Infant Negative Emotionality Research Articles

Association between prenatal maternal sleep quality, neonatal uncinate fasciculus white matter, and infant negative emotionality

Poor prenatal maternal sleep is a pervasive, yet modifiable, health concern affecting maternal and foetal wellbeing. Experimental rodent studies demonstrate that prenatal maternal sleep deprivation affects offspring brain development and leads to adverse outcomes, including increased anxiety-like behaviour. We examined the relation between prenatal maternal sleep quality and neonatal white matter development and subsequent infant negative emotionality. Participants included 116 mother-infant (53% female) dyads. Prenatal sleep quality was prospectively assessed three times during gestation (16, 29, and 35 gestational weeks) using the Pittsburgh Sleep Quality Index. Neonatal white matter, as indexed by fractional anisotropy (FA), was assessed via diffusion weighted magnetic resonance imaging. Negative emotionality was measured via behavioural observation and maternal report when the infant was 6-months of age. More prenatal sleep problems across pregnancy were associated with higher neonatal FA in the uncinate fasciculus (left: b=0.20, p=.004; right: b=0.15, p=.027). Higher neonatal uncinate FA was linked to infant negative emotionality, and uncinate FA partially mediated the association between prenatal maternal sleep and behavioural observation of infant negative emotionality. Findings highlight prenatal sleep as an environmental signal that affects the developing neonatal brain and later infant negative emotionality. National Institutes of Health (R01MH109662, R01HL155744, P50HD103573, K12AR084226, F32 Training fellowships MH125572, HL165844, MH106440, and diversity supplement R01HL155744-01S1).

The role of prenatal depression and infant negative emotionality on maternal mind-mindedness

Mind-mindedness (MM) promotes children’s socio-cognitive skills and attachment, yet relatively less is known about the earliest precursors of MM. This longitudinal study examined the role of prenatal depression, alone and in combination with infant negative emotionality on MM. Turkish mothers completed depression questionnaires in pregnancy and at 9 months postnatally. MM and infant negative emotionality were coded from observational tasks at infant age 12-13 months. A total of 50 dyads (56% boys) participated at all time points. A statistically significant interaction was detected such that prenatal depression predicted less appropriate MM when infants were low in negative emotionality. Yet, this relation was non-significant for distress-prone infants. Findings suggest that MM has its origins in antenatal experiences, moderated by child characteristics, with implications for the relational nature of MM. Findings also have significance for early childhood professionals to facilitate MM among mothers with prenatal depression.

Four hours with dad, but 10 minutes with mom: variations in young children's media use and limits based on parent gender and child temperament

IntroductionResearch on children's media use has disproportionately focused on maternal reports of use. As such, we know little about how mothers' and fathers' reports of children's media use align, how such reports might be related to parental beliefs about the benefits of media for children, or the potential differential impact of child characteristics, such as temperament and gender.MethodUsing a sample of 210 low-to-moderate income, racially and ethnically diverse families, we asked new mothers and fathers about their child's media use and limits at 9, 18 and 24 months of age.ResultsOn average, reports of co-use of media, children's use of media alone, exposure to background television, diversity of daily media use, and use of media for behavior management did not significantly differ between mothers and fathers and were moderately correlated, r(df) = 0.2–0.7. However, comparisons within dyads found that parents did not often agree on their child's media use. Couples also tended to report different limitations on use, with fathers reporting much larger time limits. For both mothers and fathers, stronger beliefs in the benefits of media when children were infants were predictive of more reported media use at 24 months. Infant negative emotionality was predictive of the use of media for behavior management for both mothers and fathers, and for other types of media use for fathers.ConclusionParents of the same child reported media use over the first two years differently, which may indicate informant effects in media research or actual differences in young children's media use with each parent. Given the risks of media use in early childhood to displace important developmental processes, understanding young children's media use within the family system is important.

Interplay between interparental relationship quality and infant temperament predicts toddler transdiagnostic psychopathology.

Although exposure to interparental conflict (IPC) in late childhood and adolescence appears to be a robust risk factor for the development of child psychopathology, less work has examined how very early exposure to IPC poses risk for the development of psychopathology in the first 2 years of life. Further, it is unclear whether IPC is uniquely related to child psychopathology relative to other critical dimensions of the interparental relationship. This study aimed to investigate the unique effects of IPC and low levels of emotional intimacy in the interparental relationship during pregnancy and infancy on toddler psychopathology and whether children with higher negative emotionality during infancy were most vulnerable to these conditions. One hundred fifty-one cohabitating couples completed semistructured interviews and questionnaires once during pregnancy and three times postpartum. Results demonstrated that consistent and sustained interparental emotional intimacy, first observed during pregnancy and persisting throughout infancy, was a unique predictor of toddler psychopathology, controlling for sustained and persistent exposure to IPC. The negative association between emotional intimacy and toddler general psychopathology was stronger at higher levels of infant negative emotionality. Results highlight the importance of early exposure to a warm, affectionate interparental relationship for healthy child socioemotional development. These findings have potential for informing early prevention and intervention efforts, including prenatal programs, aimed at reducing psychopathology across the lifespan. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

The indirect impact of infant negative emotionality on interparental conflict via perceptions of coparenting challenges: What prenatal resources mitigate this risk?

AbstractResearch clearly demonstrates that conflictual interparental relationship dynamics can create a family context that contributes to child emotional insecurity and psychopathology. Significantly less research has examined familial factors that contribute to maladaptive conflict between parents. Scholars have alluded to the disruptive impacts of parenting a child with certain temperamental characteristics (e.g., negative emotionality). Yet, there is a lack of empirical research examining if and how child temperament contributes to later interparental conflict. Using an established multi‐informant, multi‐method sample of 150 families first assessed during pregnancy, and again when the child was 1, 2, and 3.5 years of age, the present study aimed to test an integrated conceptual model examining whether infants' negative emotionality assessed at age 1 predicts interparental conflict at age 3.5, as mediated through destructive coparenting dynamics in toddlerhood, and identifying prenatal protective factors mitigating this maladaptive pathway. Findings suggest that greater infant negative emotionality predicts worse interparental conflict management during preschool age by undermining the mother's (but not the father's) report of coparenting relationship quality during toddlerhood. However, these results were significant only to the extent that parents were lacking certain prenatal regulatory resources (i.e., low paternal self‐compassion; less secure relationship between parents). Importantly, results point to the need for intervention and prevention efforts during pregnancy that might disrupt the deleterious impacts of parenting a child who is more reactive and prone to expressing negative emotions.

Early Infant Prefrontal Cortical Microstructure Predicts Present and Future Emotionality

BackgroundHigh levels of infant negative emotionality (NE) and low positive emotionality (PE) predict future emotional and behavioral problems. The prefrontal cortex (PFC) supports emotional regulation, with each PFC subregion specializing in specific emotional processes. Neurite orientation dispersion and density imaging estimates microstructural integrity and myelination via the neurite density index (NDI) and dispersion via the orientation dispersion index (ODI), with potential to more accurately evaluate microstructural alterations in the developing brain. Yet, no study has used these indices to examine associations between PFC microstructure and concurrent or developing infant emotionality. MethodsWe modeled PFC subregional NDI and ODI at 3 months with caregiver-reported infant NE and PE at 3 months (n = 61) and at 9 months (n = 50), using multivariable and subsequent bivariate regression models. ResultsThe most robust statistically significant findings were positive associations among 3-month rostral anterior cingulate cortex (ACC) ODI and caudal ACC NDI and concurrent NE, a positive association between 3-month lateral orbitofrontal cortex ODI and prospective NE, and a negative association between 3-month dorsolateral PFC ODI and concurrent PE. Multivariate models also revealed that other PFC subregional microstructure measures, as well as infant and caregiver sociodemographic and clinical factors, predicted infant 3- and 9-month NE and PE. ConclusionsGreater NDI and ODI, reflecting greater microstructural complexity, in PFC regions supporting salience perception (rostral ACC), decision making (lateral orbitofrontal cortex), action selection (caudal ACC), and attentional processes (dorsolateral PFC) might result in greater integration of these subregions with other neural networks and greater attention to salient negative external cues, thus higher NE and/or lower PE. These findings provide potential infant cortical markers of future psychopathology risk.

Poor sleep quality during pregnancy predicts neonatal white matter integrity and subsequent negative emotionality in infancy

Poor sleep quality during pregnancy predicts neonatal white matter integrity and subsequent negative emotionality in infancy

COVID-19 pandemic effects: Examining prenatal internalizing symptoms and infant temperament.

For pregnant women, the COVID-19 pandemic has resulted in unprecedented stressors, including uncertainty regarding prenatal care and the long-term consequences of perinatal infection. However, few studies have examined the role of this adverse event on maternal wellbeing and infant socioemotional development following the initial wave of the pandemic when less stringent public health restrictions were in place. The current study addressed these gaps in the literature by first comparing prenatal internalizing symptoms and infant temperament collected after the first wave of the pandemic to equivalent measures in a pre-pandemic sample. Second, associations between prenatal pandemic-related stress and infant temperament were examined. Women who were pregnant during the COVID-19 pandemic endorsed higher pregnancy-specific anxiety relative to the pre-pandemic sample. They also reported greater infant negative emotionality and lower positive affectivity and regulatory capacity at 2months postpartum. Prenatal infection stress directly predicted infant negative affect. Both prenatal infection and preparedness stress were indirectly related to infant negative emotionality through depression symptoms during pregnancy and at 2months postpartum. These results have implications for prenatal mental health screening procedures during the pandemic and the development of early intervention programs for infants born to mothers during this adverse event.

Online peer-delivered group cognitive-behavioral therapy for postpartum depression: A randomized controlled trial.

Postpartum depression (PPD) affects up to one in five mothers and birthing parents, yet just 10% receive evidence-based care. This randomized controlled trial aimed to determine if a synchronous online 9-week group cognitive-behavioral therapy (CBT) intervention delivered by mothers who have recovered from postpartum depression (i.e., peers) could effectively improve PPD and its comorbidities. Participants (n = 183) in this study lived in Ontario, Canada, were ≥18 years-old, had an infant <12 months, were fluent in English, and scored ≥10 on the Edinburgh Postnatal Depression Scale (EPDS). They were randomized to experimental (received intervention plus treatment as usual (TAU)) or waitlist control (TAU plus the intervention after a 9-week wait) groups. Depression, anxiety, social support, mother-infant bonding, and infant temperament were assessed at baseline and 9 weeks later. Outcomes were assessed in the experimental group 3 months post-intervention to assess stability. Statistically significant reductions were observed in EPDS (B = 5.99; p < 0.001; d = 1.32) and Generalized Anxiety Disorder Questionnaire-7 scores (B = 5.94; p < 0.001; d = 1.22), improvements that remained stable 3 months post-intervention in the experimental group. Maternal social support (p = 0.02; d = 0.40), infant-focused anxiety (p = 0.02; d = 0.54), and infant negative emotionality (p < 0.01; d = 0.23) also improved post-intervention and remained stable 3 months later. Online peer-delivered group CBT for PPD can effectively treat PPD and anxiety, and improve social support, infant-focused anxiety, and negative emotionality in infants. This intervention could provide the means to increase access to treatment for those experiencing PPD and improve outcomes for mothers, birthing parents, and families.

Examining transactional associations between maternal internalizing symptoms, infant negative emotionality, and infant respiratory sinus arrhythmia

The current study examined transactional associations between maternal internalizing symptoms, infant negative emotionality, and infant resting respiratory sinus arrhythmia (RSA). We used data from the Longitudinal Attention and Temperament Study (N = 217) to examine the associations between maternal internalizing symptoms, infant negative emotionality, and infant resting RSA from 4-months to 18-months using a random-intercepts cross-lagged panel model. We found that mothers with higher average internalizing symptoms have infants with higher levels of resting RSA. However, there were no stable, between-individual differences in infant negative emotionality across time. Additionally, we found significant negative within-dyad cross-lagged associations from maternal internalizing symptoms to subsequent measures of infant negative emotionality, as well as a significant negative cross-lagged association from maternal internalizing symptoms to child resting RSA after 12-months of age. Lastly, we find evidence for infant-directed effects of negative emotionality and resting RSA to maternal internalizing symptoms. Results highlight the complex, bidirectional associations in maternal-infant dyads during the first two years of life, and the importance of considering the co-development of infant reactivity and regulatory processes in the context of maternal internalizing symptoms.

The longitudinal association between infant negative emotionality, childhood maltreatment, and ADHD symptoms: A secondary analysis of data from the Fragile Families and Child Wellbeing Study.

Infant temperament predicts harsh parenting, and attention deficit/ hyperactivity disorder (ADHD) symptoms. Moreover, childhood maltreatment has consistently been associated with later ADHD symptoms. We hypothesized that infant negative emotionality predicted both ADHD symptoms and maltreatment, and that there was a bidirectional association between maltreatment experiences and ADHD symptoms. The study used secondary data from the longitudinal Fragile Families and Child Wellbeing Study (N = 2860). A structural equation model was conducted, using maximum likelihood with robust standard errors. Infant negative emotionality acted as a predictor. Outcome variables were childhood maltreatment and ADHD symptoms at ages 5 and 9. The model demonstrated good fit (root-mean-square error of approximation = .02, comparative fit index = .99, Tucker-Lewis index = .96). Infant negative emotionality positively predicted childhood maltreatment at ages 5 and 9, and ADHD symptoms at age 5. Age 5 maltreatment/ADHD symptoms predicted age 9 ADHD symptoms/maltreatment. Additionally, both childhood maltreatment and ADHD symptoms at age 5 mediated the association between negative emotionality and childhood maltreatment/ADHD symptoms at age 9. Given the bidirectional relationship between ADHD and experiences of maltreatment, it is vital to identify early shared risk factors to prevent negative downstream effects and support families at risk. Our study showed that infant negative emotionality, poses one of these risk factors.

0098 Prenatal Maternal Sleep Quality Predicts Neonatal White Matter Microstructure and Infant Negative Emotionality

Abstract Introduction Poor prenatal sleep health is a pervasive reproductive health concern that informs the health of the mother and fetal development. Despite the almost ubiquitous nature of sleep disturbances across pregnancy, sleep health within pregnant populations, and its effects on the next generation, remain poorly studied. We recently showed that prenatal maternal sleep quality predicts newborn hippocampal volume. However, the relation between prenatal sleep quality and neonatal neural circuit development remains unknown. Changes in neonatal white matter microstructure presage compromised socioemotional and cognitive health, including the development of psychopathology and neurocognitive disorders, making it a plausible neurobiological pathway linking prenatal maternal sleep and offspring socioemotional health. This study first examined the relations between trajectories of prenatal maternal sleep quality and subsequent neonatal white matter integrity. We next evaluated whether neonatal white matter integrity partially mediates associations between prenatal sleep and infant negative emotionality. Methods Pregnant participants (n = 116) provided prospective and longitudinal data of prenatal maternal sleep quality at 16, 29, and 35 gestational weeks using the Pittsburgh Sleep Quality Index. Neonatal (53% female) white matter integrity was assessed via diffusion weighed images using magnetic resonance imaging (MRI). Infant negative emotionality was collected at 6 postpartum months using the Infant Behavior Questionnaire. Results Trajectories of prenatal maternal sleep quality predicted higher bilateral neonatal fractional anisotropy (FA) in the uncinate fasciculus (e.g., right: b = 0.15, p = .023). Further, higher uncinate FA predicted more infant negative emotionality (e.g., right: b = 0.25, p = .011) and uncinate FA partially mediated the association between prenatal maternal sleep and infant negative emotionality (right: indirect effect = 0.014, CI = [.0001, .0323], p &amp;lt; .05). Associations remained after covarying for infant postconceptional age at MRI, motion in MRI scan, sex, and income-to-needs ratio. Conclusion These findings highlight prenatal maternal sleep health as a prenatal signal with intergenerational connections to offspring neurobiology and negative emotionality, both of which have been previously implicated in the development of psychopathology. Pregnancy is a sensitive period in which interventions may inform the health of two generations. Support (if any) NIMH R01MH109662, NHLBI R01HL155744, and diversity training supplement for 1st author; F32MH125572 for 2nd author.

Early infant prefrontal gray matter volume is associated with concurrent and future infant emotionality

High levels of infant negative emotionality (NE) are associated with emotional and behavioral problems later in childhood. Identifying neural markers of high NE as well as low positive emotionality (PE) in infancy can provide neural markers to aid early identification of vulnerability, and inform interventions to help delay or even prevent psychiatric disorders before the manifestation of symptoms. Prefrontal cortical (PFC) subregions support the regulation of NE and PE, with each PFC subregion differentially specializing in distinct emotional regulation processes. Gray matter (GM) volume measures show good test-retest reliability, and thus have potential use as neural markers of NE and PE. Yet, while studies showed PFC GM structural abnormalities in adolescents and young adults with affective disorders, few studies examined how PFC subregional GM measures are associated with NE and PE in infancy. We aimed to identify relationships among GM in prefrontal cortical subregions at 3 months and caregiver report of infant NE and PE, covarying for infant age and gender and caregiver sociodemographic and clinical variables, in two independent samples at 3 months (Primary: n = 75; Replication sample: n = 40) and at 9 months (Primary: n = 44; Replication sample: n = 40). In the primary sample, greater 3-month medial superior frontal cortical volume was associated with higher infant 3-month NE (p < 0.05); greater 3-month ventrolateral prefrontal cortical volume predicted lower infant 9-month PE (p < 0.05), even after controlling for 3-month NE and PE. GM volume in other PFC subregions also predicted infant 3- and 9-month NE and PE, together with infant demographic factors, caregiver age, and/or caregiver affective instability and anxiety. These findings were replicated in the independent sample. To our knowledge, this is the first study to determine in primary and replication samples associations among infant PFC GM volumes and concurrent and prospective NE and PE, and identify promising, early markers of future psychopathology risk.

Transactional associations between infant negative emotionality and maternal sensitivity: Maternal emotion dysregulation as a moderator.

The relations between maternal sensitivity and infant negative emotionality have been tested extensively in the previous literature. However, the extent to which these associations reflect unidirectional or bidirectional effects over time remains somewhat uncertain. Further, the possibility that maternal characteristics moderate the extent to which infant negative emotionality predicts maternal sensitivity over time has yet to be tested in cross-lag models. The goal of the present study is to address these gaps. First time mothers (N = 259; 50% White; 50% Black) and their infants participated when infants were 6, 14, and 26 months of age. Infant negative emotionality was assessed via maternal report and direct observation during standardized laboratory tasks, which were subsequently combined to yield a multimethod measure at each wave. Maternal sensitivity was observationally coded at each wave and mothers self-reported emotion dysregulation at 6 and 14 months. A random intercepts cross-lagged model with maternal emotion dysregulation specified as a moderator revealed that infant negative emotionality at 6 months was negatively associated with maternal sensitivity at 14 months, but only among mothers higher in emotion dysregulation. Higher maternal sensitivity was in turn associated with lower infant negative emotionality when infants were 26 months of age. The indirect pathway was significant, lending support for the transactional model. Implications for future research and prevention/intervention are discussed. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Parental Pre and Postnatal Depression: The Longitudinal Associations with Child Negative Affectivity and Dysfunctional Mother-Child Feeding Interactions.

Many studies have shown the influence of maternal perinatal depression on a child's emotional and behavioral regulation ability; yet there is scarce research on the impact of the father's perinatal depression on the caregiver-infant relationship and the child's development. Through a longitudinal study, we investigated maternal and paternal depression and its association with infants' emotionality and mother-infant feeding interactions The sample was constituted of 136 first-time parents (68 couples, and their full-term babies at 3 and 6 months old). At T1 (28th week of pregnancy), T2 (three months old), and T3 (at six months age) parents responded to the Edinburgh Postpartum Depression Scale. At Times 2 and 3, mothers and fathers completed the Infant Behavior Questionnaire, and recorded mother-infant interactions were coded by means of the Feeding Scale. Statistical analyses indicated stability of maternal and paternal depression over time. Correlations emerged between mother's higher depression scores, negative affective state during interactions at three months age, infant food refusal and mother-infant interactional conflict at six months age. Paternal higher depressive scores were associated with the mother-child interactional conflict. To finish, higher parental depression scores were related with infant negative emotionality. The current study confirms the relevance of embracing a cumulative risk model to support the child's development with early caregiver-child interventions.

Neural Network Functional Interactions Mediate or Suppress White Matter–Emotional Behavior Relationships in Infants

BackgroundElucidating the neural basis of infant positive emotionality and negative emotionality can identify biomarkers of pathophysiological risk. Our goal was to determine how functional interactions among large-scale networks supporting emotional regulation influence white matter (WM) microstructural–emotional behavior relationships in 3-month-old infants. We hypothesized that microstructural–emotional behavior relationships would be differentially mediated or suppressed by underlying resting-state functional connectivity (rsFC), particularly between default mode network and central executive network structures. MethodsThe analytic sample comprised primary caregiver–infant dyads (52 infants [42% female, mean age at scan = 15.10 weeks]), with infant neuroimaging and emotional behavior assessments conducted at 3 months. Infant WM and rsFC were assessed by diffusion-weighted imaging/tractography and resting-state magnetic resonance imaging during natural, nonsedated sleep. The Infant Behavior Questionnaire-Revised provided measures of infant positive emotionality and negative emotionality. ResultsAfter significant WM–emotional behavior relationships were observed, multimodal analyses were performed using whole-brain voxelwise mediation. Results revealed that greater cingulum bundle volume was significantly associated with lower infant positive emotionality (β = −0.263, p = .031); however, a pattern of lower rsFC between central executive network and default mode network structures suppressed this otherwise negative relationship. Greater uncinate fasciculus volume was significantly associated with lower infant negative emotionality (β = −0.296, p = .022); however, lower orbitofrontal cortex–amygdala rsFC suppressed this otherwise negative relationship, while greater orbitofrontal cortex–central executive network rsFC mediated this relationship. ConclusionsFunctional interactions among neural networks have an important influence on WM microstructural–emotional behavior relationships in infancy. These relationships can elucidate neural mechanisms that contribute to future behavioral and emotional problems in childhood.

Sex-dimorphic pathways in the associations between maternal trait anxiety, infant BDNF methylation, and negative emotionality.

Maternal antenatal anxiety is an emerging risk factor for child emotional development. Both sex and epigenetic mechanisms, such as DNA methylation, may contribute to the embedding of maternal distress into emotional outcomes. Here, we investigated sex-dependent patterns in the association between antenatal maternal trait anxiety, methylation of the brain-derived neurotrophic factor gene (BDNF DNAm), and infant negative emotionality (NE). Mother-infant dyads (N = 276) were recruited at delivery. Maternal trait anxiety, as a marker of antenatal chronic stress exposure, was assessed soon after delivery using the Stait-Trait Anxiety Inventory (STAI-Y). Infants' BDNF DNAm at birth was assessed in 11 CpG sites in buccal cells whereas infants' NE was assessed at 3 (N = 225) and 6 months (N = 189) using the Infant Behavior Questionnaire-Revised (IBQ-R). Hierarchical linear analyses showed that higher maternal antenatal anxiety was associated with greater 6-month-olds' NE. Furthermore, maternal antenatal anxiety predicted greater infants' BDNF DNAm in five CpG sites in males but not in females. Higher methylation at these sites was associated with greater 3-to-6-month NE increase, independently of infants' sex. Maternal antenatal anxiety emerged as a risk factor for infant's NE. BDNF DNAm might mediate this effect in males. These results may inform the development of strategies to promote mothers and infants' emotional well-being.

Maternal adverse childhood experiences and infant subcortical brain volume

BackgroundA large body of research supports the deleterious effects of adverse childhood experiences (ACEs) on disease susceptibility and health for both the exposed individual and the next generation. It is likely that there is an intergenerational transmission of risk from mother to child; however, the mechanisms through which such risk is conferred remain unknown. The current study evaluated the association between maternal ACEs, neonatal brain development of the amygdala and hippocampus, and later infant negative emotionality at six months of age. MethodsThe sample included 85 mother-infant dyads (44 female infants) from a longitudinal study. Maternal ACEs were assessed with the Adverse Childhood Experiences Questionnaire (ACE-Q) and neonatal hippocampal and amygdala volume was assessed using structural magnetic resonance imaging (MRI). Infant negative emotionality was assessed at 6 months using the Infant Behavior Questionnaire (IBQ). ResultsMultivariate analyses demonstrated that maternal ACEs were associated with bilateral amygdala volume (F(2,78) = 3.697,p = .029). Specifically, higher maternal ACEs were associated with smaller left (β = -0.220, t(79) = -2.661, p = .009, R2= 0.494, and right (β = −0.167, t(79) = -2.043, p = .044, R2= 0.501) amygdala volume. No significant association between maternal ACEs and bilateral hippocampal volume (F(2,78) = 0.215,p = .0807) was found. Follow-up regression analyses demonstrated that both high maternal ACEs and smaller left amygdala volume were associated with higher infant negative emotionality at six months of age (β = .232, p = .040, R2= 0.094, and β = −0.337, p = .022, R2= 0.16, respectively) although statistically significant mediation of this effect was not observed (Indirect effect = 0.0187, 95% CI [-0.0016-0.0557]). ConclusionsMaternal ACEs are associated with both newborn amygdala volume and subsequent infant negative emotionality. These findings linking maternal adverse childhood experiences and infant brain development and temperament provide evidence to support the intergenerational transmission of adversity from mother to child.

A randomized wait-list controlled trial to investigate the role of cognitive mechanisms in parenting interventions on mothers with substance use disorder

BackgroundMaternal substance use disorder (SUD) represents a risk condition for quality of parenting and child development. The current literature highlights the need to identify interventions that effectively enhance the quality of parenting and to better understand which mechanisms are involved in the process of change. The present study protocol describes a randomized wait-list controlled trial that aims to examine (1) the efficacy of the Video-feedback Intervention to promote Positive Parenting and Sensitive Discipline (VIPP-SD) in improving the quality of parenting (i.e., sensitive parenting and sensitive discipline) in mothers with SUD, (2) whether the intervention affects parental cognitive mechanisms (i.e., attentional disengagement to infant negative emotions, inhibitory control confronted with children’s affective expression, and parental reflective functioning), and (3) whether changes in these processes act as mechanisms of change, mediating the effect of the VIPP-SD program on quality of parenting. Moreover, the study aims (4) to explore whether the VIPP-SD has an effect on parenting stress and (5) to compare mothers with SUD to low-risk mothers on the outcome measures.MethodsThe study will involve 40 mothers with SUD and 20 low-risk mothers of children aged between 14 months and 6 years old. Mothers in the SUD group will be randomly divided into two groups, one receiving the intervention (SUD experimental group) and one undergoing treatment as usual (SUD control group). All the mothers will be assessed pre-test and post-test. Quality of parenting will be assessed through observed parenting behaviors, whereas parental cognitive mechanisms will be assessed through neuropsychological tasks and self-report measures.DiscussionThe results of the study will reveal whether an intervention that has been proven effective in other at-risk samples is also effective in improving parenting behaviors in the context of SUD. The results will also provide insight into potential cognitive mechanisms involved in the process of change.Trial registrationISRCTN registry ISRCTN63070968. Registered on 25 June 2021. Retrospectively registered

Maternal Mental Health Symptom Profiles and Infant Sleep: A Cross-Sectional Survey.

The distinct influence of different, but comorbid, maternal mental health (MMH) difficulties (postpartum depression, anxiety, childbirth-related posttraumatic stress disorder) on infant sleep is unknown, although associations between MMH and infant sleep were reported. This cross-sectional survey aimed: (1) to examine associations between MMH symptoms and infant sleep; (2) to extract data-driven maternal MMH symptom profiles from MMH symptoms; and (3) to investigate the distinct influence of these MMH symptom profiles on infant sleep when including mediators and moderators. Mothers of 3–12-month-old infants (n = 410) completed standardized questionnaires on infant sleep, maternal perception of infant negative emotionality, and MMH symptoms. Data was analyzed using: (1) simple linear regressions; (2) factor analysis; and (3) structural equation modelling. MMH symptoms were all negatively associated with nocturnal sleep duration and only postpartum depression and anxiety symptoms were associated with night waking. Three MMH symptom profiles were extracted: depressive, anxious, and birth trauma profiles. Maternal perception of infant negative emotionality mediated the associations between the depressive or anxious profiles and infant sleep but only for particular infant ages or maternal education levels. The birth trauma profile was not associated with infant sleep. The relationships between MMH and infant sleep may involve distinct mechanisms contingent on maternal symptomatology.