Creating a positive psychosocial learning environment (PsLE) that holistically considers the learners’ needs is vital to optimizing learning productivity in Science. This study investigates the Science learning environment as perceived by the students in actual Science classes. Anchored on the three PsLE dimensions namely: relationship, personal development, and systems maintenance and change, it tracks for alignment of the current Science teaching and learning practices to the expectations of the Kto12 Science curriculum standards. A survey method was done to gather the students’ perception ratings based on a 5-point Likert scale (with 5 as most indicative) using the adapted established learning environment instruments, namely, the Constructivist Learning Environment Survey, the Individualized Classroom Environment Questionnaire, and the Science Laboratory Environment Inventory. The data was collected from 105 Grade 10 students in one of the provinces in Central Visayas, Philippines, and treated statistically using descriptive statistics to get the mean percentage score and standard deviation. Results showed a high perception rating of the scales in the relationship dimension with a mean perception score (MPS = 3.7, SD= 0.36) and least in the personal development dimension. The specific scales that are of low perception include independence, open-endedness, shared control, and differentiation. These findings bear implications for potential interventions for the improvement of Kto12 Science teaching. Re-tooling the teachers with professional development training is a practical move that can be undertaken by the school leadership. Some concrete teaching practices anchored on the PsLE framework are discussed for the enhancement of Kto12 Science teaching.