Indoor Environmental Exposures Research Articles

Household fuel use, smoking and prevalence of self-reported allergic rhinitis in university students in Palestine: a cross-sectional study.

In Palestine, few studies investigated the prevalence of allergies and the factors associated with their occurrence. An online survey was conducted on health complex University students in Jerusalem to determine the prevalence of allergy rhinitis (AR) and its relationship with indoor environmental exposures. This study employed a modified online Google form of the Global Asthma Network's Adult Questionnaire. The data were reported as frequency and percentage. The chi-square test of independence was performed to investigate the association between AR diagnosis and other factors. Multivariable models were used to identify the independent risk factors for AR after adjusting for potential confounders. Data was collected from a total of 819 participants. The mean age of the participants was 20 ± 2 years and 78.1% (n = 640) were females. The AR diagnostic rate was 10.3%. In addition, having asthma and eczema were found to be substantially associated with AR. Additionally, a family history of AR and other allergens were major predictors of AR. The findings revealed that utilizing animal dung for heating increased the likelihood of AR fourfold (AOR = 4.870, p-value = 0.004), whereas e-cigarette vaping increased the possibility of AR by 2.5 times. However, using natural gas for cooking was not significantly associated with AR, and participant age was only slightly associated with AR diagnosis. Our study found that the AR prevalence rate is low when compared to the same population in other countries. Genetics, biomass fuel consumption, and e-smoking are all significant risk factors for AR in Palestine. An awareness campaign must be developed to educate university students and the general public about the risks of smoking, indoor air pollution, respiratory disorders, and AR. Longitudinal research is required to discover whether these associations are only transient.

The impact of residential winter HVAC usage behavior on arthritis in older adults: A PLS-SEM analysis

Environmental factors like temperature and humidity have been shown to influence arthritis symptoms in older adults, and HVAC equipment can regulate indoor environmental parameters. This study aimed to explore the pathways and effectiveness of residential HVAC usage behavior during winter on arthritis conditions. Conducted across four major climate zones in China, this cross-sectional study involved 3579 older adults aged 60–74 years and collected data on demographics, residential environments, lifestyles, and health outcomes. Utilizing Partial Least Squares - Structural Equation Modeling (PLS-SEM), a complex structural equation model (SEM) and an HVAC-Health mediation model was developed to analyze the relationships among influencing factors and health outcomes. Results revealed that socio-economic status, building characteristics, lifestyles, HVAC usage behavior, and indoor environmental exposure significantly affect the frequency of arthritis flare-ups (p < 0.05). Specifically, lifestyles, indoor wet and cold exposures have strong direct effects on health outcomes, with path coefficients of 0.178, 0.155 and 0.143, respectively. Moreover, HVAC usage indirectly influences health through mediators, with cold exposure (β = 0.045, p < 0.001), air pollution (β = 0.025, p < 0.001), and wet exposure (β = 0.012, p = 0.001) ranked in terms of their mediating effects. This research underscores the crucial role of HVAC systems in mitigating arthritis symptoms in older adults, advocating for enhanced implementation of HVAC technologies in senior housing to promote health and well-being. The originality of this study lies in employing the PLS-SEM method to elucidate how the indoor environment—particularly under the premise of HVAC usage—affect arthritis symptoms in older adults.

Indoor environmental quality assessment in passively ventilated classrooms in Germany and estimation of ventilation energy losses

In this field study we present an approach for the comprehensive and room-specific assessment of parameters with the overall aim to realize energy-efficient provision of hygienically harmless and thermally comfortable indoor environmental quality in naturally ventilated non-residential buildings. The approach is based on (i) conformity assessment of room design parameters, (ii) empirical determination of theoretically expected occupant-specific supply air flow rates and corresponding air exchange rates, (iii) experimental determination of real occupant-specific supply air flow rates and corresponding air exchange rates, (iv) measurement of indoor environmental exposure conditions of T, RH, cCO2, cPM2.5 and cTVOC, and (v) determination of real energy demands for the prevailing ventilation scheme. Underlying assessment criteria comprise the indoor environmental parameters of category II of EN 16798-1: Temperature T = 20 °C–24 °C, and relative humidity RH = 25 %–60 % as well as the guide values of the German Federal Environment Agency for cCO2cPM2.5 and cTVOC of 1000 ppm, 15 μg m−3, and 1 mg m−3, respectively.Investigation objects are six naturally ventilated classrooms of a German secondary school. Major factors influencing indoor environmental quality in these classrooms are the specific room volume per occupant and the window opening area. It is concluded that the rigorous implementation of ventilation recommendations laid down by the German Federal Environment Agency is ineffective with respect to anticipated indoor environmental parameters and inefficient with respect to ventilation energy losses on the order of about 10 kWh m−2 a−1 to 30 kWh m−2 a−1.

Parental stress interaction with environmental factors in childhood allergic asthma: Early life significance

Although stress and indoor/outdoor environments have been independently linked with asthma, their interactions on childhood physician-diagnosed allergic asthma (PDAA) remain undisclosed. We aimed to research the effect of parental stress and their interactions with indoor/outdoor environmental factors on childhood PDAA. A retrospective cohort study was undertaken of preschoolers at Changsha, a city in central China. We collected information on parental stress levels and various indoor environmental exposures, through questionnaire surveys. Outdoor air pollution exposure was obtained from ten ambient pollution monitoring stations in Changsha, and individual pollution exposure were calculated. Using logistic regression models, we assessed the individual and synergistic impacts of parental stress and indoor/outdoor factors on childhood PDAA. We found that preschoolers' PDAA showed a significant association with high parental gross annual income and psychological stress indicators including fatigue, headache, and inattention, with ORs = 2.10 (1.31–3.35), 1.38 (1.04–1.82), 1.33 (1.07–1.65), and 1.42 (1.14–1.76), respectively. Furthermore, in preschoolers with high parental economic stress, the association between indoor mold/moisture spots and PDAA was notably more pronounced. Significantly stronger association between outdoor SO2 exposure in the past year in preschoolers with socially stressed parents. Parental headache and inattention exacerbated the effects of PM2.5-10 and PM10 exposure during the 7-9th months before pregnancy and throughout the pregnancy on PDAA. Preschoolers with high parental psychological stress and high exposure to outdoor atmospheric pollutants showed an increased likelihood of developing PDAA. Our research suggests that both parental stress and its interaction with hazardous environments from indoor sources and atmospheric pollutants contribute to PDAA.

Phthalates on indoor surfaces and associated exposure via surface touch behavior: Observation in university dormitories and its implications

Phthalates are typical emerging indoor pollutants and ubiquitously distributed in the indoor air, settled dust and on surfaces. Phthalates have the potential to be transported by human hands through surface touch behaviors. Although the contribution of subsequent exposure via hand-to-mouth contact in real indoor environments has not been thoroughly characterized, it is an important factor to consider. In this study, six commonly-used phthalates (dimethyl phthalate (DMP), diethyl phthalate (DEP), di-n-butyl phthalate (DnBP), butyl benzyl phthalate (BBzP), di-2-ethylhexyl phthalate (DEHP), and di-n-octyl phthalate (DOP)) were measured in surface wipes, air and dust samples collected from university dormitories. Video-cameras were used to monitor occupants’ real surface touch behaviors. Primary surfaces being touched included desks, cellphones, keyboards and computer mice, with averaged touch frequencies ranging from 10.4 h−1 to 25.4 h−1. Phthalate levels on computer mice were the highest, with DEHP being present as the most predominant compound (mean: 2621 μg/m2). Exposures via inhalation, dust ingestion, dermal absorption and hand-to-mouth contact were further estimated using Monte-Carlo simulations. The results suggest that the exposure resulting from surface touching and subsequent hand-mouthing could contribute 35 %–55 % to total exposure for targeted phthalates, which were generally higher than intakes via dust ingestion. This study provides a better understanding of phthalate transfer through surface touch behavior, and highlights the significance of hand-to-mouth contact exposure in indoor environments.

Association of 1-bromopropane exposure with asthma prevalence: A Korean National health and Nutritional examination survey (2020–2021)-based study

Exposure to 1-bromopropane (1-BP) is an emerging environmental and health concern due to its increasing environmental prevalence. Although the health effects of 1-BP exposure have been under-recognized, current evidence suggests the possibility of adverse pulmonary health effects due to 1-BP exposure. However, the association between 1-BP exposure and asthma prevalence remains unclear. Thus, we aimed to examine the association between 1-BP exposure and asthma prevalence in the general population. Using nationally representative data, we explored the potential impacts of indoor air quality (IAQ)-related behavioral factors on the level of 1-BP exposure. This study included 1506 adults from the 2020–2021 Korea National Health and Nutrition Examination Survey. The prevalence of asthma was based on self-reported physician-diagnosed asthma. Urinary N-acetyl-S-(n-propyl)-L-cysteine (BPMA) levels were measured as a biomarker of 1-BP exposure, using high-performance liquid chromatography-mass spectrometry. Multiple logistic regression models were performed to investigate the associations between urinary BPMA metabolite and asthma prevalence after adjusting for potential confounders. Log-linear multiple regression models were used to examine the association between IAQ-related behavior and urinary BPMA concentration. Forty-seven individuals with asthma and 1459 without asthma were included. Individuals in the highest quartile of urinary BPMA concentration had a 2.9 times higher risk of asthma than those in the lowest quartile (odds ratio [OR]: 2.85, 95% confidence interval [CI]: 1.02–7.98). The combination of natural and mechanical ventilation was associated with a reduced urinary BPMA concentration. Our findings suggest that 1-BP exposure is associated with the prevalence of asthma in adults and revealed higher urinary levels of BPMA in our study population compared to those in other countries. Given the emerging importance of IAQ, actively managing and modifying behavioral patterns to reduce 1-BP exposure in indoor environments could substantially attenuate the risk of asthma-related to 1-BP exposure.

Children's exposure to halogenated flame retardants and organophosphate esters through dermal absorption and hand-to-mouth ingestion in Swedish preschools

Children are exposed to endocrine disrupting chemicals (EDCs) through inhalation and ingestion, as well as through dermal contact in their everyday indoor environments. The dermal loadings of EDCs may contribute significantly to children's total EDC exposure due to dermal absorption as well as hand-to-mouth behaviors. The aim of this study was to measure potential EDCs, specifically halogenated flame retardants (HFRs) and organophosphate esters (OPEs), on children's hands during preschool attendance and to assess possible determinants of exposure in preschool indoor environments in Sweden. For this, 115 handwipe samples were collected in winter and spring from 60 participating children (arithmetic mean age 4.5 years, standard deviation 1.0) and analyzed for 50 compounds. Out of these, 31 compounds were identified in the majority of samples. Levels were generally several orders of magnitude higher for OPEs than HFRs, and 2-ethylhexyl diphenyl phosphate (EHDPP) and tris(2-butoxyethyl) phosphate (TBOEP) were detected in the highest median masses, 61 and 56 ng/wipe, respectively. Of the HFRs, bis(2-ethyl-1-hexyl)-2,3,4,5-tetrabromobenzoate (BEH-TEBP) and 2,2′,3,3′,4,4′,5,5′,6,6′-decabromodiphenyl ether (BDE-209) were detected in the highest median masses, 2.8 and 1.8 ng/wipe, respectively.HFR and/or OPE levels were found to be affected by the number of plastic toys, and electrical and electronic devices, season, municipality, as well as building and/or renovation before/after 2004. Yet, the calculated health risks for single compounds were below available reference dose values for exposure through dermal uptake as well as for ingestion using mean hand-to-mouth contact rate. However, assuming a high hand-to-mouth contact rate, at the 95th percentile, the calculated hazard quotient was above 1 for the maximum handwipe mass of TBOEP found in this study, suggesting a risk of negative health effects. Furthermore, considering additive effects from similar compounds, the results of this study indicate potential concern if additional exposure from other routes is as high.

A spatial analysis of ozone and PM2.5 distribution for assessing design factors of healthy buildings

Indoor air quality (IAQ) represents one of the significant challenges in healthy building design, with thermal comfort and daylighting being primary design objectives. This study aims to demonstrate the potential of energy-independent building infrastructure as a passive design solution to mitigate the impact of outdoor air pollution. This paper presents experimental and numerical investigations to establish the relationship between design factors (e.g., building orientation, geometry, and window opening location) and the spatial distribution of ozone and fine particulate matter (PM2.5) in residential houses. Our case study involves experimentally validated computational fluid dynamics (CFD) simulations for typical rowhouse archetypes in one of the United States' most polluted cities. Our findings indicate that higher ozone levels are observed on upper floors, posing a significant exposure risk at a breathing zone height of 1.7 m. In contrast, PM2.5 levels are most concerning at a height of 1 m, directly impacting children's health. Alarmingly, future trends of ozone pollution suggest that these risks could be almost three times higher compared to current conditions. Given the distinctive diurnal patterns of outdoor air pollution, the study also finds that the strategic placement of windows for nighttime air flushing, specifically in the upper two-thirds of the building, can improve IAQ. Our analysis of the spatial placement of the air purifier reveals that the optimal location is at the middle center of the windward wall. Our work underscores the potential of building design features in mitigating pollution exposure in indoor environments, emphasizing the importance of architectural solutions in public health.

Inhibition of Pseudomonas aeruginosa biofilm formation on copper-based thin foils.

The development of Healthcare-Associated Infections (HAIs) represents an increasing threat to patient health. In this context, Pseudomonas aeruginosa is responsible for various HAIs, determining about 20% of the infections in hospitalized patients, which makes it one of the most effective pathogens due to its strong ability to form biofilms. Using Cu-based materials as foils on high-touch surfaces can help to prevent and mitigate P. aeruginosa contamination in biohazardous settings. However, the antibiofilm properties of Cu-based surfaces against P. aeruginosa may vary due to frequent touches combined with indoor environmental exposure. The main aim of this study is to investigate the impact of accelerated ageing, mimicking a high-touch frequency by cyclic exposure to artificial sweat solution as well as to temperature and relative humidity variations, on the efficacy of Cu-based thin foils against P. aeruginosa biofilms. Three Cu-based materials (rolled and annealed Phosphorous High-Conductivity (PHC) Cu, Cu15Zn brass, and Cu18Ni20Zn nickel silver) were evaluated. The ageing process enhanced the antibiofilm properties, due to an increment in Cu ion release: aged PHC Cu and Cu15Zn exhibited the highest Cu ion release and hence the highest biofilm inhibition (decrease in colony forming unit (CFU)) in comparison to their pristine counterpart, while aged Cu18Ni20Zn displayed the lowest biofilm formation reduction, despite showing the highest aesthetic and morphological stability. The Cu-based surface, which highlited the highest biofilm formation inhibition due to accelerated ageing, was Cu15Zn.

Formation kinetics of SVOC organic films and their impact on child exposure in indoor environments

We conducted an SVOC mass transfer and child-exposure modeling analysis considering the combined sorption of multiple SVOCs containing DnBP, BBP, DEHP, DINP and DINCH in indoor environments. A mechanistic model was applied to describe the organic film formation, and a partition-coefficient-prediction model was originally developed for the realistic organic films. The characteristics of film formation on impermeable surfaces were examined based on three different assumptions: the widely-used constant Kns,im assumption, Koa assumption, and the proposed Kom assumption (predicted specifically for the realistic organic films in this study). After long-term SVOC sorption, the organic film reached increasing equilibrium gradually under constant Kns,im assumption. While under Koa and Kom assumption, organic films exhibited nearly linear increases on surfaces, the trends of which agreed well with field studies. However, the film thicknesses calculated under Kom assumption with larger film partition coefficients were approximately twice larger than those under Koa assumption. Meanwhile, Horizontal surfaces with higher deposition rates of particle-phase SVOCs exhibited larger velocities of film growth compared to vertical surfaces. Under the Kom assumption, exposures of hazardous SVOCs for a 3-year-old child increased by 87.5 %–198.7 % even with the weekly cleaning of indoor impermeable surfaces, carpet and cloth. This study is anticipated to provide valuable insights into the film-forming characteristics of multiple SVOCs and the accompanying significant health risks to human beings in indoor environments.

Participant-collected household dust for assessing microorganisms and semi-volatile organic compounds in urban homes

Dust samples collected by researchers and study participants from 43 U.S. urban homes were analyzed and compared to evaluate the feasibility of using participant-collected samples to assess indoor environmental exposures. The microbial and chemical composition of participant-collected (and shipped) samples were compared to researcher-collected samples from the same household, using dust recovered from each home's heating, ventilation, and air conditioning (HVAC) filter. The bacterial and fungal communities present in all dust samples were determined via MiSeq 16S and ITS sequencing, and the concentrations of 27 semi-volatile organic compounds (7 orthophosphates, 6 phthalates, and 14 brominated flame retardants) were determined via GC–MS. Self-report data on the home environment was collected via an online survey of study participants. While the researcher-collected samples (RCS) yielded greater mass than the participant-collected samples (PCS), the alpha and beta diversities of the bacterial and fungal communities recovered in the RCS and PCS were not significantly different, indicating that PCS is a viable option for indoor microbiome studies of residential homes. The microbial communities recovered in both cases reflected the dominance of human-associated bacterial taxa and outdoor-associated fungal taxa with similar pathogen-associated taxa present in each sample type. In both PCS and RCS, the amount of carpet in the home and the frequency of bleach use had a significant effect on the composition of fungal communities. Semi-volatile organic compounds (SVOCs) of potential human health concern, were commonly detected in the homes. Organophosphates and phthalates were recovered at a similar frequency in both PCS and RCS. Measured SVOC concentration levels were consistent with previous indoor studies although differences were observed between PCS and RCS for several SVOCs. This study demonstrates the potential and challenges associated with participant-collected dust samples for indoor environment studies.

Indoor Environmental Exposures and Their Relationship to Allergic Diseases

Indoor Environmental Exposures and Their Relationship to Allergic Diseases

Indoor Environmental Exposures and Their Relationship to Allergic Diseases.

Cockroach, dust mite, cat, dog, mouse, and molds are major indoor allergens that have been associated with the development of allergic diseases and disease morbidity in allergen-sensitized individuals. Physical characteristics, such as allergen particle size, hydrophobicity, and charge, can determine an allergen's propensity to become airborne, location of respiratory tract penetration, and ability to elicit IgE responses in genetically predisposed individuals. Standardization and recent advancements in indoor allergen assessment serve to identify sources and distribution of allergens in a patient's home and public environment, inform public policy, and monitor the efficacy of allergen avoidance and therapeutics. Allergen exposure interventions have yielded mixed results with current US and international asthma guidelines differing on recommendations. A pragmatic, patient-centered approach to allergen avoidance includes: (1) tailoring intervention to the patient's sensitization and exposure status, (2) using a rigorous multifaceted intervention strategy to reduce allergen exposure as much as possible, and (3) beginning the intervention as soon as the patient is diagnosed. Further research into the risks/benefits of early allergen exposure, rapid and affordable in-home allergen assessment, and best practices for environmental control measures for asthma is needed.

Real-Time Measurements of Indoor-Outdoor Exchange of Gaseous and Particulate Atmospheric Pollutants in an Urban Area.

Air pollution is one of the greatest environmental risks to health, causing millions of deaths and deleterious health effects worldwide, especially in urban areas where citizens are exposed to high ambient levels of pollutants, also influencing indoor air quality (IAQ). Many sources of indoor air are fairly obvious and well known, but the contribution of outside sources to indoor air still leads to significant uncertainties, in particular the influence that environmental variables have on outdoor/indoor pollutant exchange mechanisms. This is a critical aspect to consider in IAQ studies. In this respect, an experimental study was performed at a public site such as a university classroom during a non-academic period in Madrid city. This includes two field campaigns, in summer (2021) and winter (2020), where instruments for measuring gases and particle air pollutants simultaneously measured outdoor and indoor real-time concentrations. This study aimed to investigate the dynamic variations in the indoor/outdoor (I/O) ratios in terms of ambient outdoor conditions (meteorology, turbulence and air quality) and indoor features (human presence or natural ventilation). The results show that the I/O ratio is pollutant-dependent. In this sense, the infiltration capacity is higher for gaseous compounds, and in the case of particles, it depends on the particle size, with a higher infiltration capacity for smaller particles (<PM2.5). Additionally, under specific situations of high atmospheric stability, the concentrations of gases derived from traffic tend to accumulate in the room, keeping the background concentrations. These concentrations decreased when room ventilation was produced simultaneously with well-ventilated (high wind speed) external conditions. This suggests that the meteorology and turbulence parameters played a key role in influencing indoor ambient pollution conditions by enhancing the dispersion or accumulation of pollutants. The obtained results highlight the high number of variables involved in the outdoor/indoor exchange of air pollutants and, consequently, how complex its study is. Thus, the knowledge of these factors is critical for understanding the behavior of indoor pollutants and controlling human exposure in indoor environments.

Comparison between estimation and measurement of inhalation exposure to active substances for disinfection workers

As disinfection has been strongly recommended to prevent coronavirus disease 2019 (COVID-19) infection, potential health risks from exposure to active substances in disinfectants for disinfection workers have increased. Estimated exposure of disinfection workers to active substances using the exposure algorithm may differ from actual exposure in indoor environments. Therefore, it is necessary to compare and validate the actual exposure of disinfection workers to active substances through measurement. The target active substances were quaternary ammonium compounds (QACs), benzalkonium chloride (BKC), and isopropyl alcohol (IPA), which are commonly used in Korea. The measured personal exposure concentration of disinfection workers simulated by the researcher for QACs in the indoor environment was 0.10 ± 0.05 mg/m3, which was approximately twice lower than the estimated concentration using exposure algorithm (0.22 ± 0.02 mg/m3). The measured BKC personal exposure concentration was six times lower than the estimated exposure. Whereas the measured IPA personal exposure concentration was 11 times higher than the estimated exposure. From the risk assessment conducted, QACs had a potential health risk, whereas BKC and IPA did not. Evaluating the exposure to active substances using the exposure algorithm could be over or under-estimated depending on the physicochemical properties of the active substance such as vapor pressure and volatility. Therefore, risk assessment for disinfection workers using exposure algorithms could be inaccurate. Although risk assessment using an exposure algorithm has been widely used to manage the exposure and health risks of general population as well as disinfection workers, validation and supplementation through measurement are required for efficient risk assessment.

Molecular Characteristics, Sources, and Health Risk Assessment of Gaseous Carbonyl Compounds in Residential Indoor and Outdoor Environments in a Megacity of Northwest China

Carbonyl compounds (CCs) in indoor air pose a significant threat to residents’ health and have garnered considerable attention in recent years. However, most studies have focused on low-molecular-weight carbonyl compounds (LMW-CCs) and have underestimated the impact of high-molecular-weight ones (HMW-CCs), causing a failure to comprehensively understand their effects on health. In this study, we analyzed twenty carbonyls in the indoor and outdoor air at typical residential communities in a megacity in Northwest China by using high-performance liquid chromatography (HPLC) coupled with a photodiode array detector (DAD). The total concentration of indoor carbonyls was 1.4-3.4 times that of outdoor carbonyls. In addition, the concentration of indoor carbonyls was much higher during the heating season than that during the nonheating season. Conversely, the concentration of outdoor carbonyls was higher during the nonheating season than that during the heating season. The principal component analysis (PCA) revealed that indoor carbonyl pollution was primarily influenced by building materials, cooking fume, and wooden furniture. Formaldehyde exposure in indoor environments posed a greater health risk to children than acetaldehyde exposure. HMW-CCs were the primary contributors to indoor odor pollution, which was considered a significant cause of sick building syndrome (SBS). Our findings underscore the crucial role of HMW-CCs in indoor environments in exerting adverse impacts on health.

Quantifying the reduction of airborne infectious viral load using a ventilated patient hood

Healthcare workers treating SARS-CoV-2 patients are at risk of infection by respiratory exposure to patient-emitted, virus-laden aerosols. Source control devices such as ventilated patient isolation hoods have been shown to limit the dissemination of non-infectious airborne particles in laboratory tests, but data on their performance in mitigating the airborne transmission risk of infectious viruses are lacking. We used an infectious airborne virus to quantify the ability of a ventilated hood to reduce infectious virus exposure in indoor environments. We nebulized 109 plaque forming units (pfu) of bacteriophage PhiX174 virus into a ∼30-m3 room when the hood was active or inactive. The airborne concentration of infectious virus was measured by BioSpot-VIVAS and settle plates using plaque assay quantification on the bacterial host Escherichia coli C. The airborne particle number concentration (PNC) was also monitored continuously using an optical particle sizer. The median airborne viral concentration in the room reached 1.41× 105pfu/m3 with the hood inactive. When active, the hood reduced infectious virus concentration in air samples by 374-fold. The deposition of infectious virus on the surface of settle plates was reduced by 87-fold. This was associated with a 109-fold reduction in total airborne particle number escape rate. A personal ventilation hood significantly reduced airborne particle escape, considerably lowering infectious virus contamination in an indoor environment. Our findings support the further development of source control devices to mitigate nosocomial infection risk among healthcare workers exposed to airborne viruses in clinical settings.

Coupled mass and heat transfer modelling in building envelopes to consistently assess human exposure and energy performance in indoor environments

We develop a numerical model coupling heat and chemical transfers in the building envelope to predict human exposure to pollutants and heating load as affected by changes in temperature and building design. We characterize the effect of temperature variation by season and location on chemical emission dynamics from building materials and the resulting human exposure. Peak concentrations of organics are sensitive to temperatures, and increasing indoor temperature by 10°C doubles the maximum indoor air concentration reached by both VOCs and SVOCs contained in a vinyl flooring. SVOCs mean concentration over the flooring lifetime increases by a factor of 2, and, as a result, the fraction of chemical taken in by the occupants increases by 50%. Occupants’ exposure to SVOCs emission in the city of Lille is likely to increase by 20% in 2050 because of temperature increase induced by climate change.

Socioeconomic determinants of asthma health.

The current review provides an assessment of the recent pediatric literature evaluating socioeconomic drivers of asthma incidence and morbidity. The review addresses the specific social determinants of health related to housing, indoor and outdoor environmental exposures, healthcare access and quality, and the impact of systematic racism. Many social risk factors are associated with adverse asthma outcomes. Children living in low-income, urban neighborhoods have greater exposure to both indoor and outdoor hazards, including molds, mice, second-hand smoke, chemicals, and air pollutants, all of which are associated with adverse asthma outcomes. Providing asthma education in the community - via telehealth, school-based health centers, or peer mentors - are all effective methods for improving medication adherence and asthma outcomes. The racially segregated neighborhoods created by the racist 'redlining' policies implemented decades ago, persist today as hotspots of poverty, poor housing conditions, and adverse asthma outcomes. Routine screening for social determinants of health in clinical settings is important to identify the social risk factors of pediatric patients with asthma. Interventions targeting social risk factors can improve pediatric asthma outcomes, but more studies are needed related to social risk interventions.

A review on aero-allergen induced allergy in India.

Allergic diseases such as bronchial asthma, rhinitis and eczema are an important public health issue globally in 21st century. Their prevalence and impact in India is high, in terms of total numbers of people affected. Due to diverse climate and lifestyle, the Indian population is exposed to a rich and varied range of aerobiological particles. In the last two decades in India, 83 pollens, 34 fungi, six dust mite and 19 insect species were reported as allergenic, often contributing to heavy allergenic exposure in indoor and outdoor environments. There are currently few practitioners who offer allergy diagnosis and treatment in India, but there is active basic and molecular research aiming to improve the health of allergic patients. This review explores the field of aero-allergy in India during the last two decades, with special emphasis on prevalence across various centres and relevant scientific advances such as genetic associations and new therapeutics. This review will be helpful for clinicians to select aero-allergens for sensitisation testing in patients suffering from symptoms in different regions of India, and to support patients undertaking prophylaxis of allergic symptoms in India according to local environmental conditions. This study also helps to define patient selection for allergy testing and the role of test results in guiding allergic disease management in the Indian context. Finally, we summarize genetic findings relevant to aero-allergy in India and discuss the development of novel therapeutics for investigation and management of aero-allergy in India.