Indian Herb Research Articles

An Overview of the Osteogenic potential of Indian herb Cissus quadrangularis (Veldt Grape)

Cissus quadrangularis (CQ) is a widely known herb in India and southern part of India in particular. The bone healing ability of CQ is outlined in Ayurvedic medicine and other ancient medical texts. Bone loss in elderly especially osteoporosis is a public health problem across the globe. Bioactive molecules present in medicinal plants like CQ helps not only in bone healing but also in improving overall health. CQ is suggested as a plant herb in treatment of bone fractures and bone loss as it is safe or usage and side effects are not identified so far.However, research on the effect of CQ in humans are few and far. This review attempts to give a clear picture on the available literature that describes the osteogenic role of CQ in improving bone health and healing fractures in general and maxillofacial fractures in particular. Also, the role of CQ in green synthesis of bone scaffolds and its osteogenic potential in regeneration of bone using scaffolds are also discussed.

Bacopa monnieri confers neuroprotection by influencing signaling pathways associated with interleukin 4, 13 and extracellular matrix organization in Alzheimer's disease: A proteomics-based perspective

Alzheimer's disease, a prevalent neurodegenerative disorder in the elderly, is characterized by the accumulation of senile plaques and neurofibrillary tangles, triggering oxidative stress, neuroinflammation, and neuronal apoptosis. Current therapies focus on symptomatic treatment rather than targeting the underlying disease-modifying molecular mechanisms and are often associated with significant side effects. Bacopa monnieri, a traditional Indian herb with nootropic properties, has shown promise in neurological disorder treatment from ancient times. However, its mechanisms of action in Alzheimer's disease remain elusive. In this study, a cellular model for Alzheimer's disease was created by treating differentiated IMR-32 cells with beta-amyloid, 1–42 peptide (Aβ42). Additionally, a recovery model was established through co-treatment with Bacopa monnieri to explore its protective mechanism. Co-treatment with Bacopa monnieri extract recovered Aβ42 induced damage as evidenced by the decreased apoptosis and reduced reactive oxygen species production. Mass spectrometry-based quantitative proteomic analysis identified 21,674 peptides, corresponding to 3626 proteins from the Alzheimer's disease model. The proteins dysregulated by Aβ42 were implicated in cellular functions, such as negative regulation of cell proliferation and microtubule cytoskeleton organization. The enriched pathways include extracellular matrix organization and interleukin-4 and interleukin-13 signaling. Bacopa monnieri co-treatment showed remarkable restoration of Aβ42 altered proteins, including FOSL1, and TDO2. The protein-protein interaction network analysis of Bacopa monnieri restored proteins identified the hub gene involved in Alzheimer's disease. The findings from this study may open up new avenues for creating innovative therapeutic approaches for Alzheimer's disease.

Current Trends in Potential Traditional Indian Herbs: Emblica officinalis and its Medicinal Importance

Emblica officinalis, commonly known as Amla, is a potent natural antioxidant and is renowned as one of the richest natural sources of Vitamin C. The berries of this plant contain the highest levels of naturally occurring Vitamin C among ripe fruits, traditionally used in various dietary practices. Research has highlighted the anti-viral, anti-bacterial, and anti-fungal properties of Emblica officinalis. The fruit, which resembles a small plum, offers heat-stable Vitamin C that has been clinically shown to be more readily absorbed than synthetic alternatives, particularly in patients with pulmonary tuberculosis. Both historical and modern studies suggest that Emblica officinalis, whether used alone or in combination with other herbs, can be beneficial in treating various conditions such as colds, skin ailments, influenza, anemia, diabetes, lung issues, high cholesterol, and even as an immune booster in cancer therapies. Recognized as one of the most effective natural anti-aging remedies, Emblica officinalis is also used to treat acne and other skin disorders. Additionally, it is effective against acidity and peptic ulcers. Rich in Vitamin C, calcium, iron, essential amino acids, and a variety of other vitamins, minerals, and antioxidants, regular consumption of Emblica officinalis is said to enhance immunity, support cancer prevention, and rejuvenate the body. It also helps manage chronic conditions like hypertension, high cholesterol, diabetes, AIDS, influenza, persistent coughs, chronic infections, chronic fatigue, and inflammation. In Ayurveda, Emblica officinalis is highly regarded for managing diabetes, bleeding disorders, and promoting strength and stamina.

Phytochemical Screening and Pharmacological Study of Aegle Marmelos : A Review

Aegle marmelos, commonly called "Bael," is a native Indian herb. The Bael tree—also referred to as the golden apple or Bengal quince—belongs to the Rutaceae family of medium-sized deciduous trees. Traditional medicine has traditionally utilized all portions of the sapling, including the fruit, woof, roots, leaves, and stems because they all have medicinal properties. Regardless of how old the fruit is, this is accurate. The composition of Aegle marmelos has been found to include flavonoids, fatty acids, carbohydrates, tannins, alkaloids, terpenoids, vitamins, and essential oils, among other things. The plant has pharmacological properties that can modulate the immune system, relieve pain, reduce inflammation, treat arthritis, lower blood cholesterol, fight cancer, fight viruses, treat ulcers, and promote wound healing. Its other properties include anti-proliferative, hepatoprotective, antidiabetic, antibacterial, and antifungal properties. Therefore, those who are keen to carry out further research on.

Formulation and Evaluation of Herbal Soap

Crinum latifoliuma - a well-known ornamental species, a well-known domestic herb in India, belonging to the Amaryllidaceae family. Crinum latifolium. The plant is Ayurveda known as "Sudarshana" or Sukhdarshan. It means that just looking at it brings peace and satisfaction (seeing it). The roots, stems, flowers and leaves of Crinum latifolium are used in herbal therapy and are also used as an ornamental plant. Qualitative analysis of different phytochemical components and evaluation of leaves, sieving in different solutions, preparation of leaf juice soap all available information from literature.

Efficacy and Significance of Bio Choline as Choline Source in Poultry

Choline chloride, an organic, colorless, alkaline substance that is treated as a vitamin, though not a vitamin of B complex category, due to its multifaceted functions in animal husbandry too. Specifically, in Poultry where it seems to be the prime reason for hepatic health, apart from its role in the various metabolic and physiological activities. The economic importance of Choline in Poultry has led to the stocking up of innumerable number of its Synthetic forms in the market. These are hygroscopic, corrosive, offensive, off-flavored, non eco-friendly and in being inferior quality and working wise. This has led to an effort and search for alternatives, leading to Phytogenic Herbals as ideal sources. The Bio choline from Indigenous Indian herbs like Azardarictha, Achyranthes, Andrographis, Allium sativum, Fumaria, Solanum, Silibum, and Tachyspermum, was non hygroscopic, non-corrosive, non-off flavored and ecofriendly. The Bio choline equivalence of these herbs was as Phosphotidylcholine with a capability of replacing Synthetic choline completely with good quality and excellent working.

Evaluation of the Effects of Edible Coatings of Ocimum sanctum and Aloe vera on Jaggery Shelf Life

Background: In western Uttar Pradesh, jaggery is a widespread cottage enterprise based on agriculture, and farmers are forced to sell their product at a lesser price when it is still fresh. Therefore, it was thought to be desirable to create better storage techniques in order to extend its shelf life. Aloe vera, and Ocimum sanctum, often known as "Tulsi," are frequently utilised as antimicrobial food additives because they offer a host of other health advantages in addition to their well-known antibacterial qualities. Because the edible coatings made of these herbs provide a semi-permeable barrier to gases and water vapours, they may prolong the shelf life of jaggery by preventing degradation. Objective: The goal of the current study was to assess the ability of edible coatings of common Indian herbs, such as tulsi and Aloe vera,, to extend the shelf life of jaggery while maintaining attributes that are equal to those of fresh jaggery, in accordance with the guidelines set forth by the Food Safety and Standards Authority of India (FSSAI). Methodology: The physicochemical characteristics, antioxidant activity, total viable count, and antibacterial activity of tulsi-Aloe vera, coated (TAC), Ocimum sanctum, and Aloe vera, (AC) jaggery were assessed and compared with non-coated control. The physicochemical properties were ascertained using standard methodology for measurement of reducing sugars, proteins, phenols, saponins, tannin, alkaloids, and flavonoids. The antimicrobial activity was ascertained by means of the agar double diffusion method. According to established protocol, antioxidant activity was assessed using the DPPH radical scavenging assay and the reducing power assay. Results: According to the research, there is no discernible microbiological deterioration and the edible coatings containing tulsi and Aloe vera, extend the shelf life of jaggery during storage. When compared to uncoated jaggery, coatings were efficient at preventing the growth of both Gramme positive and Gramme negative microorganisms. Over the course of six months, the herb-infused coatings also retained their phenolic, flavonoid, and tannin contents, which improved their anti-oxidant efficacy when compared to the untreated control group.

An overview of Indian herbs with the potential in the treatment of the Alzheimerrsquo;s disease

An overview of Indian herbs with the potential in the treatment of the Alzheimerrsquo;s disease

Design, Development and Evaluation of Methi-Shikakai Herbal Shampoo

Shikakai, scientifically known as Acacia concinna, is a traditional Indian herb widely used for hair care due to its cleansing and conditioning properties. This research paper aims to Design, develop and evaluation of a shampoo incorporating shikakai extract, assessing its efficacy in terms of cleansing ability, hair conditioning, and overall performance. The formulation process involves selecting appropriate surfactants, additives, and optimizing concentrations to achieve desired attributes. Evaluation methods include physical characterization, such as pH, viscosity, and foam ability, as well as performance testing through sensory evaluation and hair analysis. The results of this study will provide valuable insights into the development of herbal-based shampoos and their potential benefits for hair health and maintenance.

NADES extraction, UHPLC-ELSD-based quantification, and network pharmacology-guided target identification of fourteen specialised metabolites from Trillium govanianum Wall. ex D.Don.

Trillium govanianum Wall. ex D.Don is a folk medicinal herb rich in structurally diverse steroidal saponins. The annual demand for this herb in India is about 200-500 metric tons, highlighting the need for a thorough quality assessment. The objective of this study is to develop an easy and reliable ultrahigh-performance liquid chromatography-evaporative light scattering detector (UHPLC-ELSD)-based quality assessment method with 14 specialised metabolites of T. govanianum and identify the potential targets of this herb using network pharmacology. A UHPLC-ELSD method was developed and validated with 14 markers of T. govanianum. The developed method and natural deep eutectic solvent (NADES)-assisted extraction were utilised for the recovery enhancement study of targeted specialised metabolites from rhizome samples (collected from five geographically distinct areas). In addition, the network pharmacology approach was performed for these 14 markers to predict the plausible biological targets of T. govanianum. The developed method showed good linearity (r2: 0.940-0.998), limit of detection (LOD) (2.4-9.0μg), limit of quantification (LOQ) (7.92-29.7μg), precision (intra-day relative standard deviations [RSDs] 0.77%-1.96% and inter-day RSDs 2.19-4.97%), and accuracy (83.24%-118.90%). NADES sample TG-1* showed the highest recovery (yield: 167.66 ± 4.39 mg/g of dry weight) of total saponin content (TSC) as compared to its hydroethanolic extract (yield: 103.95 ± 5.36 mg/g of dry weight). Sample TG-1* was the most favourable (yield: 167.66 ± 4.39 mg/g) in terms of TSC as compared to other analysed samples (32.68 ± 1.04-88.22 ± 6.79 mg/g). Govanoside D (yield: 3.43-28.06 mg/g), 22β-hydroxyprotodioscin (yield: 3.22-114.79 mg/g), and dioscin (yield: 1.07-20.82 mg/g) were quantified as the major metabolites. Furthermore, network pharmacology analysis of targeted 14 markers indicated that these molecules could be possible therapeutic agents for managing neuralgia, diabetes mellitus, and hyperalgesia. The current study represents the first report for the simultaneous quantification and a network pharmacology-based analysis of 14 chemical marker compounds isolated from T. govanianum.

Comprehensive Pharmacognostic and Phytochemical Analysis of Select Indian Herbs: In Vitro Anti-oxidant Assessment

This groundbreaking study aims to thoroughly investigate specific Indian herbs, including Giloy, Black Pepper, Amla, Ginger, Cinnamon, and Basil leaves, using a systematic evaluation of their medicinal properties and analysis of their chemical components. The study involves the methodical gathering, conservation, and extraction of these herbs using solvents with different polarity to determine their physicochemical properties. The moisture content, ash value, acid-insoluble ash, water-soluble ash, and water and alcohol-soluble extractive values were accurately measured to gain important information about the quality characteristics of these herbs. In addition, initial phytochemical analyses using various identification assays identified a wide range of components in the extracts, including as alkaloids, glycosides, tannins, resins, flavonoids, steroids, amino acids, proteins, carbohydrates, fats & oils, phenols, diterpenes, and saponins. Furthermore, the research examined the antioxidant capabilities of a poly-herbal extract obtained from these herbs in a laboratory setting. It clarified the extract's effectiveness in neutralising free radicals by conducting DPPH and ABTS assays. Significantly, the poly-herbal extract had antioxidant activity that increased in proportion to its concentration, as indicated by larger scavenging percentages at increasing concentrations. The extract also exhibited a significant overall antioxidant capacity, suggesting its potential in counteracting free radicals and addressing oxidative stress. Moreover, this study resulted in the creation of rapidly dissolving tablets enhanced with these herbs, demonstrating a new method for using their immunomodulatory capabilities. This study's findings emphasise the varied phytochemical composition of the chosen Indian herbs, as well as their promising antioxidant capabilities and suitability for medicinal use. This research enables further investigations into the precise bioactive compounds found in these herbs, providing valuable knowledge for their use in pharmacological, nutraceutical, or therapeutic formulations. This contributes significantly to the field of herbal medicine and the development of drugs based on natural products

Zinc Nanoparticles and Nanocomposite Membrane Synthesized Using Leaves of Cinnamomum Tamala(Tejpatta) and Packaging Potential in Food Sector

ABSTRACT: Zinc oxide nanoparticles were synthesized using leaves of Tejpatta (Cinnamomum tamala) readily available as local herb in India. First confirmation was made by change of color of plant extract into cream color solution for zinc nanoparticle synthesis. The plant used as capping and reducing agent showed absorption peak of 329.4nm for zinc nanoparticle. While FESEM analysis further validated the nature of nano-particle synthesized of tetrahedral and crystalline zinc nanoparticles. The plant parts can be exploited for drug development as the plant is available in plenty growing all over arid region. Nanobiotech has served in recent years and utilized natural polymers or polymeric films, which have overcome the side effects of synthetic packaging films available commercially. The safety assessment should be in agreement with scientific advisory committee before permitting to packaging industries. The texture, flavor, processing, shelf life and transport of foods will become economical to meet the demand of food safety for future generations. Generally regarded as safe, packaging materials can be considered for globalization and revolution in food packaging sector. The present investigation reports zinc nanoparticle synthesis where potent zone of inhibition were reported against standard pathogen S. aureus and nanocomposite membranes were synthesized using different polymeric components available in reach like gelatin, sodium alginate and agarose instead of cellulose. The research will be further supplemented with application of biomembrane synthesized in antimicrobial resistance offered to food products.

YUMMZ Sugar Free Ice Cream

YUMMZ, epitomizes innovation and health-consciousness in the ice cream industry, striving to redefine indulgence with guilt-free frozen treats. At its core, YUMMZ is driven by a mission to revolutionize ice cream consumption, intertwining traditional Indian flavors with modern dietary considerations, thus offering consumers a harmonious blend of taste and nutrition. Committed to this mission, YUMMZ sets forth ambitious goals, encompassing the development of diet ice cream options that are not only low in calories, sugar, and saturated fat but also imbued with the rich tapestry of Indian herbs and spices, aiming to provide a novel experience that prioritizes health without compromising on indulgence. Moreover, customer satisfaction stands as a cornerstone of YUMMZ's ethos, with a focus on offering a diverse range of flavors, shapes, and toppings that cater to the varied preferences and dietary needs of consumers, ensuring that each frozen delight is a personalized and delightful experience. This dedication to the customer extends beyond mere product offerings, as YUMMZ actively engages with its consumer base through both business-to-business and business-to-consumer channels, fostering connections and gathering feedback to continuously refine its products and services, thereby cementing its position as a customer-centric brand. As YUMMZ looks towards the future, expansion looms large on its horizon, with plans to diversify its product offerings and distribution channels both nationally and internationally, capitalizing on emerging trends in health-conscious eating and global flavor preferences, thus solidifying its status as a trailblazer in the ice cream landscape.

Indian Herbs a potential source of antimicrobial drugs as Non-antibiotics

New sources of antimicrobial drugs need to be identified to combat multidrug resistance problem in pathogenic bacteria. Plant extract and phytochemicals demonstrating anti-microbial action needs to be exploited in modern phytomedicine as Non-antibiotics and in combinational therapy. The present investigation reveals the scientific evaluation of the root of Hemidesmus indicus (anantamool) against pathogenic bacteria and it is suggested that this plant could be exploited in the management of infectious diseases caused by the test pathogenic bacteria and Candida albicans in the human system. The in vitro antibacterial activity of 3 different extracts (Hexane, Methanol and Aqueous) was performed. The most active extract was found to be the hexane extract showing the maximum zone of inhibition of 22 mm against Staphylococcus Aureus followed by E.coli (18mm) and Candida Albicans (18mm).

Potential of Indian herbs and herbs derived compounds in the treatment of Acne – A Commonly occurring skin disease: A Review

Acne, known as acne vulgaris, is said to be a recurrent disease related to the skin that becomes visible and the blockage of hair follicles becomes irresistible with skin cells that are supposed to be dead, bacteria, and sebum or oil. Hypersecretion of sebum in disrupted follicles can be considered for the pathogenesis of acne which leads to the formation of microcomedones. Inflammation occurs as the cause of hyperproliferation insisted by the follicles of microcomedones and comedones in both closed and open types. Then the appearance of pustules, papules, cysts, and nodules was observed. The aforementioned state of the skin with sebum or oil confinement is said to be a predisposed condition to the anaerobic growth of C. acnes. Various synthetic drugs are available for the treatment of acne but they are responsible for several adverse effects and show resistance of C. acnes to the available antibiotics. Plant parts or plant-derived compounds are traditionally used in the treatment of acne in India. Even today also a large section of the Indian population is using herbs to cure acne. So, the herbal agents derived from nature, have received considerable interest as they show hardly any detrimental effect and are cost-effective. This article aims to enumerate the role of a few Indian herbs such as Aloe vera, Azadirachta indica, Curcuma longa, etc. in the treatment of acne.

A Review on Therapeutic Potential of Indian Herbal Plants to Counter Viral Infection and Disease Pathogenesis

Abstract: Herbal plant extracts or purified phytocomponents have been extensively acknowledged in treating several diseases since time immemorial. The Indian Ayurvedic system and Chinese traditional medicines have documented the medicinal properties of important herbs and their effects. In Ayurveda, polyherbal formulation is known to exhibit better therapeutic efficacy compared to single herb. This review focuses on six key ayurvedic herbal plants namely, Tinosporacordifolia (giloi/guduchi), Withaniasomnifera (Ashwagandha), Glycyrrhiza glabra/Licorice (Mulethi), Zingiberofficinale (Ginger), Emblicaofficinalis(Amla) and Ocimum sanctum (Tulsi).Each of these herbal plants possesses specific phytocomponents that aid them in fighting infections and keeping body healthy and stress free. These medicinal plants are known to exhibit several protective features against various diseases or infections. Here we have particularly emphasized on antioxidant, anti-inflammatory, antimicrobial and immunomodulatory properties which are common in these six plants. Recent literature analysis has revealed Ashwagandha to be protective for Covid-19 too. The formulation from such herbs can exhibit synergism and hence better effectiveness against infection and related diseases. Hence, the importance of these medicinal herbs becomes highly prominent as it maintains the harmonious balance by way of boosting the immunity in a human body. Further, greater mechanistic analyses are required to prove their efficacy to fight infectious diseases like Covid-19. It further opens the arena for in-depth research of identifying and isolating the active components from these herbs and evaluating their potency to inhibit viral infections as polyherbal formulation.

In-Vitro and In-Silico Approach Distinguish ER-α and HER-2 Antagonistic Properties of Indian Herbal Formulation on Breast Cancer

Objectives: The anticancer effect of an Indian herbal preparation was studied under a cancer cell line, as well as the in silico computational methods that explain the probability of protein ligands binding to ER- α and HER-2 receptors.
 Method: The in vitro anticancer activity of Body Revival® suspension (BR) was determined using cytotoxicity tests, cell invasion and migration assays, and metastatic protein expression assays using MCF-7 breast cancer cells. The computational predictive biological method was applied to find out the pharmacodynamic and pharmacokinetic interactions between the active molecules present in the BR and ER- α/and HER-2 of breast cancer.
 Results: BR showed significant and dose dependent cytotoxic effects on MCF-7 cells. The 50% effective cytotoxic dose of BR was 34.27µl/ml. It restricted invasion (26%) and migration (28%) of cancer cells than BSA control. MMP-9 and IL-6 concentration were reduced significantly (p<0.001) after treatment. Cucurbitacin B had maximum in silico binding energy score (-7.8) with ER-α, while symconoside B had with HER-2 (-8.4); but, among the other interactions between the two ligands and receptors, withaferin A had the highest affinity (-15.3). Additionally, withaferin A, symconoside A, and symconoside B curcurbitacin A demonstrated bioavailability and fulfilled safety standards. 
 Conclusion: Body Revival® showed as a powerful multi-target inhibitor of ER- α and HER-2 that has prospective anticancer action without side effects, and may be useful in the therapy management following a successful trial in breast cancer patients.
 Keywords: Breast cancer, Cytotoxicity, MCF-7, ER- α, HER-2, Herbs, In Silico

Investigating the molecular mechanisms of Ashwagandha phytocompounds in epilepsy through differential gene expression and pathway analysis

Introduction and Aim: Withania somnifera (Ashwagandha) is a traditional Indian herb used in Ayurveda and Unani medicine, particularly in anti-inflammatory, anti-cancer, anti-stress, antioxidant, immune-boosting, and rejuvenating effects. Epilepsy is a severe neuropsychological condition that occurs sporadically and has a long-term effect on the electrical signals that travel between brain cells. The disorder is characterized by recurrent seizures that are brought on by a sudden increase in brain electrical activity. This is the outcome of abnormal neuronal discharges or coordinated neuronal hyperexcitability. The study’s main objective is to find out the therapeutic phytocompound in treating Epileptic disorder. Materials and Methods: This study investigated the potential use of phytochemicals from the Ashwagandha plant as epileptic seizure treatments that target key genes strongly associated with the disease. To forecast the binding affinity between the phytochemicals and the receptors, molecular docking simulations (PyRx) were used for the virtual screening. Results: The preliminary screening of the twenty-two phytocompounds from Withania somnifera was based on their affinity for epilepsy. The results showed that withasomnine exhibited great binding affinity to the receptors, indicating their potential as targeted epileptic seizure therapeutics. The ligands revealed stronger binding with the epilepsy targets, and the binding score less than -7 kcal/mol was taken into consideration for further exploration. This research lays the groundwork for upcoming in-vitro and in-vivo studies to confirm the effectiveness of these phytochemicals as cancer therapies. Conclusion: The results suggest that withasomnine derivatives from Withania somnifera could be a promising source of epilepsy therapies.

In Vitro Evaluation of Botanicals Against Fusarium Oxysporum Causing Wilt of Cumin

Cumin (Cuminum cyminum L), known as Zeera or Jill, belongs to the Apiaceae family. Cumin is an essential seed herb in India. The most feared disease of cumin plants is Fusarium wilt caused by Fusarium oxysporum, and it is a significant production constraint for growing cumin crops in Gujarat as in India. Seven different plant species have been used for the environmentally friendly treatment of this disease. Crude plant extracts were prepared with water, acetone, and cow urine as solvents at different concentrations (5%, 10%, and 15%). The in vitro antifungal activity of these plant extracts was determined by the poisoned food method. The highest inhibition was recorded with plant extracts prepared in acetone followed by cow urine. All plants showed significant antifungal activity. The highest inhibition was found with Senna alexandrina (85.53%) extract with acetone followed by Azadirachtaindic (82.72%) extract with acetone and 77.70% by Psidium guajava prepared with cow urine (at p ≤ 0.01). The lowest inhibition was recorded for Aloe barbadensis miller (35.49%) and Asparagus racemosus 48.74% with water extract. This study might be the first report of Fusarium oxysporum as a causal agent of cumin wilt in the Saurashtra region of Gujarat in India. A plant extract prepared with cow urine may be the first report of this study.

Moringa induces its beneficial effect via hormesis.

Moringa oleifera, a traditional Indian herb, is widely known for its capacity to induce antioxidant, anti-inflammatory and other chemoprotective effects in a broad range of biomedical models. These perspectives have led to an extensive number of studies using various moringa extracts to evaluate its capacity to protect biological systems from oxidative stress and to explore whether it could be used to slow the onset of numerous age-related conditions and diseases. Moringa extracts have also been applied to prevent damage to plants from oxidative and saline stresses, following hormetic dose–response patterns. The present paper provides the first integrated and mechanistically based assessment showing that moringa extracts commonly induce hormetic dose responses and that many, perhaps most, of the beneficial effects of moringa are due to its capacity to act as an hormetic agent.