Due to Industry 4.0 (I4.0), the Industrial and Systems Engineering (ISE) undergraduate programs are changing; likewise, the complexity in organizations is increasing. Moreover, international competition, rising market volatility, and the demand for highly customized products are challenging enterprises. Against this scenario, the ISE educational programs should develop creative ways to quickly adequate new requirements. Beyond using advanced technologies, a discussion about the evolution and development of new competences in the ISE field is opened. Thus, this work analyzes the I4.0 impact on the ISE professionals’ desired skills by performing a literature review analysis and developing a cross-reference with the ISE skills. As a result, possible curricular innovations are identified to endeavor the current needs of the profession, and a new “ISE Education 4.0” framework is proposed, which includes five main pillars providing an overview of the new courses, strategies, and components driving the I4.0 education for ISE curricula.
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