Abstract Aim This research evaluated the water quality of the Taquacetuba Compartment, Billings Reservoir (Brazil), through analyzes of water quality data. The Taquacetuba Compartment has multiple uses such as public water supply and professional fishing activity and is of fundamental importance for the population of São Paulo State. Methods Sampling were conducted at the Compartment entrance (P1), close to the collecting point for public water supply transposition (P2), and in the mouths of the main tributaries (P3 - P6) forming the Compartment. Samplings were concentrated in the wet and dry periods of 2017. The physical and chemical variables measured were temperature, dissolved oxygen, pH, electrical conductivity, turbidity, chlorophyll α, ammonia nitrogen, nitrite, nitrate, total nitrogen, orthophosphate and total phosphorus. Results The Taquacetuba Compartment exhibited impaired water quality evidenced by high electrical conductivity, chlorophyll α and total phosphorus, above the legislation limits, classifying the sampling point as super or hyper eutrophic condition. The P1 sampling point presented the greatest environmental stress with worse water quality during the rainy season, while the other points (P2 - P6) showed an improvement during rainfalls. The P5 and P6, located at the tributaries mouth of the Monos and Curucutu River respectively, presented the best environmental conditions, evidenced by tendency to higher oxygen levels and lower turbidity in the rainy period. Conclusions From the observed result, we recognized two principal sources responsible for the impairment of the water quality in the Taquacetuba Compartment: i) the contribution from the central body of Billing Reservoir, related to the greater negative influence of the water pumping from the Pinheiros River with great organic load, especially in the wet period, and ii) the contribution from the tributaries, being that the Monos and Curucutu tributaries, as they are in an indigenous reserve area have better water quality. This study recognize the importance of land use and soil occupation around the tributaries and contribute with original data to support management measures for improving water quality in the Taquacetuba Compartment.