Abstract Background The adverse health effects from exposure to air pollution is increasingly known. A recent report shows that at least 95% of the world’s population breathe air containing dangerous levels of pollutants. According to estimates from the World Health Organization (WHO), ambient air pollution is related to 4.2 million deaths every year. Less is known about the association between indoor air (especially particulate matter 2.5 and volatile organic compounds (VOC) pollution and mental health conditions. Many sources of indoor air pollution exist, such as pressed wood products, pesticides, secondhand smoke, stoves, heaters, overcrowding and fireplaces. Aims We aim to synthesize knowledge on the effects of particulate matter 2.5 in indoor air and mental health conditions. Methods We systematically reviewed the association of indoor air pollution with mental health conditions using the databases Pubmed and EMBASE. Results Exposure to indoor air pollutants is associated with increased anxiety and depression and less cognitive performance. These results are robust; however, the impact of PM2.5 is larger for less-educated and female respondents. Females cook with solid fuels and biomass more often. Physical exposure and gender factors overlap in the exposure to indoor air pollutants. Discussion Poor indoor air quality should be part of a comprehensive assessment of factors influencing mental health and cognition. Neuroinflammation might explain the effects of poor air on mental health and cognition. Further research is needed to combine research on the social determinants of mental health and the effects of indoor air. Studies in different settings such as home, work, and hospitals are needed to better understand the specific exposures of indoor air pollution and mental health conditions in different population groups.