Design standards across the world use different parameters to quantify degree of torsional irregularity of buildings. Popular among such descriptors are the normalized static eccentricity ratio, torsional radius to mass radius of gyration ratio, maximum to minimum (or average) elastic floor displacement ratio, etc. However prior research, particularly on idealized single storey systems have indicated that these parameters do not correlate well with the seismic demands at all stages of structural behaviour (i.e. elastic and inelastic). The present study aims to identify a robust torsional irregularity index that captures the susceptibility of a structure to torsional effects at all ground motion intensity levels. To this end, the correlation between the maximum interstorey drift demands and popular torsional irregularity descriptors is first examined under different intensities of ground shaking using an approach that integrates multiple stripe analysis and statistical regression analysis. The numerical study is based on the nonlinear seismic assessment of thirteen three-storey gravity designed RC moment frame buildings subjected to bidirectional seismic excitation. The results indicate that none of the scalar indices considered correlate well with the drift demands at all intensities of ground shaking. A vector comprising of the normalized static eccentricity ratio and the torsional radius to mass radius of gyration ratio is found to perform well at low shaking intensity levels, where the structure responds in an elastic manner. However, at high intensity levels where the structure undergoes significant excursions into the inelastic range of behaviour, the strength eccentricity is observed to be a better descriptor of torsional irregularity. A three-element vector comprising of the above indices is found to capture the maximum interstorey drifts accurately at all ground motion intensity levels. A seismic demand model for maximum interstorey drift, sensitive to the above torsional irregularity descriptors, is also defined.