Individuals Of Chinese Ethnicity Research Articles

Acceptability of COVID-19 booster vaccine in malaysia: a cross-sectional study

Despite the high efficacy and safety demonstrated in clinical trials, COVID-19 booster vaccination rates in Malaysia remain below 50% among the general public. This study explores the factors influencing public acceptance of the COVID-19 booster vaccine among the Malaysian population. The questionnaire included variables on sociodemographics, knowledge, and the Health Belief Model (HBM) constructs. Based on the Chi-squared test of contingencies, a t-test and multivariate logistic regression analysis on 411 collected responses, the findings revealed that older participants, individuals of Chinese ethnicity, and those with higher education levels and incomes were more willing to accept booster vaccinations. The analysis further identified perceived susceptibility, perceived severity and perceived barriers as significant predictors influencing booster vaccination acceptance rates. Healthcare policymakers may consider targeting interventions to diminish the obstacles associated with booster vaccinations. These intervention strategies include implementing health intervention programmes, such as public health awareness initiatives, to raise awareness of the risks and severity of COVID-19, ultimately encouraging higher uptake of booster vaccines.

Effect of myopia and astigmatism deepening on the corneal biomechanical parameter stress-strain index in individuals of Chinese ethnicity.

Purpose: To investigate the differences in corneal biomechanical parameter stress-strain index (SSI) among different degrees of myopic eyes in Chinese individuals and to analyze the relevant factors of the SSI. Methods: This study analyzed the right eyes of 240 participants (240 eyes) aged 18-34years. The participants were divided into low-, moderate-, high-, and ultra-high myopia groups according to their spherical equivalent (SE), with 60 eyes included in each group. Spherical, cylinder, and SE were measured via automatically integrated optometry. Intraocular pressure (IOP) was measured using a non-contact tonometer. AL was measured using an IOLMaster device. Corneal curvature and central corneal thickness (CCT) were measured using a Pentacam. SSI and biomechanical corrected IOP (bIOP) were measured via corneal visualization Scheimpflug technology (Corvis ST). The statistical analyses included one-sample Kolmogorov-Smirnov tests and normal distribution histogram methods, Levene variance homogeneity tests, Pearson's correlation analyses, multiple linear stepwise regression analyses, one-way ANOVA, and LSD t-tests. Results: The mean (±SD) age of the 240 participants was (24.97 ± 4.16) years. The SSI was positively correlated with spherical, cylinder, SE, CCT, IOP, and bIOP and negatively correlated with K1 and AL (r = 0.475, 0.371, 0.497, 0.169, 0.291, 0.144, -0.154, and -0.464, respectively; all p < 0.05), but were not correlated with age, K2, or Km (all p > 0.05). Multiple linear regression analysis performed with SSI as the dependent variable, and spherical, cylinder, K1, CCT, and IOP as independent variables produced the following regression equation: SSI = 0.989 + 0.017 spherical + 0.042 cylinder +0.018 IOP (R 2 = 0.402, F = 31.518, p < 0.001). The SSI values in the low-, moderate-, high-, and ultra-high myopia groups were 0.945 ± 0.135, 0.940 ± 0.128, 0.874 ± 0.110, and 0.771 ± 0.104, respectively. The values decreased sequentially, and the differences between pairs were statistically significant (all p < 0.05), except for that between the low- and moderate-myopia groups (p > 0.05). Conclusion: SSI decreased with increasing myopia and astigmatism in the Chinese participants. The SSI was significantly lower in high and ultra-high myopia, especially ultra-high myopia. These findings indicate that increased corneal elasticity may be related to the pathogenesis of high and ultra-high myopia.

Chinese and South Asian ethnicity, immigration status and head and neck cancer outcomes: A population based study.

While it is known that certain ethnic and immigrant groups are at increased risk of developing head and neck cancer, the individual effects of immigration status and ethnicity on head and neck cancer outcomes is less clear. We sought examine the independent effects of immigration and Chinese and South Asian ethnicity on overall survival in a head and neck cancer patient population. This was a population-based retrospective matched cohort study using linked Ontario administrative databases between 1994 and 2017. Incident cancer cases were captured in long-standing residents of Chinese and South Asian ethnicity, Chinese and South Asian immigrants, as well as a reference population. Subjects were followed until death. A hard-matching approach was used to adjust for key differences and ensure both groups were balanced with respect to age, sex and cancer site. Cox proportional hazard models were used to estimate the impact of Chinese and South Asian ethnicity on overall survival while further adjusting for baseline covariates. Among 1639 immigrants with head and neck cancer, matched to 3278 controls, the overall 5-year survival rate was 66% and 59%, respectively. After adjusting for between group-differences, all-cause mortality was lower for immigrants (HR 0.76[95%CI 0.69-0.83]) and individuals of Chinese ethnicity (HR 0.78[95%CI 0.68-0.90]), relative to the general population. In Ontario, immigrants experience lower mortality rates following a head and neck cancer diagnosis. Individuals of Chinese ethnicity with head and neck cancer experience a survival advantage, relative to South Asian individuals and the general population.

Development of duplex-crossed allele-specific PCR targeting of TPMT*3B and *3C using crossed allele-specific blockers to eliminate non-specific amplification

Prospective testing for variants in the thiopurine S-methyltransferase (TPMT) is considered a key process in the development of thiopurine therapy. This testing is done to avoid toxicity and side effects in the management of diverse immunological and malignant conditions. Real-time fluorescent PCR techniques using duplex-crossed allele-specific primers in a single tube (DCAS-PCR) were developed in this study to genotype the common loss-of-function TPMT*3B c.460G > A (rs1800460) and TPMT*3C c.719A > G (rs1142345) usually occurring in individuals of Chinese ethnicity. In this method, several integrated strategies were used to completely eliminate the non-specific amplification that is commonly presented in traditional allele-specific (AS) PCR. These strategies include using AS-primers (ASP) that both are artificially mismatched in the penultimate positions and phosphorothioate modifications in the 5′-termini positions. In the assay, an AS-blocker was used, locus-specific TaqMan (LST) probes were used and we used at least two fragments were simultaneously amplified in a single tube which satisfy the thermodynamic characteristics of DNA polymerase to eliminate non-specific amplification. In a group of 200 unselected subjects, the results showed that 8 samples were heterozygous of TPMT*3C, and all samples possessed wild-type TPMT*3B. There was no non-specific amplification, and the genotypes were 100% consistent with Sanger sequencing.

Incidence and mortality rates of colorectal cancer in Malaysia.

OBJECTIVESThis is the first study that estimates the incidence and mortality rate for colorectal cancer (CRC) patients in Malaysia by sex and ethnicity.METHODSThe 4,501 patients were selected from National Cancer Patient Registry-Colorectal Cancer data. Patient survival status was cross-checked with the National Registration Department. The age-standardised rate (ASR) was calculated as the proportion of CRC cases (incidence) and deaths (mortality) from 2008 to 2013, weighted by the age structure of the population, as determined by the Department of Statistics Malaysia and the World Health Organization world standard population distribution.RESULTSThe overall incidence rate for CRC was 21.32 cases per 100,000. Those of Chinese ethnicity had the highest CRC incidence (27.35), followed by the Malay (18.95), and Indian (17.55) ethnicities. The ASR incidence rate of CRC was 1.33 times higher among males than females (24.16 and 18.14 per 100,000, respectively). The 2011 (44.7%) CRC deaths were recorded. The overall ASR of mortality was 9.79 cases, with 11.85 among the Chinese, followed by 9.56 among the Malays and 7.08 among the Indians. The ASR of mortality was 1.42 times higher among males (11.46) than females (8.05).CONCLUSIONSCRC incidence and mortality is higher in males than females. Individuals of Chinese ethnicity have the highest incidence of CRC, followed by the Malay and Indian ethnicities. The same trends were observed for the age-standardised mortality rate.

Is human cytomegalovirus infection associated with essential hypertension? A meta-analysis of 11,878 participants.

Human cytomegalovirus (HCMV) has been reported to be highly expressed in essential hypertension (EH), and it has been proposed that HCMV infection may contribute to EH development. However, different studies showed opposite results. The present meta-analysis was performed to investigate the association between HCMV infection and the risk of EH. All relevant literature from 1980 to 2015 was extracted from six electronic databases. Odds ratios (OR) and 95% confidence intervals (CI) were used to assess the strength of the association of HCMV infection and risk of EH. Sensitivity analysis and examination for bias were conducted to evaluate cumulative evidence of the association. The random-effect model using the Mantel-Haenszel method was used to give the individual effect-size estimates. Of the 11,878 participants included in this study, there were 3,864 EH patients and 8,014 control subjects. Meta-analysis of nine studies performed in a random-effect model found that EH patients had a higher risk of HCMV infection than normal control subjects (OR = 1.47, 95%CI: 1.13-1.90, P = 0.004; heterogeneity: I(2) = 66%, P = 0.002). Sensitivity analysis and bias examination showed the overall quality and consistency of the studies to be acceptable. For subgroup analysis, studies of Chinese populations were selected for further analysis. There was a significant association between HCMV infection and EH among Chinese patients (OR = 2.18, 95%CI:1.43-3.31, P = 0.0003) but not among other ethnic groups (OR = 1.11, 95%CI:0.95-1.31, P = 0.19). These findings provide quantitative support for the association between HCMV infection and high risk of EH in individuals of Chinese ethnicity.

Dietary Sodium Intakes and Food Sources of Sodium in Canadian-Born and Asian-Born Individuals of Chinese Ethnicity at a Canadian University Campus

Objective: To document the sodium intake and food sources of sodium of Canadian-born Chinese (CBC) and Asian-born Chinese (ABC) individuals at a Canadian university campus. Participants: Healthy adults aged 18–58 years originating from Canada, China, Hong Kong, or Taiwan were recruited from the University of Alberta (n = 40 CBC, n = 41 ABC) between May and December 2010. Methods: Two in-person multipass 24-hour dietary recall interviews were administered for 1 weekday and 1 weekend day. Results: The mean sodium intake was 3,623 ± 1,406 mg/day. The major food sources of sodium were commercially prepared and processed foods for both CBC and ABC (59.9% and 54.7% of sodium, respectively). Condiments contributed substantially to dietary sodium intake of CBC and ABC (27.8% and 35.1% of sodium, respectively). Conclusions: Efforts to reduce dietary sodium among students and other adults of Chinese ethnicity should focus on limiting consumption of commercially processed foods and moderation in discretionary use of salt and soy sauce.

Chlamydia trachomatis epidemiology in Canadians of Chinese ethnicity: a population-based study.

To compare the rates of Chlamydia trachomatis infection between those of Chinese ethnicity and non-Chinese ethnicity in a large Canadian urban setting. We examined rates of Chlamydia among residents of Vancouver and Richmond, Canada, by Chinese and non-Chinese ethnicity, from 2006 to 2010. We stratified cases by age group, sex and ethnicity. We analyzed 12,555 cases of Chlamydia from 2006 to 2010. The overall rate of Chlamydia was 276 per 100,000 per year. Chlamydia rates were 236 per 100,000 among those of Chinese ethnicity and 338 per 100,000 among non-Chinese. While overall rates among individuals of Chinese ethnicity were lower, rates among older Chinese women were significantly higher than among their non-Chinese counterparts. Physicians serving patients of Chinese ethnicity should be aware that rates among Chinese-Canadians are substantial, with rates among older women higher than among non-Chinese women, and they should consider this when screening for sexually transmitted infections in this population. Further research is needed to elucidate why this is the case.

CYP2C19 genotype has a major influence on labetalol pharmacokinetics in healthy male Chinese subjects

The pharmacokinetics (PK) of labetalol show wide inter-subject variability, but the genetic causes for this are largely undetermined. This study was performed to examine whether common polymorphisms in UGT1A1, UGT2B7, CYP2C19 and ABCB1 affect the PK of labetalol. The PK of labetalol were determined in 37 Chinese healthy male subjects who took a single oral dose of 200 mg labetalol. Plasma concentrations of labetalol were determined by a high-performance liquid chromatographic method. Subjects were genotyped for the CYP2C19 2 and 3, UGT1A1 6, 28 and 60, UGT2B7 2 and ABCB1 1236C>T, 2677G>T/A and 3435C>T polymorphisms. Subjects with the CYP2C19 2/ 2 genotype had a higher peak concentration (255.5 ± 80.1 vs. 156.0 ± 66.3 ng/mL; P < 0.05) and area under the concentration-time curve (AUC0-∞; 1,473.7 ± 493.6 vs. 502.8 ± 176.1 ng[Symbol: see text]h/mL; P < 0.001) than subjects with 60 or 28, and UGT2B7 2 did not result in a significant effect. Subjects with ABCB1 2677TA or TT or ABCB1 3435TT genotypes had higher AUC0-∞ and lower total clearance than the wild-types (P < 0.05), but this appeared to be related to the distribution of CYP2C19 genotypes. The CYP2C19 genotype appeared to be the only predictor of labetalol concentrations, accounting for approximately 60 % of the total variance in the AUC0-∞. Our results suggest that the PK of labetalol are significantly affected by the common CYP2C19 polymorphisms in individuals of Chinese ethnicity. Future larger studies are needed to evaluate the effect of CYP2C19 and UGT1A1 polymorphisms on the PK of labetalol stereoisomers and the pharmacodynamic effects.

Ethnic aspects of acute primary angle closure in a UK mulicultural conurbation

To investigate the incidence and ethnic distribution of patients with symptomatic acute primary angle closure (APAC) who presented to a UK hospital serving a multicultural conurbation by a population-wide case series investigation. Case series chart review of patients aged 30 years and above, who required laser peripheral iridotomy (LPI) for a primary acute angle closure event over a 7-year period. Demographic data for cases were compared to the local resident census data. A total of 46 local residents aged > or =30 years required LPI for APAC. In all, 96% of patients were Caucasian compared to the local resident population of 89% Caucasian. The overall annual APAC rate for Bolton was 4.14 cases per 100 000 population (95% CI 3.03-5.52). The standardised incidence ratio for the South Asian population was 0.78 (95% CI 0.02-4.34) and 26.6 (95% CI 0.67-148.40) for the Chinese population. APAC incidence in South Asians was similar to that among Caucasians. The incidence of APAC patients treated in this UK department is consistent with international experience. Individuals of Chinese ethnicity were at an enhanced risk of APAC. However, these results should be interpreted with caution, as patient numbers are small.

Stereotyping Physical Attractiveness

Why does stereotyping based on physical attractiveness occur? We proposed a sociocultural hypothesis that physical attractiveness is less likely to be a salient evaluative cue in cultural contexts where collectivism, rather than individualism, is the basis for the dominant system of values. In collectivist cultures, the group rather than the individual is stressed, suggesting that social judgments, such as first impressions of others, are more likely to be based on group-related attributes (e.g., family, position in a social network), rather than personal or individuating elements, such as physical attractiveness. From this perspective, we predicted that individuals of Chinese ethnicity, who were mostly from Asian Pacific Rim countries and cities and were attending university in Canada, would be less prone to physical attractiveness stereotyping if they reported high involvement in Toronto's Chinese community, rather than low involvement. We suggested that high Chinese community involvement would reinforce and maintain a more collectivist value orientation, which should reduce the likelihood of stereotyping of own-group members based on physical attractiveness for the reasons discussed above. To test this hypothesis, subjects were asked to complete a measure of participation in various aspects of the Chinese community and to rate the personality traits and expected life outcomes of stimulus persons who varied in physical attractiveness. Our sociocultural hypothesis was supported in the case of personality trait ratings (the principal measure in attractiveness stereotyping research), but not on expected life outcome ratings. Implications of these findings for understanding attractiveness stereotyping are discussed.

Stereotyping Physical Attractiveness

Why does stereotyping based on physical attractiveness occur? We proposed a sociocultural hypothesis that physical attractiveness is less likely to be a salient evaluative cue in cultural contexts where collectivism, rather than individualism, is the basis for the dominant system of values. In collectivist cultures, the group rather than the individual is stressed, suggesting that social judgments, such as first impressions of others, are more likely to be based on group-related attributes (e.g., family, position in a social network), rather than personal or individuating elements, such as physical attractiveness. From this perspective, we predicted that individuals of Chinese ethnicity, who were mostly from Asian Pacific Rim countries and cities and were attending university in Canada, would be less prone to physical attractiveness stereotyping if they reported high involvement in Toronto's Chinese community, rather than low involvement. We suggested that high Chinese community involvement would reinforce and maintain a more collectivist value orientation, which should reduce the likelihood of stereotyping of own-group members based on physical attractiveness for the reasons discussed above. To test this hypothesis, subjects were asked to complete a measure of participation in various aspects of the Chinese community and to rate the personality traits and expected life outcomes of stimulus persons who varied in physical attractiveness. Our sociocultural hypothesis was supported in the case of personality trait ratings (the principal measure in attractiveness stereotyping research), but not on expected life outcome ratings. Implications of these findings for understanding attractiveness stereotyping are discussed.