylococcus aureus, Pseudomonas aeruginosa, Proteus mirabilis. Isolation of Candida albicans is extremely rare and only a few cases are reported in literature. Aggressive therapy is necessary with surgical drainage and antimicrobials. We suggest a high level of suspicion for Candida infected Pancreatic Pseudocyst for patients with persistent or worsening symptoms.