Abstract: After the application of Moringa oleifera as a herbal agent upon the infected Catfish Clarias batrachus (Linnaeus, 1758) by Fenvalerate and Cypermethrin used as Insecticide and Pesticides shows many Biochemical fluctuations in their Comparative parameters. Fishes were acclimatized with pesticides for 96 hours (4 days) in two different tanks. Concentration of toxic agent Cypermethrin and Fenvalerate was taken as 0.25 µg/l of LC50 ¼ from 20EC stock solution and 25 µg/l of LC50 1/10 respectively which was continued as studies at every 24h of time interval as lethal concentration for acute toxicity. Powder of dried grinded green leaves and pod of herbal agent Moringa oleifera used in ratio of 1:1 proportion respectively taken as 0.125 gm / litre according to the capacity of water per day continued till 120 h of dose acclimatization upon fish infected with both pesticidal agents individually. Haematological changes were observed and compared among Normal, Fenvalerate, Cypermethrin, Fen Mo and Cyp Mo conditions.