In this study, energetic, exergetic, economic and environmental (4E) assessment of a micro-cogeneration system implemented in a multi-family building with 137 flats in Konya is conducted. Although industrial CHP applications are prevalent in Turkey, the first residential use is reported and thoroughly analysed in this communication. Thermodynamic analyses showed that the micro-CHP system was capable of reaching 87% of cycle efficiency with 70 kWe of electrical and 115 kWt of thermal power, respectively. Moreover, II. Law analysis revealed inefficiencies across the system such that the high temperature heat exchanger had the lowest exergy efficiency of 63.7% which is the part requiring improvement. The economic analyses showed that the system could generate $22.10/month of economic return per flat and the payback period was found to be 5.48 years. Lastly, environmental analysis indicated that how environmentally friendly the CHP system is and argued that the system has prevented more CO2 emissions in winter than summer due to operating at full capacity. The findings support the potential and elucidate the specific conclusion for the practice of residential CHP applications in Turkey.