ABSTRACT This article examines transnational Indigenous cooperation among Permanent Participants in the Arctic Council using decolonialism and Indigenization in Canadian foreign policy analysis. The mainstream IR approaches primarily consider Indigenous NGOs as civil society groups united by common interests and cultures and as organizations that promote social change. This study argues that unlike other types of NGOs, Indigenous organizations have a complex social identity, which is influenced by settler-colonial heritage. Besides this, transnationalism promotes collective Indigenous agency. Like feminist IR, Indigenous IR scholarship challenges dominant worldviews and conceptualizations of Westphalian sovereignty, nation-state, and security. This study suggests comparing the state-centred IR concepts and Inuit within Canada’s understandings of the same terms. Although the Inuit within Canada perceive international relations distinctly, their conceptualizations of IR should be recognized by state structures. The article suggests that CFPA should incorporate Indigenous ways of knowing and promote transnational Indigenous IR studies to decolonize foreign policy and include Indigenous views in analysis.