Purpose The objective of this study was to evaluate the compatibility of the medial femoral condyle (MFC) dimensions in the Indian population with the standard femoral components of three commercially available unicompartmental knee arthroplasty (UKA) implants. Methods This analytical study utilized CTmorphometric data from 100 consecutive non-arthritic adult knees. MFC dimensions were measured to assess their compatibility with UKA prostheses. The proportion of knees that could be optimally replaced using three commercially available UKA femoral implant systems, Link, DePuy, and Smith & Nephew, was calculated. Results The study cohort comprised 56 males and 44 females, with a mean age of 43.28 ± 10.53 years. For the Link implant system, the 'small' size was the most compatible, fitting 43% (43) of the patients, followed by 'medium-small' (35%, n = 35) and 'medium' (16%, n = 16). For the DePuy Sigma Uni implant, the best fit was 'size 1' for 38% (38) of the patients, followed by 'size 3' (25%, n = 25), 'size 4' (13%, n = 13), 'size 2' (10%, n = 10), and 'size 5' (2%, n = 2). In the case of the Smith & Nephew system, 'size 2' was the best fit for 30% (30) of the knees, followed by 'size 3' (27%, n = 27), 'size 4' (15%, n = 15), 'size 1' (12%, n = 12), and 'size 5' (8%, n = 8). Overhang of the femoral component, due to the MFC being smaller than the smallest available femoral component size, was observed in 6% (6) of knees with Link implants, 12% (12) with DePuy implants, and 8% (8) with Smith & Nephew implants. Conclusion The findings indicate that the most suitable femoral component sizes for Indian knees were 'small' in the Link system (43%, n = 43), 'size 1' in the DePuy system (38%, n = 38), and 'size 2' in the Smith & Nephew system (30%, n = 30). The results suggest a need for implant manufacturers to consider developing customized components tailored to the Indian population to enhance fit and minimize the occurrence of femoral component overhang.
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