Indian Diabetic Retinopathy Image Dataset Research Articles

An Efficient Feature Selection and Extraction using Metaheuristic Technique for Diabetic Retinopathy

Diabetic retinopathy (DR) is associated with diabetes, which causes harm to the retina as a result of persistent elevated blood sugar levels, resulting in symptoms such as impaired vision. Regular eye examinations are crucial for the timely identification of any issues. The process of selecting characteristics in DR involves optimizing important features using a combination of Hybridized Weight-Optimized Particle Swarm Optimization and Whale Optimization Algorithm (HWOPSO-WOA). This leads to an enhancement in the accuracy of detection, which is crucial for appropriate diagnosis and therapy. Pre-processing encompasses the utilization of linear filters such as Sobel and Prewitt for image manipulation, mean filters for the reduction of noise, and Gaussian filters for the purpose of smoothing. Feature selection employs an objective function that considers significant performance measure, which utilizes binary encoding and conducts fitness evaluation. The methodology is utilized for the analysis of DR utilizing the Indian Diabetic Retinopathy Image Dataset. The results comprise convergence graphs, and a comparative analysis, which emphasize the greater accuracy and efficiency of the Proposed technique. Visual representations, such as fundus images with selected features, highlight the importance of the chosen features in detecting DR. The proposed HWOPSO-WOA achieves highest accuracy of 97.3% and minimal processing time 98.45seconds that outperforms the state-of-art techniques.

Level-set based adaptive-active contour segmentation technique with long short-term memory for diabetic retinopathy classification.

Diabetic Retinopathy (DR) is a major type of eye defect that is caused by abnormalities in the blood vessels within the retinal tissue. Early detection by automatic approach using modern methodologies helps prevent consequences like vision loss. So, this research has developed an effective segmentation approach known as Level-set Based Adaptive-active Contour Segmentation (LBACS) to segment the images by improving the boundary conditions and detecting the edges using Level Set Method with Improved Boundary Indicator Function (LSMIBIF) and Adaptive-Active Counter Model (AACM). For evaluating the DR system, the information is collected from the publically available datasets named as Indian Diabetic Retinopathy Image Dataset (IDRiD) and Diabetic Retinopathy Database 1 (DIARETDB 1). Then the collected images are pre-processed using a Gaussian filter, edge detection sharpening, Contrast enhancement, and Luminosity enhancement to eliminate the noises/interferences, and data imbalance that exists in the available dataset. After that, the noise-free data are processed for segmentation by using the Level set-based active contour segmentation technique. Then, the segmented images are given to the feature extraction stage where Gray Level Co-occurrence Matrix (GLCM), Local ternary, and binary patterns are employed to extract the features from the segmented image. Finally, extracted features are given as input to the classification stage where Long Short-Term Memory (LSTM) is utilized to categorize various classes of DR. The result analysis evidently shows that the proposed LBACS-LSTM achieved better results in overall metrics. The accuracy of the proposed LBACS-LSTM for IDRiD and DIARETDB 1 datasets is 99.43% and 97.39%, respectively which is comparably higher than the existing approaches such as Three-dimensional semantic model, Delimiting Segmentation Approach Using Knowledge Learning (DSA-KL), K-Nearest Neighbor (KNN), Computer aided method and Chronological Tunicate Swarm Algorithm with Stacked Auto Encoder (CTSA-SAE).

Joint DR-DME grading classification using optimal feature selection-based deep graph correlation network

Diabetic macular edema (DME) and diabetic retinopathy (DR) are the leading causes of human blindness, and accurate grading of individual DME, individual DR, and the joint DR-DME is very important for the diagnosis of human eye diseases. However, the conventional methods failed to separate the features such as disease-specific, disease-dependent, and joint DR-DME, which resulted in poor grading accuracy. In addition, optimal feature selection is also vital in DR-DME grading classification for improving the performance of joint DR-DME grading classification. Therefore, this work focuses on the implementation of an advanced deep graph correlation learning model based on a joint DR-DME network (JDD-Net) for disease detection and classification from color fundus images. Initially, convolutional block attention module (CBAM) and joint disease attention (JDA) modules are combined to extract the DR-specific, DME-specific, and joint DR-DME disease-dependent features. Here, interdependent DR and DME features are separated by a CBAM-based channel-spatial split attention mechanism. In addition, an iterative random forest network (IRF-Net) is used to select the optimal features by adopting fast machine learning properties. Finally, a deep graph correlation network (DGCN) is used to classify the different diseases using a pre-trained model. The simulations conducted on the Indian Diabetic Retinopathy Image Dataset (IDRiD) disclose that the proposed JDD-Net results in improved individual DR, individual DME, and joint DR-DME performance as compared to state-of-the-art approaches with DR, DME, and joint DR-DME accuracy of 99.53%, 99.1%, and 99.01%, respectively.

Simultaneous multiclass retinal lesion segmentation using fully automated RILBP-YNet in diabetic retinopathy

This paper presents a novel method for segmenting the multiple lesions like Microaneurysms, Haemorrhages, Hard and Soft exudates that occurs on the surface of the retina due to diabetes. If these lesions are left untreated in their early stage, they may cause irrevocable vision loss to diabetic patients. However, the manual assessment of these vision threatening diseases is prone to errors and time-consuming process. As a result, the proposed model, RILBP-YNet (Residual Inception Local Binary Pattern - YNetwork) is implemented as a dual encoder and single decoder architecture in which one encoder extracts the features from the fundus image. Whereas the parallel encoder extracts the textural features from Local Binary Patterns (LBPs) of the corresponding fundus image simultaneously. The extracted features of the two encoders are concatenated at the end of every encoder level and fed as input to the next encoder. Finally, the concatenated features of the last encoder are transposed by performing the up-sampling operation and fed as input to the first decoder. Furthermore, at the end of every decoder, the features of the decoder and concatenated features of the respective encoder are fused and provided as input to the next decoder. As a result, at the end of the last decoder, segmented masks of each lesion are generated. The novelty of the proposed work lies in adding a parallel encoder to traditional encoder-decoder architecture to induce textural features to improve the segmentation results. The proposed model is trained and tested on the Indian Diabetic Retinopathy Image Dataset (IDRiD), and e-ophtha datasets and achieved competitive results compared to the existing methods in terms of AUC score. The proposed method is also tested on datasets like DRIVE, STARE, CHASE-DB1, and one locally real-time dataset.

Automatic detection of microaneurysms using a novel segmentation algorithm based on deep learning techniques

AbstractMicroaneurysms is the first stage of diabetic retinopathy (DR) and it plays a vital role in the computerized diagnosis. However, it is difficult to automatically detect microaneurysms in fundus images due to the complicated background and various illumination reasons. The motivation behind this, is the number of increases in diabetic patients is very large when compared with the number of ophthalmologists. The FSCA‐UNET (Frequency Spatial Channel Attention UNET) segmentation model, is proposed and it is an improvement over UNET. We first use the frequency channel attention mechanism to analyze the features that were extracted from the first stage of the convolution layer, and we obtain good results. Then, we included a spatial attention map with frequency attention, also known as FSCA‐UNET, which makes use of inter‐spatial connections between features. Our deep neural model with an encoder‐decoder structure termed FSCA‐UNET produced more accurate results. Our novel algorithm outdated the performance measures of the existing segmentation algorithms. The proposed segmentation algorithm was trained and tested on Indian Diabetic Retinopathy Image Dataset (IDRiD), and E‐ophtha Dataset and we got promising results in terms of sensitivity, specificity, dice coefficient, precision, F1 score, and accuracy.

RetU-Net: An Enhanced U-Net Architecture for Retinal Lesion Segmentation

Diabetic retinopathy is a predominant vision-threatening disease affecting working-aged people specifically. Timely diagnosis through early detection and prevention helps to reduce the risk of severe vision loss. Computer-aided diagnosis in retinal image analysis through Machine Learning techniques will help medical professionals perform their analysis better. Automated image processing through Convolutional Neural Networks has proven to be a promising technique, mainly in medical image segmentation. Convolutional Neural Network techniques like 3D CNN, Deep CNN and architectures like U-Net, V-Net, SegNet, and DeepMedic have outperformed medical image analysis results. However, the baseline CNN architectures struggle to retain high-quality information at the output and thus affect the performance. This work focuses on addressing the issue of translational variance and overfitting scenarios of U-Net architecture by experimenting with adaptable window sizes, pretrained weights and linear interpolation technique. A novel U-Net based architecture called RetU-Net that segments abnormal retinopathy lesion structures by retaining higher-level feature is proposed. The experiments are conducted using Indian Diabetic Retinopathy Image Dataset provided in “Diabetic Retinopathy: Segmentation and Grading Challenge” initially. The results have been compared with other state-of-art CNN architectures. Further evaluation is carried out on public datasets: STARE and DRIVE, and the performance is compared with U-Net based architectures used for retinal image segmentation. The proposed approach is efficient in terms of precision, sensitivity, specificity and accuracy. It received accuracy scores of 0.9612, 0.9712 while experimenting with STARE and DRIVE datasets respectively.

Quantum Computing Meets Deep Learning: A Promising Approach for Diabetic Retinopathy Classification

Diabetic retinopathy seems to be the cause of micro-vascular retinal alterations. It remains a leading reason for blindness and vision loss in adults around the age of 20 to 74. Screening for this disease has become vital in identifying referable cases that require complete ophthalmic evaluation and treatment to avoid permanent loss of vision. The computer-aided design could ease this screening process, which requires limited time, and assist clinicians. The main complexity in classifying images involves huge computation, leading to slow classification. Certain image classification approaches integrating quantum computing have recently evolved to resolve this. With its parallel computing ability, quantum computing could assist in effective classification. The notion of integrating quantum computing with conventional image classification methods is theoretically feasible and advantageous. However, as existing image classification techniques have failed to procure high accuracy in classification, a robust approach is needed. The present research proposes a quantum-based deep convolutional neural network to avert these pitfalls and identify disease grades from the Indian Diabetic Retinopathy Image Dataset. Typically, quantum computing could make use of the maximum number of entangled qubits for image reconstruction without any additional information. This study involves conceptual enhancement by proposing an optimized structural system termed an optimized multiple-qbit gate quantum neural network for the classification of DR. In this case, multiple qubits are regarded as the ability of qubits in multiple states to exist concurrently, which permits performance improvement with the distinct additional qubit. The overall performance of this system is validated in accordance with performance metrics, and the proposed method achieves 100% accuracy, 100% precision, 100% recall, 100% specificity, and 100% f1-score.

Combining transfer learning with retinal lesion features for accurate detection of diabetic retinopathy.

Diabetic retinopathy (DR) is a late microvascular complication of Diabetes Mellitus (DM) that could lead to permanent blindness in patients, without early detection. Although adequate management of DM via regular eye examination can preserve vision in in 98% of the DR cases, DR screening and diagnoses based on clinical lesion features devised by expert clinicians; are costly, time-consuming and not sufficiently accurate. This raises the requirements for Artificial Intelligent (AI) systems which can accurately detect DR automatically and thus preventing DR before affecting vision. Hence, such systems can help clinician experts in certain cases and aid ophthalmologists in rapid diagnoses. To address such requirements, several approaches have been proposed in the literature that use Machine Learning (ML) and Deep Learning (DL) techniques to develop such systems. However, these approaches ignore the highly valuable clinical lesion features that could contribute significantly to the accurate detection of DR. Therefore, in this study we introduce a framework called DR-detector that employs the Extreme Gradient Boosting (XGBoost) ML model trained via the combination of the features extracted by the pretrained convolutional neural networks commonly known as transfer learning (TL) models and the clinical retinal lesion features for accurate detection of DR. The retinal lesion features are extracted via image segmentation technique using the UNET DL model and captures exudates (EXs), microaneurysms (MAs), and hemorrhages (HEMs) that are relevant lesions for DR detection. The feature combination approach implemented in DR-detector has been applied to two common TL models in the literature namely VGG-16 and ResNet-50. We trained the DR-detector model using a training dataset comprising of 1,840 color fundus images collected from e-ophtha, retinal lesions and APTOS 2019 Kaggle datasets of which 920 images are healthy. To validate the DR-detector model, we test the model on external dataset that consists of 81 healthy images collected from High-Resolution Fundus (HRF) dataset and MESSIDOR-2 datasets and 81 images with DR signs collected from Indian Diabetic Retinopathy Image Dataset (IDRID) dataset annotated for DR by expert. The experimental results show that the DR-detector model achieves a testing accuracy of 100% in detecting DR after training it with the combination of ResNet-50 and lesion features and 99.38% accuracy after training it with the combination of VGG-16 and lesion features. More importantly, the results also show a higher contribution of specific lesion features toward the performance of the DR-detector model. For instance, using only the hemorrhages feature to train the model, our model achieves an accuracy of 99.38 in detecting DR, which is higher than the accuracy when training the model with the combination of all lesion features (89%) and equal to the accuracy when training the model with the combination of all lesions and VGG-16 features together. This highlights the possibility of using only the clinical features, such as lesions that are clinically interpretable, to build the next generation of robust artificial intelligence (AI) systems with great clinical interpretability for DR detection. The code of the DR-detector framework is available on GitHub at https://github.com/Janga-Lab/DR-detector and can be readily employed for detecting DR from retinal image datasets.

Research on grading algorithm of diabetic retinopathy based on cross-layer bilinear pooling

Considering the small differences between different types in the diabetic retinopathy (DR) grading task, a retinopathy grading algorithm based on cross-layer bilinear pooling is proposed. Firstly, the input image is cropped according to the Hough circle transform (HCT), and then the image contrast is improved by the preprocessing method; then the squeeze excitation group residual network (SEResNeXt) is used as the backbone of the model, and a cross-layer bilinear pooling module is introduced for classification. Finally, a random puzzle generator is introduced in the training process for progressive training, and the center loss (CL) and focal loss (FL) methods are used to further improve the effect of the final classification. The quadratic weighted Kappa (QWK) is 90.84% in the Indian Diabetic Retinopathy Image Dataset (IDRiD), and the area under the receiver operating characteristic curve (AUC) in the Messidor-2 dataset (Messidor-2) is 88.54%. Experiments show that the algorithm proposed in this paper has a certain application value in the field of diabetic retina grading.

Anomaly segmentation in retinal images with poisson-blending data augmentation

Diabetic retinopathy (DR) is one of the most important complications of diabetes. Accurate segmentation of DR lesions is of great importance for the early diagnosis of DR. However, simultaneous segmentation of multi-type DR lesions is technically challenging because of 1) the lack of pixel-level annotations and 2) the large diversity between different types of DR lesions. In this study, first, we propose a novel Poisson-blending data augmentation (PBDA) algorithm to generate synthetic images, which can be easily utilized to expand the existing training data for lesion segmentation. We perform extensive experiments to recognize the important attributes in the PBDA algorithm. We show that position constraints are of great importance and that the synthesis density of one type of lesion has a joint influence on the segmentation of other types of lesions. Second, we propose a convolutional neural network architecture, named DSR-U-Net++ (i.e., DC-SC residual U-Net++), for the simultaneous segmentation of multi-type DR lesions. Ablation studies showed that the mean area under precision recall curve (AUPR) for all four types of lesions increased by >5% with PBDA. The proposed DSR-U-Net++ with PBDA outperformed the state-of-the-art methods by 1.7%-9.9% on the Indian Diabetic Retinopathy Image Dataset (IDRiD) and 67.3% on the e-ophtha dataset with respect to mean AUPR. The developed method would be an efficient tool to generate large-scale task-specific training data for other medical anomaly segmentation tasks.

Gray wolf optimization-extreme learning machine approach for diabetic retinopathy detection.

Many works have employed Machine Learning (ML) techniques in the detection of Diabetic Retinopathy (DR), a disease that affects the human eye. However, the accuracy of most DR detection methods still need improvement. Gray Wolf Optimization-Extreme Learning Machine (GWO-ELM) is one of the most popular ML algorithms, and can be considered as an accurate algorithm in the process of classification, but has not been used in solving DR detection. Therefore, this work aims to apply the GWO-ELM classifier and employ one of the most popular features extractions, Histogram of Oriented Gradients-Principal Component Analysis (HOG-PCA), to increase the accuracy of DR detection system. Although the HOG-PCA has been tested in many image processing domains including medical domains, it has not yet been tested in DR. The GWO-ELM can prevent overfitting, solve multi and binary classifications problems, and it performs like a kernel-based Support Vector Machine with a Neural Network structure, whilst the HOG-PCA has the ability to extract the most relevant features with low dimensionality. Therefore, the combination of the GWO-ELM classifier and HOG-PCA features might produce an effective technique for DR classification and features extraction. The proposed GWO-ELM is evaluated based on two different datasets, namely APTOS-2019 and Indian Diabetic Retinopathy Image Dataset (IDRiD), in both binary and multi-class classification. The experiment results have shown an excellent performance of the proposed GWO-ELM model where it achieved an accuracy of 96.21% for multi-class and 99.47% for binary using APTOS-2019 dataset as well as 96.15% for multi-class and 99.04% for binary using IDRiD dataset. This demonstrates that the combination of the GWO-ELM and HOG-PCA is an effective classifier for detecting DR and might be applicable in solving other image data types.

Automated detection of diabetic retinopathy using custom convolutional neural network.

Diabetic retinopathy is an eye deficiency that affects retina as a result of the patient having diabetes mellitus caused by high sugar levels, which may eventually lead to macular edema. The objective of this study is to design and compare several deep learning models that detect severity of diabetic retinopathy, determine risk of leading to macular edema, and segment different types of disease patterns using retina images. Indian Diabetic Retinopathy Image Dataset (IDRiD) dataset was used for disease grading and segmentation. Since images of the dataset have different brightness and contrast, we employed three techniques for generating processed images from the original images, which include brightness, color and, contrast (BCC) enhancing, color jitters (CJ), and contrast limited adaptive histogram equalization (CLAHE). After image preporcessing, we used pre-trained ResNet50, VGG16, and VGG19 models on these different preprocessed images both for determining the severity of the retinopathy and also the chances of macular edema. UNet was also applied to segment different types of diseases. To train and test these models, image dataset was divided into training, testing, and validation data at 70%, 20%, and 10% ratios, respectively. During model training, data augmentation method was also applied to increase the number of training images. Study results show that for detecting the severity of retinopathy and macular edema, ResNet50 showed the best accuracy using BCC and original images with an accuracy of 60.2% and 82.5%, respectively, on validation dataset. In segmenting different types of diseases, UNet yielded the highest testing accuracy of 65.22% and 91.09% for microaneurysms and hard exudates using BCC images, 84.83% for optic disc using CJ images, 59.35% and 89.69% for hemorrhages and soft exudates using CLAHE images, respectively. Thus, image preprocessing can play an important role to improve efficacy and performance of deep learning models.

A Transfer Learning Approach for Diabetic Retinopathy and Diabetic Macular Edema Severity Grading

Diabetic Retinopathy (DR) and Diabetic Macular Edema (DME) are complication that occurs in diabetic patient especially among working age group that leads to vision impairment problem and sometimes even permanent blindness. Early detection is very much needed for diagnosis and to reduce blindness or deterioration. The diagnosis phase of DR consumes more time, effort and cost when manually performed by ophthalmologists and more chances of misdiagnosis still there. Research community is working on to design computer aided diagnosis system for prior detection and for DR grading based on its severity. Ongoing researches in Artificial Intelligence (AI) have set out the advancement of deep learning technique which comes as a best technique to perform analysis and classification of medical images. In this paper, research is applied on Resnet50 model for classification of DR and DME based on its severity grading on public benchmark dataset. Transfer learning approach accomplishes the best outcome on Indian Diabetic Retinopathy Image Dataset (IDRiD).

Convolutional neural-network-based classification of retinal images with different combinations of filtering techniques

Abstract Retinal image analysis is one of the important diagnosis methods in modern ophthalmology because eye information is present in the retina. The image acquisition process may have some effects and can affect the quality of the image. This can be improved by better image enhancement techniques combined with the computer-aided diagnosis system. Deep learning is one of the important computational application techniques used for a medical imaging application. The main aim of this article is to find the best enhancement techniques for the identification of diabetic retinopathy (DR) and are tested with the commonly used deep learning techniques, and the performances are measured. In this article, the input image is taken from the Indian-based database named as Indian Diabetic Retinopathy Image Dataset, and 13 filters are used including smoothing and sharpening filters for enhancing the images. Then, the quality of the enhancement techniques is compared using performance metrics and better results are obtained for Median, Gaussian, Bilateral, Wiener, and partial differential equation filters and are combined for improving the enhancement of images. The output images from all the enhanced filters are given as the convolutional neural network input and the results are compared to find the better enhancement method.

Systematic Comparison of Heatmapping Techniques in Deep Learning in the Context of Diabetic Retinopathy Lesion Detection.

PurposeHeatmapping techniques can support explainability of deep learning (DL) predictions in medical image analysis. However, individual techniques have been mainly applied in a descriptive way without an objective and systematic evaluation. We investigated comparative performances using diabetic retinopathy lesion detection as a benchmark task.MethodsThe Indian Diabetic Retinopathy Image Dataset (IDRiD) publicly available database contains fundus images of diabetes patients with pixel level annotations of diabetic retinopathy (DR) lesions, the ground truth for this study. Three in advance trained DL models (ResNet50, VGG16 or InceptionV3) were used for DR detection in these images. Next, explainability was visualized with each of the 10 most used heatmapping techniques. The quantitative correspondence between the output of a heatmap and the ground truth was evaluated with the Explainability Consistency Score (ECS), a metric between 0 and 1, developed for this comparative task.ResultsIn case of the overall DR lesions detection, the ECS ranged from 0.21 to 0.51 for all model/heatmapping combinations. The highest score was for VGG16+Grad-CAM (ECS = 0.51; 95% confidence interval [CI]: [0.46; 0.55]). For individual lesions, VGG16+Grad-CAM performed best on hemorrhages and hard exudates. ResNet50+SmoothGrad performed best for soft exudates and ResNet50+Guided Backpropagation performed best for microaneurysms.ConclusionsOur empirical evaluation on the IDRiD database demonstrated that the combination DL model/heatmapping affects explainability when considering common DR lesions. Our approach found considerable disagreement between regions highlighted by heatmaps and expert annotations.Translational RelevanceWe warrant a more systematic investigation and analysis of heatmaps for reliable explanation of image-based predictions of deep learning models.

Deep Learning Grading System for Diabetic Retinopathy using Fundus Images. (Dept. E)

Diabetic Retinopathy (DR) is one of the main causes of blindness that can be overcome, if it is early detected. This work proposes an automated early detection and grading of DR using fundus images. The proposed detection and grading system investigate different deep learning architectures (i.e., ResNet and AlexNet) that are applied to an augment data to extract deep compact features of the fundus images. The extracted features are input to a pixel-wise Neural Network (NN) classifier or a Support Vector Machine (SVM) classifier for automated DR grading. The performance of the proposed system is evaluated using a publically available fundus Indian Diabetic Retinopathy Image Dataset (IDRiD), collected for ISBI-2018 challenge. The IDRiD dataset consists of 516 retinal images of normal and different DR grades, i.e., mild, moderate, severe, and Proliferative Diabetic Retinopathy (PDR). Our system achieves an overall accuracy of 95.73%, sensitivity of 95.73%, and specificity of 98.51% utilizing an AlexNet-based architecture and a pixel-wise NN classifier. Compared to the previous related work, the proposed system shows promising DR grading performance.

An Integrated System for Detection Exudates and Severity Quantification for Diabetic Macular Edema

The prevalence of vision loss because of Diabetic macular edema (DME), which is a complication caused by diabetes mellitus, is increasing. Seven per cent of Indian diabetic population suffer from DME or damage to macula. The study proposes an integrated model to contribute to the prevention of loss of visual acuity. For detection of exudates and visualization of severity of DME image processing, machine learning and data analysis strategies are used. Experimentation on Indian population is done using Indian Diabetic Eye Diseases Dataset (IDEDD), acquired from metropolitan region of Mumbai and publicly available Indian Diabetic Retinopathy Image Dataset (IDRiD, Nanded) and a standard public database DIARETDB1- Standard Diabetic Retinopathy Database. To negate the effect of increase in the dimensionality and overfitting of the dataset parameters, a tree-based forward search algorithm for optimal feature subset identification is proposed. This provides global insight of effect of the statistical and spatial features on model behaviour. Machine learning algorithms of random forest and support vector machine are used for classification. The sensitivity and specificity of 97.1% and 100% is achieved for IDEDD data. Severity grading is done using image processing for segmenting the vessel mesh, optic disk, and macula from the abnormal retinal scans for detecting clinically significant macular edema by visualizing exudates. The distance between optic disc—fovea (OF) and the ratio of distance (OF) to that of disc diameter is formulated for localization of macula. Region-based and distance-based grading methods for quantification of the severity and visualization are implemented. The proposed algorithm enables the building of a predictive model for primordial and secondary prevention of DME with high classification accuracy and visualization of severity grading.

Automatic Segmentation of Microaneurysm in Retinal Fundus Images

Diabetes interferes with the body’s ability to use and store sugar (glucose), which it can cause damage throughout the body. Generally, Microaneurysm (MA) is the first clinically observable lesions in the Diabetic Retinopathy (DR). Since interference of biological objects in eye fundus images are similar to MA, locate Microaneurysm lesions precisely is a challenging task for researches. This research employs U-Net Convolutional Neural Network to model saliency of objects in images, global and local context are both taken into account to provide a better initialization for the process. Feature extraction techniques are applied first to assign a local saliency value to each pixel by considering its local context from fundus images such as ORB, SURF, and MSER. The extracted feature vectors are applied for training the network. The sum of the weighted salient object regions produce the final saliency map, then implements U-Net to segment MA lesions.Our experiment has carried out using the publicly available Indian Diabetic Retinopathy Image Dataset (IDRiD), which has used in "Diabetic Retinopathy: Segmentation and Grading Challenge" workshop and our proposed method has given an outstanding accuracy of 98.78 %.

IDRiD: Diabetic Retinopathy - Segmentation and Grading Challenge.

Diabetic Retinopathy (DR) is the most common cause of avoidable vision loss, predominantly affecting the working-age population across the globe. Screening for DR, coupled with timely consultation and treatment, is a globally trusted policy to avoid vision loss. However, implementation of DR screening programs is challenging due to the scarcity of medical professionals able to screen a growing global diabetic population at risk for DR. Computer-aided disease diagnosis in retinal image analysis could provide a sustainable approach for such large-scale screening effort. The recent scientific advances in computing capacity and machine learning approaches provide an avenue for biomedical scientists to reach this goal. Aiming to advance the state-of-the-art in automatic DR diagnosis, a grand challenge on "Diabetic Retinopathy - Segmentation and Grading" was organized in conjunction with the IEEE International Symposium on Biomedical Imaging (ISBI - 2018). In this paper, we report the set-up and results of this challenge that is primarily based on Indian Diabetic Retinopathy Image Dataset (IDRiD). There were three principal sub-challenges: lesion segmentation, disease severity grading, and localization of retinal landmarks and segmentation. These multiple tasks in this challenge allow to test the generalizability of algorithms, and this is what makes it different from existing ones. It received a positive response from the scientific community with 148 submissions from 495 registrations effectively entered in this challenge. This paper outlines the challenge, its organization, the dataset used, evaluation methods and results of top-performing participating solutions. The top-performing approaches utilized a blend of clinical information, data augmentation, and an ensemble of models. These findings have the potential to enable new developments in retinal image analysis and image-based DR screening in particular.

Automatic screening of fundus images using a combination of convolutional neural network and hand-crafted features.

Diabetic retinopathy (DR) and especially diabetic macular edema (DME) are common causes of vision loss as complications of diabetes. In this work, we consider an ensemble that organizes a convolutional neural network (CNN) and traditional hand-crafted features into a single architecture for retinal image classification. This approach allows the joint training of a CNN and the fine-tuning of the weights of handcrafted features to provide a final prediction. Our solution is dedicated to the automatic classification of fundus images according to the severity level of DR and DME. For an objective evaluation of our approach, we have tested its performance on the official test datasets of the IEEE International Symposium on Biomedical Imaging (ISBI) 2018 Challenge 2: Diabetic Retinopathy Segmentation and Grading Challenge, section B. Disease Grading: Classification of fundus images according to the severity level of diabetic retinopathy and diabetic macular edema. As for our experimental results based on testing on the Indian Diabetic Retinopathy Image Dataset (IDRiD), the classification accuracies have been found to be 90.07% for the 5-class DR challenge, and 96.85% for the 3-class DME one.